Alnylam 製藥公司
DE ˙ XTRA ˙ US02043Q1076
€260.50 ↑8.70 (3.46%)
2026-06-04
分享價格
SecurityDE:DUL / Alnylam Pharmaceuticals, Inc.
InstitutionState Street Corp
Latest Disclosed Ownership3,322,698 shares
Latest Disclosed Value $ 1,099,381,087
State Street Corp reports 2.90% increase in ownership of DUL / Alnylam Pharmaceuticals, Inc.

On May 15, 2026 - State Street Corp filed a 13F-HR form disclosing ownership of 3,322,698 shares of Alnylam Pharmaceuticals, Inc. (DE:DUL) valued at $949,294,819 USD as of March 31, 2026. The entity filed a previous 13F-HR on February 13, 2026 disclosing 3,228,956 shares of Alnylam Pharmaceuticals, Inc.. This represents a change in shares of 2.90% during the quarter. The current value of the position is $865,562,829 USD.

Institutional Ownership: 13F and NPORT Filings

The Security and Class in the table below are shown exactly as filed by the investor. We do our best to track continuity of investments through acquisitions, and this will be reflected in the table as changes in names. In addition to descriptive data, performance of the investment is shown over time. To calculate quarterly performance, we first calculate cost basis of the shares purchased during the quarter, then use that to calculate gross profit. Quarterly return is Gross Profit / Starting Portfolio value.

Note that cost basis is calculated and stored in thousands, so small quarterly changes in shares frequently result in a cost basis of zero.

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Disclosed Equity Positions (from 13F/NPORT Filings)
File
Date		 Effective
Date		Form Security Class ID Avg Price
Paid (Est)		 Reported
Shares		 ΔShares ΔShares
(%)		 Reported
Value
(x1000)		 ΔValue
(%)		 Alloc
(%)		 ΔAlloc ΔAlloc (%) Cost Basis
(x1000)		 Unrealized
Gain/Loss
(x1000)
2026-05-15 2026-03-31 13F ALNYLAM PHARMACEUTICALS COM 02043Q107 3,322,698 93,742 2.90 1,099,381 -14.38 0.0380
2026-02-13 2025-12-31 13F ALNYLAM PHARMACEUTICALS COM 02043Q107 3,228,956 147,481 4.79 1,283,994 -8.62 0.0431
2025-11-14 2025-09-30 13F ALNYLAM PHARMACEUTICALS COM 02043Q107 3,081,475 -91,630 -2.89 1,405,153 35.80 0.0487
2025-08-14 2025-06-30 13F ALNYLAM PHARMACEUTICALS COM 02043Q107 3,173,105 -193,478 -5.75 1,034,718 13.82 0.0388
2025-05-15 2025-03-31 13F ALNYLAM PHARMACEUTICALS COM 02043Q107 3,366,583 -56,294 -1.64 909,045 12.86 0.0375
2025-02-14 2024-12-31 13F ALNYLAM PHARMACEUTICALS COM 02043Q107 3,422,877 -45,438 -1.31 805,462 -15.56 0.0318
2024-11-14 2024-09-30 13F ALNYLAM PHARMACEUTICALS COM 02043Q107 3,468,315 -66,521 -1.88 953,891 11.05 0.0388
2024-08-14 2024-06-30 13F ALNYLAM PHARMACEUTICALS COM 02043Q107 3,534,836 343,463 10.76 858,965 80.10 0.0375
2024-05-15 2024-03-31 13F ALNYLAM PHARMACEUTICALS COM 02043Q107 3,191,373 72,821 2.34 476,951 -20.10 0.0213
2024-02-14 2023-12-31 13F ALNYLAM PHARMACEUTICALS COM 02043Q107 3,118,552 219,039 7.55 596,922 16.25 0.0290
2023-11-14 2023-09-30 13F ALNYLAM PHARMACEUTICALS COM 02043Q107 2,899,513 7,266 0.25 513,504 -6.53 0.0285
2023-08-14 2023-06-30 13F ALNYLAM PHARMACEUTICALS COM 02043Q107 2,892,247 37,366 1.31 549,353 -3.94 0.0289
2023-05-15 2023-03-31 13F ALNYLAM PHARMACEUTICALS COM 02043Q107 2,854,881 68,339 2.45 571,885 -13.64 0.0323
2023-05-15 2022-12-31 13F/A-99 ALNYLAM PHARMACEUTICALS COM 02043Q107 2,786,542 -8,943 -0.32 662,222 18.35 0.0389
2023-05-15 2022-12-31 13F ALNYLAM PHARMACEUTICALS COM 02043Q107 2,786,542 -8,943 662,222 0.0389
2022-11-15 2022-09-30 13F ALNYLAM PHARMACEUTICALS COM 02043Q107 2,795,485 -193,374 -6.47 559,544 28.36 0.0354
2022-08-15 2022-06-30 13F ALNYLAM PHARMACEUTICALS COM 02043Q107 2,988,859 79,369 2.73 435,925 -8.24 0.0261
2022-05-16 2022-03-31 13F ALNYLAM PHARMACEUTICALS COM 02043Q107 2,909,490 59,101 2.07 475,091 -1.71 0.0235
2022-02-14 2021-12-31 13F ALNYLAM PHARMACEUTICALS COM 02043Q107 2,850,389 49,564 1.77 483,369 -8.60 0.0229
2021-11-15 2021-09-30 13F ALNYLAM PHARMACEUTICALS COM 02043Q107 2,800,825 15,887 0.57 528,824 12.01 0.0280
2021-08-16 2021-06-30 13F ALNYLAM PHARMACEUTICALS COM 02043Q107 2,784,938 154,082 5.86 472,103 27.10 0.0249
2021-07-09 2021-03-31 13F/A-1 ALNYLAM PHARMACEUTICALS COM 02043Q107 2,630,856 -173,848 -6.20 371,451 1.90 0.0213
2021-05-17 2021-03-31 13F ALNYLAM PHARMACEUTICALS COM 02043Q107 2,630,856 -173,848 371,451 0.0213
2021-02-16 2020-12-31 13F ALNYLAM PHARMACEUTICALS COM 02043Q107 2,804,704 12,552 0.45 364,527 -10.33 0.0223
2020-11-10 2020-09-30 13F ALNYLAM PHARMACEUTICALS COM 02043Q107 2,792,152 4,506 0.16 406,537 -1.54 0.0278
2020-08-14 2020-06-30 13F ALNYLAM PHARMACEUTICALS COM 02043Q107 2,787,646 -196,495 -6.58 412,878 27.11 0.0300
2020-06-19 2020-03-31 13F/A-1 ALNYLAM PHARMACEUTICALS COM 02043Q107 2,984,141 85,603 2.95 324,824 -2.70 0.0284
2020-05-11 2020-03-31 13F ALNYLAM PHARMACEUTICALS COM 02043Q107 2,984,141 85,603 324,824 28,526.0876
2020-02-06 2019-12-31 13F ALNYLAM PHARMACEUTICALS COM 02043Q107 2,898,538 -102,619 -3.42 333,825 38.31 0.0229
2019-11-14 2019-09-30 13F ALNYLAM PHARMACEUTICALS COM 02043Q107 3,001,157 108,000 3.73 241,353 14.97 0.0180
2019-08-14 2019-06-30 13F ALNYLAM PHARMACEUTICALS COM 02043Q107 2,893,157 144,663 5.26 209,927 -18.27 0.0157
2019-05-15 2019-03-31 13F ALNYLAM PHARMACEUTICALS COM 02043Q107 2,748,494 343,759 14.30 256,847 46.49 0.0200
2019-02-12 2018-12-31 13F ALNYLAM PHARMACEUTICALS COM 02043Q107 2,404,735 17,161 0.72 175,329 -16.10 0.0160
2018-11-09 2018-09-30 13F ALNYLAM PHARMACEUTICALS Common equity shares 02043Q107 2,387,574 137,332 6.10 208,978 -5.71 0.0160
2018-08-14 2018-06-30 13F ALNYLAM PHARMACEUTICALS Common equity shares 02043Q107 2,250,242 118,425 5.56 221,627 -12.71 0.0185
2018-05-15 2018-03-31 13F ALNYLAM PHARMACEUTICALS Common equity shares 02043Q107 2,131,817 129,428 6.46 253,903 -0.20 0.0216
2018-02-14 2017-12-31 13F ALNYLAM PHARMACEUTICALS Common equity shares 02043Q107 2,002,389 -40,932 -2.00 254,402 5.97 0.0205
2017-11-14 2017-09-30 13F ALNYLAM PHARMACEUTICALS Common equity shares 02043Q107 2,043,321 106,170 5.48 240,063 55.37 0.0207
2017-08-14 2017-06-30 13F ALNYLAM PHARMACEUTICALS Common equity shares 02043Q107 1,937,151 -229,081 -10.58 154,514 39.17 0.0137
2017-05-15 2017-03-31 13F ALNYLAM PHARMACEUTICALS Common equity shares 02043Q107 2,166,232 -195,766 -8.29 111,022 25.55 0.0099
2017-02-09 2016-12-31 13F ALNYLAM PHARMACEUTICALS Common equity shares 02043Q107 2,361,998 28,822 1.24 88,430 -44.08 0.0083
2017-01-13 2016-09-30 13F/A-1 ALNYLAM PHARMACEUTICALS Common equity shares 02043Q107 2,333,176 137,672 6.27 158,145 29.81 0.0159
2016-11-14 2016-09-30 13F ALNYLAM PHARMACEUTICALS Common equity shares 02043Q107 2,318,116 157,125
2016-08-12 2016-06-30 13F ALNYLAM PHARMACEUTICALS Common equity shares 02043Q107 2,195,504 258,984 13.37 121,832 0.23 0.0131
2016-05-20 2016-03-31 13F/A-1 ALNYLAM PHARMACEUTICALS Common equity shares 02043Q107 1,936,520 262,783 15.70 121,553 -22.86 0.0131
2016-05-12 2016-03-31 13F ALNYLAM PHARMACEUTICALS Common equity shares 02043Q107 1,936,520 121,553
2016-02-16 2015-12-31 13F ALNYLAM PHARMACEUTICALS Common equity shares 02043Q107 1,673,737 126,382 8.17 157,572 26.74 0.0172
2015-11-16 2015-09-30 13F ALNYLAM PHARMACEUTICALS Common equity shares 02043Q107 1,547,355 81,342 5.55 124,326 -29.26 0.0145
2015-08-13 2015-06-30 13F ALNYLAM PHARMACEUTICALS Common equity shares 02043Q107 1,466,013 305,414 26.32 175,746 45.02 0.0188
2015-05-15 2015-03-31 13F ALNYLAM PHARMACEUTICALS Common equity shares 02043Q107 1,160,599 89,989 8.41 121,190 16.69 0.0124
2015-02-11 2014-12-31 13F ALNYLAM PHARMACEUTICALS Common equity shares 02043Q107 1,070,610 -38,220 -3.45 103,852 19.91 0.0103
2014-11-12 2014-09-30 13F/A-1 ALNYLAM PHARMACEUTICALS Common equity shares 02043Q107 1,108,830 39,479 3.69 86,605 28.20 0.0093
2014-11-10 2014-09-30 13F ALNYLAM PHARMACEUTICALS Common equity shares 02043Q107 1,108,830 86,605
2014-08-12 2014-06-30 13F ALNYLAM PHARMACEUTICALS Common equity shares 02043Q107 1,069,351 -357,034 -25.03 67,555 -29.46 0.0073
2014-05-15 2014-03-31 13F/A-1 ALNYLAM PHARMACEUTICALS Common equity shares 02043Q107 1,426,385 10,979 0.78 95,773 5.19 0.0109
2014-05-13 2014-03-31 13F ALNYLAM PHARMACEUTICALS Common equity shares 02043Q107 1,426,885 95,807
2014-02-06 2013-12-31 13F/A-1 ALNYLAM PHARMACEUTICALS Common equity shares 02043Q107 1,415,406 -112,432 -7.36 91,049 -6.90 0.0101
2014-02-06 2013-12-31 13F ALNYLAM PHARMACEUTICALS Common equity shares 02043Q107 1,183,800 21,604
2013-11-12 2013-09-30 13F ALNYLAM PHARMACEUTICALS Common Stock 02043Q107 1,527,838 -60,471 -3.81 97,797 98.57 0.0121
2013-08-08 2013-06-30 13F ALNYLAM PHARMACEUTICALS Common Stock 02043Q107 1,588,309 1,588,309 49,251 0.0064
Legend
Shares
The total number of shares held by the institution at the end of the reporting period (the effective date). This is provided in the filing.
Value
The total value of the shares as of the effective date. This is provided in the filing.
Avg. Share Price
The weighted average share price of the shares held by the institution. We use FIFO accounting to determine this price
Class
This is the security class as indicated by the filer. There are a variety of values for this field. Common values include "EC" = equity common, "EP" - equity preferred
Allocation (%)
The percent of the institution's portfolio that this position represents. This is provided in NPORT filings. For 13F filings, we calculate it.
Change in Allocation
The change in allocation from the prior reporting period. This is calculated as current allocation - prior allocation.
Change in Allocation (%)
The percent change in allocation from the prior reporting period. This is calculated as (current allocation - prior allocation) / prior allocation.
Cost Basis
The total cost of the shares held. This is calculated as reported shares * avg. share price
Unrealized Gain/Loss
This is the market value of the position as of the effective date minus the cost basis.