| 內部人士股份 | 6,872,638 shares |
內部人士情緒分數
「內部人士情緒分數」用於查找被公司內部人士購入的公司。
它是一個複雜的多因素量化模型的結果，該模型能夠辨識具有最高內部人士累積持有水平的公司。該評分模型結合了內部人士在過去90天內購買的淨數量、總購買股份佔流通股比例，以及內部人士擁有的總股份的指標。該分數的範圍從0到100，數值越高表示相對於同行業而言具有更高程度的內部人士持股水平，50為平均值。
更新頻率：每日
高管情緒分數
「高管情緒分數」用於查找被公司管理層購入的公司。
根據定義，公司高管是公司內部人士，但與其他內部人士（10%的股東和董事會成員）不同，公司高管每天在公司工作，而且他們使用自己的資金進行交易。（10%的股東和董事會成員通常是基金經理，管理著其他人的資金。）因此，公司高管進行的內幕交易更為重要性，應該被適當地重視和關注。
如同「內部人士情緒分數」，「高管情緒分數」也是一個複雜的多因素量化模型的計算結果，該模型能夠辨識具有最高高管累積持有水平的公司。
更新頻率：每日
關鍵內部人士指標
此表格顯示了公司在各種內部人士指標上的排名。百分位數排名顯示了這家公司在美國市場與其他公司相比的表現。排名越高表明公司所處狀況越好。
舉例來說，一般認為內部人士的買入是一個積極的指標，因此具有更多內部人士買入的公司將排名高於那些內部人士買入較少（甚至有內部人士賣出）的公司。
內部人士買入淨數（排名）
N/A
內部人士買入淨數是過去90天內買入的內部人士總數減去賣出的內部人士總數。以百分位排名顯示（範圍從0到100%）。
內部人士買入佔流通股比例（排名）
N/A
內部人士買入佔流通股比例是內部人士在過去90天內購買的股份總數減去賣出的股份總數，除以總流通股數並乘以100。
內幕交易圖表
以下圖表顯示了Regulus Therapeutics Inc.內部人士交易。內部人士包括公司的高管、董事或重要投資者。一般而言，基於內幕、非公開信息進行交易是非法的。這並不意味著他們在自己的公司進行任何交易都是非法的。但是，他們必須透過Form 4向美國證券交易委員會（SEC）報告所有交易。
內部人員名單及盈利指標
這張表格顯示已知的內部人員名單，從向SEC披露的申報文件中自動生成。除了姓名、最近的職稱和董事、高管或10%擁有人的標誌外，我們還提供了最新披露的持股信息。此外，我們盡可能提供內部人的歷史交易表現。歷史交易表現是內部人士實際進行的公開市場購買交易表現的加權平均值。有關此計算方式的更多資訊，請查看YouTube網絡研討會。
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| 內部人士 | 平均收益（%） | 持股 數量 |
分拆 調整 |
|---|
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追蹤內部人士買入記錄 - 短期收益分析
在這一部分，我們分析了在 RGLS / Regulus Therapeutics Inc. 中進行的每筆非計劃的公開市場內部人士購買的盈利情況。這種分析有助於了解內部人士是否持續產生異常的回報，以及是否值得跟踪。該分析基於每筆交易後一年的情況， 結果僅為理論值。 .
以下表格顯示了最近的自動交易計劃之外的公開市場購買。
經調整價格 已按拆股調整。 經調整股數 已按拆股調整。
追蹤內部人士賣出記錄 - 短期虧損分析
在這一部分，我們分析了在 RGLS / Regulus Therapeutics Inc. 中進行的每筆非計劃的公開市場內部人士賣出所達成的短期虧損規避。如果存在持續的虧損規避模式，可能表明未來的內部人士賣出交易預示著價格的下跌。該分析基於每筆交易後一年的情況， 結果僅為理論值。 .
以下表格顯示了最近的自動交易計劃之外的公開市場購買。
經調整價格 已按拆股調整。 經調整股數 已按拆股調整。
交易歷史
點擊連結圖示即可查看完整的交易記錄。作為 10b5-1 自動交易計畫的一部分進行報告的交易，將在標記為 10b-5 的欄位中顯示 X。
| 呈報 日期 |
交易 日期 |
表格 | 內部人士 | 證券代碼 | 證券種類 | 代碼 | 直接 | 行使 價格 |
單位 價格 |
股數 變化 |
價值 變化 (1K) |
剩餘 期權 |
剩餘 股份 |
|
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 2025-06-27 | 2025-06-25 | 4 | RASTETTER WILLIAM H By The Rastetter Family Trust | RGLS | Common Stock | I | -57,292 | 0 | ||||||
| 2025-06-27 | 2025-06-25 | 4 | RASTETTER WILLIAM H By The Rastetter Family Trust | RGLS | Common Stock | I | -44,264 | 57,292 | ||||||
| 2025-06-27 | 2025-06-25 | 4 | Witz Pascale | RGLS | Common Stock | D | -67,233 | 0 | ||||||
| 2025-06-27 | 2025-06-25 | 4 | PAPADOPOULOS STELIOS | RGLS | Common Stock | D | -64,635 | 0 | ||||||
| 2025-06-27 | 2025-06-25 | 4 | PAPADOPOULOS STELIOS | RGLS | Common Stock | D | -976,253 | 64,635 | ||||||
| 2025-06-27 | 2025-06-25 | 4 | Rosen Hugh | RGLS | Common Stock | D | -57,292 | 0 | ||||||
| 2025-06-27 | 2025-06-25 | 4 | Rosen Hugh | RGLS | Common Stock | D | -6,979 | 57,292 | ||||||
| 2025-06-27 | 2025-06-25 | 4 | Aker Christopher Ray | RGLS | Common Stock | D | -83,125 | 0 | ||||||
| 2025-06-27 | 2025-06-25 | 4 | Aker Christopher Ray | RGLS | Common Stock | D | -60,796 | 83,125 | ||||||
| 2025-06-27 | 2025-06-25 | 4 | Klassen Preston | RGLS | Common Stock | D | -115,555 | 0 | ||||||
| 2025-06-27 | 2025-06-25 | 4 | Hagan Joseph P | RGLS | Common Stock | D | -571,558 | 0 | ||||||
| 2025-06-27 | 2025-06-25 | 4 | BALTIMORE DAVID | RGLS | Common Stock | D | -57,292 | 0 | ||||||
| 2025-06-27 | 2025-06-25 | 4 | BALTIMORE DAVID By Spouse | RGLS | Common Stock | I | -57,292 | 0 | ||||||
| 2025-06-27 | 2025-06-25 | 4 | BALTIMORE DAVID By Spouse | RGLS | Common Stock | I | -5,208 | 57,292 | ||||||
| 2025-06-27 | 2025-06-25 | 4 | BALTIMORE DAVID | RGLS | Common Stock | D | -27,377 | 57,292 | ||||||
| 2025-06-27 | 2025-06-25 | 4 | Nunn Jason Raleigh | RGLS | Common Stock | D | -62,500 | 0 | ||||||
| 2025-06-27 | 2025-06-25 | 4 | Huang Alice Shih-hou | RGLS | Common Stock | D | -57,292 | 0 | ||||||
| 2025-06-27 | 2025-06-25 | 4 | Huang Alice Shih-hou By Spouse | RGLS | Common Stock | I | -57,292 | 0 | ||||||
| 2025-06-27 | 2025-06-25 | 4 | Huang Alice Shih-hou By Spouse | RGLS | Common Stock | I | -27,377 | 57,292 | ||||||
| 2025-06-27 | 2025-06-25 | 4 | Huang Alice Shih-hou | RGLS | Common Stock | D | -5,208 | 57,292 | ||||||
| 2025-06-27 | 2025-06-25 | 4 | Collier Kathryn J | RGLS | Common Stock | D | -75,565 | 0 | ||||||
| 2025-06-27 | 2025-06-25 | 4 | CALSADA CRISPINA | RGLS | Common Stock | D | -140,228 | 0 | ||||||
| 2025-06-18 | 2025-06-17 | 4 | Collier Kathryn J | RGLS | Common Stock | D | 8.8000 | 2,325 | 20 | 62,915 | ||||
| 2025-06-18 | 2025-06-17 | 4 | Collier Kathryn J | RGLS | Common Stock | D | 9.9000 | 2,604 | 26 | 65,240 | ||||
| 2025-06-18 | 2025-06-16 | 4 | Collier Kathryn J | RGLS | Common Stock | D | 9.9000 | 1,396 | 14 | 67,844 | ||||
| 2025-06-04 | 2025-06-03 | 4 | Klassen Preston | RGLS | Common Stock | D | 7.9877 | 12,000 | 96 | 48,055 | ||||
| 2025-04-30 | 2025-04-30 | 4 | Nunn Jason Raleigh | RGLS | Common Stock | D | 62,500 | 62,500 | ||||||
| 2025-04-30 | 2025-04-30 | 4 | Collier Kathryn J | RGLS | Common Stock | D | 62,500 | 69,240 | ||||||
| 2025-04-30 | 2025-04-30 | 4 | Witz Pascale | RGLS | Common Stock | D | 62,500 | 67,233 | ||||||
| 2025-04-30 | 2025-04-30 | 4 | Huang Alice Shih-hou | RGLS | Common Stock | D | 62,500 | 84,669 | ||||||
| 2025-04-30 | 2025-04-30 | 4 | Huang Alice Shih-hou By Spouse | RGLS | Common Stock | I | 62,500 | 84,669 | ||||||
| 2025-04-30 | 2025-04-30 | 4 | BALTIMORE DAVID | RGLS | Common Stock | D | 62,500 | 62,500 | ||||||
| 2025-04-30 | 2025-04-30 | 4 | BALTIMORE DAVID By Spouse | RGLS | Common Stock | I | 62,500 | 62,500 | ||||||
| 2025-04-30 | 2025-04-30 | 4 | PAPADOPOULOS STELIOS | RGLS | Common Stock | D | 62,500 | 1,040,888 | ||||||
| 2025-04-30 | 2025-04-30 | 4 | RASTETTER WILLIAM H The Rastetter Family Trust | RGLS | Common Stock | I | 62,500 | 101,556 | ||||||
| 2025-04-30 | 2025-04-30 | 4 | Rosen Hugh | RGLS | Common Stock | D | 62,500 | 64,271 | ||||||
| 2025-01-31 | 2025-01-30 | 4 | BALTIMORE DAVID | RGLS | Common Stock | D | 1.0600 | 19,610 | 21 | 22,169 | ||||
| 2025-01-31 | 2025-01-30 | 4 | Hagan Joseph P | RGLS | Common Stock | D | 1.0852 | 50,000 | 54 | 260,808 | ||||
| 2025-01-15 | 2025-01-13 | 4 | Klassen Preston | RGLS | Common Stock | D | 1.2632 | -31,445 | -40 | 36,055 | ||||
| 2025-01-15 | 2025-01-14 | 4 | CALSADA CRISPINA | RGLS | Common Stock | D | 1.2632 | -5,088 | -6 | 45,478 | ||||
| 2025-01-15 | 2025-01-13 | 4 | CALSADA CRISPINA | RGLS | Common Stock | D | 1.2632 | -38,716 | -49 | 50,566 | ||||
| 2025-01-15 | 2025-01-14 | 4 | Hagan Joseph P | RGLS | Common Stock | D | 1.2632 | -11,764 | -15 | 210,808 | ||||
| 2025-01-15 | 2025-01-13 | 4 | Hagan Joseph P | RGLS | Common Stock | D | 1.2632 | -115,290 | -146 | 222,572 | ||||
| 2025-01-15 | 2025-01-14 | 4 | Aker Christopher Ray | RGLS | Common Stock | D | 1.2632 | -5,088 | -6 | 49,546 | ||||
| 2025-01-15 | 2025-01-13 | 4 | Aker Christopher Ray | RGLS | Common Stock | D | 1.2632 | -38,547 | -49 | 54,634 | ||||
| 2025-01-10 | 2025-01-09 | 4 | CALSADA CRISPINA | RGLS | Common Stock | D | 1.3000 | 21,000 | 27 | 89,282 | ||||
| 2025-01-10 | 2025-01-09 | 4 | CALSADA CRISPINA | RGLS | Common Stock | D | 1.3600 | 62,500 | 85 | 68,282 | ||||
| 2025-01-10 | 2025-01-09 | 4 | Hagan Joseph P | RGLS | Common Stock | D | 1.3000 | 62,000 | 81 | 337,862 | ||||
| 2025-01-10 | 2025-01-09 | 4 | Hagan Joseph P | RGLS | Common Stock | D | 1.3600 | 218,750 | 298 | 275,862 | ||||
| 2025-01-10 | 2025-01-09 | 4 | Klassen Preston | RGLS | Common Stock | D | 1.3000 | 30,000 | 39 | 67,500 | ||||
| 2025-01-10 | 2025-01-09 | 4 | Klassen Preston | RGLS | Common Stock | D | 1.3600 | 37,500 | 51 | 37,500 | ||||
| 2025-01-10 | 2025-01-09 | 4 | Aker Christopher Ray | RGLS | Common Stock | D | 1.3000 | 17,500 | 23 | 93,181 | ||||
| 2025-01-10 | 2025-01-09 | 4 | Aker Christopher Ray | RGLS | Common Stock | D | 1.3600 | 66,625 | 91 | 75,681 | ||||
| 2024-07-29 | 2024-07-25 | 4 | Collier Kathryn J | RGLS | Common Stock | D | 1.8200 | 4,000 | 7 | 6,740 | ||||
| 2024-03-15 | 2024-03-14 | 4 | PAPADOPOULOS STELIOS | RGLS | Common Stock | D | 1.6000 | 250,000 | 400 | 978,388 | ||||
| 2024-01-18 | 2024-01-18 | 4 | CALSADA CRISPINA | RGLS | Common Stock | D | 1.1906 | -5,468 | -7 | 5,782 | ||||
| 2024-01-18 | 2024-01-18 | 4 | Aker Christopher Ray | RGLS | Common Stock | D | 1.1906 | -5,468 | -7 | 10,056 | ||||
| 2024-01-18 | 2024-01-18 | 4 | Hagan Joseph P | RGLS | Common Stock | D | 1.1906 | -14,580 | -17 | 57,112 | ||||
| 2024-01-17 | 2024-01-12 | 4 | Hagan Joseph P | RGLS | Common Stock | D | 30,000 | 71,692 | ||||||
| 2024-01-17 | 2024-01-12 | 4 | CALSADA CRISPINA | RGLS | Common Stock | D | 11,250 | 11,250 | ||||||
| 2024-01-17 | 2024-01-12 | 4 | Aker Christopher Ray | RGLS | Common Stock | D | 11,250 | 15,524 | ||||||
| 2023-04-14 | 2023-04-13 | 4 | PAPADOPOULOS STELIOS | RGLS | Common Stock | D | 0.9001 | 222,198 | 200 | 728,388 | ||||
| 2022-05-11 | 2022-05-10 | 4 | Hagan Joseph P | RGLS | Stock Option (Right to Buy) | D | 1.31 | 300,000 | 300,000 | |||||
| 2022-05-11 | 2022-05-10 | 4 | CALSADA CRISPINA | RGLS | Stock Option (Right to Buy) | D | 1.31 | 50,000 | 50,000 | |||||
| 2022-05-11 | 2022-05-09 | 4 | Aker Christopher Ray | RGLS | Stock Option (Right to Buy) | D | 1.31 | 70,000 | 70,000 | |||||
| 2022-03-01 | 2022-03-01 | 4 | Drygin Denis | RGLS | Common Stock | D | 0.2300 | 76,686 | 18 | 100,000 | ||||
| 2022-02-07 | 2022-02-04 | 4 | Drygin Denis | RGLS | Common Stock | D | 0.2300 | 23,314 | 5 | 23,314 | ||||
| 2022-01-26 | 2022-01-26 | 4 | Hagan Joseph P | RGLS | Common Stock | D | 0.2152 | 100,000 | 22 | 417,006 | ||||
| 2022-01-26 | 2022-01-12 | 4 | Hagan Joseph P | RGLS | Stock Option (Right to Buy) | D | 0.26 | 1,600,000 | 1,600,000 | |||||
| 2022-01-26 | 2022-01-12 | 4 | Drygin Denis | RGLS | Stock Option (Right to Buy) | D | 0.26 | 400,000 | 400,000 | |||||
| 2022-01-26 | 2022-01-12 | 4 | CALSADA CRISPINA | RGLS | Stock Option (Right to Buy) | D | 0.26 | 480,000 | 480,000 | |||||
| 2022-01-26 | 2022-01-12 | 4 | Aker Christopher Ray | RGLS | Stock Option (Right to Buy) | D | 0.26 | 480,000 | 480,000 | |||||
| 2021-12-01 | 2021-11-30 | 4 | PAPADOPOULOS STELIOS | RGLS | Common Stock | D | 0.3600 | 2,222,222 | 800 | 5,061,929 | ||||
| 2021-06-15 | 2021-06-14 | 4 | Simeonidis Simos | RGLS | Stock Option (Right to Buy) | D | 0.99 | 40,000 | 40,000 | |||||
| 2021-06-15 | 2021-06-14 | 4 | Witz Pascale | RGLS | Stock Option (Right to Buy) | D | 0.99 | 40,000 | 40,000 | |||||
| 2021-06-15 | 2021-06-14 | 4 | Rosen Hugh | RGLS | Stock Option (Right to Buy) | D | 0.99 | 40,000 | 40,000 | |||||
| 2021-06-15 | 2021-06-14 | 4 | RASTETTER WILLIAM H | RGLS | Stock Option (Right to Buy) | D | 0.99 | 40,000 | 40,000 | |||||
| 2021-06-15 | 2021-06-14 | 4 | Nunn Jason Raleigh | RGLS | Stock Option (Right to Buy) | D | 0.99 | 40,000 | 40,000 | |||||
| 2021-06-15 | 2021-06-14 | 4 | PAPADOPOULOS STELIOS | RGLS | Stock Option (Right to Buy) | D | 0.99 | 40,000 | 40,000 | |||||
| 2021-06-15 | 2021-06-14 | 4 | Huang Alice Shih-hou | RGLS | Stock Option (Right to Buy) | D | 0.99 | 40,000 | 40,000 | |||||
| 2021-06-15 | 2021-06-14 | 4 | Collier Kathryn J | RGLS | Stock Option (Right to Buy) | D | 0.99 | 40,000 | 40,000 | |||||
| 2021-06-15 | 2021-06-14 | 4 | BALTIMORE DAVID | RGLS | Stock Option (Right to Buy) | D | 0.99 | 40,000 | 40,000 | |||||
| 2021-05-17 | 2021-05-17 | 4 | Hagan Joseph P | RGLS | Common Stock | D | 0.8900 | -4,186 | -4 | 316,292 | ||||
| 2021-05-17 | 2021-05-17 | 4 | Aker Christopher Ray | RGLS | Common Stock | D | 0.8900 | -860 | -1 | 41,754 | ||||
| 2021-04-16 | 2021-04-14 | 4 | Hagan Joseph P PACIFIC PREMIER TRUST OBO JOSEPH P. HAGAN IRA | RGLS | Class A-2 Convertible Preferred Stock | I | 7,585 | 0 | ||||||
| 2021-04-16 | 2021-04-14 | 4 | Hagan Joseph P | RGLS | Common Stock | D | 75,850 | 320,478 | ||||||
| 2021-04-16 | 2021-02-16 | 4/A | Hagan Joseph P | RGLS | Common Stock | D | 1.7200 | -4,144 | -7 | 244,628 | ||||
| 2021-02-17 | 2021-02-16 | 4 | Hagan Joseph P | RGLS | Common Stock | D | 1.7200 | -4,144 | -7 | 485,756 | ||||
| 2021-02-17 | 2021-02-16 | 4 | Aker Christopher Ray | RGLS | Common Stock | D | 1.7200 | -828 | -1 | 42,614 | ||||
| 2021-02-05 | 2021-02-04 | 4 | Hagan Joseph P | RGLS | Stock Option (Right to Buy) | D | 1.59 | 600,000 | 600,000 | |||||
| 2021-02-05 | 2021-02-04 | 4 | Drygin Denis | RGLS | Stock Option (Right to Buy) | D | 1.59 | 120,000 | 120,000 | |||||
| 2021-02-05 | 2021-02-04 | 4 | Aker Christopher Ray | RGLS | Stock Option (Right to Buy) | D | 1.59 | 180,000 | 180,000 | |||||
| 2021-02-05 | 2021-02-04 | 4 | CALSADA CRISPINA | RGLS | Stock Option (Right to Buy) | D | 1.59 | 150,000 | 150,000 | |||||
| 2021-01-27 | 2021-01-26 | 4 | Huang Alice Shih-hou | RGLS | Stock Option (Right to Buy) | D | 1.55 | 80,000 | 80,000 | |||||
| 2021-01-27 | 3 | Huang Alice Shih-hou By Spouse | RGLS | Common Stock | I | 25,604 | ||||||||
| 2021-01-27 | 2020-12-04 | 4/A | PAPADOPOULOS STELIOS | RGLS | Common Stock | D | 0.6301 | 793,528 | 500 | 2,839,707 | ||||
| 2020-12-07 | 2020-12-04 | 4 | Sonsini Peter W. See Note 2 | RGLS | Class A-3 Convertible Preferred Stock | I | 6.2200 | 258,707 | 1,609 | 258,707 | ||||
| 2020-12-07 | 2020-12-04 | 4 | Sonsini Peter W. See Note 2 | RGLS | Common Stock Purchase Warrant (right to buy) | I | 0.75 | 0.1250 | 5,239,254 | 655 | 5,239,254 | |||
| 2020-12-07 | 2020-12-04 | 4 | Sonsini Peter W. See Note 2 | RGLS | Common Stock | I | 0.6220 | 4,398,602 | 2,736 | 6,451,056 | ||||
| 2020-12-07 | 2020-12-04 | 4 | Walker Paul Edward See Note 2 | RGLS | Class A-3 Convertible Preferred Stock | I | 6.2200 | 258,707 | 1,609 | 258,707 | ||||
| 2020-12-07 | 2020-12-04 | 4 | Walker Paul Edward See Note 2 | RGLS | Common Stock Purchase Warrant (right to buy) | I | 0.75 | 0.1250 | 5,239,254 | 655 | 5,239,254 | |||
| 2020-12-07 | 2020-12-04 | 4 | Walker Paul Edward See Note 2 | RGLS | Common Stock | I | 0.6220 | 4,398,602 | 2,736 | 6,451,056 | ||||
| 2020-12-07 | 2020-12-04 | 4 | BASKETT FOREST See Note 2 | RGLS | Class A-3 Convertible Preferred Stock | I | 6.2200 | 258,707 | 1,609 | 258,707 | ||||
| 2020-12-07 | 2020-12-04 | 4 | BASKETT FOREST See Note 2 | RGLS | Common Stock Purchase Warrant (right to buy) | I | 0.75 | 0.1250 | 5,239,254 | 655 | 5,239,254 | |||
| 2020-12-07 | 2020-12-04 | 4 | BASKETT FOREST See Note 2 | RGLS | Common Stock | I | 0.6220 | 4,398,602 | 2,736 | 6,451,056 | ||||
| 2020-12-07 | 2020-12-04 | 4 | Behbahani Ali See Note 2 | RGLS | Class A-3 Convertible Preferred Stock | I | 6.2200 | 258,707 | 1,609 | 258,707 | ||||
| 2020-12-07 | 2020-12-04 | 4 | Behbahani Ali See Note 2 | RGLS | Common Stock Purchase Warrant (right to buy) | I | 0.75 | 0.1250 | 5,239,254 | 655 | 5,239,254 | |||
| 2020-12-07 | 2020-12-04 | 4 | Behbahani Ali See Note 2 | RGLS | Common Stock | I | 0.6220 | 4,398,602 | 2,736 | 6,451,056 | ||||
| 2020-12-07 | 2020-12-04 | 4 | Chang Carmen See Note 2 | RGLS | Class A-3 Convertible Preferred Stock | I | 6.2200 | 258,707 | 1,609 | 258,707 | ||||
| 2020-12-07 | 2020-12-04 | 4 | Chang Carmen See Note 2 | RGLS | Common Stock Purchase Warrant (right to buy) | I | 0.75 | 0.1250 | 5,239,254 | 655 | 5,239,254 | |||
| 2020-12-07 | 2020-12-04 | 4 | Chang Carmen See Note 2 | RGLS | Common Stock | I | 0.6220 | 4,398,602 | 2,736 | 6,451,056 | ||||
| 2020-12-07 | 2020-12-04 | 4 | Florence Anthony A. Jr. See Note 2 | RGLS | Class A-3 Convertible Preferred Stock | I | 6.2200 | 258,707 | 1,609 | 258,707 | ||||
| 2020-12-07 | 2020-12-04 | 4 | Florence Anthony A. Jr. See Note 2 | RGLS | Common Stock Purchase Warrant (right to buy) | I | 0.75 | 0.1250 | 5,239,254 | 655 | 5,239,254 | |||
| 2020-12-07 | 2020-12-04 | 4 | Florence Anthony A. Jr. See Note 2 | RGLS | Common Stock | I | 0.6220 | 4,398,602 | 2,736 | 6,451,056 | ||||
| 2020-12-07 | 2020-12-04 | 4 | Makhzoumi Mohamad See Note 2 | RGLS | Class A-3 Convertible Preferred Stock | I | 6.2200 | 258,707 | 1,609 | 258,707 | ||||
| 2020-12-07 | 2020-12-04 | 4 | Makhzoumi Mohamad See Note 2 | RGLS | Common Stock Purchase Warrant (right to buy) | I | 0.75 | 0.1250 | 5,239,254 | 655 | 5,239,254 | |||
| 2020-12-07 | 2020-12-04 | 4 | Makhzoumi Mohamad See Note 2 | RGLS | Common Stock | I | 0.6220 | 4,398,602 | 2,736 | 6,451,056 | ||||
| 2020-12-07 | 2020-12-04 | 4 | MAKOWER JOSHUA See Note 2 | RGLS | Class A-3 Convertible Preferred Stock | I | 6.2200 | 258,707 | 1,609 | 258,707 | ||||
| 2020-12-07 | 2020-12-04 | 4 | MAKOWER JOSHUA See Note 2 | RGLS | Common Stock Purchase Warrant (right to buy) | I | 0.75 | 0.1250 | 5,239,254 | 655 | 5,239,254 | |||
| 2020-12-07 | 2020-12-04 | 4 | MAKOWER JOSHUA See Note 2 | RGLS | Common Stock | I | 0.6220 | 4,398,602 | 2,736 | 6,451,056 | ||||
| 2020-12-07 | 2020-12-04 | 4 | SANDELL SCOTT D See Note 2 | RGLS | Class A-3 Convertible Preferred Stock | I | 6.2200 | 258,707 | 1,609 | 258,707 | ||||
| 2020-12-07 | 2020-12-04 | 4 | SANDELL SCOTT D See Note 2 | RGLS | Common Stock Purchase Warrant (right to buy) | I | 0.75 | 0.1250 | 5,239,254 | 655 | 5,239,254 | |||
| 2020-12-07 | 2020-12-04 | 4 | SANDELL SCOTT D See Note 2 | RGLS | Common Stock | I | 0.6220 | 4,398,602 | 2,736 | 6,451,056 | ||||
| 2020-12-07 | 2020-12-04 | 4 | Growth Equity Opportunities V, LLC | RGLS | Class A-3 Convertible Preferred Stock | D | 6.2200 | 258,707 | 1,609 | 258,707 | ||||
| 2020-12-07 | 2020-12-04 | 4 | Growth Equity Opportunities V, LLC | RGLS | Common Stock Purchase Warrant (right to buy) | D | 0.75 | 0.1250 | 5,239,254 | 655 | 5,239,254 | |||
| 2020-12-07 | 2020-12-04 | 4 | Growth Equity Opportunities V, LLC | RGLS | Common Stock | D | 0.6220 | 4,398,602 | 2,736 | 6,451,056 | ||||
| 2020-12-07 | 2020-12-04 | 4 | PAPADOPOULOS STELIOS | RGLS | Common Stock Purchase Warrant (Right to Buy) | D | 0.75 | 0.1250 | 595,146 | 74 | 595,146 | |||
| 2020-12-07 | 2020-12-04 | 4 | PAPADOPOULOS STELIOS | RGLS | Common Stock | D | 0.6301 | 793,528 | 500 | 1,986,729 | ||||
| 2020-12-07 | 2020-12-04 | 4 | Hagan Joseph P Securities purchased through an affiliated investment entity | RGLS | Common Stock Purchase Warrant (Right to Buy) | I | 0.75 | 0.1250 | 29,760 | 4 | 29,760 | |||
| 2020-12-07 | 2020-12-04 | 4 | Hagan Joseph P Securities purchased through an affiliated investment entity | RGLS | Common Stock | I | 0.6301 | 39,680 | 25 | 225,674 | ||||
| 2020-11-18 | 2020-11-16 | 4 | Aker Christopher Ray | RGLS | Common Stock | D | 0.5211 | -876 | -0 | 25,762 | ||||
| 2020-11-18 | 2020-11-16 | 4 | Hagan Joseph P | RGLS | Common Stock | D | 0.5211 | -6,094 | -3 | 215,994 | ||||
| 2020-08-17 | 2020-08-14 | 4 | Hagan Joseph P | RGLS | Common Stock | D | 0.6049 | -4,245 | -3 | 222,088 | ||||
| 2020-08-17 | 2020-08-14 | 4 | Aker Christopher Ray | RGLS | Common Stock | D | 0.6050 | -872 | -1 | 26,638 | ||||
| 2020-08-05 | 2020-03-03 | 4 | Drygin Denis | RGLS | Stock Option (Right to Buy) | D | 0.69 | 300,000 | 300,000 | |||||
| 2020-06-19 | 2020-06-17 | 4 | BALTIMORE DAVID | RGLS | Stock Option (Right to Buy) | D | 0.88 | 23,250 | 23,250 | |||||
| 2020-06-19 | 2020-06-17 | 4 | Collier Kathryn J | RGLS | Stock Option (Right to Buy) | D | 0.88 | 23,250 | 23,250 | |||||
| 2020-06-19 | 2020-06-17 | 4 | Nunn Jason Raleigh | RGLS | Stock Option (Right to Buy) | D | 0.88 | 23,250 | 23,250 | |||||
| 2020-06-19 | 2020-06-17 | 4 | PAPADOPOULOS STELIOS | RGLS | Stock Option (Right to Buy) | D | 0.88 | 23,250 | 23,250 | |||||
| 2020-06-19 | 2020-06-17 | 4 | RASTETTER WILLIAM H THE RASTETTER FAMILY TRUST DTD 9-2-2010 | RGLS | Stock Option (Right to Buy) | I | 0.88 | 23,250 | 23,250 | |||||
| 2020-06-19 | 2020-06-17 | 4 | Rosen Hugh | RGLS | Stock Option (Right to Buy) | D | 0.88 | 23,250 | 23,250 | |||||
| 2020-06-19 | 2020-06-17 | 4 | Simeonidis Simos | RGLS | Stock Option (Right to Buy) | D | 0.88 | 23,250 | 23,250 | |||||
| 2020-06-19 | 2020-06-17 | 4 | Witz Pascale | RGLS | Stock Option (Right to Buy) | D | 0.88 | 23,250 | 23,250 | |||||
| 2020-05-18 | 2020-05-15 | 4 | Aker Christopher Ray | RGLS | Common Stock | D | 0.6268 | -909 | -1 | 27,510 | ||||
| 2020-05-18 | 2020-05-15 | 4 | Hagan Joseph P | RGLS | Common Stock | D | 0.6267 | -4,426 | -3 | 226,333 | ||||
| 2020-05-08 | 3 | Sarissa Capital Master Fund II LP | RGLS | Common Stock | D | 152,712 | ||||||||
| 2020-05-08 | 3 | Sarissa Capital Master Fund II LP | RGLS | Common Stock | D | 152,712 | ||||||||
| 2020-05-08 | 3 | Sarissa Capital Master Fund II LP | RGLS | Common Stock | D | 152,712 | ||||||||
| 2020-05-08 | 2020-04-01 | 4 | Sarissa Capital Offshore Master Fund LP | RGLS | Warrants to Purchase Common Stock | D | 0.67 | -53,113 | 2,627,037 | |||||
| 2020-05-08 | 2020-04-01 | 4 | Sarissa Capital Offshore Master Fund LP | RGLS | Warrants to Purchase Common Stock | D | 1.08 | -23,243 | 1,149,649 | |||||
| 2020-05-08 | 2020-04-01 | 4 | Sarissa Capital Offshore Master Fund LP | RGLS | Class A-2 Convertible Preferred Stock | D | -5,311 | 262,704 | ||||||
| 2020-02-19 | 2020-02-18 | 4 | Hagan Joseph P | RGLS | Common Stock | D | 0.8304 | -4,324 | -4 | 230,759 | ||||
| 2020-02-19 | 2020-02-18 | 4 | Aker Christopher Ray | RGLS | Common Stock | D | 0.8305 | -888 | -1 | 28,419 | ||||
| 2020-02-04 | 2020-02-03 | 4 | RASTETTER WILLIAM H The Rastetter Family Trust dtd 9-2-2010 | RGLS | Class A-2 Convertible Preferred Stock | I | -22,594 | 0 | ||||||
| 2020-02-04 | 2020-02-03 | 4 | RASTETTER WILLIAM H The Rastetter Family Trust dtd 9-2-2010 | RGLS | Common Stock | I | 225,940 | 390,584 | ||||||
| 2020-02-04 | 2020-02-03 | 4 | PAPADOPOULOS STELIOS | RGLS | Class A-2 Convertible Preferred Stock | D | -84,632 | 0 | ||||||
| 2020-02-04 | 2020-02-03 | 4 | PAPADOPOULOS STELIOS | RGLS | Common Stock | D | 846,320 | 2,039,521 | ||||||
| 2020-01-24 | 2020-01-22 | 4 | Aker Christopher Ray | RGLS | Stock Option (Right to Buy) | D | 1.31 | 210,000 | 210,000 | |||||
| 2020-01-24 | 2020-01-22 | 4 | CALSADA CRISPINA | RGLS | Stock Option (Right to Buy) | D | 1.31 | 150,000 | 150,000 | |||||
| 2020-01-24 | 2020-01-22 | 4 | Hagan Joseph P | RGLS | Stock Option (Right to Buy) | D | 1.31 | 900,000 | 900,000 | |||||
| 2020-01-03 | 2019-12-24 | 4 | DENNER ALEXANDER J See Footnotes | RGLS | Warrants to Purchase Common Stock | I | 6.66 | 4,231,620 | 6,083,471 | |||||
| 2020-01-03 | 2019-12-24 | 4 | DENNER ALEXANDER J See Footnotes | RGLS | Class A-2 Convertible Preferred Stock | I | 0.67 | 423,162 | 423,162 | |||||
| 2020-01-03 | 2020-01-02 | 4 | Aker Christopher Ray | RGLS | Common Stock | D | 0.9667 | -2,239 | -2 | 29,307 | ||||
| 2020-01-03 | 2020-01-02 | 4 | Hagan Joseph P | RGLS | Common Stock | D | 0.9667 | -8,345 | -8 | 235,083 | ||||
| 2019-12-26 | 2019-12-24 | 4 | SANDELL SCOTT D See Note 1 | RGLS | Class A-2 Convertible Preferred Stock | I | 6.6600 | 900,900 | 6,000 | 900,900 | ||||
| 2019-12-26 | 2019-12-24 | 4 | SANDELL SCOTT D See Note 1 | RGLS | Common Stock Purchase Warrant (Right to Buy) | I | 0.67 | 0.1250 | 9,009,000 | 1,126 | 9,009,000 | |||
| 2019-12-26 | 2019-12-24 | 4 | Sonsini Peter W. See Note 1 | RGLS | Class A-2 Convertible Preferred Stock | I | 6.6600 | 900,900 | 6,000 | 900,900 | ||||
| 2019-12-26 | 2019-12-24 | 4 | Sonsini Peter W. See Note 1 | RGLS | Common Stock Purchase Warrant (Right to Buy) | I | 0.67 | 0.1250 | 9,009,000 | 1,126 | 9,009,000 | |||
| 2019-12-26 | 2019-12-24 | 4 | Walker Paul Edward See Note 1 | RGLS | Class A-2 Convertible Preferred Stock | I | 6.6600 | 900,900 | 6,000 | 900,900 | ||||
| 2019-12-26 | 2019-12-24 | 4 | Walker Paul Edward See Note 1 | RGLS | Common Stock Purchase Warrant (Right to Buy) | I | 0.67 | 0.1250 | 9,009,000 | 1,126 | 9,009,000 | |||
| 2019-12-26 | 2019-12-24 | 4 | Growth Equity Opportunities V, LLC | RGLS | Class A-2 Convertible Preferred Stock | D | 6.6600 | 900,900 | 6,000 | 900,900 | ||||
| 2019-12-26 | 2019-12-24 | 4 | Growth Equity Opportunities V, LLC | RGLS | Common Stock Purchase Warrant (Right to Buy) | D | 0.67 | 0.1250 | 9,009,000 | 1,126 | 9,009,000 | |||
| 2019-12-26 | 2019-12-24 | 4 | BARRIS PETER J See Note 1 | RGLS | Class A-2 Convertible Preferred Stock | I | 6.6600 | 900,900 | 6,000 | 900,900 | ||||
| 2019-12-26 | 2019-12-24 | 4 | BARRIS PETER J See Note 1 | RGLS | Common Stock Purchase Warrant (Right to Buy) | I | 0.67 | 0.1250 | 9,009,000 | 1,126 | 9,009,000 | |||
| 2019-12-26 | 2019-12-24 | 4 | BASKETT FOREST See Note 1 | RGLS | Class A-2 Convertible Preferred Stock | I | 6.6600 | 900,900 | 6,000 | 900,900 | ||||
| 2019-12-26 | 2019-12-24 | 4 | BASKETT FOREST See Note 1 | RGLS | Common Stock Purchase Warrant (Right to Buy) | I | 0.67 | 0.1250 | 9,009,000 | 1,126 | 9,009,000 | |||
| 2019-12-26 | 2019-12-24 | 4 | Behbahani Ali See Note 1 | RGLS | Class A-2 Convertible Preferred Stock | I | 6.6600 | 900,900 | 6,000 | 900,900 | ||||
| 2019-12-26 | 2019-12-24 | 4 | Behbahani Ali See Note 1 | RGLS | Common Stock Purchase Warrant (Right to Buy) | I | 0.67 | 0.1250 | 9,009,000 | 1,126 | 9,009,000 | |||
| 2019-12-26 | 2019-12-24 | 4 | Chang Carmen See Note 1 | RGLS | Class A-2 Convertible Preferred Stock | I | 6.6600 | 900,900 | 6,000 | 900,900 | ||||
| 2019-12-26 | 2019-12-24 | 4 | Chang Carmen See Note 1 | RGLS | Common Stock Purchase Warrant (Right to Buy) | I | 0.67 | 0.1250 | 9,009,000 | 1,126 | 9,009,000 | |||
| 2019-12-26 | 2019-12-24 | 4 | Florence Anthony A. Jr. See Note 1 | RGLS | Class A-2 Convertible Preferred Stock | I | 6.6600 | 900,900 | 6,000 | 900,900 | ||||
| 2019-12-26 | 2019-12-24 | 4 | Florence Anthony A. Jr. See Note 1 | RGLS | Common Stock Purchase Warrant (Right to Buy) | I | 0.67 | 0.1250 | 9,009,000 | 1,126 | 9,009,000 | |||
| 2019-12-26 | 2019-12-24 | 4 | Makhzoumi Mohamad See Note 1 | RGLS | Class A-2 Convertible Preferred Stock | I | 6.6600 | 900,900 | 6,000 | 900,900 | ||||
| 2019-12-26 | 2019-12-24 | 4 | Makhzoumi Mohamad See Note 1 | RGLS | Common Stock Purchase Warrant (Right to Buy) | I | 0.67 | 0.1250 | 9,009,000 | 1,126 | 9,009,000 | |||
| 2019-12-26 | 2019-12-24 | 4 | MAKOWER JOSHUA See Note 1 | RGLS | Class A-2 Convertible Preferred Stock | I | 6.6600 | 900,900 | 6,000 | 900,900 | ||||
| 2019-12-26 | 2019-12-24 | 4 | MAKOWER JOSHUA See Note 1 | RGLS | Common Stock Purchase Warrant (Right to Buy) | I | 0.67 | 0.1250 | 9,009,000 | 1,126 | 9,009,000 | |||
| 2019-12-26 | 2019-12-24 | 4 | MOTT DAVID M See Note 1 | RGLS | Class A-2 Convertible Preferred Stock | I | 6.6600 | 900,900 | 6,000 | 900,900 | ||||
| 2019-12-26 | 2019-12-24 | 4 | MOTT DAVID M See Note 1 | RGLS | Common Stock Purchase Warrant (Right to Buy) | I | 0.67 | 0.1250 | 9,009,000 | 1,126 | 9,009,000 | |||
| 2019-12-26 | 2019-12-24 | 4 | Hagan Joseph P PENSCO TRUST CO OBO JOSEPH HAGAN IRA | RGLS | Common Stock Purchase Warrant (Right to Buy) | I | 0.67 | 0.1250 | 75,850 | 9 | 75,850 | |||
| 2019-12-26 | 2019-12-24 | 4 | Hagan Joseph P PENSCO TRUST CO OBO JOSEPH HAGAN IRA | RGLS | Class A-2 Convertible Preferred Stock | I | 6.6600 | 7,585 | 51 | 7,585 | ||||
| 2019-12-26 | 2019-12-24 | 4 | RASTETTER WILLIAM H THE RASTETTER FAMILY TRUST DTD 9-2-2010 | RGLS | Common Stock Purchase Warrant (Right to Buy) | I | 0.67 | 0.1250 | 225,940 | 28 | 225,940 | |||
| 2019-12-26 | 2019-12-24 | 4 | RASTETTER WILLIAM H THE RASTETTER FAMILY TRUST DTD 9-2-2010 | RGLS | Class A-2 Convertible Preferred Stock | I | 6.6600 | 22,594 | 150 | 22,594 | ||||
| 2019-12-26 | 2019-12-24 | 4 | Witz Pascale | RGLS | Common Stock Purchase Warrant (Right to Buy) | D | 0.67 | 0.1250 | 67,700 | 8 | 67,700 | |||
| 2019-12-26 | 2019-12-24 | 4 | Witz Pascale | RGLS | Class A-2 Convertible Preferred Stock | D | 6.6600 | 6,770 | 45 | 6,770 | ||||
| 2019-12-26 | 2019-12-24 | 4 | PAPADOPOULOS STELIOS | RGLS | Common Stock Purchase Warrant (Right to Buy) | D | 0.67 | 0.1250 | 846,320 | 106 | 846,320 | |||
| 2019-12-26 | 2019-12-24 | 4 | PAPADOPOULOS STELIOS | RGLS | Class A-2 Convertible Preferred Stock | D | 6.6600 | 84,632 | 564 | 84,632 | ||||
| 2019-11-15 | 2019-11-14 | 4 | Hagan Joseph P | RGLS | Common Stock | D | 0.6400 | -5,838 | -4 | 243,428 | ||||
| 2019-11-15 | 2019-11-14 | 4 | Aker Christopher Ray | RGLS | Common Stock | D | 0.6400 | -833 | -1 | 31,546 | ||||
| 2019-10-15 | 2019-10-10 | 4 | Aker Christopher Ray | RGLS | Stock Option (Right to Buy) | D | 0.64 | 335,000 | 335,000 | |||||
| 2019-10-15 | 2019-10-10 | 4 | BALTIMORE DAVID | RGLS | Stock Option (Right to Buy) | D | 0.64 | 46,500 | 46,500 | |||||
| 2019-10-15 | 2019-10-10 | 4 | CALSADA CRISPINA | RGLS | Stock Option (Right to Buy) | D | 0.64 | 210,000 | 210,000 | |||||
| 2019-10-15 | 2019-10-10 | 4 | Collier Kathryn J | RGLS | Stock Option (Right to Buy) | D | 0.64 | 46,500 | 46,500 | |||||
| 2019-10-15 | 2019-10-10 | 4 | Hagan Joseph P | RGLS | Stock Option (Right to Buy) | D | 0.64 | 1,000,000 | 1,000,000 | |||||
| 2019-10-15 | 2019-10-10 | 4 | Nunn Jason Raleigh | RGLS | Stock Option (Right to Buy) | D | 0.64 | 46,500 | 46,500 | |||||
| 2019-10-15 | 2019-10-10 | 4 | PAPADOPOULOS STELIOS | RGLS | Stock Option (Right to Buy) | D | 0.64 | 46,500 | 46,500 | |||||
| 2019-10-15 | 2019-10-10 | 4 | RASTETTER WILLIAM H THE RASTETTER FAMILY TRUST DTD 9-2-2010 | RGLS | Stock Option (Right to Buy) | I | 0.64 | 46,500 | 46,500 | |||||
| 2019-10-15 | 2019-10-10 | 4 | Rosen Hugh | RGLS | Stock Option (Right to Buy) | D | 0.64 | 46,500 | 46,500 | |||||
| 2019-10-15 | 2019-10-10 | 4 | Simeonidis Simos | RGLS | Stock Option (Right to Buy) | D | 0.64 | 46,500 | 46,500 | |||||
| 2019-10-15 | 2019-10-10 | 4 | Witz Pascale | RGLS | Stock Option (Right to Buy) | D | 0.64 | 46,500 | 46,500 | |||||
| 2019-10-02 | 2019-10-01 | 4 | Hagan Joseph P | RGLS | Common Stock | D | 0.6827 | -8,743 | -6 | 249,266 | ||||
| 2019-10-02 | 2019-10-01 | 4 | Aker Christopher Ray | RGLS | Common Stock | D | 0.6827 | -2,346 | -2 | 32,379 | ||||
| 2019-09-03 | 2019-08-30 | 4 | CALSADA CRISPINA | RGLS | Stock Option (Right to Buy) | D | 0.62 | 100,000 | 100,000 | |||||
| 2019-08-16 | 2019-08-15 | 4 | Aker Christopher Ray | RGLS | Common Stock | D | 0.5506 | -899 | -0 | 34,725 | ||||
| 2019-08-16 | 2019-08-15 | 4 | Hagan Joseph P | RGLS | Common Stock | D | 0.5506 | -4,375 | -2 | 258,009 | ||||
| 2019-07-02 | 2019-07-01 | 4 | Chevallard Daniel R. | RGLS | Common Stock | D | 1.3115 | -2,669 | -4 | 77,870 | ||||
| 2019-07-02 | 2019-07-01 | 4 | Aker Christopher Ray | RGLS | Common Stock | D | 1.3115 | -2,225 | -3 | 35,624 | ||||
| 2019-07-02 | 2019-07-01 | 4 | Hagan Joseph P | RGLS | Common Stock | D | 1.3115 | -5,783 | -8 | 262,384 | ||||
| 2019-06-11 | 3 | Simeonidis Simos By Sarissa Capital | RGLS | Common Stock | I | 3,703,702 | ||||||||
| 2019-06-11 | 3 | Simeonidis Simos By Sarissa Capital | RGLS | Common Stock | I | 3,703,702 | ||||||||
| 2019-06-11 | 3 | Simeonidis Simos By Sarissa Capital | RGLS | Common Stock | I | 3,703,702 | ||||||||
| 2019-05-21 | 2019-05-07 | 4/A | Hagan Joseph P | RGLS | Common Stock Purchase Warrant (Right to Buy) | D | 1.08 | 0.1250 | 33,194 | 4 | 33,194 | |||
| 2019-05-21 | 2019-05-07 | 4/A | Hagan Joseph P | RGLS | Common Stock | D | 1.0800 | 33,194 | 36 | 64,542 | ||||
| 2019-05-21 | 2019-05-07 | 4/A | Witz Pascale | RGLS | Common Stock Purchase Warrant (Right to Buy) | D | 1.08 | 0.1250 | 29,630 | 4 | 29,630 | |||
| 2019-05-21 | 2019-05-07 | 4/A | Witz Pascale | RGLS | Common Stock | D | 1.0800 | 29,630 | 32 | 37,849 | ||||
| 2019-05-21 | 2019-05-07 | 4/A | RASTETTER WILLIAM H The Rastetter Family Trust DTD 9-2-2010 | RGLS | Common Stock Purchase Warrant (Right to Buy) | I | 1.08 | 0.1250 | 92,889 | 12 | 92,889 | |||
| 2019-05-21 | 2019-05-07 | 4/A | RASTETTER WILLIAM H The Rastetter Family Trust DTD 9-2-2010 | RGLS | Common Stock | I | 1.0800 | 92,889 | 100 | 154,223 | ||||
| 2019-05-21 | 2019-05-07 | 4/A | PAPADOPOULOS STELIOS | RGLS | Common Stock Purchase Warrant (Right to Buy) | D | 1.08 | 0.1250 | 370,370 | 46 | 370,370 | |||
| 2019-05-21 | 2019-05-07 | 4/A | PAPADOPOULOS STELIOS | RGLS | Common Stock | D | 1.0800 | 370,370 | 400 | 1,189,872 | ||||
| 2019-05-17 | 3 | Sarissa Capital Offshore Master Fund LP See Footnotes | RGLS | Common Stock | I | 3,703,702 | ||||||||
| 2019-05-17 | 3 | Sarissa Capital Offshore Master Fund LP See Footnotes | RGLS | Common Stock | I | 3,703,702 | ||||||||
| 2019-05-17 | 3 | Sarissa Capital Offshore Master Fund LP See Footnotes | RGLS | Common Stock | I | 3,703,702 | ||||||||
| 2019-05-17 | 3 | Sarissa Capital Offshore Master Fund LP See Footnotes | RGLS | Common Stock | I | 3,703,702 | ||||||||
| 2019-05-17 | 3 | Sarissa Capital Offshore Master Fund LP See Footnotes | RGLS | Common Stock | I | 3,703,702 | ||||||||
| 2019-05-17 | 3 | Sarissa Capital Offshore Master Fund LP See Footnotes | RGLS | Common Stock | I | 3,703,702 | ||||||||
| 2019-05-17 | 3 | Sarissa Capital Offshore Master Fund LP See Footnotes | RGLS | Common Stock | I | 3,703,702 | ||||||||
| 2019-05-16 | 2019-05-14 | 4/A | Chevallard Daniel R. | RGLS | Stock Option (Right to Buy) | D | 0.95 | 8,000 | 8,000 | |||||
| 2019-05-16 | 2019-05-15 | 4 | Aker Christopher Ray | RGLS | Common Stock | D | 1.4095 | -6,950 | -10 | 59,309 | ||||
| 2019-05-16 | 2019-05-14 | 4 | Aker Christopher Ray | RGLS | Stock Option (Right to Buy) | D | 0.95 | 7,500 | 7,500 | |||||
| 2019-05-16 | 2019-05-14 | 4 | Aker Christopher Ray | RGLS | Common Stock | D | 38,512 | 66,259 | ||||||
| 2019-05-16 | 2019-05-15 | 4 | Chevallard Daniel R. | RGLS | Common Stock | D | 1.4089 | -10,000 | -14 | 80,539 | ||||
| 2019-05-16 | 2019-05-14 | 4 | Chevallard Daniel R. | RGLS | Stock Option (Right to Buy) | D | 0.95 | 8,000 | 7,500 | |||||
| 2019-05-16 | 2019-05-14 | 4 | Chevallard Daniel R. | RGLS | Common Stock | D | 55,414 | 90,539 | ||||||
| 2019-05-16 | 2019-05-16 | 4 | Hagan Joseph P | RGLS | Common Stock | D | 1.2189 | -39,352 | -48 | 268,167 | ||||
| 2019-05-16 | 2019-05-14 | 4 | Hagan Joseph P | RGLS | Stock Option (Right to Buy) | D | 0.95 | 10,000 | 10,000 | |||||
| 2019-05-16 | 2019-05-14 | 4 | Hagan Joseph P | RGLS | Common Stock | D | 188,385 | 307,519 | ||||||
| 2019-05-10 | 2019-05-07 | 4/A | Walker Paul Edward See Note 2 | RGLS | Class A-1 Convertible Preferred Stock | I | 10.8000 | 256,700 | 2,772 | 256,700 | ||||
| 2019-05-10 | 2019-05-07 | 4/A | Walker Paul Edward See Note 2 | RGLS | Common Stock Purchase Warrant (Right to Buy) | I | 1.08 | 0.1250 | 3,703,704 | 463 | 3,703,704 | |||
| 2019-05-10 | 2019-05-07 | 4/A | Walker Paul Edward See Note 2 | RGLS | Common Stock | I | 1.0800 | 1,136,704 | 1,228 | 2,052,454 | ||||
| 2019-05-09 | 2019-05-07 | 4 | Growth Equity Opportunities V, LLC | RGLS | Class A-1 Convertible Preferred Stock | D | 10.8000 | 256,700 | 2,772 | 256,700 | ||||
| 2019-05-09 | 2019-05-07 | 4 | Growth Equity Opportunities V, LLC | RGLS | Common Stock Purchase Warrant (Right to Buy) | D | 1.08 | 0.1250 | 3,703,704 | 463 | 3,703,704 | |||
| 2019-05-09 | 2019-05-07 | 4 | Growth Equity Opportunities V, LLC | RGLS | Common Stock | D | 1.0800 | 1,136,704 | 1,228 | 2,052,454 | ||||
| 2019-05-09 | 2019-05-07 | 4 | BARRIS PETER J See Note 2 | RGLS | Class A-1 Convertible Preferred Stock | I | 10.8000 | 256,700 | 2,772 | 256,700 | ||||
| 2019-05-09 | 2019-05-07 | 4 | BARRIS PETER J See Note 2 | RGLS | Common Stock Purchase Warrant (Right to Buy) | I | 1.08 | 0.1250 | 3,703,704 | 463 | 3,703,704 | |||
| 2019-05-09 | 2019-05-07 | 4 | BARRIS PETER J See Note 2 | RGLS | Common Stock | I | 1.0800 | 1,136,704 | 1,228 | 2,052,454 | ||||
| 2019-05-09 | 2019-05-07 | 4 | BASKETT FOREST See Note 2 | RGLS | Class A-1 Convertible Preferred Stock | I | 10.8000 | 256,700 | 2,772 | 256,700 | ||||
| 2019-05-09 | 2019-05-07 | 4 | BASKETT FOREST See Note 2 | RGLS | Common Stock Purchase Warrant (Right to Buy) | I | 1.08 | 0.1250 | 3,703,704 | 463 | 3,703,704 | |||
| 2019-05-09 | 2019-05-07 | 4 | BASKETT FOREST See Note 2 | RGLS | Common Stock | I | 1.0800 | 1,136,704 | 1,228 | 2,052,454 | ||||
| 2019-05-09 | 2019-05-07 | 4 | Behbahani Ali See Note 2 | RGLS | Class A-1 Convertible Preferred Stock | I | 10.8000 | 256,700 | 2,772 | 256,700 | ||||
| 2019-05-09 | 2019-05-07 | 4 | Behbahani Ali See Note 2 | RGLS | Common Stock Purchase Warrant (Right to Buy) | I | 1.08 | 0.1250 | 3,703,704 | 463 | 3,703,704 | |||
| 2019-05-09 | 2019-05-07 | 4 | Behbahani Ali See Note 2 | RGLS | Common Stock | I | 1.0800 | 1,136,704 | 1,228 | 2,052,454 | ||||
| 2019-05-09 | 2019-05-07 | 4 | Chang Carmen See Note 2 | RGLS | Class A-1 Convertible Preferred Stock | I | 10.8000 | 256,700 | 2,772 | 256,700 | ||||
| 2019-05-09 | 2019-05-07 | 4 | Chang Carmen See Note 2 | RGLS | Common Stock Purchase Warrant (Right to Buy) | I | 1.08 | 0.1250 | 3,703,704 | 463 | 3,703,704 | |||
| 2019-05-09 | 2019-05-07 | 4 | Chang Carmen See Note 2 | RGLS | Common Stock | I | 1.0800 | 1,136,704 | 1,228 | 2,052,454 | ||||
| 2019-05-09 | 2019-05-07 | 4 | Florence Anthony A. Jr. See Note 2 | RGLS | Class A-1 Convertible Preferred Stock | I | 10.8000 | 256,700 | 2,772 | 256,700 | ||||
| 2019-05-09 | 2019-05-07 | 4 | Florence Anthony A. Jr. See Note 2 | RGLS | Common Stock Purchase Warrant (Right to Buy) | I | 1.08 | 0.1250 | 3,703,704 | 463 | 3,703,704 | |||
| 2019-05-09 | 2019-05-07 | 4 | Florence Anthony A. Jr. See Note 2 | RGLS | Common Stock | I | 1.0800 | 1,136,704 | 1,228 | 2,052,454 | ||||
| 2019-05-09 | 2019-05-07 | 4 | Makhzoumi Mohamad See Note 2 | RGLS | Class A-1 Convertible Preferred Stock | I | 10.8000 | 256,700 | 2,772 | 256,700 | ||||
| 2019-05-09 | 2019-05-07 | 4 | Makhzoumi Mohamad See Note 2 | RGLS | Common Stock Purchase Warrant (Right to Buy) | I | 1.08 | 0.1250 | 3,703,704 | 463 | 3,703,704 | |||
| 2019-05-09 | 2019-05-07 | 4 | Makhzoumi Mohamad See Note 2 | RGLS | Common Stock | I | 1.0800 | 1,136,704 | 1,228 | 2,052,454 | ||||
| 2019-05-09 | 2019-05-07 | 4 | MAKOWER JOSHUA See Note 2 | RGLS | Class A-1 Convertible Preferred Stock | I | 10.8000 | 256,700 | 2,772 | 256,700 | ||||
| 2019-05-09 | 2019-05-07 | 4 | MAKOWER JOSHUA See Note 2 | RGLS | Common Stock Purchase Warrant (Right to Buy) | I | 1.08 | 0.1250 | 3,703,704 | 463 | 3,703,704 | |||
| 2019-05-09 | 2019-05-07 | 4 | MAKOWER JOSHUA See Note 2 | RGLS | Common Stock | I | 1.0800 | 1,136,704 | 1,228 | 2,052,454 | ||||
| 2019-05-09 | 2019-05-07 | 4 | MOTT DAVID M See Note 2 | RGLS | Class A-1 Convertible Preferred Stock | I | 10.8000 | 256,700 | 2,772 | 256,700 | ||||
| 2019-05-09 | 2019-05-07 | 4 | MOTT DAVID M See Note 2 | RGLS | Common Stock Purchase Warrant (Right to Buy) | I | 1.08 | 0.1250 | 3,703,704 | 463 | 3,703,704 | |||
| 2019-05-09 | 2019-05-07 | 4 | MOTT DAVID M See Note 2 | RGLS | Common Stock | I | 1.0800 | 1,136,704 | 1,228 | 2,052,454 | ||||
| 2019-05-09 | 2019-05-07 | 4 | SANDELL SCOTT D See Note 2 | RGLS | Class A-1 Convertible Preferred Stock | I | 10.8000 | 256,700 | 2,772 | 256,700 | ||||
| 2019-05-09 | 2019-05-07 | 4 | SANDELL SCOTT D See Note 2 | RGLS | Common Stock Purchase Warrant (Right to Buy) | I | 1.08 | 0.1250 | 3,703,704 | 463 | 3,703,704 | |||
| 2019-05-09 | 2019-05-07 | 4 | SANDELL SCOTT D See Note 2 | RGLS | Common Stock | I | 1.0800 | 1,136,704 | 1,228 | 2,052,454 | ||||
| 2019-05-09 | 2019-05-07 | 4 | Sonsini Peter W. See Note 2 | RGLS | Class A-1 Convertible Preferred Stock | I | 10.8000 | 256,700 | 2,772 | 256,700 | ||||
| 2019-05-09 | 2019-05-07 | 4 | Sonsini Peter W. See Note 2 | RGLS | Common Stock Purchase Warrant (Right to Buy) | I | 1.08 | 0.1250 | 3,703,704 | 463 | 3,703,704 | |||
| 2019-05-09 | 2019-05-07 | 4 | Sonsini Peter W. See Note 2 | RGLS | Common Stock | I | 1.0800 | 1,136,704 | 1,228 | 2,052,454 | ||||
| 2019-05-09 | 2019-05-07 | 4 | Walker Paul Edward See Note 2 | RGLS | Class A-1 Convertible Preferred Stock | I | 10.8000 | 256,700 | 2,772 | 256,700 | ||||
| 2019-05-09 | 2019-05-07 | 4 | Walker Paul Edward See Note 2 | RGLS | Common Stock Purchase Warrant (Right to Buy) | I | 1.08 | 0.1250 | 3,703,704 | 463 | 3,703,704 | |||
| 2019-05-09 | 2019-05-07 | 4 | Walker Paul Edward See Note 2 | RGLS | Common Stock | I | 1.0800 | 1,136,704 | 1,228 | 2,052,454 | ||||
| 2019-05-08 | 2019-05-07 | 4 | PAPADOPOULOS STELIOS | RGLS | Common Stock Purchase Warrant (Right to Buy) | D | 1.08 | 0.1250 | 370,370 | 46 | 370,370 | |||
| 2019-05-08 | 2019-05-07 | 4 | PAPADOPOULOS STELIOS | RGLS | Common Stock | D | 1.0800 | 370,370 | 400 | 1,189,872 | ||||
| 2019-05-08 | 2019-05-07 | 4 | RASTETTER WILLIAM H THE RASTETTER FAMILY TRUST DTD 09-02-2010 | RGLS | Common Stock Purchase Warrant (Right to Buy) | I | 1.08 | 0.1250 | 92,889 | 12 | 92,889 | |||
| 2019-05-08 | 2019-05-07 | 4 | RASTETTER WILLIAM H THE RASTETTER FAMILY TRUST DTD 9-2-2010 | RGLS | Common Stock | I | 1.0800 | 92,889 | 100 | 154,223 | ||||
| 2019-05-08 | 2019-05-07 | 4 | Witz Pascale | RGLS | Common Stock Purchase Warrant (Right to Buy) | D | 1.08 | 0.1250 | 29,630 | 4 | 29,630 | |||
| 2019-05-08 | 2019-05-07 | 4 | Witz Pascale | RGLS | Common Stock | D | 1.0800 | 29,630 | 32 | 37,849 | ||||
| 2019-05-08 | 2019-05-07 | 4 | Hagan Joseph P | RGLS | Common Stock Purchase Warrant (Right to Buy) | D | 1.08 | 0.1250 | 33,194 | 4 | 33,194 | |||
| 2019-05-08 | 2019-05-07 | 4 | Hagan Joseph P | RGLS | Common Stock | D | 1.0800 | 33,194 | 36 | 64,542 | ||||
| 2019-04-03 | 2019-04-01 | 4 | Hagan Joseph P | RGLS | Common Stock | D | 0.9810 | -5,842 | -6 | 31,348 | ||||
| 2019-04-03 | 2019-04-01 | 4 | Aker Christopher Ray | RGLS | Common Stock | D | 0.9812 | -2,710 | -3 | 6,287 | ||||
| 2019-04-03 | 2019-04-01 | 4 | Chevallard Daniel R. | RGLS | Common Stock | D | 0.9814 | -3,253 | -3 | 9,372 | ||||
| 2019-02-06 | 2019-02-05 | 4 | Aker Christopher Ray | RGLS | Stock Option (Right to Buy) | D | 0.95 | 25,000 | 25,000 | |||||
| 2019-02-06 | 2019-02-05 | 4 | Aker Christopher Ray | RGLS | Common Stock | D | 25,000 | 27,747 | ||||||
| 2019-02-06 | 2019-02-05 | 4 | Chevallard Daniel R. | RGLS | Stock Option (Right to Buy) | D | 0.95 | 30,000 | 30,000 | |||||
| 2019-02-06 | 2019-02-05 | 4 | Chevallard Daniel R. | RGLS | Common Stock | D | 0.9500 | 30,000 | 28 | 34,578 | ||||
| 2019-02-06 | 2019-02-05 | 4 | Hagan Joseph P | RGLS | Stock Option (Right to Buy) | D | 0.95 | 65,000 | 65,000 | |||||
| 2019-02-06 | 2019-02-05 | 4 | Hagan Joseph P | RGLS | Common Stock | D | 0.9500 | 65,000 | 62 | 84,148 | ||||
| 2019-02-06 | 2019-02-05 | 4 | WRIGHT TIMOTHY MICHAEL | RGLS | Stock Option (Right to Buy) | D | 0.95 | 40,000 | 40,000 | |||||
| 2019-02-06 | 2019-02-05 | 4 | WRIGHT TIMOTHY MICHAEL | RGLS | Common Stock | D | 0.9500 | 40,000 | 38 | 62,893 | ||||
| 2019-01-02 | 3 | Aker Christopher Ray | RGLS | Common Stock | D | 5,494 | ||||||||
| 2019-01-02 | 3 | Aker Christopher Ray | RGLS | Common Stock | D | 5,494 | ||||||||
| 2019-01-02 | 3 | Aker Christopher Ray | RGLS | Common Stock | D | 5,494 | ||||||||
| 2019-01-02 | 2018-12-28 | 4 | PAPADOPOULOS STELIOS | RGLS | Common Stock | D | 1.0914 | 50,000 | 55 | 835,073 | ||||
| 2018-12-28 | 2018-12-27 | 4 | PAPADOPOULOS STELIOS | RGLS | Common Stock | D | 1.0401 | 26,401 | 27 | 785,073 | ||||
| 2018-12-28 | 2018-12-26 | 4 | PAPADOPOULOS STELIOS | RGLS | Common Stock | D | 0.9542 | 90,000 | 86 | 758,672 | ||||
| 2018-11-21 | 2018-11-12 | 4 | PAPADOPOULOS STELIOS | RGLS | Stock Option (Right to Buy) | D | 8.76 | -4,583 | 0 | |||||
| 2018-11-21 | 2018-11-12 | 4 | PAPADOPOULOS STELIOS | RGLS | Stock Option (Right to Buy) | D | 8.52 | -6,250 | 0 | |||||
| 2018-11-21 | 2018-11-12 | 4 | PAPADOPOULOS STELIOS | RGLS | Stock Option (Right to Buy) | D | 17.40 | -2,500 | 0 | |||||
| 2018-11-21 | 2018-11-12 | 4 | PAPADOPOULOS STELIOS | RGLS | Stock Option (Right to Buy) | D | 74.40 | -3,051 | 0 | |||||
| 2018-11-21 | 2018-11-12 | 4 | PAPADOPOULOS STELIOS | RGLS | Stock Option (Right to Buy) | D | 111.84 | -1,458 | 0 | |||||
| 2018-11-21 | 2018-11-12 | 4 | PAPADOPOULOS STELIOS | RGLS | Stock Option (Right to Buy) | D | 120.24 | -1,458 | 0 | |||||
| 2018-11-21 | 2018-11-12 | 4 | PAPADOPOULOS STELIOS | RGLS | Stock Option (Right to Buy) | D | 74.64 | -1,458 | 0 | |||||
| 2018-11-21 | 2018-11-12 | 4 | PAPADOPOULOS STELIOS | RGLS | Stock Option (Right to Buy) | D | 31.92 | -152 | 0 | |||||
| 2018-11-21 | 2018-11-12 | 4 | PAPADOPOULOS STELIOS | RGLS | Common Stock | D | 20,910 | 168,672 | ||||||
| 2018-11-19 | 2018-11-16 | 4 | Collier Kathryn J | RGLS | Common Stock | D | 1.4100 | 7,100 | 10 | 27,596 | ||||
| 2018-11-19 | 2018-11-16 | 4 | PAPADOPOULOS STELIOS | RGLS | Common Stock | D | 1.3849 | 300,000 | 415 | 668,672 | ||||
| 2018-11-19 | 2018-11-15 | 4 | PAPADOPOULOS STELIOS | RGLS | Common Stock | D | 1.3254 | 200,000 | 265 | 368,672 | ||||
| 2018-11-13 | 2018-11-12 | 4 | Witz Pascale | RGLS | Stock Option (Right to Buy) | D | 8.76 | -4,583 | 0 | |||||
| 2018-11-13 | 2018-11-12 | 4 | Witz Pascale | RGLS | Stock Option (Right to Buy) | D | 8.52 | -6,250 | 0 | |||||
| 2018-11-13 | 2018-11-12 | 4 | Witz Pascale | RGLS | Stock Option (Right to Buy) | D | 17.40 | -5,000 | 0 | |||||
| 2018-11-13 | 2018-11-12 | 4 | Witz Pascale | RGLS | Common Stock | D | 15,833 | 19,625 | ||||||
| 2018-11-13 | 2018-11-12 | 4 | Rosen Hugh | RGLS | Stock Option (Right to Buy) | D | 8.76 | -4,583 | 0 | |||||
| 2018-11-13 | 2018-11-12 | 4 | Rosen Hugh | RGLS | Stock Option (Right to Buy) | D | 8.52 | -6,250 | 0 | |||||
| 2018-11-13 | 2018-11-12 | 4 | Rosen Hugh | RGLS | Stock Option (Right to Buy) | D | 17.40 | -2,500 | 0 | |||||
| 2018-11-13 | 2018-11-12 | 4 | Rosen Hugh | RGLS | Stock Option (Right to Buy) | D | 74.40 | -5,912 | 0 | |||||
| 2018-11-13 | 2018-11-12 | 4 | Rosen Hugh | RGLS | Common Stock | D | 19,245 | 22,756 | ||||||
| 2018-11-13 | 2018-11-12 | 4 | RASTETTER WILLIAM H William H. Rastetter TTEE, Marisa Rastetter TTEE 9-2-2010 FBO Rastetter Family Trus | RGLS | Stock Option (Right to Buy) | I | 8.76 | -4,583 | 0 | |||||
| 2018-11-13 | 2018-11-12 | 4 | RASTETTER WILLIAM H William H. Rastetter TTEE, Marisa Rastetter TTEE 9-2-2010 FBO Rastetter Family Trus | RGLS | Stock Option (Right to Buy) | I | 8.52 | -6,250 | 0 | |||||
| 2018-11-13 | 2018-11-12 | 4 | RASTETTER WILLIAM H William H. Rastetter TTEE, Marisa Rastetter TTEE 9-2-2010 FBO Rastetter Family Trus | RGLS | Stock Option (Right to Buy) | I | 17.40 | -2,500 | 0 | |||||
| 2018-11-13 | 2018-11-12 | 4 | RASTETTER WILLIAM H William H. Rastetter TTEE, Marisa Rastetter TTEE 9-2-2010 FBO Rastetter Family Trus | RGLS | Stock Option (Right to Buy) | I | 92.04 | -2,500 | 0 | |||||
| 2018-11-13 | 2018-11-12 | 4 | RASTETTER WILLIAM H William H. Rastetter TTEE, Marisa Rastetter TTEE 9-2-2010 FBO Rastetter Family Trus | RGLS | Stock Option (Right to Buy) | I | 74.40 | -3,051 | 0 | |||||
| 2018-11-13 | 2018-11-12 | 4 | RASTETTER WILLIAM H William H. Rastetter TTEE, Marisa Rastetter TTEE 9-2-2010 FBO Rastetter Family Trus | RGLS | Stock Option (Right to Buy) | I | 120.24 | -1,458 | 0 | |||||
| 2018-11-13 | 2018-11-12 | 4 | RASTETTER WILLIAM H William H. Rastetter TTEE, Marisa Rastetter TTEE 9-2-2010 FBO Rastetter Family Trus | RGLS | Stock Option (Right to Buy) | I | 111.84 | -1,458 | 0 | |||||
| 2018-11-13 | 2018-11-12 | 4 | RASTETTER WILLIAM H William H. Rastetter TTEE, Marisa Rastetter TTEE 9-2-2010 FBO Rastetter Family Trus | RGLS | Stock Option (Right to Buy) | I | 74.64 | -1,458 | 0 | |||||
| 2018-11-13 | 2018-11-12 | 4 | RASTETTER WILLIAM H William H. Rastetter TTEE, Marisa Rastetter TTEE 9-2-2010 FBO Rastetter Family Trust | RGLS | Common Stock | I | 23,258 | 79,672 | ||||||
| 2018-11-13 | 2018-11-12 | 4 | Collier Kathryn J | RGLS | Stock Option (Right to Buy) | D | 8.67 | -4,583 | 0 | |||||
| 2018-11-13 | 2018-11-12 | 4 | Collier Kathryn J | RGLS | Stock Option (Right to Buy) | D | 8.52 | -3,125 | 0 | |||||
| 2018-11-13 | 2018-11-12 | 4 | Collier Kathryn J | RGLS | Stock Option (Right to Buy) | D | 9.45 | -9,166 | 0 | |||||
| 2018-11-13 | 2018-11-12 | 4 | Collier Kathryn J | RGLS | Common Stock | D | 16,874 | 20,496 | ||||||
| 2018-11-13 | 2018-11-12 | 4 | BALTIMORE DAVID | RGLS | Stock Option (Right to Buy) | D | 8.76 | -4,583 | 0 | |||||
| 2018-11-13 | 2018-11-12 | 4 | BALTIMORE DAVID | RGLS | Stock Option (Right to Buy) | D | 8.52 | -6,250 | 0 | |||||
| 2018-11-13 | 2018-11-12 | 4 | BALTIMORE DAVID | RGLS | Stock Option (Right to Buy) | D | 17.40 | -2,500 | 0 | |||||
| 2018-11-13 | 2018-11-12 | 4 | BALTIMORE DAVID | RGLS | Stock Option (Right to Buy) | D | 74.40 | -3,051 | 0 | |||||
| 2018-11-13 | 2018-11-12 | 4 | BALTIMORE DAVID | RGLS | Stock Option (Right to Buy) | D | 120.24 | -1,458 | 0 | |||||
| 2018-11-13 | 2018-11-12 | 4 | BALTIMORE DAVID | RGLS | Stock Option (Right to Buy) | D | 4.56 | -1,458 | 0 | |||||
| 2018-11-13 | 2018-11-12 | 4 | BALTIMORE DAVID | RGLS | Stock Option (Right to Buy) | D | 74.64 | -416 | 0 | |||||
| 2018-11-13 | 2018-11-12 | 4 | BALTIMORE DAVID | RGLS | Stock Option (Right to Buy) | D | 111.84 | -416 | 0 | |||||
| 2018-11-13 | 2018-11-12 | 4 | BALTIMORE DAVID | RGLS | Stock Option (Right to Buy) | D | 74.64 | -1,458 | 0 | |||||
| 2018-11-13 | 2018-11-12 | 4 | BALTIMORE DAVID | RGLS | Stock Option (Right to Buy) | D | 111.84 | -1,458 | 0 | |||||
| 2018-11-13 | 2018-11-12 | 4 | BALTIMORE DAVID | RGLS | Stock Option (Right to Buy) | D | 31.92 | -1,458 | 0 | |||||
| 2018-11-13 | 2018-11-12 | 4 | BALTIMORE DAVID | RGLS | Stock Option (Right to Buy) | D | 4.56 | -625 | 0 | |||||
| 2018-11-13 | 2018-11-12 | 4 | BALTIMORE DAVID | RGLS | Stock Option (Right to Buy) | D | 31.92 | -625 | 0 | |||||
| 2018-11-13 | 2018-11-12 | 4 | BALTIMORE DAVID | RGLS | Stock Option (Right to Buy) | D | 20.88 | -1,458 | 0 | |||||
| 2018-11-13 | 2018-11-12 | 4 | BALTIMORE DAVID | RGLS | Stock Option (Right to Buy) | D | 20.88 | -625 | 0 | |||||
| 2018-11-13 | 2018-11-12 | 4 | BALTIMORE DAVID | RGLS | Stock Option (Right to Buy) | D | 4.56 | -1,875 | 0 | |||||
| 2018-11-13 | 2018-11-12 | 4 | BALTIMORE DAVID | RGLS | Stock Option (Right to Buy) | D | 4.56 | -10,625 | 0 | |||||
| 2018-11-13 | 2018-11-12 | 4 | BALTIMORE DAVID | RGLS | Common Stock | D | 40,339 | 44,131 | ||||||
| 2018-07-17 | 3 | Behbahani Ali See Note 1 | RGLS | Common Stock | I | 21,978,020 | ||||||||
| 2018-07-17 | 3 | Behbahani Ali See Note 1 | RGLS | Common Stock | I | 21,978,020 | ||||||||
| 2018-07-17 | 3 | Behbahani Ali See Note 1 | RGLS | Common Stock | I | 21,978,020 | ||||||||
| 2018-07-17 | 3 | Chang Carmen See Note 1 | RGLS | Common Stock | I | 21,978,020 | ||||||||
| 2018-07-17 | 3 | Chang Carmen See Note 1 | RGLS | Common Stock | I | 21,978,020 | ||||||||
| 2018-07-17 | 3 | Chang Carmen See Note 1 | RGLS | Common Stock | I | 21,978,020 | ||||||||
| 2018-06-05 | 2018-06-05 | 4 | Collier Kathryn J | RGLS | Common Stock | D | 0.7400 | 7,695 | 6 | 7,695 | ||||
| 2018-06-05 | 2018-06-01 | 4 | Collier Kathryn J | RGLS | Stock Option (Right to Buy) | D | 0.73 | 55,000 | 55,000 | |||||
| 2018-06-05 | 2018-06-01 | 4 | BALTIMORE DAVID | RGLS | Stock Option (Right to Buy) | D | 0.73 | 55,000 | 55,000 | |||||
| 2018-06-05 | 2018-06-01 | 4 | PAPADOPOULOS STELIOS | RGLS | Stock Option (Right to Buy) | D | 0.73 | 55,000 | 55,000 | |||||
| 2018-06-05 | 2018-06-01 | 4 | RASTETTER WILLIAM H Rastetter Family Trust dated 9-2-2010 | RGLS | Stock Option (Right to Buy) | I | 0.73 | 55,000 | 55,000 | |||||
| 2018-06-05 | 2018-06-01 | 4 | Rosen Hugh | RGLS | Stock Option (Right to Buy) | D | 0.73 | 55,000 | 55,000 | |||||
| 2018-06-05 | 2018-06-01 | 4 | Witz Pascale | RGLS | Stock Option (Right to Buy) | D | 0.73 | 55,000 | 55,000 | |||||
| 2018-05-21 | 2018-05-17 | 4 | Deeg Mark Albert | RGLS | Common Stock (Right to Buy) | D | 0.71 | 100,000 | 100,000 | |||||
| 2018-05-21 | 2018-05-17 | 4 | Hagan Joseph P | RGLS | Stock Option (Right to Buy) | D | 0.71 | 725,000 | 725,000 | |||||
| 2018-05-21 | 2018-05-17 | 4 | PAPADOPOULOS STELIOS | RGLS | Stock Option (Right to Buy) | D | 0.71 | 75,000 | 75,000 | |||||
| 2018-05-21 | 2018-05-17 | 4 | RASTETTER WILLIAM H Rastetter Family Trust dated 9-2-2010 | RGLS | Stock Option (Right to Buy) | I | 0.71 | 75,000 | 75,000 | |||||
| 2018-05-21 | 2018-05-17 | 4 | Rosen Hugh | RGLS | Stock Option (Right to Buy) | D | 0.71 | 75,000 | 75,000 | |||||
| 2018-05-21 | 2018-05-17 | 4 | Witz Pascale | RGLS | Stock Option (Right to Buy) | D | 0.71 | 75,000 | 75,000 | |||||
| 2018-05-21 | 2018-05-17 | 4 | WRIGHT TIMOTHY MICHAEL | RGLS | Stock Option (Right to Buy) | D | 0.71 | 350,000 | 350,000 | |||||
| 2018-05-21 | 2018-05-17 | 4 | BALTIMORE DAVID | RGLS | Stock Option (Right to Buy) | D | 0.71 | 75,000 | 75,000 | |||||
| 2018-05-21 | 2018-05-17 | 4 | Chevallard Daniel R. | RGLS | Stock Option (Right to Buy) | D | 0.71 | 250,000 | 250,000 | |||||
| 2018-05-21 | 2018-05-17 | 4 | Collier Kathryn J | RGLS | Stock Option (Right to Buy) | D | 0.71 | 37,500 | 37,500 | |||||
| 2018-04-17 | 2018-04-14 | 4 | Collier Kathryn J | RGLS | Stock Option (Right to Buy) | D | 0.64 | 110,000 | 110,000 | |||||
| 2018-04-17 | 2018-04-14 | 4 | Collier Kathryn J | RGLS | Common Stock | D | 0.6400 | 60,234 | 39 | 60,234 | ||||
| 2018-01-05 | 2018-01-05 | 4 | Chevallard Daniel R. | RGLS | Stock Option (Right to Buy) | D | 1.24 | 350,000 | 350,000 | |||||
| 2018-01-05 | 2018-01-05 | 4 | Deeg Mark Albert | RGLS | Stock Option (Right to Buy) | D | 1.24 | 175,000 | 175,000 | |||||
| 2018-01-05 | 2018-01-05 | 4 | WRIGHT TIMOTHY MICHAEL | RGLS | Stock Option (Right to Buy) | D | 1.24 | 500,000 | 500,000 | |||||
| 2018-01-05 | 2018-01-05 | 4 | Hagan Joseph P | RGLS | Stock Option (Right to Buy) | D | 1.24 | 1,000,000 | 1,000,000 | |||||
| 2017-12-06 | 2017-12-04 | 4 | Witz Pascale | RGLS | Common Stock | D | 0.8900 | 60,674 | 54 | 60,674 | ||||
| 2017-12-06 | 2017-12-04 | 4 | Rosen Hugh | RGLS | Common Stock | D | 0.8900 | 56,179 | 50 | 56,179 | ||||
| 2017-12-06 | 2017-12-04 | 4 | PAPADOPOULOS STELIOS | RGLS | Common Stock | D | 0.8900 | 96,629 | 86 | 1,797,306 | ||||
| 2017-12-06 | 2017-12-04 | 4 | FOLETTA MARK G | RGLS | Common Stock | D | 0.8900 | 71,910 | 64 | 81,910 | ||||
| 2017-12-06 | 2017-12-04 | 4 | BALTIMORE DAVID | RGLS | Common Stock | D | 0.8900 | 60,674 | 54 | 60,674 | ||||
| 2017-12-06 | 2017-12-04 | 4 | RASTETTER WILLIAM H WILLIAM H RASTETTER TTEE INVESTMENT 2002 TRUST U/A DTD 11/11/2002 | RGLS | Common Stock | I | 0.8900 | 69,662 | 62 | 694,387 | ||||
| 2017-12-05 | 2017-12-04 | 4 | WRIGHT TIMOTHY MICHAEL | RGLS | Stock Option (Right to Buy) | D | 3.30 | 100,000 | 100,000 | |||||
| 2017-11-27 | 3 | BVF PARTNERS L P/IL | RGLS | Common Stock, $0.001 par value per share | D | 17,248,837 | ||||||||
| 2017-11-27 | 3 | BVF PARTNERS L P/IL | RGLS | Common Stock, $0.001 par value per share | D | 17,248,837 | ||||||||
| 2017-11-27 | 3 | BVF PARTNERS L P/IL | RGLS | Common Stock, $0.001 par value per share | D | 15,027,176 | ||||||||
| 2017-11-27 | 3 | BVF PARTNERS L P/IL | RGLS | Common Stock, $0.001 par value per share | D | 12,158,047 | ||||||||
| 2017-11-27 | 3 | BVF PARTNERS L P/IL | RGLS | Common Stock, $0.001 par value per share | D | 17,248,837 | ||||||||
| 2017-11-27 | 3 | BVF PARTNERS L P/IL | RGLS | Common Stock, $0.001 par value per share | D | 15,027,176 | ||||||||
| 2017-11-27 | 3 | BVF PARTNERS L P/IL | RGLS | Common Stock, $0.001 par value per share | D | 12,158,047 | ||||||||
| 2017-11-27 | 3 | BVF PARTNERS L P/IL | RGLS | Common Stock, $0.001 par value per share | D | 17,248,837 | ||||||||
| 2017-11-27 | 3 | BVF PARTNERS L P/IL | RGLS | Common Stock, $0.001 par value per share | D | 15,027,176 | ||||||||
| 2017-11-27 | 3 | BVF PARTNERS L P/IL | RGLS | Common Stock, $0.001 par value per share | D | 12,158,047 | ||||||||
| 2017-11-27 | 3 | BVF PARTNERS L P/IL | RGLS | Common Stock, $0.001 par value per share | D | 17,248,837 | ||||||||
| 2017-11-27 | 3 | BVF PARTNERS L P/IL | RGLS | Common Stock, $0.001 par value per share | D | 15,027,176 | ||||||||
| 2017-11-27 | 3 | BVF PARTNERS L P/IL | RGLS | Common Stock, $0.001 par value per share | D | 12,158,047 | ||||||||
| 2017-11-27 | 3 | BVF PARTNERS L P/IL | RGLS | Common Stock, $0.001 par value per share | D | 15,027,176 | ||||||||
| 2017-11-27 | 3 | BVF PARTNERS L P/IL | RGLS | Common Stock, $0.001 par value per share | D | 12,158,047 | ||||||||
| 2017-11-27 | 3 | BVF PARTNERS L P/IL | RGLS | Common Stock, $0.001 par value per share | D | 17,248,837 | ||||||||
| 2017-11-27 | 3 | BVF PARTNERS L P/IL | RGLS | Common Stock, $0.001 par value per share | D | 15,027,176 | ||||||||
| 2017-11-27 | 3 | BVF PARTNERS L P/IL | RGLS | Common Stock, $0.001 par value per share | D | 12,158,047 | ||||||||
| 2017-11-27 | 3 | BVF PARTNERS L P/IL | RGLS | Common Stock, $0.001 par value per share | D | 17,248,837 | ||||||||
| 2017-11-27 | 3 | BVF PARTNERS L P/IL | RGLS | Common Stock, $0.001 par value per share | D | 15,027,176 | ||||||||
| 2017-11-27 | 3 | BVF PARTNERS L P/IL | RGLS | Common Stock, $0.001 par value per share | D | 12,158,047 | ||||||||
| 2017-11-27 | 3 | BVF PARTNERS L P/IL | RGLS | Common Stock, $0.001 par value per share | D | 17,248,837 | ||||||||
| 2017-11-27 | 3 | BVF PARTNERS L P/IL | RGLS | Common Stock, $0.001 par value per share | D | 15,027,176 | ||||||||
| 2017-11-27 | 3 | BVF PARTNERS L P/IL | RGLS | Common Stock, $0.001 par value per share | D | 12,158,047 | ||||||||
| 2017-07-31 | 3 | Growth Equity Opportunities V, LLC | RGLS | Common Stock | D | 21,978,020 | ||||||||
| 2017-07-31 | 3 | Growth Equity Opportunities V, LLC | RGLS | Common Stock | D | 21,978,020 | ||||||||
| 2017-07-31 | 3 | Growth Equity Opportunities V, LLC | RGLS | Common Stock | D | 21,978,020 | ||||||||
| 2017-07-31 | 3 | Growth Equity Opportunities V, LLC | RGLS | Common Stock | D | 21,978,020 | ||||||||
| 2017-07-31 | 3 | Growth Equity Opportunities V, LLC | RGLS | Common Stock | D | 21,978,020 | ||||||||
| 2017-07-31 | 3 | Sonsini Peter W. See Note 1 | RGLS | Common Stock | I | 21,978,020 | ||||||||
| 2017-07-31 | 3 | Sonsini Peter W. See Note 1 | RGLS | Common Stock | I | 21,978,020 | ||||||||
| 2017-07-31 | 3 | Viswanathan Ravi See Note 1 | RGLS | Common Stock | I | 21,978,020 | ||||||||
| 2017-07-31 | 3 | Viswanathan Ravi See Note 1 | RGLS | Common Stock | I | 21,978,020 | ||||||||
| 2017-07-31 | 3 | SANDELL SCOTT D See Note 1 | RGLS | Common Stock | I | 21,978,020 | ||||||||
| 2017-07-31 | 3 | SANDELL SCOTT D See Note 1 | RGLS | Common Stock | I | 21,978,020 | ||||||||
| 2017-07-31 | 3 | MOTT DAVID M See Note 1 | RGLS | Common Stock | I | 21,978,020 | ||||||||
| 2017-07-31 | 3 | MOTT DAVID M See Note 1 | RGLS | Common Stock | I | 21,978,020 | ||||||||
| 2017-07-31 | 3 | Puttagunta Chetan See Note 1 | RGLS | Common Stock | I | 21,978,020 | ||||||||
| 2017-07-31 | 3 | Puttagunta Chetan See Note 1 | RGLS | Common Stock | I | 21,978,020 | ||||||||
| 2017-07-31 | 3 | Sakoda Jon See Note 1 | RGLS | Common Stock | I | 21,978,020 | ||||||||
| 2017-07-31 | 3 | Sakoda Jon See Note 1 | RGLS | Common Stock | I | 21,978,020 | ||||||||
| 2017-07-31 | 3 | BASKETT FOREST See Note 1 | RGLS | Common Stock | I | 21,978,020 | ||||||||
| 2017-07-31 | 3 | BASKETT FOREST See Note 1 | RGLS | Common Stock | I | 21,978,020 | ||||||||
| 2017-07-31 | 3 | Florence Anthony A. Jr. See Note 1 | RGLS | Common Stock | I | 21,978,020 | ||||||||
| 2017-07-31 | 3 | Florence Anthony A. Jr. See Note 1 | RGLS | Common Stock | I | 21,978,020 | ||||||||
| 2017-07-31 | 3 | BARRIS PETER J See Note 1 | RGLS | Common Stock | I | 21,978,020 | ||||||||
| 2017-07-31 | 3 | BARRIS PETER J See Note 1 | RGLS | Common Stock | I | 21,978,020 | ||||||||
| 2017-07-31 | 3 | Makhzoumi Mohamad See Note 1 | RGLS | Common Stock | I | 21,978,020 | ||||||||
| 2017-07-31 | 3 | Makhzoumi Mohamad See Note 1 | RGLS | Common Stock | I | 21,978,020 | ||||||||
| 2017-07-31 | 3 | MAKOWER JOSHUA See Note 1 | RGLS | Common Stock | I | 21,978,020 | ||||||||
| 2017-07-31 | 3 | MAKOWER JOSHUA See Note 1 | RGLS | Common Stock | I | 21,978,020 | ||||||||
| 2017-07-25 | 2017-07-25 | 4 | RASTETTER WILLIAM H WILLIAM H RASTETTER TTEE INVESTMENT 2002 TRUST U/A DTD 11/11/2002 | RGLS | Common Stock | I | 0.9100 | 274,725 | 250 | 624,625 | ||||
| 2017-07-25 | 2017-07-25 | 4 | WRIGHT TIMOTHY MICHAEL | RGLS | Common Stock | D | 0.9100 | 274,725 | 250 | 274,725 | ||||
| 2017-07-25 | 2017-07-25 | 4 | PAPADOPOULOS STELIOS | RGLS | Common Stock | D | 0.9100 | 1,000,000 | 910 | 1,770,677 | ||||
| 2017-07-25 | 2017-07-25 | 4 | Chevallard Daniel R. | RGLS | Common Stock | D | 0.9100 | 54,945 | 50 | 59,415 | ||||
| 2017-07-25 | 2017-07-25 | 4 | Hagan Joseph P | RGLS | Common Stock | D | 0.9100 | 219,780 | 200 | 241,297 | ||||
| 2017-06-23 | 2017-06-22 | 4 | Deeg Mark Albert | RGLS | Stock Option (Right to Buy) | D | 0.99 | 100,000 | 100,000 | |||||
| 2017-06-02 | 2017-06-01 | 4 | Witz Pascale | RGLS | Stock Option (Right to Buy) | D | 1.45 | 60,000 | 60,000 | |||||
| 2017-06-02 | 2017-06-01 | 4 | BALTIMORE DAVID | RGLS | Common Stock (Option to Buy) | D | 1.45 | 30,000 | 30,000 | |||||
| 2017-06-02 | 2017-06-01 | 4 | FOLETTA MARK G | RGLS | Stock Option (Right to Buy) | D | 1.45 | 30,000 | 30,000 | |||||
| 2017-06-02 | 2017-06-01 | 4 | PAPADOPOULOS STELIOS | RGLS | Stock Option (Right to Buy) | D | 1.45 | 30,000 | 30,000 | |||||
| 2017-06-02 | 2017-06-01 | 4 | RASTETTER WILLIAM H | RGLS | Stock Option (Right to Buy) | D | 1.45 | 30,000 | 30,000 | |||||
| 2017-06-02 | 2017-06-01 | 4 | Rosen Hugh | RGLS | Stock Option (Right to Buy) | D | 1.45 | 30,000 | 30,000 | |||||
| 2017-05-12 | 2017-05-10 | 4 | Chevallard Daniel R. | RGLS | Stock Option (Right to Buy) | D | 1.65 | 100,000 | 100,000 | |||||
| 2017-05-10 | 3 | Chevallard Daniel R. | RGLS | Common Stock | D | 8,940 | ||||||||
| 2017-05-10 | 3 | Chevallard Daniel R. | RGLS | Common Stock | D | 8,940 | ||||||||
| 2017-05-08 | 2017-05-04 | 4 | Hagan Joseph P | RGLS | Stock Option (Right to Buy) | D | 1.70 | 750,000 | 750,000 | |||||
| 2017-05-08 | 2017-05-04 | 4 | WRIGHT TIMOTHY MICHAEL | RGLS | Stock Option (Right to Buy) | D | 1.70 | 350,000 | 350,000 | |||||
| 2017-03-23 | 2017-03-22 | 4 | PAPADOPOULOS STELIOS | RGLS | Common Stock | D | 1.2270 | 300,000 | 368 | 700,677 | ||||
| 2017-03-23 | 2017-03-21 | 4 | PAPADOPOULOS STELIOS | RGLS | Common Stock | D | 1.1990 | 200,000 | 240 | 400,677 | ||||
| 2017-03-07 | 2017-03-07 | 4 | RASTETTER WILLIAM H WILLIAM H RASTETTER TTEE INVESTMENT TRUST 2002 TRUST BOARDS U/A DATED 11/11/2002 | RGLS | Common Stock | I | 1.1500 | 250,000 | 288 | 350,000 | ||||
| 2017-02-23 | 2017-02-15 | 4 | Hagan Joseph P | RGLS | Stock Option (Right to Buy) | D | 1.20 | 160,000 | 160,000 | |||||
| 2017-02-23 | 2017-02-15 | 4 | GRINT PAUL C | RGLS | Stock Option (Right to Buy) | D | 1.20 | 410,000 | 410,000 | |||||
| 2017-02-23 | 2017-02-15 | 4 | WRIGHT TIMOTHY MICHAEL | RGLS | Stock Option (Right to Buy) | D | 1.20 | 32,412 | 32,412 | |||||
| 2017-02-01 | 2017-01-30 | 4 | GRINT PAUL C | RGLS | Stock Option (Right to Buy) | D | 6.35 | 130,000 | 130,000 | |||||
| 2017-02-01 | 2017-01-30 | 4 | Hagan Joseph P | RGLS | Stock Option (Right to Buy) | D | 5.77 | 30,000 | 30,000 | |||||
| 2016-10-07 | 2016-10-05 | 4 | GRINT PAUL C | RGLS | Stock Option (Right to Buy) | D | 3.52 | 186,640 | 186,640 | |||||
| 2016-10-07 | 2016-10-05 | 4 | Hagan Joseph P | RGLS | Stock Option (Right to Buy) | D | 3.52 | 59,625 | 59,625 | |||||
| 2016-10-05 | 2016-10-03 | 4 | WRIGHT TIMOTHY MICHAEL | RGLS | Stock Option (Right to Buy) | D | 3.30 | 450,000 | 450,000 | |||||
| 2016-06-03 | 2016-06-02 | 4 | BALTIMORE DAVID | RGLS | Stock Option (Right to Buy) | D | 6.20 | 36,620 | 36,620 | |||||
| 2016-06-03 | 2016-06-02 | 4 | FOLETTA MARK G | RGLS | Stock Option (Right to Buy) | D | 6.20 | 36,620 | 36,620 | |||||
| 2016-06-03 | 2016-06-02 | 4 | PAPADOPOULOS STELIOS | RGLS | Stock Option (Right to Buy) | D | 6.20 | 36,620 | 36,620 | |||||
| 2016-06-03 | 2016-06-02 | 4 | RASTETTER WILLIAM H | RGLS | Stock Option (Right to Buy) | D | 6.20 | 36,620 | 36,620 | |||||
| 2016-06-03 | 2016-06-02 | 4 | WILLIAMS DOUGLAS E | RGLS | Stock Option (Right to Buy) | D | 6.20 | 36,620 | 36,620 | |||||
| 2016-06-03 | 2016-06-02 | 4 | Rosen Hugh | RGLS | Stock Option (Right to Buy) | D | 6.20 | 70,952 | 70,952 | |||||
| 2016-03-07 | 2016-03-03 | 4 | Hagan Joseph P | RGLS | Common Stock | D | 7.1900 | 10,000 | 72 | 10,000 | ||||
| 2016-02-24 | 2016-02-23 | 4 | ALNYLAM PHARMACEUTICALS, INC. | RGLS | Common Stock | D | 7.1800 | -1,000,000 | -7,180 | 4,896,716 | ||||
| 2016-02-05 | 2016-02-04 | 4 | GRINT PAUL C | RGLS | Stock Option (Right to Buy) | D | 6.35 | 265,000 | 265,000 | |||||
| 2016-01-06 | 2016-01-04 | 4 | Hagan Joseph P | RGLS | Stock Option (Right to Buy) | D | 8.57 | 420,000 | 420,000 | |||||
| 2016-01-06 | 2015-12-16 | 4 | GRINT PAUL C | RGLS | Stock Option (Right to Buy) | D | 7.58 | 30,000 | 30,000 | |||||
| 2015-08-13 | 2015-08-13 | 4 | FOLETTA MARK G | RGLS | Common Stock | D | 7.6405 | 10,000 | 76 | 10,000 | ||||
| 2015-08-07 | 2015-08-07 | 4 | PAPADOPOULOS STELIOS | RGLS | Stock Option (Right to Buy) | D | 2.66 | -15,677 | 1,823 | |||||
| 2015-08-07 | 2015-08-07 | 4 | PAPADOPOULOS STELIOS | RGLS | Stock Option (Right to Buy) | D | 1.74 | -17,500 | 0 | |||||
| 2015-08-07 | 2015-08-07 | 4 | PAPADOPOULOS STELIOS | RGLS | Stock Option (Right to Buy) | D | 0.38 | -17,500 | 0 | |||||
| 2015-08-07 | 2015-08-07 | 4 | PAPADOPOULOS STELIOS | RGLS | Common Stock | D | 2.6600 | 15,677 | 42 | 200,677 | ||||
| 2015-08-07 | 2015-08-07 | 4 | PAPADOPOULOS STELIOS | RGLS | Common Stock | D | 1.7400 | 17,500 | 30 | 185,000 | ||||
| 2015-08-07 | 2015-08-07 | 4 | PAPADOPOULOS STELIOS | RGLS | Common Stock | D | 0.3800 | 17,500 | 7 | 167,500 | ||||
| 2015-07-21 | 2015-07-21 | 4 | RASTETTER WILLIAM H William H. Rastetter TTEE Investment 2002 Trust Boards U/A dated 11/11/2002 | RGLS | Common Stock | I | 10.1935 | 61,235 | 624 | 100,000 | ||||
| 2015-07-21 | 2015-07-20 | 4 | RASTETTER WILLIAM H William H. Rastetter TTEE Investment 2002 Trust Boards U/A dated 11/11/2002 | RGLS | Common Stock | I | 10.1323 | 38,765 | 393 | 38,765 | ||||
| 2015-07-17 | 2015-07-17 | 4 | ISIS PHARMACEUTICALS INC | RGLS | Common Stock | D | 10.2140 | -111,000 | -1,134 | 5,173,172 | ||||
| 2015-07-17 | 2015-07-16 | 4 | ISIS PHARMACEUTICALS INC | RGLS | Common Stock | D | 10.7866 | -167,000 | -1,801 | 5,284,172 | ||||
| 2015-07-17 | 2015-07-15 | 4 | ISIS PHARMACEUTICALS INC | RGLS | Common Stock | D | 10.7620 | -65,133 | -701 | 5,451,172 | ||||
| 2015-07-02 | 2015-06-30 | 4 | ISIS PHARMACEUTICALS INC | RGLS | Common Stock | D | 10.7948 | -13,248 | -143 | 5,516,305 | ||||
| 2015-07-02 | 2015-06-23 | 4 | ISIS PHARMACEUTICALS INC | RGLS | Common Stock | D | 13,248 | 5,529,553 | ||||||
| 2015-06-26 | 2015-06-10 | 4 | WILLIAMS DOUGLAS E | RGLS | Stock Option (Right to Buy) | D | 10.02 | 17,500 | 17,500 | |||||
| 2015-06-26 | 2015-06-10 | 4 | CARTER BRUCE L A | RGLS | Stock Option (Right to Buy) | D | 10.02 | 17,500 | 17,500 | |||||
| 2015-06-26 | 2015-06-10 | 4 | BALTIMORE DAVID | RGLS | Stock Option (Right to Buy) | D | 10.02 | 17,500 | 17,500 | |||||
| 2015-06-26 | 2015-06-10 | 4 | CARTER BRUCE L A | RGLS | Stock Option (Right to Buy) | D | 10.02 | 17,500 | 17,500 | |||||
| 2015-06-26 | 2015-06-10 | 4 | RASTETTER WILLIAM H | RGLS | Stock Option (Right to Buy) | D | 10.02 | 17,500 | 17,500 | |||||
| 2015-06-26 | 2015-06-10 | 4 | FOLETTA MARK G | RGLS | Stock Option (Right to Buy) | D | 10.02 | 17,500 | 17,500 | |||||
| 2015-06-26 | 2015-06-10 | 4 | PAPADOPOULOS STELIOS | RGLS | Stock Option (Right to Buy) | D | 10.02 | 17,500 | 17,500 | |||||
| 2015-06-26 | 2015-06-25 | 4 | GRINT PAUL C | RGLS | Stock Option (Right to Buy) | D | 10.22 | 500,000 | 500,000 | |||||
| 2015-04-21 | 2015-04-21 | 4 | XANTHOPOULOS KLEANTHIS G | RGLS | Stock Option (Right to Buy) | D | 0.38 | -60,000 | 8,287 | |||||
| 2015-04-21 | 2015-04-21 | 4 | XANTHOPOULOS KLEANTHIS G | RGLS | Common Stock | D | 17.7330 | -60,000 | -1,064 | 3,705 | ||||
| 2015-04-21 | 2015-04-21 | 4 | XANTHOPOULOS KLEANTHIS G | RGLS | Common Stock | D | 0.3800 | 60,000 | 23 | 63,705 | ||||
| 2015-04-21 | 2015-04-20 | 4 | XANTHOPOULOS KLEANTHIS G | RGLS | Stock Option (Right to Buy) | D | 0.38 | -66,071 | 68,287 | |||||
| 2015-04-21 | 2015-04-20 | 4 | XANTHOPOULOS KLEANTHIS G | RGLS | Common Stock | D | 16.8533 | -66,071 | -1,114 | 3,705 | ||||
| 2015-04-21 | 2015-04-20 | 4 | XANTHOPOULOS KLEANTHIS G | RGLS | Common Stock | D | 0.3800 | 66,071 | 25 | 69,776 | ||||
| 2015-04-21 | 2015-04-17 | 4 | XANTHOPOULOS KLEANTHIS G | RGLS | Stock Option (Right to Buy) | D | 0.38 | -73,929 | 134,358 | |||||
| 2015-04-21 | 2015-04-17 | 4 | XANTHOPOULOS KLEANTHIS G | RGLS | Common Stock | D | 16.9352 | -73,929 | -1,252 | 3,705 | ||||
| 2015-04-21 | 2015-04-17 | 4 | XANTHOPOULOS KLEANTHIS G | RGLS | Common Stock | D | 0.3800 | 73,929 | 28 | 77,634 | ||||
| 2015-04-14 | 2015-04-13 | 4 | CARTER BRUCE L A | RGLS | Stock Option (Right to Buy) | D | 4.78 | -20,000 | 10,000 | |||||
| 2015-04-14 | 2015-04-13 | 4 | CARTER BRUCE L A | RGLS | Common Stock | D | 17.6582 | -20,000 | -353 | 0 | ||||
| 2015-04-14 | 2015-04-13 | 4 | CARTER BRUCE L A | RGLS | Common Stock | D | 4.7800 | 20,000 | 96 | 20,000 | ||||
| 2015-03-05 | 2015-03-05 | 4 | XANTHOPOULOS KLEANTHIS G | RGLS | Stock Option (Right to Buy) | D | 0.38 | -89,230 | 208,287 | |||||
| 2015-03-05 | 2015-03-05 | 4 | XANTHOPOULOS KLEANTHIS G | RGLS | Common Stock | D | 20.8143 | -23,616 | -492 | 2,466 | ||||
| 2015-03-05 | 2015-03-05 | 4 | XANTHOPOULOS KLEANTHIS G | RGLS | Common Stock | D | 20.0645 | -65,614 | -1,317 | 26,082 | ||||
| 2015-03-05 | 2015-03-05 | 4 | XANTHOPOULOS KLEANTHIS G | RGLS | Common Stock | D | 0.3800 | 89,230 | 34 | 91,696 | ||||
| 2015-03-03 | 2015-02-27 | 4 | XANTHOPOULOS KLEANTHIS G | RGLS | Stock Option (Right to Buy) | D | 0.38 | -70 | 297,517 | |||||
| 2015-03-03 | 2015-02-27 | 4 | XANTHOPOULOS KLEANTHIS G | RGLS | Common Stock | D | 19.5000 | -70 | -1 | 2,466 | ||||
| 2015-03-03 | 2015-02-27 | 4 | XANTHOPOULOS KLEANTHIS G | RGLS | Common Stock | D | 0.3800 | 70 | 0 | 2,536 | ||||
| 2015-02-03 | 2015-02-02 | 4 | XANTHOPOULOS KLEANTHIS G | RGLS | Stock Option (Right to Buy) | D | 0.38 | -2,400 | 297,587 | |||||
| 2015-02-03 | 2015-02-02 | 4 | XANTHOPOULOS KLEANTHIS G | RGLS | Common Stock | D | 19.7667 | -2,400 | -47 | 2,466 | ||||
| 2015-02-03 | 2015-02-02 | 4 | XANTHOPOULOS KLEANTHIS G | RGLS | Common Stock | D | 0.3800 | 2,400 | 1 | 4,866 | ||||
| 2015-02-03 | 2015-01-30 | 4 | XANTHOPOULOS KLEANTHIS G | RGLS | Stock Option (Right to Buy) | D | 0.38 | -3,300 | 299,987 | |||||
| 2015-02-03 | 2015-01-30 | 4 | XANTHOPOULOS KLEANTHIS G | RGLS | Common Stock | D | 19.5004 | -3,300 | -64 | 2,466 | ||||
| 2015-02-03 | 2015-01-30 | 4 | XANTHOPOULOS KLEANTHIS G | RGLS | Common Stock | D | 0.3800 | 3,300 | 1 | 5,766 | ||||
| 2015-01-30 | 2015-01-28 | 4 | Gibson Neil W | RGLS | Common Stock | D | 18.6589 | -8,655 | -161 | 0 | ||||
| 2015-01-30 | 2015-01-28 | 4 | Gibson Neil W | RGLS | Common Stock | D | 17.9804 | -71,345 | -1,283 | 8,655 | ||||
| 2015-01-30 | 2015-01-29 | 4 | XANTHOPOULOS KLEANTHIS G | RGLS | Stock Option (Right to Buy) | D | 0.38 | -60,000 | 303,287 | |||||
| 2015-01-30 | 2015-01-29 | 4 | XANTHOPOULOS KLEANTHIS G | RGLS | Common Stock | D | 18.4019 | -26,227 | -483 | 2,466 | ||||
| 2015-01-30 | 2015-01-29 | 4 | XANTHOPOULOS KLEANTHIS G | RGLS | Common Stock | D | 17.7659 | -33,773 | -600 | 28,693 | ||||
| 2015-01-30 | 2015-01-29 | 4 | XANTHOPOULOS KLEANTHIS G | RGLS | Common Stock | D | 0.3800 | 60,000 | 23 | 62,466 | ||||
| 2015-01-30 | 2015-01-28 | 4 | XANTHOPOULOS KLEANTHIS G | RGLS | Stock Option (Right to Buy) | D | 0.38 | -85,000 | 363,287 | |||||
| 2015-01-30 | 2015-01-28 | 4 | XANTHOPOULOS KLEANTHIS G | RGLS | Common Stock | D | 18.6851 | -12,989 | -243 | 2,466 | ||||
| 2015-01-30 | 2015-01-28 | 4 | XANTHOPOULOS KLEANTHIS G | RGLS | Common Stock | D | 17.9669 | -72,011 | -1,294 | 15,455 | ||||
| 2015-01-30 | 2015-01-28 | 4 | XANTHOPOULOS KLEANTHIS G | RGLS | Common Stock | D | 0.3800 | 85,000 | 32 | 87,466 | ||||
| 2014-12-15 | 2014-12-12 | 4 | PAPADOPOULOS STELIOS | RGLS | Stock Option (Right to Buy) | D | 0.38 | -150,000 | 0 | |||||
| 2014-12-15 | 2014-12-12 | 4 | PAPADOPOULOS STELIOS | RGLS | Common Stock | D | 0.3800 | 150,000 | 57 | 150,000 | ||||
| 2014-12-04 | 2014-12-02 | 4 | Szekeres David Leslie | RGLS | Stock Option (Right to Buy) | D | 17.76 | 81,101 | 81,101 | |||||
| 2014-12-04 | 2014-12-02 | 4 | Gibson Neil W | RGLS | Stock Option (Right to Buy) | D | 17.76 | 90,378 | 90,378 | |||||
| 2014-12-04 | 2014-12-02 | 4 | GRINT PAUL C | RGLS | Stock Option (Right to Buy) | D | 17.76 | 50,870 | 50,870 | |||||
| 2014-12-04 | 2014-12-02 | 4 | XANTHOPOULOS KLEANTHIS G | RGLS | Stock Option (Right to Buy) | D | 17.76 | 231,634 | 231,634 | |||||
| 2014-12-01 | 2014-11-28 | 4 | Gibson Neil W | RGLS | Stock Option (Right to Buy) | D | 1.74 | -2,500 | 111,500 | |||||
| 2014-12-01 | 2014-11-28 | 4 | Gibson Neil W | RGLS | Common Stock | D | 19.6300 | -1,500 | -29 | 80,000 | ||||
| 2014-12-01 | 2014-11-28 | 4 | Gibson Neil W | RGLS | Common Stock | D | 18.8000 | -1,000 | -19 | 81,500 | ||||
| 2014-12-01 | 2014-11-28 | 4 | Gibson Neil W | RGLS | Common Stock | D | 1.7400 | 2,500 | 4 | 82,500 | ||||
| 2014-11-14 | 2014-11-12 | 4 | ASTRAZENECA PLC | RGLS | COMMON STOCK | I | 17.0000 | -2,000,000 | -34,000 | 4,250,000 | ||||
| 2014-11-05 | 2014-11-03 | 4 | ISIS PHARMACEUTICALS INC | RGLS | Common Stock | D | 15.9375 | -1,279,411 | -20,391 | 5,516,305 | ||||
| 2014-10-31 | 2014-10-29 | 4 | Gibson Neil W | RGLS | Stock Option (Right to Buy) | D | 1.74 | -2,500 | 114,000 | |||||
| 2014-10-31 | 2014-10-29 | 4 | Gibson Neil W | RGLS | Common Stock | D | 20.4100 | -200 | -4 | 80,000 | ||||
| 2014-10-31 | 2014-10-29 | 4 | Gibson Neil W | RGLS | Common Stock | D | 19.6700 | -1,200 | -24 | 80,200 | ||||
| 2014-10-31 | 2014-10-29 | 4 | Gibson Neil W | RGLS | Common Stock | D | 18.6800 | -1,100 | -21 | 81,400 | ||||
| 2014-10-31 | 2014-10-29 | 4 | Gibson Neil W | RGLS | Common Stock | D | 1.7400 | 2,500 | 4 | 82,500 | ||||
| 2014-10-31 | 2014-10-29 | 4 | XANTHOPOULOS KLEANTHIS G | RGLS | Stock Option (Right to Buy) | D | 0.38 | -3,505 | 448,287 | |||||
| 2014-10-31 | 2014-10-29 | 4 | XANTHOPOULOS KLEANTHIS G | RGLS | Common Stock | D | 20.4100 | -100 | -2 | 2,466 | ||||
| 2014-10-31 | 2014-10-29 | 4 | XANTHOPOULOS KLEANTHIS G | RGLS | Common Stock | D | 19.7800 | -2,005 | -40 | 2,566 | ||||
| 2014-10-31 | 2014-10-29 | 4 | XANTHOPOULOS KLEANTHIS G | RGLS | Common Stock | D | 18.6600 | -1,400 | -26 | 4,571 | ||||
| 2014-10-31 | 2014-10-29 | 4 | XANTHOPOULOS KLEANTHIS G | RGLS | Common Stock | D | 0.3800 | 3,505 | 1 | 5,971 | ||||
| 2014-10-28 | 2014-10-24 | 4/A | ALNYLAM PHARMACEUTICALS, INC. | RGLS | Common Stock | D | 16.2922 | -446 | -7 | 5,896,716 | ||||
| 2014-10-28 | 2014-10-24 | 4/A | ALNYLAM PHARMACEUTICALS, INC. | RGLS | Common Stock | D | 15.5014 | -350 | -5 | 5,897,162 | ||||
| 2014-10-28 | 2014-10-24 | 4/A | ALNYLAM PHARMACEUTICALS, INC. | RGLS | Common Stock | D | 14.6277 | -1,054 | -15 | 5,897,512 | ||||
| 2014-10-28 | 2014-10-23 | 4/A | ALNYLAM PHARMACEUTICALS, INC. | RGLS | Common Stock | D | 15.4500 | -50 | -1 | 5,898,566 | ||||
| 2014-10-28 | 2014-10-23 | 4/A | ALNYLAM PHARMACEUTICALS, INC. | RGLS | Common Stock | D | 14.8956 | -450 | -7 | 5,898,616 | ||||
| 2014-10-28 | 2014-10-23 | 4/A | ALNYLAM PHARMACEUTICALS, INC. | RGLS | Common Stock | D | 13.9390 | -1,200 | -17 | 5,899,066 | ||||
| 2014-10-28 | 2014-10-22 | 4/A | ALNYLAM PHARMACEUTICALS, INC. | RGLS | Common Stock | D | 17.1100 | -175 | -3 | 5,900,266 | ||||
| 2014-10-28 | 2014-10-22 | 4/A | ALNYLAM PHARMACEUTICALS, INC. | RGLS | Common Stock | D | 16.5881 | -11,376 | -189 | 5,900,441 | ||||
| 2014-10-28 | 2014-10-22 | 4/A | ALNYLAM PHARMACEUTICALS, INC. | RGLS | Common Stock | D | 14.6707 | -15,156 | -222 | 5,911,817 | ||||
| 2014-10-28 | 2014-10-22 | 4/A | ALNYLAM PHARMACEUTICALS, INC. | RGLS | Common Stock | D | 13.9112 | -57,753 | -803 | 5,926,973 | ||||
| 2014-10-28 | 2014-10-22 | 4/A | ALNYLAM PHARMACEUTICALS, INC. | RGLS | Common Stock | D | 12.8309 | -15,791 | -203 | 5,984,726 | ||||
| 2014-10-28 | 2014-10-22 | 4/A | ALNYLAM PHARMACEUTICALS, INC. | RGLS | Common Stock | D | 12.1792 | -9,283 | -113 | 6,000,517 | ||||
| 2014-10-28 | 2014-10-24 | 4/A | ISIS PHARMACEUTICALS INC | RGLS | Common Stock | D | 16.2922 | -446 | -7 | 6,795,716 | ||||
| 2014-10-28 | 2014-10-24 | 4/A | ISIS PHARMACEUTICALS INC | RGLS | Common Stock | D | 15.5014 | -350 | -5 | 6,796,162 | ||||
| 2014-10-28 | 2014-10-24 | 4/A | ISIS PHARMACEUTICALS INC | RGLS | Common Stock | D | 14.6277 | -1,054 | -15 | 6,796,512 | ||||
| 2014-10-28 | 2014-10-23 | 4/A | ISIS PHARMACEUTICALS INC | RGLS | Common Stock | D | 15.4500 | -50 | -1 | 6,797,566 | ||||
| 2014-10-28 | 2014-10-23 | 4/A | ISIS PHARMACEUTICALS INC | RGLS | Common Stock | D | 14.8956 | -450 | -7 | 6,797,616 | ||||
| 2014-10-28 | 2014-10-23 | 4/A | ISIS PHARMACEUTICALS INC | RGLS | Common Stock | D | 13.9390 | -1,200 | -17 | 6,798,066 | ||||
| 2014-10-28 | 2014-10-22 | 4/A | ISIS PHARMACEUTICALS INC | RGLS | Common Stock | D | 17.1100 | -175 | -3 | 6,799,266 | ||||
| 2014-10-28 | 2014-10-22 | 4/A | ISIS PHARMACEUTICALS INC | RGLS | Common Stock | D | 16.5881 | -11,376 | -189 | 6,799,441 | ||||
| 2014-10-28 | 2014-10-22 | 4/A | ISIS PHARMACEUTICALS INC | RGLS | Common Stock | D | 14.6707 | -15,156 | -222 | 6,810,817 | ||||
| 2014-10-28 | 2014-10-22 | 4/A | ISIS PHARMACEUTICALS INC | RGLS | Common Stock | D | 13.9112 | -57,753 | -803 | 6,825,973 | ||||
| 2014-10-28 | 2014-10-22 | 4/A | ISIS PHARMACEUTICALS INC | RGLS | Common Stock | D | 12.8309 | -15,791 | -203 | 6,883,726 | ||||
| 2014-10-28 | 2014-10-22 | 4/A | ISIS PHARMACEUTICALS INC | RGLS | Common Stock | D | 12.1792 | -9,283 | -113 | 6,899,517 | ||||
| 2014-10-24 | 2014-10-24 | 4 | ISIS PHARMACEUTICALS INC | RGLS | Common Stock | D | 15.1943 | -1,850 | -28 | 6,795,716 | ||||
| 2014-10-24 | 2014-10-23 | 4 | ISIS PHARMACEUTICALS INC | RGLS | Common Stock | D | 14.2367 | -1,700 | -24 | 6,797,566 | ||||
| 2014-10-24 | 2014-10-22 | 4 | ISIS PHARMACEUTICALS INC | RGLS | Common Stock | D | 13.9968 | -109,534 | -1,533 | 6,799,266 | ||||
| 2014-10-24 | 2014-10-24 | 4 | ALNYLAM PHARMACEUTICALS, INC. | RGLS | Common Stock | D | 15.1943 | -1,850 | -28 | 5,896,716 | ||||
| 2014-10-24 | 2014-10-23 | 4 | ALNYLAM PHARMACEUTICALS, INC. | RGLS | Common Stock | D | 14.2367 | -1,700 | -24 | 5,898,566 | ||||
| 2014-10-24 | 2014-10-22 | 4 | ALNYLAM PHARMACEUTICALS, INC. | RGLS | Common Stock | D | 13.9968 | -109,534 | -1,533 | 5,900,266 | ||||
| 2014-10-24 | 2014-10-22 | 4 | Gibson Neil W | RGLS | Stock Option (Right to Buy) | D | 1.74 | -3,300 | 116,500 | |||||
| 2014-10-24 | 2014-10-22 | 4 | Gibson Neil W | RGLS | Common Stock | D | 14.4376 | -3,300 | -48 | 80,000 | ||||
| 2014-10-24 | 2014-10-22 | 4 | Gibson Neil W | RGLS | Common Stock | D | 1.7400 | 3,300 | 6 | 83,300 | ||||
| 2014-10-22 | 2014-10-20 | 4 | Gibson Neil W | RGLS | Stock Option (Right to Buy) | D | 6.13 | 40,000 | 40,000 | |||||
| 2014-10-22 | 2014-10-20 | 4 | Szekeres David Leslie | RGLS | Stock Option (Right to Buy) | D | 8.51 | 40,000 | 40,000 | |||||
| 2014-10-22 | 2014-10-20 | 4 | XANTHOPOULOS KLEANTHIS G | RGLS | Stock Option (Right to Buy) | D | 6.13 | 88,000 | 88,000 | |||||
| 2014-10-22 | 2014-10-20 | 4 | GRINT PAUL C | RGLS | Stock Option (Right to Buy) | D | 7.58 | 40,000 | 40,000 | |||||
| 2014-10-21 | 2014-10-20 | 4 | XANTHOPOULOS KLEANTHIS G | RGLS | Stock Option (Right to Buy) | D | 0.38 | -300 | 451,792 | |||||
| 2014-10-21 | 2014-10-20 | 4 | XANTHOPOULOS KLEANTHIS G | RGLS | Common Stock | D | 7.0000 | -300 | -2 | 2,466 | ||||
| 2014-10-21 | 2014-10-20 | 4 | XANTHOPOULOS KLEANTHIS G | RGLS | Common Stock | D | 0.3800 | 300 | 0 | 2,766 | ||||
| 2014-10-21 | 2014-10-17 | 4 | XANTHOPOULOS KLEANTHIS G | RGLS | Stock Option (Right to Buy) | D | 0.38 | -400 | 452,092 | |||||
| 2014-10-21 | 2014-10-17 | 4 | XANTHOPOULOS KLEANTHIS G | RGLS | Common Stock | D | 7.0400 | -400 | -3 | 2,466 | ||||
| 2014-10-21 | 2014-10-17 | 4 | XANTHOPOULOS KLEANTHIS G | RGLS | Common Stock | D | 0.3800 | 400 | 0 | 2,866 | ||||
| 2014-10-17 | 2014-10-17 | 4 | ALNYLAM PHARMACEUTICALS, INC. | RGLS | Common Stock | D | 6.7903 | -3,000 | -20 | 6,009,800 | ||||
| 2014-10-17 | 2014-10-16 | 4 | ALNYLAM PHARMACEUTICALS, INC. | RGLS | Common Stock | D | 6.7605 | -4,800 | -32 | 6,012,800 | ||||
| 2014-10-17 | 2014-10-15 | 4 | ALNYLAM PHARMACEUTICALS, INC. | RGLS | Common Stock | D | 6.6714 | -4,300 | -29 | 6,017,600 | ||||
| 2014-10-17 | 2014-10-17 | 4 | ISIS PHARMACEUTICALS INC | RGLS | Common Stock | D | 6.7903 | -3,000 | -20 | 6,908,800 | ||||
| 2014-10-17 | 2014-10-16 | 4 | ISIS PHARMACEUTICALS INC | RGLS | Common Stock | D | 6.7605 | -4,800 | -32 | 6,911,800 | ||||
| 2014-10-17 | 2014-10-15 | 4 | ISIS PHARMACEUTICALS INC | RGLS | Common Stock | D | 6.6714 | -4,300 | -29 | 6,916,600 | ||||
| 2014-10-14 | 2014-10-14 | 4 | XANTHOPOULOS KLEANTHIS G | RGLS | Stock Option (Right to Buy) | D | 0.38 | -400 | 452,492 | |||||
| 2014-10-14 | 2014-10-14 | 4 | XANTHOPOULOS KLEANTHIS G | RGLS | Common Stock | D | 7.0000 | -400 | -3 | 2,466 | ||||
| 2014-10-14 | 2014-10-14 | 4 | XANTHOPOULOS KLEANTHIS G | RGLS | Common Stock | D | 0.3800 | 400 | 0 | 2,866 | ||||
| 2014-10-14 | 2014-10-09 | 4 | XANTHOPOULOS KLEANTHIS G | RGLS | Stock Option (Right to Buy) | D | 0.38 | -105 | 452,892 | |||||
| 2014-10-14 | 2014-10-09 | 4 | XANTHOPOULOS KLEANTHIS G | RGLS | Common Stock | D | 7.0000 | -105 | -1 | 2,466 | ||||
| 2014-10-14 | 2014-10-09 | 4 | XANTHOPOULOS KLEANTHIS G | RGLS | Common Stock | D | 0.3800 | 105 | 0 | 2,571 | ||||
| 2014-10-10 | 2014-10-10 | 4 | ALNYLAM PHARMACEUTICALS, INC. | RGLS | Common Stock | D | 6.4063 | -2,000 | -13 | 6,021,900 | ||||
| 2014-10-10 | 2014-10-09 | 4 | ALNYLAM PHARMACEUTICALS, INC. | RGLS | Common Stock | D | 6.5764 | -4,750 | -31 | 6,023,900 | ||||
| 2014-10-10 | 2014-10-08 | 4 | ALNYLAM PHARMACEUTICALS, INC. | RGLS | Common Stock | D | 6.6326 | -3,300 | -22 | 6,028,650 | ||||
| 2014-10-10 | 2014-10-10 | 4 | ISIS PHARMACEUTICALS INC | RGLS | Common Stock | D | 6.4063 | -2,000 | -13 | 6,920,900 | ||||
| 2014-10-10 | 2014-10-09 | 4 | ISIS PHARMACEUTICALS INC | RGLS | Common Stock | D | 6.5764 | -4,750 | -31 | 6,922,900 | ||||
| 2014-10-10 | 2014-10-08 | 4 | ISIS PHARMACEUTICALS INC | RGLS | Common Stock | D | 6.6326 | -3,300 | -22 | 6,927,650 | ||||
| 2014-10-03 | 2014-10-03 | 4 | ALNYLAM PHARMACEUTICALS, INC. | RGLS | Common Stock | D | 6.8751 | -3,300 | -23 | 6,031,950 | ||||
| 2014-10-03 | 2014-10-02 | 4 | ALNYLAM PHARMACEUTICALS, INC. | RGLS | Common Stock | D | 6.6407 | -3,750 | -25 | 6,035,250 | ||||
| 2014-10-03 | 2014-10-01 | 4 | ALNYLAM PHARMACEUTICALS, INC. | RGLS | Common Stock | D | 6.7103 | -3,250 | -22 | 6,039,000 | ||||
| 2014-10-03 | 2014-10-03 | 4 | ISIS PHARMACEUTICALS INC | RGLS | Common Stock | D | 6.8751 | -3,300 | -23 | 6,930,950 | ||||
| 2014-10-03 | 2014-10-02 | 4 | ISIS PHARMACEUTICALS INC | RGLS | Common Stock | D | 6.6407 | -3,750 | -25 | 6,934,250 | ||||
| 2014-10-03 | 2014-10-01 | 4 | ISIS PHARMACEUTICALS INC | RGLS | Common Stock | D | 6.7103 | -3,250 | -22 | 6,938,000 | ||||
| 2014-10-02 | 2014-09-30 | 4 | XANTHOPOULOS KLEANTHIS G | RGLS | Stock Option (Right to Buy) | D | 0.38 | -2,300 | 452,997 | |||||
| 2014-10-02 | 2014-09-30 | 4 | XANTHOPOULOS KLEANTHIS G | RGLS | Common Stock | D | 7.0163 | -2,300 | -16 | 2,466 | ||||
| 2014-10-02 | 2014-09-30 | 4 | XANTHOPOULOS KLEANTHIS G | RGLS | Common Stock | D | 0.3800 | 2,300 | 1 | 4,766 | ||||
| 2014-09-26 | 2014-09-26 | 4 | ALNYLAM PHARMACEUTICALS, INC. | RGLS | Common Stock | D | 7.0393 | -2,500 | -18 | 6,042,250 | ||||
| 2014-09-26 | 2014-09-25 | 4 | ALNYLAM PHARMACEUTICALS, INC. | RGLS | Common Stock | D | 7.1160 | -2,500 | -18 | 6,044,750 | ||||
| 2014-09-26 | 2014-09-24 | 4 | ALNYLAM PHARMACEUTICALS, INC. | RGLS | Common Stock | D | 7.1942 | -3,750 | -27 | 6,047,250 | ||||
| 2014-09-26 | 2014-09-26 | 4 | ISIS PHARMACEUTICALS INC | RGLS | Common Stock | D | 7.0393 | -2,500 | -18 | 6,941,250 | ||||
| 2014-09-26 | 2014-09-25 | 4 | ISIS PHARMACEUTICALS INC | RGLS | Common Stock | D | 7.1160 | -2,500 | -18 | 6,943,750 | ||||
| 2014-09-26 | 2014-09-24 | 4 | ISIS PHARMACEUTICALS INC | RGLS | Common Stock | D | 7.1942 | -3,750 | -27 | 6,946,250 | ||||
| 2014-09-19 | 2014-09-19 | 4 | ALNYLAM PHARMACEUTICALS, INC. | RGLS | Common Stock | D | 7.2163 | -4,100 | -30 | 6,051,000 | ||||
| 2014-09-19 | 2014-09-18 | 4 | ALNYLAM PHARMACEUTICALS, INC. | RGLS | Common Stock | D | 7.3984 | -1,500 | -11 | 6,055,100 | ||||
| 2014-09-19 | 2014-09-17 | 4 | ALNYLAM PHARMACEUTICALS, INC. | RGLS | Common Stock | D | 7.4331 | -2,100 | -16 | 6,056,600 | ||||
| 2014-09-19 | 2014-09-19 | 4 | ISIS PHARMACEUTICALS INC | RGLS | Common Stock | D | 7.2163 | -4,100 | -30 | 6,950,000 | ||||
| 2014-09-19 | 2014-09-18 | 4 | ISIS PHARMACEUTICALS INC | RGLS | Common Stock | D | 7.3984 | -1,500 | -11 | 6,954,100 | ||||
| 2014-09-19 | 2014-09-17 | 4 | ISIS PHARMACEUTICALS INC | RGLS | Common Stock | D | 7.4331 | -2,100 | -16 | 6,955,600 | ||||
| 2014-09-15 | 2014-09-12 | 4 | Gibson Neil W | RGLS | Stock Option (Right to Buy) | D | 1.74 | -2,200 | 119,800 | |||||
| 2014-09-15 | 2014-09-12 | 4 | Gibson Neil W | RGLS | Common Stock | D | 8.0075 | -2,200 | -18 | 80,000 | ||||
| 2014-09-15 | 2014-09-12 | 4 | Gibson Neil W | RGLS | Common Stock | D | 1.7400 | 2,200 | 4 | 82,200 | ||||
| 2014-09-15 | 2014-09-11 | 4 | Gibson Neil W | RGLS | Stock Option (Right to Buy) | D | 1.74 | -2,000 | 122,000 | |||||
| 2014-09-15 | 2014-09-11 | 4 | Gibson Neil W | RGLS | Common Stock | D | 8.0050 | -2,000 | -16 | 80,000 | ||||
| 2014-09-15 | 2014-09-11 | 4 | Gibson Neil W | RGLS | Common Stock | D | 1.7400 | 2,000 | 3 | 82,000 | ||||
| 2014-09-12 | 2014-09-12 | 4 | ALNYLAM PHARMACEUTICALS, INC. | RGLS | Common Stock | D | 7.9602 | -3,500 | -28 | 6,058,700 | ||||
| 2014-09-12 | 2014-09-11 | 4 | ALNYLAM PHARMACEUTICALS, INC. | RGLS | Common Stock | D | 7.8341 | -3,400 | -27 | 6,062,200 | ||||
| 2014-09-12 | 2014-09-10 | 4 | ALNYLAM PHARMACEUTICALS, INC. | RGLS | Common Stock | D | 7.6996 | -2,000 | -15 | 6,065,600 | ||||
| 2014-09-12 | 2014-09-12 | 4 | ISIS PHARMACEUTICALS INC | RGLS | Common Stock | D | 7.9602 | -3,500 | -28 | 6,957,700 | ||||
| 2014-09-12 | 2014-09-11 | 4 | ISIS PHARMACEUTICALS INC | RGLS | Common Stock | D | 7.8341 | -3,400 | -27 | 6,961,200 | ||||
| 2014-09-12 | 2014-09-10 | 4 | ISIS PHARMACEUTICALS INC | RGLS | Common Stock | D | 7.6996 | -2,000 | -15 | 6,964,600 | ||||
| 2014-09-05 | 2014-09-05 | 4 | ALNYLAM PHARMACEUTICALS, INC. | RGLS | Common Stock | D | 7.0727 | -2,400 | -17 | 6,067,600 | ||||
| 2014-09-05 | 2014-09-04 | 4 | ALNYLAM PHARMACEUTICALS, INC. | RGLS | Common Stock | D | 7.1094 | -6,000 | -43 | 6,070,000 | ||||
| 2014-09-05 | 2014-09-03 | 4 | ALNYLAM PHARMACEUTICALS, INC. | RGLS | Common Stock | D | 6.9519 | -1,650 | -11 | 6,076,000 | ||||
| 2014-09-05 | 2014-09-05 | 4 | ISIS PHARMACEUTICALS INC | RGLS | Common Stock | D | 7.0727 | -2,400 | -17 | 6,966,600 | ||||
| 2014-09-05 | 2014-09-04 | 4 | ISIS PHARMACEUTICALS INC | RGLS | Common Stock | D | 7.1094 | -6,000 | -43 | 6,969,000 | ||||
| 2014-09-05 | 2014-09-03 | 4 | ISIS PHARMACEUTICALS INC | RGLS | Common Stock | D | 6.9519 | -1,650 | -11 | 6,975,000 | ||||
| 2014-08-29 | 2014-08-28 | 4 | XANTHOPOULOS KLEANTHIS G | "RGLS" | Stock Option (Right to Buy) | D | 0.38 | -3,505 | 455,297 | |||||
| 2014-08-29 | 2014-08-28 | 4 | XANTHOPOULOS KLEANTHIS G | "RGLS" | Common Stock | D | 7.0626 | -3,505 | -25 | 0 | ||||
| 2014-08-29 | 2014-08-28 | 4 | XANTHOPOULOS KLEANTHIS G | "RGLS" | Common Stock | D | 0.3800 | 3,505 | 1 | 3,505 | ||||
| 2014-08-29 | 2014-08-29 | 4 | ALNYLAM PHARMACEUTICALS, INC. | "RGLS" | Common Stock | D | 6.8360 | -1,500 | -10 | 6,077,650 | ||||
| 2014-08-29 | 2014-08-28 | 4 | ALNYLAM PHARMACEUTICALS, INC. | "RGLS" | Common Stock | D | 6.9604 | -2,000 | -14 | 6,079,150 | ||||
| 2014-08-29 | 2014-08-27 | 4 | ALNYLAM PHARMACEUTICALS, INC. | "RGLS" | Common Stock | D | 7.2143 | -1,500 | -11 | 6,081,150 | ||||
| 2014-08-29 | 2014-08-29 | 4 | ISIS PHARMACEUTICALS INC | "RGLS" | Common Stock | D | 6.8360 | -1,500 | -10 | 6,976,650 | ||||
| 2014-08-29 | 2014-08-28 | 4 | ISIS PHARMACEUTICALS INC | "RGLS" | Common Stock | D | 6.9604 | -2,000 | -14 | 6,978,150 | ||||
| 2014-08-29 | 2014-08-27 | 4 | ISIS PHARMACEUTICALS INC | "RGLS" | Common Stock | D | 7.2143 | -1,500 | -11 | 6,980,150 | ||||
| 2014-08-22 | 2014-08-22 | 4 | ALNYLAM PHARMACEUTICALS, INC. | "RGLS" | Common Stock | D | 6.7510 | -5,250 | -35 | 6,082,650 | ||||
| 2014-08-22 | 2014-08-21 | 4 | ALNYLAM PHARMACEUTICALS, INC. | "RGLS" | Common Stock | D | 6.8889 | -2,500 | -17 | 6,087,900 | ||||
| 2014-08-22 | 2014-08-20 | 4 | ALNYLAM PHARMACEUTICALS, INC. | "RGLS" | Common Stock | D | 7.1412 | -3,000 | -21 | 6,090,400 | ||||
| 2014-08-22 | 2014-08-22 | 4 | ISIS PHARMACEUTICALS INC | "RGLS" | Common Stock | D | 6.7510 | -5,250 | -35 | 6,981,650 | ||||
| 2014-08-22 | 2014-08-21 | 4 | ISIS PHARMACEUTICALS INC | "RGLS" | Common Stock | D | 6.8889 | -2,500 | -17 | 6,986,900 | ||||
| 2014-08-22 | 2014-08-20 | 4 | ISIS PHARMACEUTICALS INC | "RGLS" | Common Stock | D | 7.1412 | -3,000 | -21 | 6,989,400 | ||||
| 2014-08-15 | 2014-08-15 | 4 | ALNYLAM PHARMACEUTICALS, INC. | "RGLS" | Common Stock | D | 6.9761 | -1,450 | -10 | 6,093,400 | ||||
| 2014-08-15 | 2014-08-14 | 4 | ALNYLAM PHARMACEUTICALS, INC. | "RGLS" | Common Stock | D | 7.0423 | -1,750 | -12 | 6,094,850 | ||||
| 2014-08-15 | 2014-08-13 | 4 | ALNYLAM PHARMACEUTICALS, INC. | "RGLS" | Common Stock | D | 7.0167 | -2,250 | -16 | 6,096,600 | ||||
| 2014-08-15 | 2014-08-15 | 4 | ISIS PHARMACEUTICALS INC | "RGLS" | Common Stock | D | 6.9761 | -1,450 | -10 | 6,992,400 | ||||
| 2014-08-15 | 2014-08-14 | 4 | ISIS PHARMACEUTICALS INC | "RGLS" | Common Stock | D | 7.0423 | -1,750 | -12 | 6,993,850 | ||||
| 2014-08-15 | 2014-08-13 | 4 | ISIS PHARMACEUTICALS INC | "RGLS" | Common Stock | D | 7.0167 | -2,250 | -16 | 6,995,600 | ||||
| 2014-08-08 | 2014-08-08 | 4 | ALNYLAM PHARMACEUTICALS, INC. | "RGLS" | Common Stock | D | 6.8014 | -1,850 | -13 | 6,098,850 | ||||
| 2014-08-08 | 2014-08-07 | 4 | ALNYLAM PHARMACEUTICALS, INC. | "RGLS" | Common Stock | D | 6.6623 | -2,600 | -17 | 6,100,700 | ||||
| 2014-08-08 | 2014-08-06 | 4 | ALNYLAM PHARMACEUTICALS, INC. | "RGLS" | Common Stock | D | 7.0794 | -3,150 | -22 | 6,103,300 | ||||
| 2014-08-08 | 2014-08-08 | 4 | ISIS PHARMACEUTICALS INC | "RGLS" | Common Stock | D | 6.8014 | -1,850 | -13 | 6,997,850 | ||||
| 2014-08-08 | 2014-08-07 | 4 | ISIS PHARMACEUTICALS INC | "RGLS" | Common Stock | D | 6.6623 | -2,600 | -17 | 6,999,700 | ||||
| 2014-08-08 | 2014-08-06 | 4 | ISIS PHARMACEUTICALS INC | "RGLS" | Common Stock | D | 7.0794 | -3,150 | -22 | 7,002,300 | ||||
| 2014-08-07 | 2014-08-05 | 4 | XANTHOPOULOS KLEANTHIS G | "RGLS" | Stock Option (Right to Buy) | D | 0.38 | -3,505 | 458,802 | |||||
| 2014-08-07 | 2014-08-05 | 4 | XANTHOPOULOS KLEANTHIS G | "RGLS" | Common Stock | D | 7.0583 | -3,505 | -25 | 0 | ||||
| 2014-08-07 | 2014-08-05 | 4 | XANTHOPOULOS KLEANTHIS G | "RGLS" | Common Stock | D | 0.3800 | 3,505 | 1 | 3,505 | ||||
| 2014-08-01 | 2014-08-01 | 4 | ALNYLAM PHARMACEUTICALS, INC. | "RGLS" | Common Stock | D | 6.2125 | -2,600 | -16 | 6,106,450 | ||||
| 2014-08-01 | 2014-07-31 | 4 | ALNYLAM PHARMACEUTICALS, INC. | "RGLS" | Common Stock | D | 6.4198 | -1,750 | -11 | 6,109,050 | ||||
| 2014-08-01 | 2014-07-30 | 4 | ALNYLAM PHARMACEUTICALS, INC. | "RGLS" | Common Stock | D | 6.6021 | -1,000 | -7 | 6,110,800 | ||||
| 2014-08-01 | 2014-08-01 | 4 | ISIS PHARMACEUTICALS INC | "RGLS" | Common Stock | D | 6.2125 | -2,600 | -16 | 7,005,450 | ||||
| 2014-08-01 | 2014-07-31 | 4 | ISIS PHARMACEUTICALS INC | "RGLS" | Common Stock | D | 6.4198 | -1,750 | -11 | 7,008,050 | ||||
| 2014-08-01 | 2014-07-30 | 4 | ISIS PHARMACEUTICALS INC | "RGLS" | Common Stock | D | 6.6021 | -1,000 | -7 | 7,009,800 | ||||
| 2014-07-25 | 2014-07-25 | 4 | ALNYLAM PHARMACEUTICALS, INC. | "RGLS" | Common Stock | D | 6.5509 | -1,700 | -11 | 6,111,800 | ||||
| 2014-07-25 | 2014-07-24 | 4 | ALNYLAM PHARMACEUTICALS, INC. | "RGLS" | Common Stock | D | 6.8097 | -1,850 | -13 | 6,113,500 | ||||
| 2014-07-25 | 2014-07-23 | 4 | ALNYLAM PHARMACEUTICALS, INC. | "RGLS" | Common Stock | D | 6.8835 | -1,700 | -12 | 6,115,350 | ||||
| 2014-07-25 | 2014-07-25 | 4 | ISIS PHARMACEUTICALS INC | "RGLS" | Common Stock | D | 6.5509 | -1,700 | -11 | 7,010,800 | ||||
| 2014-07-25 | 2014-07-24 | 4 | ISIS PHARMACEUTICALS INC | "RGLS" | Common Stock | D | 6.8097 | -1,850 | -13 | 7,012,500 | ||||
| 2014-07-25 | 2014-07-23 | 4 | ISIS PHARMACEUTICALS INC | "RGLS" | Common Stock | D | 6.8835 | -1,700 | -12 | 7,014,350 | ||||
| 2014-07-18 | 2014-07-18 | 4 | ALNYLAM PHARMACEUTICALS, INC. | "RGLS" | Common Stock | D | 6.8002 | -5,000 | -34 | 6,117,050 | ||||
| 2014-07-18 | 2014-07-17 | 4 | ALNYLAM PHARMACEUTICALS, INC. | "RGLS" | Common Stock | D | 6.5812 | -5,000 | -33 | 6,122,050 | ||||
| 2014-07-18 | 2014-07-16 | 4 | ALNYLAM PHARMACEUTICALS, INC. | "RGLS" | Common Stock | D | 6.5881 | -3,500 | -23 | 6,127,050 | ||||
| 2014-07-18 | 2014-07-18 | 4 | ISIS PHARMACEUTICALS INC | "RGLS" | Common Stock | D | 6.8002 | -5,000 | -34 | 7,016,050 | ||||
| 2014-07-18 | 2014-07-17 | 4 | ISIS PHARMACEUTICALS INC | "RGLS" | Common Stock | D | 6.5812 | -5,000 | -33 | 7,021,050 | ||||
| 2014-07-18 | 2014-07-16 | 4 | ISIS PHARMACEUTICALS INC | "RGLS" | Common Stock | D | 6.5881 | -3,500 | -23 | 7,026,050 | ||||
| 2014-07-11 | 2014-07-11 | 4 | ALNYLAM PHARMACEUTICALS, INC. | "RGLS" | Common Stock | D | 6.4797 | -1,750 | -11 | 6,130,550 | ||||
| 2014-07-11 | 2014-07-10 | 4 | ALNYLAM PHARMACEUTICALS, INC. | "RGLS" | Common Stock | D | 6.6908 | -4,500 | -30 | 6,132,300 | ||||
| 2014-07-11 | 2014-07-09 | 4 | ALNYLAM PHARMACEUTICALS, INC. | "RGLS" | Common Stock | D | 7.0824 | -1,800 | -13 | 6,136,800 | ||||
| 2014-07-11 | 2014-07-11 | 4 | ISIS PHARMACEUTICALS INC | "RGLS" | Common Stock | D | 6.4797 | -1,750 | -11 | 7,029,550 | ||||
| 2014-07-11 | 2014-07-10 | 4 | ISIS PHARMACEUTICALS INC | "RGLS" | Common Stock | D | 6.6908 | -4,500 | -30 | 7,031,300 | ||||
| 2014-07-11 | 2014-07-09 | 4 | ISIS PHARMACEUTICALS INC | "RGLS" | Common Stock | D | 7.0824 | -1,800 | -13 | 7,035,800 | ||||
| 2014-07-07 | 2014-07-03 | 4 | ALNYLAM PHARMACEUTICALS, INC. | "RGLS" | Common Stock | D | 8.0653 | -1,200 | -10 | 6,138,600 | ||||
| 2014-07-07 | 2014-07-02 | 4 | ALNYLAM PHARMACEUTICALS, INC. | "RGLS" | Common Stock | D | 8.0680 | -3,100 | -25 | 6,139,800 | ||||
| 2014-07-07 | 2014-07-03 | 4 | ISIS PHARMACEUTICALS INC | "RGLS" | Common Stock | D | 8.0653 | -1,200 | -10 | 7,037,600 | ||||
| 2014-07-07 | 2014-07-02 | 4 | ISIS PHARMACEUTICALS INC | "RGLS" | Common Stock | D | 8.0680 | -3,100 | -25 | 7,038,800 | ||||
| 2014-07-02 | 2014-07-01 | 4 | XANTHOPOULOS KLEANTHIS G | "RGLS" | Stock Option (Right to Buy) | D | 0.38 | -3,505 | 462,307 | |||||
| 2014-07-02 | 2014-07-01 | 4 | XANTHOPOULOS KLEANTHIS G | "RGLS" | Common Stock | D | 8.1100 | -3,505 | -28 | 0 | ||||
| 2014-07-02 | 2014-07-01 | 4 | XANTHOPOULOS KLEANTHIS G | "RGLS" | Common Stock | D | 0.3800 | 3,505 | 1 | 3,505 | ||||
| 2014-07-02 | 2014-07-01 | 4 | Gibson Neil W | "RGLS" | Stock Option (Right to Buy) | D | 1.74 | -2,500 | 124,000 | |||||
| 2014-07-02 | 2014-07-01 | 4 | Gibson Neil W | "RGLS" | Common Stock | D | 8.1040 | -2,500 | -20 | 80,000 | ||||
| 2014-07-02 | 2014-07-01 | 4 | Gibson Neil W | "RGLS" | Common Stock | D | 1.7400 | 2,500 | 4 | 82,500 | ||||
| 2014-06-27 | 2014-06-27 | 4 | ALNYLAM PHARMACEUTICALS, INC. | "RGLS" | Common Stock | D | 7.9146 | -3,150 | -25 | 6,142,900 | ||||
| 2014-06-27 | 2014-06-26 | 4 | ALNYLAM PHARMACEUTICALS, INC. | "RGLS" | Common Stock | D | 7.8870 | -1,700 | -13 | 6,146,050 | ||||
| 2014-06-27 | 2014-06-25 | 4 | ALNYLAM PHARMACEUTICALS, INC. | "RGLS" | Common Stock | D | 7.8421 | -2,750 | -22 | 6,147,750 | ||||
| 2014-06-27 | 2014-06-27 | 4 | ISIS PHARMACEUTICALS INC | "RGLS" | Common Stock | D | 7.9146 | -3,150 | -25 | 7,041,900 | ||||
| 2014-06-27 | 2014-06-26 | 4 | ISIS PHARMACEUTICALS INC | "RGLS" | Common Stock | D | 7.8870 | -1,700 | -13 | 7,045,050 | ||||
| 2014-06-27 | 2014-06-25 | 4 | ISIS PHARMACEUTICALS INC | "RGLS" | Common Stock | D | 7.8421 | -2,750 | -22 | 7,046,750 | ||||
| 2014-06-18 | 2014-03-06 | 4/A | Gibson Neil W | "RGLS" | Stock Option (Right to Buy) | D | 1.74 | -2,500 | 91 | |||||
| 2014-06-18 | 2014-04-09 | 4/A | Gibson Neil W | "RGLS" | Stock Option (Right to Buy) | D | 1.74 | -2,409 | 131,500 | |||||
| 2014-06-18 | 2014-04-09 | 4/A | Gibson Neil W | "RGLS" | Stock Option (Right to Buy) | D | 1.74 | -91 | 0 | |||||
| 2014-06-18 | 2014-06-16 | 4 | GRINT PAUL C | "RGLS" | Employee Stock Option (Right to Buy) | D | 7.58 | 250,000 | 250,000 | |||||
| 2014-06-18 | 2014-06-17 | 4 | Gibson Neil W | "RGLS" | Stock Option (Right to Buy) | D | 1.74 | -5,000 | 126,500 | |||||
| 2014-06-18 | 2014-06-17 | 4 | Gibson Neil W | "RGLS" | Common Stock | D | 8.0454 | -5,000 | -40 | 80,000 | ||||
| 2014-06-18 | 2014-06-17 | 4 | Gibson Neil W | "RGLS" | Common Stock | D | 1.7400 | 5,000 | 9 | 85,000 | ||||
| 2014-06-09 | 2014-06-09 | 4 | XANTHOPOULOS KLEANTHIS G | "RGLS" | Stock Option (Right to Buy) | D | 0.38 | -3,505 | 465,812 | |||||
| 2014-06-09 | 2014-06-09 | 4 | XANTHOPOULOS KLEANTHIS G | "RGLS" | Common Stock | D | 7.1376 | -3,505 | -25 | 0 | ||||
| 2014-06-09 | 2014-06-09 | 4 | XANTHOPOULOS KLEANTHIS G | "RGLS" | Common Stock | D | 0.3800 | 3,505 | 1 | 3,505 | ||||
| 2014-05-29 | 2014-05-29 | 4 | XANTHOPOULOS KLEANTHIS G | "RGLS" | Stock Option (Right to Buy) | D | 0.38 | -887 | 469,317 | |||||
| 2014-05-29 | 2014-05-29 | 4 | XANTHOPOULOS KLEANTHIS G | "RGLS" | Common Stock | D | 7.0000 | -887 | -6 | 0 | ||||
| 2014-05-29 | 2014-05-29 | 4 | XANTHOPOULOS KLEANTHIS G | "RGLS" | Common Stock | D | 0.3800 | 887 | 0 | 887 | ||||
| 2014-05-29 | 2014-05-28 | 4 | XANTHOPOULOS KLEANTHIS G | "RGLS" | Stock Option (Right to Buy) | D | 0.38 | -875 | 470,204 | |||||
| 2014-05-29 | 2014-05-28 | 4 | XANTHOPOULOS KLEANTHIS G | "RGLS" | Common Stock | D | 7.0011 | -875 | -6 | 0 | ||||
| 2014-05-29 | 2014-05-28 | 4 | XANTHOPOULOS KLEANTHIS G | "RGLS" | Common Stock | D | 0.3800 | 875 | 0 | 875 | ||||
| 2014-05-29 | 2014-05-27 | 4 | XANTHOPOULOS KLEANTHIS G | "RGLS" | Stock Option (Right to Buy) | D | 0.38 | -1,743 | 471,079 | |||||
| 2014-05-29 | 2014-05-27 | 4 | XANTHOPOULOS KLEANTHIS G | "RGLS" | Common Stock | D | 7.0011 | -1,743 | -12 | 0 | ||||
| 2014-05-29 | 2014-05-27 | 4 | XANTHOPOULOS KLEANTHIS G | "RGLS" | Common Stock | D | 0.3800 | 1,743 | 1 | 1,743 | ||||
| 2014-05-22 | 2014-05-22 | 4 | CARTER BRUCE L A | "RGLS" | Stock Option (Right to Buy) | D | 6.22 | 17,500 | 17,500 | |||||
| 2014-05-22 | 2014-05-22 | 4 | BALTIMORE DAVID | "RGLS" | Stock Option (Right to Buy) | D | 6.22 | 5,000 | 5,000 | |||||
| 2014-05-22 | 2014-05-22 | 4 | BALTIMORE DAVID | "RGLS" | Stock Option (Right to Buy) | D | 6.22 | 17,500 | 17,500 | |||||
| 2014-05-22 | 2014-05-22 | 4 | PAPADOPOULOS STELIOS | "RGLS" | Stock Option (Right to Buy) | D | 6.22 | 17,500 | 17,500 | |||||
| 2014-05-22 | 2014-05-22 | 4 | FOLETTA MARK G | "RGLS" | Stock Option (Right to Buy) | D | 6.22 | 17,500 | 17,500 | |||||
| 2014-05-22 | 2014-05-22 | 4 | RASTETTER WILLIAM H | "RGLS" | Stock Option (Right to Buy) | D | 6.22 | 17,500 | 17,500 | |||||
| 2014-05-22 | 2014-05-22 | 4 | WILLIAMS DOUGLAS E | "RGLS" | Stock Option (Right to Buy) | D | 6.22 | 17,500 | 17,500 | |||||
| 2014-04-10 | 2014-04-09 | 4 | Gibson Neil W | "RGLS" | Stock Option (Right to Buy) | D | 1.74 | -2,500 | 42,591 | |||||
| 2014-04-10 | 2014-04-09 | 4 | Gibson Neil W | "RGLS" | Common Stock | D | 8.1085 | -2,500 | -20 | 80,000 | ||||
| 2014-04-10 | 2014-04-09 | 4 | Gibson Neil W | "RGLS" | Common Stock | D | 1.7400 | 2,500 | 4 | 82,500 | ||||
| 2014-04-09 | 2014-04-08 | 4 | XANTHOPOULOS KLEANTHIS G | "RGLS" | Stock Option (Right to Buy) | D | 0.38 | -3,505 | 472,822 | |||||
| 2014-04-09 | 2014-03-06 | 4 | XANTHOPOULOS KLEANTHIS G By the Xanthopoulos Family Trust dated September 30, 2011 | "RGLS" | Common Stock | I | 7.5957 | -3,505 | -27 | 80,216 | ||||
| 2014-04-09 | 2014-03-06 | 4 | XANTHOPOULOS KLEANTHIS G By the Xanthopoulos Family Trust dated September 30, 2011 | "RGLS" | Common Stock | I | 0.3800 | 3,505 | 1 | 83,721 | ||||
| 2014-03-07 | 2014-03-06 | 4 | XANTHOPOULOS KLEANTHIS G | "RGLS" | Stock Option (Right to Buy) | D | 0.38 | -3,505 | 476,327 | |||||
| 2014-03-07 | 2014-03-06 | 4 | XANTHOPOULOS KLEANTHIS G By the Xanthopoulos Family Trust dated September 30, 2011 | "RGLS" | Common Stock | I | 11.3490 | -3,505 | -40 | 80,216 | ||||
| 2014-03-07 | 2014-03-06 | 4 | XANTHOPOULOS KLEANTHIS G By the Xanthopoulos Family Trust dated September 30, 2011 | "RGLS" | Common Stock | I | 0.3800 | 3,505 | 1 | 83,721 | ||||
| 2014-03-07 | 2014-03-06 | 4 | Gibson Neil W | "RGLS" | Stock Option (Right to Buy) | D | 1.74 | -2,500 | 45,091 | |||||
| 2014-03-07 | 2014-03-06 | 4 | Gibson Neil W | "RGLS" | Common Stock | D | 11.3714 | -2,500 | -28 | 80,000 | ||||
| 2014-03-07 | 2014-03-06 | 4 | Gibson Neil W | "RGLS" | Common Stock | D | 1.7400 | 2,500 | 4 | 82,500 | ||||
| 2014-02-07 | 2014-02-05 | 4 | XANTHOPOULOS KLEANTHIS G | "RGLS" | Stock Option (Right to Buy) | D | 0.38 | -3,505 | 479,832 | |||||
| 2014-02-07 | 2014-02-05 | 4 | XANTHOPOULOS KLEANTHIS G By the Xanthopoulos Family Trust dated September 30, 2011 | "RGLS" | Common Stock | I | 8.3987 | -3,505 | -29 | 80,216 | ||||
| 2014-02-07 | 2014-02-05 | 4 | XANTHOPOULOS KLEANTHIS G By the Xanthopoulos Family Trust dated September 30, 2011 | "RGLS" | Common Stock | I | 0.3800 | 3,505 | 1 | 83,721 | ||||
| 2014-02-07 | 2014-02-06 | 4 | Gibson Neil W | "RGLS" | Stock Option (Right to Buy) | D | 1.74 | -45,000 | 2,591 | |||||
| 2014-02-07 | 2014-02-06 | 4 | Gibson Neil W | "RGLS" | Common Stock | D | 1.7400 | 45,000 | 78 | 80,000 | ||||
| 2014-02-07 | 2014-02-05 | 4 | Gibson Neil W | "RGLS" | Stock Option (Right to Buy) | D | 1.74 | -2,500 | 47,591 | |||||
| 2014-02-07 | 2014-02-05 | 4 | Gibson Neil W | "RGLS" | Common Stock | D | 8.3832 | -17,500 | -147 | 35,000 | ||||
| 2014-02-07 | 2014-02-05 | 4 | Gibson Neil W | "RGLS" | Common Stock | D | 1.7400 | 2,500 | 4 | 52,500 | ||||
| 2014-02-05 | 2014-02-04 | 4 | Sanofi | RGLS | Common stock, $ 0.001 par value- | I | 7.6700 | 1,303,780 | 10,000 | 5,053,779 | ||||
| 2014-01-23 | 2014-01-21 | 4 | Gibson Neil W | RGLS | Stock Option (Right to Buy) | D | 2.66 | -4,421 | 701 | |||||
| 2014-01-23 | 2014-01-21 | 4 | Gibson Neil W | RGLS | Common Stock | D | 8.0896 | -4,421 | -36 | 50,000 | ||||
| 2014-01-23 | 2014-01-21 | 4 | Gibson Neil W | RGLS | Common Stock | D | 2.6600 | 4,421 | 12 | 54,421 | ||||
| 2014-01-21 | 2014-01-17 | 4 | Gibson Neil W | RGLS | Stock Option (Right to Buy) | D | 2.66 | -2,079 | 5,122 | |||||
| 2014-01-21 | 2014-01-17 | 4 | Gibson Neil W | RGLS | Stock Option (Right to Buy) | D | 1.74 | -2,400 | 50,091 | |||||
| 2014-01-21 | 2014-01-17 | 4 | Gibson Neil W | RGLS | Common Stock | D | 8.1477 | -4,479 | -36 | 50,000 | ||||
| 2014-01-21 | 2014-01-17 | 4 | Gibson Neil W | RGLS | Common Stock | D | 2.6600 | 2,079 | 6 | 54,479 | ||||
| 2014-01-21 | 2014-01-17 | 4 | Gibson Neil W | RGLS | Common Stock | D | 1.7400 | 2,400 | 4 | 52,400 | ||||
| 2014-01-17 | 2014-01-16 | 4 | Gibson Neil W | RGLS | Stock Option (Right to Buy) | D | 1.74 | -1,100 | 52,491 | |||||
| 2014-01-17 | 2014-01-16 | 4 | Gibson Neil W | RGLS | Common Stock | D | 8.0336 | -1,100 | -9 | 50,000 | ||||
| 2014-01-17 | 2014-01-16 | 4 | Gibson Neil W | RGLS | Common Stock | D | 1.7400 | 1,100 | 2 | 51,100 | ||||
| 2014-01-02 | 2014-01-02 | 4 | XANTHOPOULOS KLEANTHIS G | RGLS | Stock Option (Right to Buy) | D | 0.38 | -3,505 | 483,337 | |||||
| 2014-01-02 | 2014-01-02 | 4 | XANTHOPOULOS KLEANTHIS G By the Xanthopoulos Family Trust dated September 30, 2011 | RGLS | Common Stock | I | 7.2492 | -3,505 | -25 | 80,216 | ||||
| 2014-01-02 | 2014-01-02 | 4 | XANTHOPOULOS KLEANTHIS G By the Xanthopoulos Family Trust dated September 30, 2011 | RGLS | Common Stock | I | 0.3800 | 3,505 | 1 | 83,721 | ||||
| 2013-12-16 | 2013-12-16 | 4 | XANTHOPOULOS KLEANTHIS G By the Xanthopoulos Family Trust dated September 30, 2011 | RGLS | Common Stock | I | -2,000 | 80,216 | ||||||
| 2013-12-16 | 2013-12-12 | 4 | XANTHOPOULOS KLEANTHIS G | RGLS | Stock Option (Right to Buy) | D | 6.13 | 220,000 | 220,000 | |||||
| 2013-12-16 | 2013-12-12 | 4 | Gibson Neil W | RGLS | Stock Option (Right to Buy) | D | 6.13 | 100,000 | 100,000 | |||||
| 2013-06-10 | 2013-06-10 | 4 | BALTIMORE DAVID | RGLS | Stock Option (Right to Buy) | D | 9.32 | 5,000 | 5,000 | |||||
| 2013-06-10 | 2013-06-10 | 4 | BALTIMORE DAVID | RGLS | Stock Option (Right to Buy) | D | 9.32 | 17,500 | 17,500 | |||||
| 2013-06-10 | 2013-06-10 | 4 | RASTETTER WILLIAM H | RGLS | Stock Option (Right to Buy) | D | 9.32 | 17,500 | 17,500 | |||||
| 2013-06-10 | 2013-06-10 | 4 | PAPADOPOULOS STELIOS | RGLS | Stock Option (Right to Buy) | D | 9.32 | 17,500 | 17,500 | |||||
| 2013-06-10 | 2013-06-10 | 4 | WILLIAMS DOUGLAS E | RGLS | Stock Option (Right to Buy) | D | 9.32 | 17,500 | 17,500 | |||||
| 2013-06-10 | 2013-06-10 | 4 | FOLETTA MARK G | RGLS | Stock Option (Right to Buy) | D | 9.32 | 17,500 | 17,500 | |||||
| 2013-06-10 | 2013-06-10 | 4 | CARTER BRUCE L A | RGLS | Stock Option (Right to Buy) | D | 9.32 | 17,500 | 17,500 | |||||
| 2013-04-01 | 3 | RASTETTER WILLIAM H | RGLS | Common Stock | D | 0 | ||||||||
| 2013-04-01 | 2013-04-01 | 4 | RASTETTER WILLIAM H | RGLS | Stock Option (Right to Buy) | D | 7.67 | 30,000 | 30,000 | |||||
| 2013-02-14 | 2013-02-04 | 4 | Gibson Neil W | RGLS | Stock Option (Right to Buy) | D | 1.74 | 50,000 | 133,909 | |||||
| 2013-02-14 | 2013-02-04 | 4 | Gibson Neil W | RGLS | Common Stock | D | 1.7400 | 50,000 | 87 | 50,000 | ||||
| 2013-01-31 | 3 | FOLETTA MARK G | RGLS | Common Stock | D | 0 | ||||||||
| 2013-01-31 | 2013-01-30 | 4 | FOLETTA MARK G | RGLS | Stock Option (Right to Buy) | D | 5.98 | 30,000 | 30,000 | |||||
| 2012-12-13 | 2012-12-11 | 4 | XANTHOPOULOS KLEANTHIS G | RGLS | Stock Option (Right to Buy) | D | 4.44 | 150,000 | 150,000 | |||||
| 2012-12-13 | 2012-12-11 | 4 | Gibson Neil W | RGLS | Stock Option (Right to Buy) | D | 4.44 | 112,500 | 112,500 | |||||
| 2012-12-13 | 2012-12-11 | 4 | Menzel Garry E | RGLS | Stock Option (Right to Buy) | D | 4.44 | 75,000 | 75,000 | |||||
| 2012-11-08 | 3 | WILLIAMS DOUGLAS E | RGLS | Common Stock | D | 0 | ||||||||
| 2012-11-08 | 2012-11-07 | 4 | CARTER BRUCE L A | RGLS | Stock Option (Right to Buy) | D | 4.97 | -15,000 | 15,000 | |||||
| 2012-11-08 | 2012-10-31 | 4 | CARTER BRUCE L A | RGLS | Stock Option (Right to Buy) | D | 4.78 | -30,000 | 30,000 | |||||
| 2012-11-08 | 2012-11-05 | 4 | WILLIAMS DOUGLAS E | RGLS | Stock Option (Right to Buy) | D | 5.03 | 30,000 | 30,000 | |||||
| 2012-11-07 | 2012-11-05 | 4 | Greene Barry E | RGLS | Stock Option (Right to Buy) | D | 5.03 | 25,000 | 25,000 | |||||
| 2012-11-07 | 2012-11-05 | 4 | CROOKE STANLEY T | RGLS | Stock Option (Right to Buy) | D | 5.03 | 25,000 | 25,000 | |||||
| 2012-10-12 | 3 | ASTRAZENECA AB | RGLS | COMMON STOCK | I | 6,250,000 | ||||||||
| 2012-10-11 | 2012-10-10 | 4 | PARSHALL B LYNNE | RGLS | Series A Preferred Stock | I | -6,299,500 | 0 | ||||||
| 2012-10-11 | 2012-10-10 | 4 | PARSHALL B LYNNE | RGLS | Common Stock | I | 4.0000 | 750,000 | 3,000 | 7,049,500 | ||||
| 2012-10-11 | 2012-10-10 | 4 | PARSHALL B LYNNE | RGLS | Common Stock | I | 6,299,500 | 6,299,500 | ||||||
| 2012-10-11 | 2012-10-10 | 4 | MARAGANORE JOHN | RGLS | Series A Preferred Stock | I | -6,150,500 | 0 | ||||||
| 2012-10-11 | 2012-10-10 | 4 | MARAGANORE JOHN | RGLS | Common Stock | I | 6,150,500 | 6,150,500 | ||||||
| 2012-10-11 | 2012-10-10 | 4 | Greene Barry E | RGLS | Series A Preferred Stock | I | -6,150,500 | 0 | ||||||
| 2012-10-11 | 2012-10-10 | 4 | Greene Barry E | RGLS | Common Stock | I | 6,150,500 | 6,150,500 | ||||||
| 2012-10-11 | 2012-10-10 | 4 | ALNYLAM PHARMACEUTICALS, INC. | RGLS | Series A Preferred Stock | D | -6,150,500 | 0 | ||||||
| 2012-10-11 | 2012-10-10 | 4 | ALNYLAM PHARMACEUTICALS, INC. | RGLS | Common Stock | D | 6,150,500 | 6,150,500 | ||||||
| 2012-10-11 | 2012-10-10 | 4 | ISIS PHARMACEUTICALS INC | RGLS | Series A Preferred Stock | D | -6,299,500 | 0 | ||||||
| 2012-10-11 | 2012-10-10 | 4 | ISIS PHARMACEUTICALS INC | RGLS | Common Stock | D | 4.0000 | 750,000 | 3,000 | 7,049,500 | ||||
| 2012-10-11 | 2012-10-10 | 4 | ISIS PHARMACEUTICALS INC | RGLS | Common Stock | D | 6,299,500 | 6,299,500 | ||||||
| 2012-10-11 | 2012-10-10 | 4 | CROOKE STANLEY T | RGLS | Series A Preferred Stock | I | -6,299,500 | 0 | ||||||
| 2012-10-11 | 2012-10-10 | 4 | CROOKE STANLEY T | RGLS | Common Stock | I | 4.0000 | 750,000 | 3,000 | 7,049,500 | ||||
| 2012-10-11 | 2012-10-10 | 4 | CROOKE STANLEY T | RGLS | Common Stock | I | 6,299,500 | 6,299,500 | ||||||
| 2012-10-09 | 3 | Sanofi | RGLS | Common Stock | I | 3,749,999 | ||||||||
| 2012-10-04 | 3 | XANTHOPOULOS KLEANTHIS G By the Xanthopoulos Family Trust dated September 30, 2011 | RGLS | Common Stock | I | 82,216 | ||||||||
| 2012-10-04 | 3 | Menzel Garry E By the Garry E. Menzel and Mary E. Henshall Family Trust | RGLS | Common Stock | I | 111,842 |
P
非衍生或衍生證券的公開市場或私下買入
S
非衍生或衍生證券的公開市場或私下賣出
A
公司向內部人員授予、獎勵或以其他方式獲取證券（例如股票期權）
C
衍生工具轉換
D
將證券賣出或轉讓回公司
F
使用從公司收到的證券的一部分來支付行使價或稅務負擔。
G
內部人士贈送或接收他人贈送公司股票
K
股權掉期和類似的避險交易
M
行使或轉換從公司獲得的衍生證券（例如期權）
V
內部人士透過Form 4自願報告的一筆交易
J
其他（附有交易描述的腳註）
