泰莎基因療法公司
US ˙ NasdaqGS ˙ US8776191061

SecurityTSHA / Taysha Gene Therapies, Inc.
InstitutionState Street Corp
Latest Disclosed Ownership11,209,078 shares
Latest Disclosed Value $ 50,104,579
State Street Corp reports 3.88% increase in ownership of TSHA / Taysha Gene Therapies, Inc.

On May 15, 2026 - State Street Corp filed a 13F-HR form disclosing ownership of 11,209,078 shares of Taysha Gene Therapies, Inc. (US:TSHA) valued at $50,104,579 USD as of March 31, 2026. The entity filed a previous 13F-HR on February 13, 2026 disclosing 10,790,084 shares of Taysha Gene Therapies, Inc.. This represents a change in shares of 3.88% during the quarter. The current value of the position is $61,649,929 USD.

Institutional Ownership: 13F and NPORT Filings

The Security and Class in the table below are shown exactly as filed by the investor. We do our best to track continuity of investments through acquisitions, and this will be reflected in the table as changes in names. In addition to descriptive data, performance of the investment is shown over time. To calculate quarterly performance, we first calculate cost basis of the shares purchased during the quarter, then use that to calculate gross profit. Quarterly return is Gross Profit / Starting Portfolio value.

Note that cost basis is calculated and stored in thousands, so small quarterly changes in shares frequently result in a cost basis of zero.

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Disclosed Equity Positions (from 13F/NPORT Filings)
File
Date		 Effective
Date		Form Security Class ID Avg Price
Paid (Est)		 Reported
Shares		 ΔShares ΔShares
(%)		 Reported
Value
(x1000)		 ΔValue
(%)		 Alloc
(%)		 ΔAlloc ΔAlloc (%) Cost Basis
(x1000)		 Unrealized
Gain/Loss
(x1000)
2026-05-15 2026-03-31 13F TAYSHA GENE THERAPIES COM SHS 877619106 11,209,078 418,994 3.88 50,105 -15.57 0.0017
2026-02-13 2025-12-31 13F TAYSHA GENE THERAPIES COM SHS 877619106 10,790,084 3,553,619 49.11 59,345 150.79 0.0020
2025-11-14 2025-09-30 13F TAYSHA GENE THERAPIES COM SHS 877619106 7,236,465 2,098,155 40.83 23,663 99.37 0.0008
2025-08-14 2025-06-30 13F TAYSHA GENE THERAPIES COM SHS 877619106 5,138,310 1,904,798 58.91 11,869 164.11 0.0004
2025-05-15 2025-03-31 13F TAYSHA GENE THERAPIES COM SHS 877619106 3,233,512 -3,240,855 -50.06 4,495 -59.87 0.0002
2025-02-14 2024-12-31 13F TAYSHA GENE THERAPIES COM SHS 877619106 6,474,367 3,005,299 86.63 11,201 60.64 0.0004
2024-11-14 2024-09-30 13F TAYSHA GENE THERAPIES COM SHS 877619106 3,469,068 150,647 4.54 6,973 -6.20 0.0003
2024-08-14 2024-06-30 13F TAYSHA GENE THERAPIES COM SHS 877619106 3,318,421 2,978,901 877.39 7,433 663.14 0.0003
2024-05-15 2024-03-31 13F TAYSHA GENE THERAPIES COM SHS 877619106 339,520 196,300 137.06 974 284.98 0.0000
2024-02-14 2023-12-31 13F TAYSHA GENE THERAPIES COM SHS 877619106 143,220 3,200 2.29 253 -42.76 0.0000
2023-11-14 2023-09-30 13F TAYSHA GENE THERAPIES COM SHS 877619106 140,020 25,100 21.84 442 489.33 0.0000
2023-08-14 2023-06-30 13F TAYSHA GENE THERAPIES COM SHS 877619106 114,920 0 0.00 76 -17.58 0.0000
2023-05-15 2023-03-31 13F TAYSHA GENE THERAPIES COM SHS 877619106 114,920 0 0.00 92 -64.86 0.0000
2023-05-15 2022-12-31 13F/A-99 TAYSHA GENE THERAPIES COM SHS 877619106 114,920 37,500 48.44 260 73.83 0.0000
2023-05-15 2022-12-31 13F TAYSHA GENE THERAPIES COM SHS 877619106 114,920 37,500 260 0.0000
2022-11-15 2022-09-30 13F TAYSHA GENE THERAPIES COM SHS 877619106 77,420 0 0.00 149 -48.26 0.0000
2022-08-15 2022-06-30 13F TAYSHA GENE THERAPIES COM SHS 877619106 77,420 -421,794 -84.49 288 -91.15 0.0000
2022-05-16 2022-03-31 13F TAYSHA GENE THERAPIES COM SHS 877619106 499,214 35,045 7.55 3,255 -39.81 0.0002
2022-02-14 2021-12-31 13F TAYSHA GENE THERAPIES COM SHS 877619106 464,169 111,983 31.80 5,408 -17.54 0.0003
2021-11-15 2021-09-30 13F TAYSHA GENE THERAPIES COM SHS 877619106 352,186 33,567 10.54 6,558 -2.92 0.0003
2021-08-16 2021-06-30 13F TAYSHA GENE THERAPIES COM SHS 877619106 318,619 196,478 160.86 6,755 172.49 0.0004
2021-07-09 2021-03-31 13F/A-1 TAYSHA GENE THERAPIES COM SHS 877619106 122,141 12,035 10.93 2,479 -15.16 0.0001
2021-05-17 2021-03-31 13F TAYSHA GENE THERAPIES COM SHS 877619106 122,141 12,035 2,479 0.0001
2021-02-16 2020-12-31 13F TAYSHA GENE THERAPIES COM SHS 877619106 110,106 110,106 2,922 0.0002
Legend
Shares
The total number of shares held by the institution at the end of the reporting period (the effective date). This is provided in the filing.
Value
The total value of the shares as of the effective date. This is provided in the filing.
Avg. Share Price
The weighted average share price of the shares held by the institution. We use FIFO accounting to determine this price
Class
This is the security class as indicated by the filer. There are a variety of values for this field. Common values include "EC" = equity common, "EP" - equity preferred
Allocation (%)
The percent of the institution's portfolio that this position represents. This is provided in NPORT filings. For 13F filings, we calculate it.
Change in Allocation
The change in allocation from the prior reporting period. This is calculated as current allocation - prior allocation.
Change in Allocation (%)
The percent change in allocation from the prior reporting period. This is calculated as (current allocation - prior allocation) / prior allocation.
Cost Basis
The total cost of the shares held. This is calculated as reported shares * avg. share price
Unrealized Gain/Loss
This is the market value of the position as of the effective date minus the cost basis.