Renaissance Technologies Llc reports 16.51% decrease in ownership of VRTX / Vertex Pharmaceuticals Incorporated

福泰製藥公司

US ˙ NasdaqGS ˙ US92532F1003

Security	VRTX / Vertex Pharmaceuticals Incorporated
Institution	Renaissance Technologies Llc
Manager	James Simons
Latest Disclosed Ownership	421,688 shares
Latest Disclosed Value	$ 188,300,560

On May 14, 2026 - Renaissance Technologies Llc filed a 13F-HR form disclosing ownership of 421,688 shares of Vertex Pharmaceuticals Incorporated (US:VRTX) valued at $188,300,560 USD as of March 31, 2026. The entity filed a previous 13F-HR on February 12, 2026 disclosing 505,048 shares of Vertex Pharmaceuticals Incorporated. This represents a change in shares of -16.51% during the quarter. The current value of the position is $186,276,457 USD.

Institutional Ownership: 13F and NPORT Filings

The Security and Class in the table below are shown exactly as filed by the investor. We do our best to track continuity of investments through acquisitions, and this will be reflected in the table as changes in names. In addition to descriptive data, performance of the investment is shown over time. To calculate quarterly performance, we first calculate cost basis of the shares purchased during the quarter, then use that to calculate gross profit. Quarterly return is Gross Profit / Starting Portfolio value.

Note that cost basis is calculated and stored in thousands, so small quarterly changes in shares frequently result in a cost basis of zero.

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Disclosed Equity Positions (from 13F/NPORT Filings)

File Date	Effective Date	Form	Security	Class	ID	Reported Shares	ΔShares	ΔShares (%)	Reported Value (x1000)	ΔValue (%)	Alloc (%)
2026-05-14	2026-03-31	13F	VERTEX PHARMACEUTICALS	COM	92532F100	421,688	-83,360	-16.51	188,301	-17.76	0.2945
2026-02-12	2025-12-31	13F	VERTEX PHARMACEUTICALS	COM	92532F100	505,048	-230,840	-31.37	228,969	-20.55	0.3552
2025-11-13	2025-09-30	13F	VERTEX PHARMACEUTICALS	COM	92532F100	735,888	-269,000	-26.77	288,203	-35.58	0.3805
2025-08-13	2025-06-30	13F	VERTEX PHARMACEUTICALS	COM	92532F100	1,004,888	-166,683	-14.23	447,376	-21.24	0.5951
2025-05-14	2025-03-31	13F	VERTEX PHARMACEUTICALS	COM	92532F100	1,171,571	-225,638	-16.15	568,001	0.95	0.8597
2025-02-13	2024-12-31	13F	VERTEX PHARMACEUTICALS	COM	92532F100	1,397,209	-234,284	-14.36	562,656	-25.85	0.8329
2024-11-13	2024-09-30	13F	VERTEX PHARMACEUTICALS	COM	92532F100	1,631,493	65,105	4.16	758,775	3.35	1.1411
2024-08-09	2024-06-30	13F	VERTEX PHARMACEUTICALS	COM	92532F100	1,566,388	-14,100	-0.89	734,197	111,141.97	1.2453
2024-05-13	2024-03-31	13F	VERTEX PHARMACEUTICALS	COM	92532F100	1,580,488	-11,200	-0.70	661	2.01	1.0384
2024-02-13	2023-12-31	13F	VERTEX PHARMACEUTICALS	COM	92532F100	1,591,688	-72,400	-4.35	648	11.94	1.0024
2023-11-14	2023-09-30	13F	VERTEX PHARMACEUTICALS	COM	92532F100	1,664,088	391,927	30.81	579	29.31	0.9866
2023-08-11	2023-06-30	13F	VERTEX PHARMACEUTICALS	COM	92532F100	1,272,161	-125,574	-8.98	448	1.59	0.6452
2023-05-12	2023-03-31	13F	VERTEX PHARMACEUTICALS	COM	92532F100	1,397,735	-849,017	-37.79	440	-32.10	0.5844
2023-02-13	2022-12-31	13F	VERTEX PHARMACEUTICALS	COM	92532F100	2,246,752	107,867	5.04	649	-99.90	0.8877
2022-11-14	2022-09-30	13F	VERTEX PHARMACEUTICALS	COM	92532F100	2,138,885	377,717	21.45	619,293	24.79	0.8761
2022-08-12	2022-06-30	13F	VERTEX PHARMACEUTICALS	COM	92532F100	1,761,168	53,800	3.15	496,280	11.38	0.5875
2022-05-13	2022-03-31	13F	VERTEX PHARMACEUTICALS	COM	92532F100	1,707,368	80,500	4.95	445,572	24.72	0.5229
2022-02-11	2021-12-31	13F	VERTEX PHARMACEUTICALS	COM	92532F100	1,626,868	-264,618	-13.99	357,260	4.13	0.4445
2021-11-12	2021-09-30	13F	VERTEX PHARMACEUTICALS	COM	92532F100	1,891,486	-385,798	-16.94	343,097	-25.28	0.4431
2021-08-13	2021-06-30	13F	VERTEX PHARMACEUTICALS	COM	92532F100	2,277,284	-123,000	-5.12	459,169	-10.98	0.5732
2021-05-13	2021-03-31	13F	VERTEX PHARMACEUTICALS	COM	92532F100	2,400,284	-1,175,646	-32.88	515,797	-38.97	0.6417
2021-02-10	2020-12-31	13F	VERTEX PHARMACEUTICALS	COM	92532F100	3,575,930	-1,631,002	-31.32	845,135	-40.35	0.9177
2020-11-13	2020-09-30	13F	VERTEX PHARMACEUTICALS	COM	92532F100	5,206,932	-574,400	-9.94	1,416,910	-15.58	1.4148
2020-08-13	2020-06-30	13F	VERTEX PHARMACEUTICALS	COM	92532F100	5,781,332	-1,078,350	-15.72	1,678,378	2.83	1.4489
2020-05-14	2020-03-31	13F	VERTEX PHARMACEUTICALS	COM	92532F100	6,859,682	-216,900	-3.07	1,632,261	5.35	1.5853
2020-02-13	2019-12-31	13F	VERTEX PHARMACEUTICALS	COM	92532F100	7,076,582	1,277,465	22.03	1,549,418	57.70	1.1907
2019-11-13	2019-09-30	13F	VERTEX PHARMACEUTICALS	COM	92532F100	5,799,117	243,300	4.38	982,486	-3.57	0.8316
2019-08-12	2019-06-30	13F	VERTEX PHARMACEUTICALS	COM	92532F100	5,555,817	477,100	9.39	1,018,826	9.06	0.8970
2019-05-14	2019-03-31	13F	VERTEX PHARMACEUTICALS	COM	92532F100	5,078,717	744,417	17.18	934,230	30.07	0.8493
2019-02-12	2018-12-31	13F	VERTEX PHARMACEUTICALS	COM	92532F100	4,334,300	245,183	6.00	718,237	-8.87	0.7864
2018-11-13	2018-09-30	13F	VERTEX PHARMACEUTICALS	COM	92532F100	4,089,117	38,500	0.95	788,136	14.48	0.8103
2018-08-13	2018-06-30	13F/A-1	VERTEX PHARMACEUTICALS	COM	92532F100	4,050,617	1,199,700	42.08	688,443	48.17	0.7504
2018-08-13	2018-06-30	13F	VERTEX PHARMACEUTICALS	COM	92532F100	2,850,917			464,642
2018-05-14	2018-03-31	13F	VERTEX PHARMACEUTICALS	COM	92532F100	2,850,917	3,000	0.11	464,642	8.87	0.5081
2018-02-13	2017-12-31	13F	VERTEX PHARMACEUTICALS	COM	92532F100	2,847,917	1,479,897	108.18	426,789	105.19	0.4705
2017-11-13	2017-09-30	13F	VERTEX PHARMACEUTICALS	COM	92532F100	1,368,020	1,346,320	6,204.24	207,994	7,338.98	0.2448
2017-08-11	2017-06-30	13F	VERTEX PHARMACEUTICALS	COM	92532F100	21,700	-18,417	-45.91	2,796	-36.27	0.0036
2017-05-12	2017-03-31	13F	VERTEX PHARMACEUTICALS	COM	92532F100	40,117	40,117		4,387		0.0061
2016-11-14	2016-09-30	13F	VERTEX PHARMACEUTICALS	COM	92532F100	0	-60,517	-100.00	0	-100.00
2016-08-12	2016-06-30	13F	VERTEX PHARMACEUTICALS	COM	92532F100	60,517	-52,100	-46.26	5,206	-41.85	0.0099
2016-05-13	2016-03-31	13F	VERTEX PHARMACEUTICALS	COM	92532F100	112,617	51,300	83.66	8,952	16.02	0.0170
2016-02-11	2015-12-31	13F	VERTEX PHARMACEUTICALS	COM	92532F100	61,317	61,317	-45.55	7,716	-13.81	0.0168
2015-08-14	2015-06-30	13F	VERTEX PHARMACEUTICALS	COM	92532F100	0	-159,317	-100.00	0	-100.00
2015-05-13	2015-03-31	13F	VERTEX PHARMACEUTICALS	COM	92532F100	159,317	-152,847	-48.96	18,795	-14.86	0.0400
2014-05-14	2014-03-31	13F	VERTEX PHARMACEUTICALS	COM	92532F100	312,164	312,164	95.94	22,076	17.46	0.0529
2014-02-14	2013-12-31	13F	VERTEX PHARMACEUTICALS	COM	92532F100	0	-139,220	-100.00	0	-100.00
2013-11-13	2013-09-30	13F	VERTEX PHARMACEUTICALS	COM	92532F100	139,220	139,220		10,556		0.0256

Legend

Shares: The total number of shares held by the institution at the end of the reporting period (the effective date). This is provided in the filing.
Value: The total value of the shares as of the effective date. This is provided in the filing.
Avg. Share Price: The weighted average share price of the shares held by the institution. We use FIFO accounting to determine this price
Class: This is the security class as indicated by the filer. There are a variety of values for this field. Common values include "EC" = equity common, "EP" - equity preferred

Allocation (%): The percent of the institution's portfolio that this position represents. This is provided in NPORT filings. For 13F filings, we calculate it.
Change in Allocation: The change in allocation from the prior reporting period. This is calculated as current allocation - prior allocation.
Change in Allocation (%): The percent change in allocation from the prior reporting period. This is calculated as (current allocation - prior allocation) / prior allocation.
Cost Basis: The total cost of the shares held. This is calculated as reported shares * avg. share price
Unrealized Gain/Loss: This is the market value of the position as of the effective date minus the cost basis.