| 內部人士股份 | 3,333,207 shares |
內部人士情緒分數
「內部人士情緒分數」用於查找被公司內部人士購入的公司。
它是一個複雜的多因素量化模型的結果，該模型能夠辨識具有最高內部人士累積持有水平的公司。該評分模型結合了內部人士在過去90天內購買的淨數量、總購買股份佔流通股比例，以及內部人士擁有的總股份的指標。該分數的範圍從0到100，數值越高表示相對於同行業而言具有更高程度的內部人士持股水平，50為平均值。
更新頻率：每日
高管情緒分數
「高管情緒分數」用於查找被公司管理層購入的公司。
根據定義，公司高管是公司內部人士，但與其他內部人士（10%的股東和董事會成員）不同，公司高管每天在公司工作，而且他們使用自己的資金進行交易。（10%的股東和董事會成員通常是基金經理，管理著其他人的資金。）因此，公司高管進行的內幕交易更為重要性，應該被適當地重視和關注。
如同「內部人士情緒分數」，「高管情緒分數」也是一個複雜的多因素量化模型的計算結果，該模型能夠辨識具有最高高管累積持有水平的公司。
更新頻率：每日
關鍵內部人士指標
此表格顯示了公司在各種內部人士指標上的排名。百分位數排名顯示了這家公司在美國市場與其他公司相比的表現。排名越高表明公司所處狀況越好。
舉例來說，一般認為內部人士的買入是一個積極的指標，因此具有更多內部人士買入的公司將排名高於那些內部人士買入較少（甚至有內部人士賣出）的公司。
內部人士買入淨數（排名）
N/A
內部人士買入淨數是過去90天內買入的內部人士總數減去賣出的內部人士總數。以百分位排名顯示（範圍從0到100%）。
內部人士買入佔流通股比例（排名）
N/A
內部人士買入佔流通股比例是內部人士在過去90天內購買的股份總數減去賣出的股份總數，除以總流通股數並乘以100。
內幕交易圖表
以下圖表顯示了IVERIC bio Inc內部人士交易。內部人士包括公司的高管、董事或重要投資者。一般而言，基於內幕、非公開信息進行交易是非法的。這並不意味著他們在自己的公司進行任何交易都是非法的。但是，他們必須透過Form 4向美國證券交易委員會（SEC）報告所有交易。
內部人員名單及盈利指標
這張表格顯示已知的內部人員名單，從向SEC披露的申報文件中自動生成。除了姓名、最近的職稱和董事、高管或10%擁有人的標誌外，我們還提供了最新披露的持股信息。此外，我們盡可能提供內部人的歷史交易表現。歷史交易表現是內部人士實際進行的公開市場購買交易表現的加權平均值。有關此計算方式的更多資訊，請查看YouTube網絡研討會。
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| 內部人士 | 平均收益（%） | 持股 數量 |
分拆 調整 |
|---|
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追蹤內部人士買入記錄 - 短期收益分析
在這一部分，我們分析了在 ISEE / IVERIC bio Inc 中進行的每筆非計劃的公開市場內部人士購買的盈利情況。這種分析有助於了解內部人士是否持續產生異常的回報，以及是否值得跟踪。該分析基於每筆交易後一年的情況， 結果僅為理論值。 .
以下表格顯示了最近的自動交易計劃之外的公開市場購買。
經調整價格 已按拆股調整。 經調整股數 已按拆股調整。
追蹤內部人士賣出記錄 - 短期虧損分析
在這一部分，我們分析了在 ISEE / IVERIC bio Inc 中進行的每筆非計劃的公開市場內部人士賣出所達成的短期虧損規避。如果存在持續的虧損規避模式，可能表明未來的內部人士賣出交易預示著價格的下跌。該分析基於每筆交易後一年的情況， 結果僅為理論值。 .
以下表格顯示了最近的自動交易計劃之外的公開市場購買。
經調整價格 已按拆股調整。 經調整股數 已按拆股調整。
交易歷史
點擊連結圖示即可查看完整的交易記錄。作為 10b5-1 自動交易計畫的一部分進行報告的交易，將在標記為 10b-5 的欄位中顯示 X。
| 呈報 日期 |
交易 日期 |
表格 | 內部人士 | 證券代碼 | 證券種類 | 代碼 | 直接 | 行使 價格 |
單位 價格 |
股數 變化 |
價值 變化 (1K) |
剩餘 期權 |
剩餘 股份 |
|
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 2023-07-13 | 2023-07-11 | 4 | Carroll David Francis | ISEE | Common Stock | D | -44,152 | 0 | ||||||
| 2023-07-13 | 2023-07-11 | 4 | Blumenkranz Mark S. | ISEE | Common Stock | D | -32,088 | 0 | ||||||
| 2023-07-13 | 2023-07-11 | 4 | Miller Christine Ann | ISEE | Common Stock | D | -13,075 | 0 | ||||||
| 2023-07-13 | 2023-07-11 | 4 | Graves Adrienne L | ISEE | Common Stock | D | -22,088 | 0 | ||||||
| 2023-07-13 | 2023-07-11 | 4 | Roberts Calvin W. | ISEE | Common Stock | D | -47,088 | 0 | ||||||
| 2023-07-13 | 2023-07-11 | 4 | Simms Christopher Paul | ISEE | Common Stock | D | -32,429 | 0 | ||||||
| 2023-07-13 | 2023-07-11 | 4 | SBLENDORIO GLENN | ISEE | Common Stock | D | -239,275 | 0 | ||||||
| 2023-07-13 | 2023-07-11 | 4 | Dugel Pravin | ISEE | Common Stock | D | -203,035 | 0 | ||||||
| 2023-07-13 | 2023-07-11 | 4 | Henderson Jane | ISEE | Common Stock | D | -22,088 | 0 | ||||||
| 2023-07-13 | 2023-07-11 | 4 | Westby Keith | ISEE | Common Stock | D | -39,652 | 0 | ||||||
| 2023-07-13 | 2023-07-11 | 4 | Gibney Anthony S | ISEE | Common Stock | D | -40,291 | 0 | ||||||
| 2023-07-13 | 2023-07-11 | 4 | Bolte Axel | ISEE | Common Stock | D | -22,088 | 0 | ||||||
| 2023-07-06 | 2023-07-03 | 4 | Westby Keith | ISEE | Common Stock | D | 39.4500 | -20,000 | -789 | 39,652 | ||||
| 2023-07-06 | 2023-07-03 | 4 | Westby Keith | ISEE | Common Stock | D | 2.9400 | 20,000 | 59 | 59,652 | ||||
| 2023-06-30 | 2023-06-28 | 4 | Gibney Anthony S | ISEE | Common Stock | D | -2,500 | 40,291 | ||||||
| 2023-06-28 | 2023-06-26 | 4 | Carroll David Francis | ISEE | Common Stock | D | -24,320 | 44,152 | ||||||
| 2023-06-26 | 2023-06-22 | 4 | SBLENDORIO GLENN | ISEE | Common Stock | D | 13.2160 | 11,084 | 146 | 239,275 | ||||
| 2023-06-06 | 2023-06-02 | 4 | Westby Keith | ISEE | Common Stock | D | 37.8700 | -20,000 | -757 | 39,652 | ||||
| 2023-06-06 | 2023-06-02 | 4 | Westby Keith | ISEE | Common Stock | D | 2.9400 | 20,000 | 59 | 59,652 | ||||
| 2023-05-15 | 2023-05-11 | 4 | Bolte Axel | ISEE | Common Stock | D | 14,588 | 22,088 | ||||||
| 2023-05-15 | 2023-05-11 | 4 | Blumenkranz Mark S. | ISEE | Common Stock | D | 14,588 | 32,088 | ||||||
| 2023-05-15 | 2023-05-11 | 4 | Roberts Calvin W. | ISEE | Common Stock | D | 14,588 | 47,088 | ||||||
| 2023-05-15 | 2023-05-11 | 4 | Graves Adrienne L | ISEE | Common Stock | D | 14,588 | 22,088 | ||||||
| 2023-05-15 | 2023-05-11 | 4 | Miller Christine Ann | ISEE | Common Stock | D | 8,075 | 13,075 | ||||||
| 2023-05-15 | 2023-05-11 | 4 | Henderson Jane | ISEE | Common Stock | D | 14,588 | 22,088 | ||||||
| 2023-05-11 | 2023-05-03 | 4 | Dugel Pravin | ISEE | Common Stock | D | 4,312 | 203,035 | ||||||
| 2023-05-03 | 2023-05-01 | 4 | Carroll David Francis | ISEE | Common Stock | D | 37.0400 | -63,500 | -2,352 | 68,472 | ||||
| 2023-05-03 | 2023-05-01 | 4 | Carroll David Francis | ISEE | Common Stock | D | 2.8100 | 63,500 | 178 | 131,972 | ||||
| 2023-05-03 | 2023-05-02 | 4 | Westby Keith | ISEE | Common Stock | D | 37.8100 | -20,000 | -756 | 39,652 | ||||
| 2023-05-03 | 2023-05-02 | 4 | Westby Keith | ISEE | Common Stock | D | 2.9400 | 20,000 | 59 | 59,652 | ||||
| 2023-05-03 | 2023-05-01 | 4 | Westby Keith | ISEE | Common Stock | D | 37.1200 | -11,214 | -416 | 39,652 | ||||
| 2023-05-03 | 2023-05-01 | 4 | Westby Keith | ISEE | Common Stock | D | 5.2200 | 11,214 | 59 | 50,866 | ||||
| 2023-05-03 | 2023-05-01 | 4 | Westby Keith | ISEE | Common Stock | D | 37.1200 | -8,786 | -326 | 39,652 | ||||
| 2023-05-03 | 2023-05-01 | 4 | Westby Keith | ISEE | Common Stock | D | 4.5200 | 8,786 | 40 | 48,438 | ||||
| 2023-04-25 | 2023-04-24 | 4 | Carroll David Francis | ISEE | Common Stock | D | 30.2100 | -48,171 | -1,455 | 68,472 | ||||
| 2023-04-25 | 2023-04-24 | 4 | Carroll David Francis | ISEE | Common Stock | D | 1.4500 | 48,171 | 70 | 116,643 | ||||
| 2023-04-25 | 2023-04-21 | 4 | Carroll David Francis | ISEE | Common Stock | D | 30.0000 | -1,829 | -55 | 68,472 | ||||
| 2023-04-25 | 2023-04-21 | 4 | Carroll David Francis | ISEE | Common Stock | D | 1.4500 | 1,829 | 3 | 70,301 | ||||
| 2023-04-25 | 2023-04-24 | 4 | Westby Keith | ISEE | Common Stock | D | 30.0700 | -18,782 | -565 | 39,652 | ||||
| 2023-04-25 | 2023-04-24 | 4 | Westby Keith | ISEE | Common Stock | D | 4.5200 | 18,782 | 85 | 58,434 | ||||
| 2023-04-25 | 2023-04-21 | 4 | Westby Keith | ISEE | Common Stock | D | 30.0000 | -1,218 | -37 | 39,652 | ||||
| 2023-04-25 | 2023-04-21 | 4 | Westby Keith | ISEE | Common Stock | D | 4.5200 | 1,218 | 6 | 40,870 | ||||
| 2023-04-05 | 2023-04-03 | 4 | Westby Keith | ISEE | Common Stock | D | 26.9800 | -22,530 | -608 | 39,652 | ||||
| 2023-04-05 | 2023-04-03 | 4 | Westby Keith | ISEE | Common Stock | D | 26.3500 | -17,470 | -460 | 62,182 | ||||
| 2023-04-05 | 2023-04-03 | 4 | Westby Keith | ISEE | Common Stock | D | 4.5200 | 20,000 | 90 | 79,652 | ||||
| 2023-04-05 | 2023-04-03 | 4 | Westby Keith | ISEE | Common Stock | D | 2.9400 | 6,214 | 18 | 59,652 | ||||
| 2023-04-05 | 2023-04-03 | 4 | Westby Keith | ISEE | Common Stock | D | 1.4500 | 13,786 | 20 | 53,438 | ||||
| 2023-04-04 | 2023-04-01 | 4 | Dugel Pravin | ISEE | Common Stock | D | 50,000 | 198,723 | ||||||
| 2023-03-06 | 2023-03-02 | 4 | Westby Keith | ISEE | Common Stock | D | 24.6000 | -600 | -15 | 39,652 | ||||
| 2023-03-06 | 2023-03-02 | 4 | Westby Keith | ISEE | Common Stock | D | 23.9100 | -19,400 | -464 | 40,252 | ||||
| 2023-03-06 | 2023-03-02 | 4 | Westby Keith | ISEE | Common Stock | D | 1.4500 | 13,298 | 19 | 59,652 | ||||
| 2023-02-27 | 2023-01-05 | 4 | Miller Christine Ann | ISEE | Common Stock | D | 5,000 | 5,000 | ||||||
| 2023-02-22 | 2023-02-17 | 4 | Westby Keith | ISEE | Common Stock | D | 25.0500 | -11,214 | -281 | 46,354 | ||||
| 2023-02-22 | 2023-02-17 | 4 | Westby Keith | ISEE | Common Stock | D | 4.5200 | 11,214 | 51 | 57,568 | ||||
| 2023-02-22 | 2023-02-17 | 4 | Westby Keith | ISEE | Common Stock | D | 25.0500 | -3,786 | -95 | 46,354 | ||||
| 2023-02-22 | 2023-02-17 | 4 | Westby Keith | ISEE | Common Stock | D | 2.9400 | 3,786 | 11 | 50,140 | ||||
| 2023-02-03 | 2023-02-02 | 4 | Westby Keith | ISEE | Common Stock | D | 23.8200 | -20,000 | -476 | 46,354 | ||||
| 2023-02-03 | 2023-02-01 | 4 | Westby Keith | ISEE | Common Stock | D | 23.0300 | -20,000 | -461 | 66,354 | ||||
| 2023-01-04 | 2023-01-03 | 4 | Simms Christopher Paul | ISEE | Common Stock | D | 20.0600 | -2,368 | -48 | 32,429 | ||||
| 2023-01-04 | 2023-01-02 | 4 | Simms Christopher Paul | ISEE | Common Stock | D | 6,250 | 34,797 | ||||||
| 2023-01-04 | 2023-01-03 | 4 | Carroll David Francis | ISEE | Common Stock | D | 20.0600 | -3,602 | -72 | 68,472 | ||||
| 2023-01-04 | 2023-01-02 | 4 | Carroll David Francis | ISEE | Common Stock | D | 8,750 | 72,074 | ||||||
| 2023-01-04 | 2023-01-03 | 4 | SBLENDORIO GLENN | ISEE | Common Stock | D | 20.0600 | -17,447 | -350 | 228,191 | ||||
| 2023-01-04 | 2023-01-02 | 4 | SBLENDORIO GLENN | ISEE | Common Stock | D | 31,500 | 245,638 | ||||||
| 2023-01-04 | 2023-01-03 | 4 | Westby Keith | ISEE | Common Stock | D | 20.0600 | -3,480 | -70 | 86,354 | ||||
| 2023-01-04 | 2023-01-02 | 4 | Westby Keith | ISEE | Common Stock | D | 8,750 | 89,834 | ||||||
| 2023-01-04 | 2023-01-02 | 4 | Dugel Pravin | ISEE | Common Stock | D | 12,500 | 148,723 | ||||||
| 2022-12-29 | 2022-12-27 | 4 | SBLENDORIO GLENN | ISEE | Common Stock | D | -30,000 | 214,138 | ||||||
| 2022-12-20 | 2022-12-19 | 4 | SBLENDORIO GLENN | ISEE | Common Stock | D | 21.5100 | -19,457 | -419 | 244,138 | ||||
| 2022-12-20 | 2022-12-18 | 4 | SBLENDORIO GLENN | ISEE | Common Stock | D | 36,658 | 263,595 | ||||||
| 2022-12-20 | 2022-12-19 | 4 | Westby Keith | ISEE | Common Stock | D | 21.5100 | -6,740 | -145 | 81,084 | ||||
| 2022-12-20 | 2022-12-18 | 4 | Westby Keith | ISEE | Common Stock | D | 12,500 | 87,824 | ||||||
| 2022-12-20 | 2022-12-18 | 4 | Dugel Pravin | ISEE | Common Stock | D | 13,750 | 136,223 | ||||||
| 2022-12-20 | 2022-12-19 | 4 | Carroll David Francis | ISEE | Common Stock | D | 21.5100 | -5,671 | -122 | 63,324 | ||||
| 2022-12-20 | 2022-12-18 | 4 | Carroll David Francis | ISEE | Common Stock | D | 14,375 | 68,995 | ||||||
| 2022-12-14 | 2022-12-13 | 4 | Gibney Anthony S | ISEE | Common Stock | D | 25,000 | 42,791 | ||||||
| 2022-12-14 | 2022-12-13 | 4 | Gibney Anthony S | ISEE | Common Stock | D | 6,000 | 17,791 | ||||||
| 2022-12-13 | 2022-12-13 | 4 | Carroll David Francis | ISEE | Common Stock | D | 21.7300 | -4,932 | -107 | 54,620 | ||||
| 2022-12-13 | 2022-12-12 | 4 | Carroll David Francis | ISEE | Common Stock | D | 12,500 | 59,552 | ||||||
| 2022-12-13 | 2022-12-12 | 4 | Carroll David Francis | ISEE | Common Stock | D | 21.2500 | -1,541 | -33 | 47,052 | ||||
| 2022-12-13 | 2022-12-12 | 4 | Carroll David Francis | ISEE | Common Stock | D | 20.6600 | -2,405 | -50 | 48,593 | ||||
| 2022-12-13 | 2022-12-09 | 4 | Carroll David Francis | ISEE | Common Stock | D | 10,000 | 50,998 | ||||||
| 2022-12-13 | 2022-12-13 | 4 | Westby Keith | ISEE | Common Stock | D | 21.7300 | -6,741 | -146 | 75,324 | ||||
| 2022-12-13 | 2022-12-12 | 4 | Westby Keith | ISEE | Common Stock | D | 12,500 | 82,065 | ||||||
| 2022-12-13 | 2022-12-12 | 4 | Westby Keith | ISEE | Common Stock | D | 21.2500 | -2,106 | -45 | 69,565 | ||||
| 2022-12-13 | 2022-12-12 | 4 | Westby Keith | ISEE | Common Stock | D | 20.6600 | -3,287 | -68 | 71,671 | ||||
| 2022-12-13 | 2022-12-09 | 4 | Westby Keith | ISEE | Common Stock | D | 10,000 | 74,958 | ||||||
| 2022-12-13 | 2022-12-12 | 4 | SBLENDORIO GLENN | ISEE | Common Stock | D | 22,950 | 226,937 | ||||||
| 2022-12-13 | 2022-12-09 | 4 | SBLENDORIO GLENN | ISEE | Common Stock | D | 23,750 | 203,987 | ||||||
| 2022-12-05 | 2022-12-02 | 4 | Westby Keith | ISEE | Common Stock | D | 10.0300 | 5,199 | 52 | 64,958 | ||||
| 2022-12-05 | 2022-12-01 | 4 | Westby Keith | ISEE | Common Stock | D | 22.9600 | -10,030 | -230 | 59,759 | ||||
| 2022-11-21 | 2022-11-17 | 4 | Dugel Pravin | ISEE | Common Stock | D | 10.0300 | 8,474 | 85 | 122,473 | ||||
| 2022-11-04 | 2022-11-02 | 4 | SBLENDORIO GLENN | ISEE | Common Stock | D | 23.0100 | -50,000 | -1,150 | 179,689 | ||||
| 2022-11-03 | 2022-11-01 | 4 | Westby Keith | ISEE | Common Stock | D | 23.9200 | -72,916 | -1,744 | 69,128 | ||||
| 2022-11-03 | 2022-11-01 | 4 | Westby Keith | ISEE | Common Stock | D | 1.4500 | 42,916 | 62 | 142,044 | ||||
| 2022-08-04 | 2022-08-03 | 4 | Simms Christopher Paul | ISEE | Common Stock | D | 11.2500 | -6,818 | -77 | 28,547 | ||||
| 2022-08-04 | 2022-08-03 | 4 | Simms Christopher Paul | ISEE | Common Stock | D | 11.2500 | -5,454 | -61 | 35,365 | ||||
| 2022-08-04 | 2022-08-02 | 4 | Simms Christopher Paul | ISEE | Common Stock | D | 18,750 | 40,819 | ||||||
| 2022-08-04 | 2022-08-02 | 4 | Simms Christopher Paul | ISEE | Common Stock | D | 15,000 | 22,069 | ||||||
| 2022-07-19 | 2022-07-15 | 4 | Blumenkranz Mark S. | ISEE | Common Stock | D | 5,000 | 17,500 | ||||||
| 2022-07-05 | 2022-07-05 | 4 | Gibney Anthony S | ISEE | Common Stock | D | 9.4100 | -7,791 | -73 | 10,959 | ||||
| 2022-07-05 | 2022-06-30 | 4 | Gibney Anthony S | ISEE | Common Stock | D | 18,750 | 18,750 | ||||||
| 2022-06-14 | 2022-06-13 | 4 | Roberts Calvin W. | ISEE | Common Stock | D | 9.6200 | 25,000 | 240 | 32,500 | ||||
| 2022-05-16 | 2022-05-12 | 4 | Miller Christine Ann | ISEE | Stock Option (right to buy) | D | 9.94 | 12,835 | 12,835 | |||||
| 2022-05-16 | 2022-05-12 | 4 | Miller Christine Ann | ISEE | Restricted Stock Units | D | 8,075 | 8,075 | ||||||
| 2022-05-13 | 2022-05-12 | 4 | Graves Adrienne L | ISEE | Stock Option (right to buy) | D | 9.94 | 23,186 | 23,186 | |||||
| 2022-05-13 | 2022-05-12 | 4 | Graves Adrienne L | ISEE | Restricted Stock Units | D | 14,588 | 14,588 | ||||||
| 2022-05-13 | 2022-05-11 | 4 | Graves Adrienne L | ISEE | Restricted Stock Units | D | -7,500 | 0 | ||||||
| 2022-05-13 | 2022-05-11 | 4 | Graves Adrienne L | ISEE | Common Stock | D | 7,500 | 7,500 | ||||||
| 2022-05-13 | 2022-05-12 | 4 | Henderson Jane | ISEE | Stock Option (right to buy) | D | 9.94 | 23,186 | 23,186 | |||||
| 2022-05-13 | 2022-05-12 | 4 | Henderson Jane | ISEE | Restricted Stock Units | D | 14,588 | 14,588 | ||||||
| 2022-05-13 | 2022-05-11 | 4 | Henderson Jane | ISEE | Restricted Stock Units | D | -7,500 | 0 | ||||||
| 2022-05-13 | 2022-05-11 | 4 | Henderson Jane | ISEE | Common Stock | D | 7,500 | 7,500 | ||||||
| 2022-05-13 | 2022-05-12 | 4 | Bolte Axel | ISEE | Stock Option (right to buy) | D | 9.94 | 23,186 | 23,186 | |||||
| 2022-05-13 | 2022-05-12 | 4 | Bolte Axel | ISEE | Restricted Stock Units | D | 14,588 | 14,588 | ||||||
| 2022-05-13 | 2022-05-11 | 4 | Bolte Axel | ISEE | Restricted Stock Units | D | -7,500 | 0 | ||||||
| 2022-05-13 | 2022-05-11 | 4 | Bolte Axel | ISEE | Common Stock | D | 7,500 | 7,500 | ||||||
| 2022-05-13 | 2022-05-12 | 4 | Roberts Calvin W. | ISEE | Stock Option (right to buy) | D | 9.94 | 23,186 | 23,186 | |||||
| 2022-05-13 | 2022-05-12 | 4 | Roberts Calvin W. | ISEE | Restricted Stock Units | D | 14,588 | 14,588 | ||||||
| 2022-05-13 | 2022-05-11 | 4 | Roberts Calvin W. | ISEE | Restricted Stock Units | D | -7,500 | 0 | ||||||
| 2022-05-13 | 2022-05-11 | 4 | Roberts Calvin W. | ISEE | Common Stock | D | 7,500 | 7,500 | ||||||
| 2022-05-13 | 2022-05-12 | 4 | Blumenkranz Mark S. | ISEE | Stock Option (right to buy) | D | 9.94 | 23,186 | 23,186 | |||||
| 2022-05-13 | 2022-05-12 | 4 | Blumenkranz Mark S. | ISEE | Restricted Stock Units | D | 14,588 | 14,588 | ||||||
| 2022-05-13 | 2022-05-11 | 4 | Blumenkranz Mark S. | ISEE | Restricted Stock Units | D | -7,500 | 0 | ||||||
| 2022-05-13 | 2022-05-11 | 4 | Blumenkranz Mark S. | ISEE | Common Stock | D | 7,500 | 12,500 | ||||||
| 2022-05-05 | 2022-05-03 | 4 | Dugel Pravin | ISEE | Restricted Stock Units | D | -4,313 | 12,937 | ||||||
| 2022-05-05 | 2022-05-03 | 4 | Dugel Pravin | ISEE | Common Stock | D | 4,313 | 113,999 | ||||||
| 2022-04-20 | 2022-04-18 | 4 | Westby Keith | ISEE | Common Stock | D | 16.6300 | -10,000 | -166 | 99,128 | ||||
| 2022-04-06 | 2022-04-05 | 4 | Westby Keith | ISEE | Stock Option (right to buy) | D | 1.45 | 1.4500 | -9,298 | -13 | 70,000 | |||
| 2022-04-06 | 2022-04-05 | 4 | Westby Keith | ISEE | Common Stock | D | 19.0157 | -9,298 | -177 | 109,128 | ||||
| 2022-04-06 | 2022-04-05 | 4 | Westby Keith | ISEE | Common Stock | D | 1.4500 | 9,298 | 13 | 118,426 | ||||
| 2022-04-06 | 2022-04-04 | 4 | Westby Keith | ISEE | Stock Option (right to buy) | D | 1.45 | 1.4500 | -20,702 | -30 | 79,298 | |||
| 2022-04-06 | 2022-04-04 | 4 | Westby Keith | ISEE | Common Stock | D | 19.0004 | -20,702 | -393 | 109,128 | ||||
| 2022-04-06 | 2022-04-04 | 4 | Westby Keith | ISEE | Common Stock | D | 1.4500 | 20,702 | 30 | 129,830 | ||||
| 2022-04-06 | 2022-04-04 | 4 | SBLENDORIO GLENN | ISEE | Common Stock | D | 18.7561 | -50,000 | -938 | 229,689 | ||||
| 2022-04-05 | 2022-04-05 | 4 | Carroll David Francis | ISEE | Stock Option (right to buy) | D | 1.45 | -4,684 | 50,000 | |||||
| 2022-04-05 | 2022-04-05 | 4 | Carroll David Francis | ISEE | Common Stock | D | 19.0100 | -4,684 | -89 | 40,166 | ||||
| 2022-04-05 | 2022-04-05 | 4 | Carroll David Francis | ISEE | Common Stock | D | 1.4500 | 4,684 | 7 | 44,850 | ||||
| 2022-04-05 | 2022-04-04 | 4 | Carroll David Francis | ISEE | Stock Option (right to buy) | D | 1.45 | -20,316 | 54,684 | |||||
| 2022-04-05 | 2022-04-04 | 4 | Carroll David Francis | ISEE | Common Stock | D | 19.0100 | -600 | -11 | 40,166 | ||||
| 2022-04-05 | 2022-04-04 | 4 | Carroll David Francis | ISEE | Common Stock | D | 18.4900 | -40,341 | -746 | 40,766 | ||||
| 2022-04-05 | 2022-04-04 | 4 | Carroll David Francis | ISEE | Common Stock | D | 1.4500 | 20,316 | 29 | 81,107 | ||||
| 2022-04-05 | 2022-04-01 | 4 | Carroll David Francis | ISEE | Common Stock | D | 17.0000 | -2,144 | -36 | 60,791 | ||||
| 2022-04-05 | 2022-04-01 | 4 | Dugel Pravin | ISEE | Restricted Stock Units | D | -50,000 | 100,000 | ||||||
| 2022-04-05 | 2022-04-01 | 4 | Dugel Pravin | ISEE | Common Stock | D | 50,000 | 109,686 | ||||||
| 2022-04-01 | 2022-04-01 | 4 | SBLENDORIO GLENN | ISEE | Stock Option (right to buy) | D | 2.94 | -40,756 | 325,000 | |||||
| 2022-04-01 | 2022-04-01 | 4 | SBLENDORIO GLENN | ISEE | Common Stock | D | 17.5000 | -40,756 | -713 | 279,689 | ||||
| 2022-04-01 | 2022-04-01 | 4 | SBLENDORIO GLENN | ISEE | Common Stock | D | 2.9400 | 40,756 | 120 | 320,445 | ||||
| 2022-04-01 | 2022-03-31 | 4 | SBLENDORIO GLENN | ISEE | Stock Option (right to buy) | D | 2.94 | -1,400 | 365,756 | |||||
| 2022-04-01 | 2022-03-31 | 4 | SBLENDORIO GLENN | ISEE | Common Stock | D | 17.0200 | -1,400 | -24 | 279,689 | ||||
| 2022-04-01 | 2022-03-31 | 4 | SBLENDORIO GLENN | ISEE | Common Stock | D | 2.9400 | 1,400 | 4 | 281,089 | ||||
| 2022-04-01 | 2022-03-30 | 4 | SBLENDORIO GLENN | ISEE | Stock Option (right to buy) | D | 2.94 | -1,213 | 367,156 | |||||
| 2022-04-01 | 2022-03-30 | 4 | SBLENDORIO GLENN | ISEE | Common Stock | D | 17.0040 | -1,213 | -21 | 279,689 | ||||
| 2022-04-01 | 2022-03-30 | 4 | SBLENDORIO GLENN | ISEE | Common Stock | D | 2.9400 | 1,213 | 4 | 280,902 | ||||
| 2022-03-29 | 2022-03-25 | 4 | Carroll David Francis | ISEE | Stock Option (right to buy) | D | 1.45 | -16,763 | 75,000 | |||||
| 2022-03-29 | 2022-03-25 | 4 | Carroll David Francis | ISEE | Common Stock | D | 17.0157 | -16,772 | -285 | 62,935 | ||||
| 2022-03-29 | 2022-03-25 | 4 | Carroll David Francis | ISEE | Common Stock | D | 1.4500 | 16,763 | 24 | 79,707 | ||||
| 2022-03-29 | 2022-03-25 | 4 | SBLENDORIO GLENN | ISEE | Stock Option (right to buy) | D | 2.94 | -18,775 | 368,369 | |||||
| 2022-03-29 | 2022-03-25 | 4 | SBLENDORIO GLENN | ISEE | Common Stock | D | 17.0600 | -18,775 | -320 | 279,689 | ||||
| 2022-03-29 | 2022-03-25 | 4 | SBLENDORIO GLENN | ISEE | Common Stock | D | 2.9400 | 18,775 | 55 | 298,464 | ||||
| 2022-03-22 | 2022-03-18 | 4 | Carroll David Francis | ISEE | Stock Option (right to buy) | D | 1.45 | -8,237 | 91,763 | |||||
| 2022-03-22 | 2022-03-18 | 4 | Carroll David Francis | ISEE | Common Stock | D | 17.0022 | -11,561 | -197 | 62,944 | ||||
| 2022-03-22 | 2022-03-18 | 4 | Carroll David Francis | ISEE | Common Stock | D | 1.4500 | 8,237 | 12 | 74,505 | ||||
| 2022-03-22 | 2022-03-18 | 4 | SBLENDORIO GLENN | ISEE | Stock Option (right to buy) | D | 2.94 | -3,479 | 387,144 | |||||
| 2022-03-22 | 2022-03-18 | 4 | SBLENDORIO GLENN | ISEE | Common Stock | D | 17.0006 | -3,479 | -59 | 279,689 | ||||
| 2022-03-22 | 2022-03-18 | 4 | SBLENDORIO GLENN | ISEE | Common Stock | D | 2.9400 | 3,479 | 10 | 283,168 | ||||
| 2022-03-18 | 2022-03-17 | 4 | Westby Keith | ISEE | Common Stock | D | 15.0628 | -2,143 | -32 | 109,128 | ||||
| 2022-03-18 | 2022-03-16 | 4 | Westby Keith | ISEE | Common Stock | D | 15.0071 | -7,857 | -118 | 111,271 | ||||
| 2022-03-02 | 2022-03-01 | 4 | Westby Keith | ISEE | Stock Option (right to buy) | D | 1.65 | -10,169 | 0 | |||||
| 2022-03-02 | 2022-03-01 | 4 | Westby Keith | ISEE | Common Stock | D | 1.6520 | 10,169 | 17 | 118,449 | ||||
| 2022-02-17 | 2022-02-15 | 4 | Westby Keith | ISEE | Common Stock | D | 15.1634 | -10,000 | -152 | 108,280 | ||||
| 2022-02-08 | 2022-02-07 | 4 | Westby Keith | ISEE | Common Stock | D | 15.0033 | -10,000 | -150 | 118,280 | ||||
| 2022-01-07 | 2022-01-05 | 4 | Miller Christine Ann | ISEE | Restricted Stock Units | D | 15,000 | 15,000 | ||||||
| 2022-01-07 | 2022-01-05 | 4 | Miller Christine Ann | ISEE | Stock Option (Right to Buy) | D | 14.31 | 31,000 | 31,000 | |||||
| 2022-01-04 | 2022-01-03 | 4 | Carroll David Francis | ISEE | Common Stock | D | 16.3923 | -15,819 | -259 | 65,504 | ||||
| 2022-01-04 | 2021-12-31 | 4 | Carroll David Francis | ISEE | Restricted Stock Units | D | -32,500 | 0 | ||||||
| 2022-01-04 | 2021-12-31 | 4 | Carroll David Francis | ISEE | Common Stock | D | 32,500 | 81,323 | ||||||
| 2022-01-04 | 2022-01-03 | 4 | Westby Keith | ISEE | Common Stock | D | 16.3923 | -12,278 | -201 | 128,280 | ||||
| 2022-01-04 | 2021-12-31 | 4 | Westby Keith | ISEE | Restricted Stock Units | D | -32,500 | 0 | ||||||
| 2022-01-04 | 2021-12-31 | 4 | Westby Keith | ISEE | Common Stock | D | 32,500 | 140,558 | ||||||
| 2022-01-03 | 2021-12-31 | 4 | SBLENDORIO GLENN | ISEE | Stock Option (Right to Buy) | D | 2.94 | -801 | 390,623 | |||||
| 2022-01-03 | 2021-12-31 | 4 | SBLENDORIO GLENN | ISEE | Common Stock | D | 17.0050 | -801 | -14 | 279,133 | ||||
| 2022-01-03 | 2021-12-31 | 4 | SBLENDORIO GLENN | ISEE | Common Stock | D | 2.9400 | 801 | 2 | 279,934 | ||||
| 2022-01-03 | 2021-12-30 | 4 | SBLENDORIO GLENN | ISEE | Stock Option (Right to Buy) | D | 2.94 | -100 | 391,424 | |||||
| 2022-01-03 | 2021-12-30 | 4 | SBLENDORIO GLENN | ISEE | Common Stock | D | 17.0100 | -100 | -2 | 279,133 | ||||
| 2022-01-03 | 2021-12-30 | 4 | SBLENDORIO GLENN | ISEE | Common Stock | D | 2.9400 | 100 | 0 | 279,233 | ||||
| 2021-12-27 | 2021-12-27 | 4 | SBLENDORIO GLENN | ISEE | Stock Option (Right to Buy) | D | 1.45 | -5,229 | 133,500 | |||||
| 2021-12-27 | 2021-12-27 | 4 | SBLENDORIO GLENN | ISEE | Common Stock | D | 16.6360 | -5,229 | -87 | 279,133 | ||||
| 2021-12-27 | 2021-12-27 | 4 | SBLENDORIO GLENN | ISEE | Common Stock | D | 1.4500 | 5,229 | 8 | 284,362 | ||||
| 2021-12-27 | 2021-12-23 | 4 | SBLENDORIO GLENN | ISEE | Stock Option (Right to Buy) | D | 2.94 | -8,476 | 391,524 | |||||
| 2021-12-27 | 2021-12-23 | 4 | SBLENDORIO GLENN | ISEE | Stock Option (Right to Buy) | D | 1.45 | -22,608 | 138,729 | |||||
| 2021-12-27 | 2021-12-23 | 4 | SBLENDORIO GLENN | ISEE | Common Stock | D | -20,000 | 279,133 | ||||||
| 2021-12-27 | 2021-12-23 | 4 | SBLENDORIO GLENN | ISEE | Common Stock | D | -20,000 | 279,133 | ||||||
| 2021-12-27 | 2021-12-23 | 4 | SBLENDORIO GLENN | ISEE | Common Stock | D | -20,000 | 299,133 | ||||||
| 2021-12-27 | 2021-12-23 | 4 | SBLENDORIO GLENN | ISEE | Common Stock | D | 16.9584 | -31,084 | -527 | 339,133 | ||||
| 2021-12-27 | 2021-12-23 | 4 | SBLENDORIO GLENN | ISEE | Common Stock | D | 2.9400 | 8,476 | 25 | 370,217 | ||||
| 2021-12-27 | 2021-12-23 | 4 | SBLENDORIO GLENN | ISEE | Common Stock | D | 1.4500 | 22,608 | 33 | 361,741 | ||||
| 2021-12-27 | 2021-12-22 | 4 | SBLENDORIO GLENN | ISEE | Stock Option (Right to Buy) | D | 1.45 | -22,163 | 161,337 | |||||
| 2021-12-27 | 2021-12-22 | 4 | SBLENDORIO GLENN | ISEE | Common Stock | D | 16.5042 | -22,163 | -366 | 339,133 | ||||
| 2021-12-27 | 2021-12-22 | 4 | SBLENDORIO GLENN | ISEE | Common Stock | D | 1.4500 | 22,163 | 32 | 361,296 | ||||
| 2021-12-23 | 2021-12-21 | 4 | Carroll David Francis | ISEE | Common Stock | D | 15.9826 | -56,207 | -898 | 48,823 | ||||
| 2021-12-23 | 2021-12-21 | 4 | Westby Keith | ISEE | Common Stock | D | 15.8872 | -20,000 | -318 | 108,058 | ||||
| 2021-12-21 | 2021-12-20 | 4 | Westby Keith | ISEE | Common Stock | D | 15.4435 | -4,516 | -70 | 128,058 | ||||
| 2021-12-21 | 2021-12-18 | 4 | Westby Keith | ISEE | Restricted Stock Units | D | -12,500 | 37,500 | ||||||
| 2021-12-21 | 2021-12-18 | 4 | Westby Keith | ISEE | Common Stock | D | 12,500 | 132,574 | ||||||
| 2021-12-21 | 2021-12-18 | 4 | Dugel Pravin | ISEE | Restricted Stock Units | D | -13,750 | 41,250 | ||||||
| 2021-12-21 | 2021-12-18 | 4 | Dugel Pravin | ISEE | Common Stock | D | 13,750 | 59,686 | ||||||
| 2021-12-21 | 2021-12-20 | 4 | SBLENDORIO GLENN | ISEE | Common Stock | D | 15.4435 | -18,524 | -286 | 339,133 | ||||
| 2021-12-21 | 2021-12-18 | 4 | SBLENDORIO GLENN | ISEE | Restricted Stock Units | D | -36,658 | 109,972 | ||||||
| 2021-12-21 | 2021-12-18 | 4 | SBLENDORIO GLENN | ISEE | Common Stock | D | 36,658 | 357,657 | ||||||
| 2021-12-21 | 2021-12-20 | 4 | Carroll David Francis | ISEE | Common Stock | D | 15.4435 | -6,710 | -104 | 105,030 | ||||
| 2021-12-21 | 2021-12-18 | 4 | Carroll David Francis | ISEE | Restricted Stock Units | D | -14,375 | 43,125 | ||||||
| 2021-12-21 | 2021-12-18 | 4 | Carroll David Francis | ISEE | Common Stock | D | 14,375 | 111,740 | ||||||
| 2021-12-20 | 2021-12-16 | 4 | SBLENDORIO GLENN | ISEE | Restricted Stock Units | D | 126,000 | 126,000 | ||||||
| 2021-12-20 | 2021-12-16 | 4 | SBLENDORIO GLENN | ISEE | Stock Option (Right to Buy) | D | 14.83 | 252,000 | 252,000 | |||||
| 2021-12-20 | 2021-12-16 | 4 | Dugel Pravin | ISEE | Restricted Stock Units | D | 50,000 | 50,000 | ||||||
| 2021-12-20 | 2021-12-16 | 4 | Dugel Pravin | ISEE | Stock Option (Right to Buy) | D | 14.83 | 100,000 | 100,000 | |||||
| 2021-12-20 | 2021-12-16 | 4 | Westby Keith | ISEE | Restricted Stock Units | D | 35,000 | 35,000 | ||||||
| 2021-12-20 | 2021-12-16 | 4 | Westby Keith | ISEE | Stock Option (Right to Buy) | D | 14.83 | 70,000 | 70,000 | |||||
| 2021-12-20 | 2021-12-16 | 4 | Carroll David Francis | ISEE | Restricted Stock Units | D | 35,000 | 35,000 | ||||||
| 2021-12-20 | 2021-12-16 | 4 | Carroll David Francis | ISEE | Stock Option (Right to Buy) | D | 14.83 | 70,000 | 70,000 | |||||
| 2021-12-20 | 2021-12-16 | 4 | Simms Christopher Paul | ISEE | Restricted Stock Units | D | 25,000 | 25,000 | ||||||
| 2021-12-20 | 2021-12-16 | 4 | Simms Christopher Paul | ISEE | Stock Option (Right to Buy) | D | 14.83 | 50,000 | 50,000 | |||||
| 2021-12-15 | 2021-12-13 | 4 | Gibney Anthony S | ISEE | Restricted Stock Units | D | 6,000 | 6,000 | ||||||
| 2021-12-15 | 2021-12-13 | 4 | Gibney Anthony S | ISEE | Restricted Stock Units | D | 75,000 | 75,000 | ||||||
| 2021-12-15 | 2021-12-13 | 4 | Gibney Anthony S | ISEE | Restricted Stock Units | D | 100,000 | 100,000 | ||||||
| 2021-12-15 | 2021-12-13 | 4 | Gibney Anthony S | ISEE | Stock Option (Right to Buy) | D | 15.16 | 200,000 | 200,000 | |||||
| 2021-12-14 | 2021-12-13 | 4 | Carroll David Francis | ISEE | Common Stock | D | 14.7449 | -5,836 | -86 | 97,365 | ||||
| 2021-12-14 | 2021-12-12 | 4 | Carroll David Francis | ISEE | Restricted Stock Units | D | -12,500 | 12,500 | ||||||
| 2021-12-14 | 2021-12-12 | 4 | Carroll David Francis | ISEE | Common Stock | D | 12,500 | 103,201 | ||||||
| 2021-12-14 | 2021-12-13 | 4 | Westby Keith | ISEE | Common Stock | D | 14.7449 | -4,517 | -67 | 120,074 | ||||
| 2021-12-14 | 2021-12-12 | 4 | Westby Keith | ISEE | Restricted Stock Units | D | -12,500 | 12,500 | ||||||
| 2021-12-14 | 2021-12-12 | 4 | Westby Keith | ISEE | Common Stock | D | 12,500 | 124,591 | ||||||
| 2021-12-14 | 2021-12-13 | 4 | SBLENDORIO GLENN | ISEE | Common Stock | D | 14.7449 | -8,293 | -122 | 320,999 | ||||
| 2021-12-14 | 2021-12-12 | 4 | SBLENDORIO GLENN | ISEE | Restricted Stock Units | D | -22,950 | 22,950 | ||||||
| 2021-12-14 | 2021-12-12 | 4 | SBLENDORIO GLENN | ISEE | Common Stock | D | 22,950 | 329,292 | ||||||
| 2021-12-13 | 2021-12-10 | 4 | Westby Keith | ISEE | Common Stock | D | 14.5315 | -3,614 | -53 | 112,091 | ||||
| 2021-12-13 | 2021-12-09 | 4 | Westby Keith | ISEE | Restricted Stock Units | D | -10,000 | 20,000 | ||||||
| 2021-12-13 | 2021-12-09 | 4 | Westby Keith | ISEE | Common Stock | D | 10,000 | 115,705 | ||||||
| 2021-12-13 | 2021-12-09 | 4 | SBLENDORIO GLENN | ISEE | Restricted Stock Units | D | -23,750 | 47,500 | ||||||
| 2021-12-13 | 2021-12-09 | 4 | SBLENDORIO GLENN | ISEE | Common Stock | D | 23,750 | 306,342 | ||||||
| 2021-12-13 | 2021-12-10 | 4 | Carroll David Francis | ISEE | Common Stock | D | 14.5315 | -3,614 | -53 | 90,701 | ||||
| 2021-12-13 | 2021-12-09 | 4 | Carroll David Francis | ISEE | Restricted Stock Units | D | -10,000 | 20,000 | ||||||
| 2021-12-13 | 2021-12-09 | 4 | Carroll David Francis | ISEE | Common Stock | D | 10,000 | 94,315 | ||||||
| 2021-11-22 | 2021-11-18 | 4 | Simms Christopher Paul | ISEE | Common Stock | D | 16.3000 | 3,069 | 50 | 7,069 | ||||
| 2021-11-15 | 2021-11-11 | 4 | Dugel Pravin | ISEE | Stock Option (Right to Buy) | D | 1.65 | -4,237 | 0 | |||||
| 2021-11-15 | 2021-11-11 | 4 | Dugel Pravin | ISEE | Common Stock | D | 1.6520 | 4,237 | 7 | 45,936 | ||||
| 2021-08-04 | 2021-08-02 | 4 | Simms Christopher Paul | (ISEE) | Restricted Stock Units | D | 15,000 | 15,000 | ||||||
| 2021-08-04 | 2021-08-02 | 4 | Simms Christopher Paul | (ISEE) | Restricted Stock Units | D | 75,000 | 75,000 | ||||||
| 2021-08-04 | 2021-08-02 | 4 | Simms Christopher Paul | (ISEE) | Stock Option (Right to Buy) | D | 8.64 | 160,000 | 160,000 | |||||
| 2021-08-04 | 3 | Simms Christopher Paul | ISEE | Common stock | D | 4,000 | ||||||||
| 2021-07-19 | 2021-07-15 | 4 | Blumenkranz Mark S. | ISEE | Restricted Stock Units | D | -5,000 | 10,000 | ||||||
| 2021-07-19 | 2021-07-15 | 4 | Blumenkranz Mark S. | ISEE | Common Stock | D | 5,000 | 5,000 | ||||||
| 2021-05-20 | 2021-05-19 | 4 | Henderson Jane | ISEE | Restricted Stock Units | D | 7,500 | 7,500 | ||||||
| 2021-05-20 | 2021-05-19 | 4 | Henderson Jane | ISEE | Stock Option (Right to Buy) | D | 6.82 | 15,500 | 15,500 | |||||
| 2021-05-20 | 2021-05-19 | 4 | Blumenkranz Mark S. | ISEE | Restricted Stock Units | D | 7,500 | 7,500 | ||||||
| 2021-05-20 | 2021-05-19 | 4 | Blumenkranz Mark S. | ISEE | Stock Option (Right to Buy) | D | 6.82 | 15,500 | 15,500 | |||||
| 2021-05-20 | 2021-05-19 | 4 | Roberts Calvin W. | ISEE | Restricted Stock Units | D | 7,500 | 7,500 | ||||||
| 2021-05-20 | 2021-05-19 | 4 | Roberts Calvin W. | ISEE | Stock Option (Right to Buy) | D | 6.82 | 15,500 | 15,500 | |||||
| 2021-05-20 | 2021-05-19 | 4 | Graves Adrienne L | ISEE | Restricted Stock Units | D | 7,500 | 7,500 | ||||||
| 2021-05-20 | 2021-05-19 | 4 | Graves Adrienne L | ISEE | Stock Option (Right to Buy) | D | 6.82 | 15,500 | 15,500 | |||||
| 2021-05-20 | 2021-05-19 | 4 | Bolte Axel | ISEE | Restricted Stock Units | D | 7,500 | 7,500 | ||||||
| 2021-05-20 | 2021-05-19 | 4 | Bolte Axel | ISEE | Stock Option (Right to Buy) | D | 6.82 | 15,500 | 15,500 | |||||
| 2021-05-04 | 2021-05-03 | 4 | Dugel Pravin | ISEE | Restricted Stock Units | D | 17,250 | 17,250 | ||||||
| 2021-05-04 | 2021-05-03 | 4 | Dugel Pravin | ISEE | Stock Option (Right to Buy) | D | 7.17 | 35,000 | 35,000 | |||||
| 2021-04-05 | 2021-04-05 | 4 | Dugel Pravin | ISEE | Common Stock | D | 6.3400 | -28,301 | -179 | 41,699 | ||||
| 2021-04-05 | 2021-04-01 | 4 | Dugel Pravin | ISEE | Restricted Stock Units | D | -20,000 | 0 | ||||||
| 2021-04-05 | 2021-04-01 | 4 | Dugel Pravin | ISEE | Restricted Stock Units | D | -50,000 | 150,000 | ||||||
| 2021-04-05 | 2021-04-01 | 4 | Dugel Pravin | ISEE | Common Stock | D | 20,000 | 70,000 | ||||||
| 2021-04-05 | 2021-04-01 | 4 | Dugel Pravin | ISEE | Common Stock | D | 50,000 | 50,000 | ||||||
| 2021-01-05 | 2021-01-04 | 4 | Westby Keith | ISEE | Common Stock | D | 6.8500 | -11,875 | -81 | 86,466 | ||||
| 2021-01-05 | 2020-12-31 | 4 | Westby Keith | ISEE | Restricted Stock Units | D | -32,500 | 32,500 | ||||||
| 2021-01-05 | 2020-12-31 | 4 | Westby Keith | ISEE | Common Stock | D | 32,500 | 98,341 | ||||||
| 2021-01-05 | 2021-01-04 | 4 | Carroll David Francis | ISEE | Common Stock | D | 6.8500 | -11,875 | -81 | 80,165 | ||||
| 2021-01-05 | 2020-12-31 | 4 | Carroll David Francis | ISEE | Restricted Stock Units | D | -32,500 | 32,500 | ||||||
| 2021-01-05 | 2020-12-31 | 4 | Carroll David Francis | ISEE | Common Stock | D | 32,500 | 92,040 | ||||||
| 2020-12-22 | 2020-12-18 | 4 | Carroll David Francis | ISEE | Restricted Stock Units | D | 57,500 | 57,500 | ||||||
| 2020-12-22 | 2020-12-18 | 4 | Carroll David Francis | ISEE | Stock Option (Right to Buy) | D | 7.50 | 115,000 | 115,000 | |||||
| 2020-12-22 | 2020-12-18 | 4 | SBLENDORIO GLENN | ISEE | Restricted Stock Units | D | 146,630 | 146,630 | ||||||
| 2020-12-22 | 2020-12-18 | 4 | SBLENDORIO GLENN | ISEE | Stock Option (Right to Buy) | D | 7.50 | 293,130 | 293,130 | |||||
| 2020-12-22 | 2020-12-18 | 4 | Westby Keith | ISEE | Restricted Stock Units | D | 50,000 | 50,000 | ||||||
| 2020-12-22 | 2020-12-18 | 4 | Westby Keith | ISEE | Stock Option (Right to Buy) | D | 7.50 | 100,000 | 100,000 | |||||
| 2020-12-22 | 2020-12-18 | 4 | Dugel Pravin | ISEE | Restricted Stock Units | D | 55,000 | 55,000 | ||||||
| 2020-12-22 | 2020-12-18 | 4 | Dugel Pravin | ISEE | Stock Option (Right to Buy) | D | 7.50 | 110,000 | 110,000 | |||||
| 2020-12-22 | 2020-12-18 | 4 | GUYER DAVID R | ISEE | Restricted Stock Units | D | 102,630 | 102,630 | ||||||
| 2020-12-22 | 2020-12-18 | 4 | GUYER DAVID R | ISEE | Stock Option (Right to Buy) | D | 7.50 | 205,150 | 205,150 | |||||
| 2020-12-15 | 2020-12-14 | 4 | GUYER DAVID R | ISEE | Common Stock | D | 7.1600 | -9,270 | -66 | 70,113 | ||||
| 2020-12-15 | 2020-12-12 | 4 | GUYER DAVID R | ISEE | Restricted Stock Units | D | -17,200 | 34,400 | ||||||
| 2020-12-15 | 2020-12-12 | 4 | GUYER DAVID R | ISEE | Common Stock | D | 17,200 | 79,383 | ||||||
| 2020-12-15 | 2020-12-14 | 4 | Westby Keith | ISEE | Common Stock | D | 7.1600 | -4,527 | -32 | 65,841 | ||||
| 2020-12-15 | 2020-12-12 | 4 | Westby Keith | ISEE | Restricted Stock Units | D | -12,500 | 25,000 | ||||||
| 2020-12-15 | 2020-12-12 | 4 | Westby Keith | ISEE | Common Stock | D | 12,500 | 70,368 | ||||||
| 2020-12-15 | 2020-12-12 | 4 | Carroll David Francis | ISEE | Restricted Stock Units | D | -12,500 | 25,000 | ||||||
| 2020-12-15 | 2020-12-12 | 4 | Carroll David Francis | ISEE | Common Stock | D | 12,500 | 59,540 | ||||||
| 2020-12-15 | 2020-12-12 | 4 | SBLENDORIO GLENN | ISEE | Restricted Stock Units | D | -22,950 | 45,900 | ||||||
| 2020-12-15 | 2020-12-12 | 4 | SBLENDORIO GLENN | ISEE | Common Stock | D | 22,950 | 273,773 | ||||||
| 2020-12-11 | 2020-12-10 | 4 | GUYER DAVID R | ISEE | Common Stock | D | 6.9600 | -9,602 | -67 | 62,183 | ||||
| 2020-12-11 | 2020-12-09 | 4 | GUYER DAVID R | ISEE | Restricted Stock Units | D | -17,813 | 53,437 | ||||||
| 2020-12-11 | 2020-12-09 | 4 | GUYER DAVID R | ISEE | Common Stock | D | 17,813 | 71,785 | ||||||
| 2020-12-11 | 2020-12-09 | 4 | SBLENDORIO GLENN | ISEE | Restricted Stock Units | D | -23,750 | 71,250 | ||||||
| 2020-12-11 | 2020-12-09 | 4 | SBLENDORIO GLENN | ISEE | Common Stock | D | 23,750 | 250,823 | ||||||
| 2020-12-11 | 2020-12-09 | 4 | Carroll David Francis | ISEE | Restricted Stock Units | D | -10,000 | 30,000 | ||||||
| 2020-12-11 | 2020-12-09 | 4 | Carroll David Francis | ISEE | Common Stock | D | 10,000 | 47,040 | ||||||
| 2020-12-11 | 2020-12-10 | 4 | Westby Keith | ISEE | Common Stock | D | 6.9600 | -3,676 | -26 | 57,868 | ||||
| 2020-12-11 | 2020-12-09 | 4 | Westby Keith | ISEE | Restricted Stock Units | D | -10,000 | 30,000 | ||||||
| 2020-12-11 | 2020-12-09 | 4 | Westby Keith | ISEE | Common Stock | D | 10,000 | 61,544 | ||||||
| 2020-07-17 | 2020-07-15 | 4 | Blumenkranz Mark S. | ISEE | Restricted Stock Units | D | 15,000 | 15,000 | ||||||
| 2020-07-17 | 2020-07-15 | 4 | Blumenkranz Mark S. | ISEE | Stock Option (Right to Buy) | D | 4.48 | 31,000 | 31,000 | |||||
| 2020-07-06 | 2020-07-01 | 4 | Carroll David Francis | ISEE | Restricted Stock Units | D | -7,500 | 0 | ||||||
| 2020-07-06 | 2020-07-01 | 4 | Carroll David Francis | ISEE | Common Stock | D | 7,500 | 33,707 | ||||||
| 2020-06-23 | 2020-06-19 | 4 | Versant Venture Capital IV, L.P. footnote | ISEE | Common Stock | I | -34,282 | 0 | ||||||
| 2020-06-23 | 2020-06-19 | 4 | Versant Venture Capital IV, L.P. footnote | ISEE | Common Stock | I | 34,282 | 34,282 | ||||||
| 2020-06-23 | 2020-06-19 | 4 | Versant Venture Capital IV, L.P. footnote | ISEE | Common Stock | I | -21,597 | 10,798 | ||||||
| 2020-06-23 | 2020-06-19 | 4 | Versant Venture Capital IV, L.P. footnote | ISEE | Common Stock | I | -3,428,221 | 1,714,111 | ||||||
| 2020-06-11 | 2020-06-09 | 4 | Henderson Jane | ISEE | Stock Option (Right to Buy) | D | 4.14 | 16,000 | 16,000 | |||||
| 2020-06-11 | 2020-06-09 | 4 | Graves Adrienne L | ISEE | Stock Option (Right to Buy) | D | 4.14 | 16,000 | 16,000 | |||||
| 2020-06-11 | 2020-06-09 | 4 | Roberts Calvin W. | ISEE | Stock Option (Right to Buy) | D | 4.14 | 16,000 | 16,000 | |||||
| 2020-06-11 | 2020-06-09 | 4 | Bolte Axel | ISEE | Stock Option (Right to Buy) | D | 4.14 | 16,000 | 16,000 | |||||
| 2020-04-03 | 2020-04-01 | 4 | SBLENDORIO GLENN | ISEE | Restricted Stock Units | D | -18,750 | 0 | ||||||
| 2020-04-03 | 2020-04-01 | 4 | SBLENDORIO GLENN | ISEE | Common Stock | D | 18,750 | 225,061 | ||||||
| 2020-01-07 | 2020-01-06 | 4 | GUYER DAVID R | ISEE | Common Stock | D | 8.0700 | -3,367 | -27 | 53,972 | ||||
| 2020-01-07 | 2020-01-04 | 4 | GUYER DAVID R | ISEE | Restricted Stock Units | D | -6,250 | 0 | ||||||
| 2020-01-07 | 2020-01-04 | 4 | GUYER DAVID R | ISEE | Common Stock | D | 6,250 | 57,339 | ||||||
| 2020-01-07 | 2020-01-06 | 4 | Westby Keith | ISEE | Common Stock | D | 8.0700 | -293 | -2 | 40,983 | ||||
| 2020-01-07 | 2020-01-04 | 4 | Westby Keith | ISEE | Restricted Stock Units | D | -700 | 0 | ||||||
| 2020-01-07 | 2020-01-04 | 4 | Westby Keith | ISEE | Common Stock | D | 700 | 41,276 | ||||||
| 2019-12-16 | 2019-12-13 | 4 | Westby Keith | ISEE | Common Stock | D | 6.6000 | -4,530 | -30 | 40,576 | ||||
| 2019-12-16 | 2019-12-12 | 4 | Westby Keith | ISEE | Restricted Stock Units | D | -12,500 | 37,500 | ||||||
| 2019-12-16 | 2019-12-12 | 4 | Westby Keith | ISEE | Common Stock | D | 12,500 | 45,106 | ||||||
| 2019-12-16 | 2019-12-13 | 4 | GUYER DAVID R | ISEE | Common Stock | D | 6.6000 | -9,275 | -61 | 51,089 | ||||
| 2019-12-16 | 2019-12-12 | 4 | GUYER DAVID R | ISEE | Restricted Stock Units | D | -17,200 | 51,600 | ||||||
| 2019-12-16 | 2019-12-12 | 4 | GUYER DAVID R | ISEE | Common Stock | D | 17,200 | 60,364 | ||||||
| 2019-12-16 | 2019-12-12 | 4 | SBLENDORIO GLENN | ISEE | Restricted Stock Units | D | -22,950 | 68,850 | ||||||
| 2019-12-16 | 2019-12-12 | 4 | SBLENDORIO GLENN | ISEE | Common Stock | D | 22,950 | 199,804 | ||||||
| 2019-12-16 | 2019-12-12 | 4 | Carroll David Francis | ISEE | Restricted Stock Units | D | -12,500 | 37,500 | ||||||
| 2019-12-16 | 2019-12-12 | 4 | Carroll David Francis | ISEE | Common Stock | D | 12,500 | 26,207 | ||||||
| 2019-12-11 | 2019-12-09 | 4 | GUYER DAVID R | ISEE | Restricted Stock Units | D | 71,250 | 71,250 | ||||||
| 2019-12-11 | 2019-12-09 | 4 | GUYER DAVID R | ISEE | Stock Option (Right to Buy) | D | 5.22 | 142,500 | 142,500 | |||||
| 2019-12-11 | 2019-12-10 | 4 | SBLENDORIO GLENN | ISEE | Common Stock | D | 4.0000 | 62,500 | 250 | 176,854 | ||||
| 2019-12-11 | 2019-12-09 | 4 | SBLENDORIO GLENN | ISEE | Restricted Stock Units | D | 95,000 | 95,000 | ||||||
| 2019-12-11 | 2019-12-09 | 4 | SBLENDORIO GLENN | ISEE | Stock Option (Right to Buy) | D | 5.22 | 190,000 | 190,000 | |||||
| 2019-12-11 | 2019-12-09 | 4 | Westby Keith | ISEE | Restricted Stock Units | D | 65,000 | 65,000 | ||||||
| 2019-12-11 | 2019-12-09 | 4 | Westby Keith | ISEE | Restricted Stock Units | D | 40,000 | 40,000 | ||||||
| 2019-12-11 | 2019-12-09 | 4 | Westby Keith | ISEE | Stock Option (Right to Buy) | D | 5.22 | 75,000 | 75,000 | |||||
| 2019-12-11 | 2019-12-09 | 4 | Carroll David Francis | ISEE | Restricted Stock Units | D | 65,000 | 65,000 | ||||||
| 2019-12-11 | 2019-12-09 | 4 | Carroll David Francis | ISEE | Restricted Stock Units | D | 40,000 | 40,000 | ||||||
| 2019-12-11 | 2019-12-09 | 4 | Carroll David Francis | ISEE | Stock Option (Right to Buy) | D | 5.22 | 75,000 | 75,000 | |||||
| 2019-11-18 | 2019-11-15 | 4 | SBLENDORIO GLENN | ISEE | Common Stock | D | 3.1234 | 15,000 | 47 | 114,354 | ||||
| 2019-07-03 | 2019-07-02 | 4 | Carroll David Francis | ISEE | Common Stock | D | 1.2500 | -2,773 | -3 | 13,707 | ||||
| 2019-07-03 | 2019-07-01 | 4 | Carroll David Francis | ISEE | Restricted Stock Units | D | -7,500 | 7,500 | ||||||
| 2019-07-03 | 2019-07-01 | 4 | Carroll David Francis | ISEE | Common Stock | D | 7,500 | 16,480 | ||||||
| 2019-05-16 | 2019-05-15 | 4 | Bolte Axel | ISEE | Stock Option (Right to Buy) | D | 1.39 | 16,000 | 16,000 | |||||
| 2019-05-16 | 2019-05-15 | 4 | Redlick David E | ISEE | Stock Option (Right to Buy) | D | 1.39 | 16,000 | 16,000 | |||||
| 2019-05-16 | 2019-05-15 | 4 | Graves Adrienne L | ISEE | Stock Option (Right to Buy) | D | 1.39 | 16,000 | 16,000 | |||||
| 2019-05-16 | 2019-05-15 | 4 | Henderson Jane | ISEE | Stock Option (Right to Buy) | D | 1.39 | 16,000 | 16,000 | |||||
| 2019-05-16 | 2019-05-15 | 4 | Roberts Calvin W. | ISEE | Stock Option (Right to Buy) | D | 1.39 | 16,000 | 16,000 | |||||
| 2019-05-13 | 2019-05-10 | 4 | SBLENDORIO GLENN | ISEE | Common Stock | D | 1.4800 | 25,000 | 37 | 93,105 | ||||
| 2019-04-03 | 2019-04-02 | 4 | SBLENDORIO GLENN | OPHT | Common Stock | D | 1.4300 | -6,914 | -10 | 68,105 | ||||
| 2019-04-03 | 2019-04-01 | 4 | SBLENDORIO GLENN | OPHT | Restricted Stock Units | D | -18,750 | 18,750 | ||||||
| 2019-04-03 | 2019-04-01 | 4 | SBLENDORIO GLENN | OPHT | Common Stock | D | 18,750 | 75,019 | ||||||
| 2019-01-16 | 2019-01-14 | 4 | Versant Venture Capital IV, L.P. | OPHT | Common Stock | I | 2.2984 | 817 | 2 | 32,394 | ||||
| 2019-01-16 | 2019-01-14 | 4 | Versant Venture Capital IV, L.P. | OPHT | Common Stock | I | 2.2984 | 129,709 | 298 | 5,142,333 | ||||
| 2019-01-07 | 2019-01-07 | 4 | GUYER DAVID R | OPHT | Common Stock | D | 1.3000 | -3,859 | -5 | 43,164 | ||||
| 2019-01-07 | 2019-01-04 | 4 | GUYER DAVID R | OPHT | Restricted Stock Units | D | -6,250 | 6,250 | ||||||
| 2019-01-07 | 2019-01-04 | 4 | GUYER DAVID R | OPHT | Common Stock | D | 6,250 | 47,023 | ||||||
| 2019-01-07 | 2019-01-07 | 4 | Westby Keith | OPHT | Common Stock | D | 1.3000 | -299 | -0 | 32,606 | ||||
| 2019-01-07 | 2019-01-04 | 4 | Westby Keith | OPHT | Restricted Stock Units | D | -700 | 700 | ||||||
| 2019-01-07 | 2019-01-04 | 4 | Westby Keith | OPHT | Common Stock | D | 700 | 32,905 | ||||||
| 2019-01-04 | 2019-01-03 | 4 | GUYER DAVID R | OPHT | Common Stock | D | 1.2400 | -3,637 | -5 | 40,773 | ||||
| 2019-01-04 | 2019-01-02 | 4 | GUYER DAVID R | OPHT | Restricted Stock Units | D | -5,750 | 0 | ||||||
| 2019-01-04 | 2019-01-02 | 4 | GUYER DAVID R | OPHT | Common Stock | D | 5,750 | 44,410 | ||||||
| 2019-01-04 | 2019-01-03 | 4 | Westby Keith | OPHT | Common Stock | D | 1.2400 | -342 | -0 | 32,205 | ||||
| 2019-01-04 | 2019-01-02 | 4 | Westby Keith | OPHT | Restricted Stock Units | D | -781 | 0 | ||||||
| 2019-01-04 | 2019-01-02 | 4 | Westby Keith | OPHT | Common Stock | D | 781 | 32,547 | ||||||
| 2019-01-03 | 2019-01-01 | 4 | Roberts Calvin W. | OPHT | Stock Option (Right to Buy) | D | 1.20 | 32,000 | 32,000 | |||||
| 2018-12-14 | 2018-12-12 | 4 | Graves Adrienne L | OPHT | Stock Option (Right to Buy) | D | 1.45 | 32,000 | 32,000 | |||||
| 2018-12-14 | 2018-12-12 | 4 | Carroll David Francis | OPHT | Restricted Stock Units | D | 50,000 | 50,000 | ||||||
| 2018-12-14 | 2018-12-12 | 4 | Carroll David Francis | OPHT | Stock Option (Right to Buy) | D | 1.45 | 100,000 | 100,000 | |||||
| 2018-12-14 | 2018-12-12 | 4 | SBLENDORIO GLENN | OPHT | Restricted Stock Units | D | 91,800 | 91,800 | ||||||
| 2018-12-14 | 2018-12-12 | 4 | SBLENDORIO GLENN | OPHT | Stock Option (Right to Buy) | D | 1.45 | 183,500 | 183,500 | |||||
| 2018-12-14 | 2018-12-12 | 4 | Westby Keith | OPHT | Restricted Stock Units | D | 50,000 | 50,000 | ||||||
| 2018-12-14 | 2018-12-12 | 4 | Westby Keith | OPHT | Stock Option (Right to Buy) | D | 1.45 | 100,000 | 100,000 | |||||
| 2018-12-14 | 2018-12-12 | 4 | GUYER DAVID R | OPHT | Restricted Stock Units | D | 68,800 | 68,800 | ||||||
| 2018-12-14 | 2018-12-12 | 4 | GUYER DAVID R | OPHT | Stock Option (Right to Buy) | D | 1.45 | 137,500 | 137,500 | |||||
| 2018-11-09 | 3 | Versant Ventures IV, LLC | OPHT | Common Stock | I | 10,056,825 | ||||||||
| 2018-11-09 | 3 | Versant Ventures IV, LLC | OPHT | Common Stock | I | 10,056,825 | ||||||||
| 2018-11-09 | 3 | Versant Ventures IV, LLC | OPHT | Common Stock | I | 10,056,825 | ||||||||
| 2018-11-09 | 3 | Versant Ventures IV, LLC | OPHT | Common Stock | I | 5,075,778 | ||||||||
| 2018-11-09 | 3 | Versant Ventures IV, LLC | OPHT | Common Stock | I | 10,056,825 | ||||||||
| 2018-11-09 | 3 | Versant Ventures IV, LLC | OPHT | Common Stock | I | 5,075,778 | ||||||||
| 2018-11-09 | 3 | Versant Ventures IV, LLC | OPHT | Common Stock | I | 5,075,778 | ||||||||
| 2018-11-09 | 3 | Versant Ventures IV, LLC | OPHT | Common Stock | I | 10,056,825 | ||||||||
| 2018-11-09 | 3 | Versant Ventures IV, LLC | OPHT | Common Stock | I | 5,075,778 | ||||||||
| 2018-11-09 | 3 | Versant Ventures IV, LLC | OPHT | Common Stock | I | 5,075,778 | ||||||||
| 2018-07-11 | 2018-05-23 | 4 | ROSS MICHAEL JAY | OPHT | Stock Option (Right to Buy) | D | 2.78 | 16,000 | 16,000 | |||||
| 2018-07-11 | 2018-05-23 | 4 | Redlick David E | OPHT | Stock Option (Right to Buy) | D | 2.78 | 16,000 | 16,000 | |||||
| 2018-07-11 | 2018-05-23 | 4 | Henderson Jane | OPHT | Stock Option (Right to Buy) | D | 2.78 | 16,000 | 16,000 | |||||
| 2018-07-11 | 2018-05-23 | 4 | Bolte Axel | OPHT | Stock Option (Right to Buy) | D | 2.78 | 16,000 | 16,000 | |||||
| 2018-07-03 | 2018-07-02 | 4 | Carroll David Francis | OPHT | Common Stock | D | 2.6800 | -2,736 | -7 | 8,980 | ||||
| 2018-07-03 | 2018-07-01 | 4 | Carroll David Francis | OPHT | Restricted Stock Units | D | -7,500 | 15,000 | ||||||
| 2018-07-03 | 2018-07-01 | 4 | Carroll David Francis | OPHT | Common Stock | D | 7,500 | 11,716 | ||||||
| 2018-04-03 | 2018-04-02 | 4 | SBLENDORIO GLENN | OPHT | Common Stock | D | 2.6900 | -6,838 | -18 | 48,407 | ||||
| 2018-04-03 | 2018-04-01 | 4 | SBLENDORIO GLENN | OPHT | Restricted Stock Units | D | -18,750 | 37,500 | ||||||
| 2018-04-03 | 2018-04-01 | 4 | SBLENDORIO GLENN | OPHT | Common Stock | D | 18,750 | 55,245 | ||||||
| 2018-01-17 | 2018-01-13 | 4 | Henderson Jane | OPHT | Stock Option (Right to Buy) | D | 2.85 | 32,000 | 32,000 | |||||
| 2018-01-05 | 2018-01-05 | 4 | GUYER DAVID R | OPHT | Common Stock | D | 3.1700 | -3,798 | -12 | 38,660 | ||||
| 2018-01-05 | 2018-01-04 | 4 | GUYER DAVID R | OPHT | Restricted Stock Units | D | -6,250 | 12,500 | ||||||
| 2018-01-05 | 2018-01-04 | 4 | GUYER DAVID R | OPHT | Common Stock | D | 6,250 | 42,458 | ||||||
| 2018-01-05 | 2018-01-05 | 4 | Westby Keith | OPHT | Common Stock | D | 3.1700 | -317 | -1 | 24,983 | ||||
| 2018-01-05 | 2018-01-04 | 4 | Westby Keith | OPHT | Restricted Stock Units | D | -700 | 1,400 | ||||||
| 2018-01-05 | 2018-01-04 | 4 | Westby Keith | OPHT | Common Stock | D | 700 | 25,300 | ||||||
| 2018-01-05 | 2018-01-05 | 4 | WOOD BARBARA A | OPHT | Common Stock | D | 3.1700 | -602 | -2 | 16,462 | ||||
| 2018-01-05 | 2018-01-04 | 4 | WOOD BARBARA A | OPHT | Restricted Stock Units | D | -1,200 | 2,400 | ||||||
| 2018-01-05 | 2018-01-04 | 4 | WOOD BARBARA A | OPHT | Common Stock | D | 1,200 | 17,064 | ||||||
| 2018-01-04 | 2018-01-03 | 4 | Westby Keith | OPHT | Common Stock | D | 3.2400 | -356 | -1 | 24,600 | ||||
| 2018-01-04 | 2018-01-02 | 4 | Westby Keith | OPHT | Restricted Stock Units | D | -781 | 781 | ||||||
| 2018-01-04 | 2018-01-02 | 4 | Westby Keith | OPHT | Common Stock | D | 781 | 24,956 | ||||||
| 2018-01-04 | 2018-01-03 | 4 | WOOD BARBARA A | OPHT | Common Stock | D | 3.2400 | -694 | -2 | 15,864 | ||||
| 2018-01-04 | 2018-01-02 | 4 | WOOD BARBARA A | OPHT | Restricted Stock Units | D | -1,375 | 1,375 | ||||||
| 2018-01-04 | 2018-01-02 | 4 | WOOD BARBARA A | OPHT | Common Stock | D | 1,375 | 16,558 | ||||||
| 2018-01-04 | 2018-01-03 | 4 | GUYER DAVID R | OPHT | Common Stock | D | 3.2400 | -3,516 | -11 | 36,208 | ||||
| 2018-01-04 | 2018-01-02 | 4 | GUYER DAVID R | OPHT | Restricted Stock Units | D | -5,750 | 5,750 | ||||||
| 2018-01-04 | 2018-01-02 | 4 | GUYER DAVID R | OPHT | Common Stock | D | 5,750 | 39,724 | ||||||
| 2018-01-03 | 2018-01-02 | 4 | WOOD BARBARA A | OPHT | Common Stock | D | 3.1900 | -5,289 | -17 | 15,183 | ||||
| 2018-01-03 | 2017-12-29 | 4 | WOOD BARBARA A | OPHT | Restricted Stock Units | D | -12,140 | 0 | ||||||
| 2018-01-03 | 2017-12-29 | 4 | WOOD BARBARA A | OPHT | Common Stock | D | 12,140 | 20,472 | ||||||
| 2018-01-03 | 2018-01-02 | 4 | GUYER DAVID R | OPHT | Common Stock | D | 3.1900 | -16,520 | -53 | 33,974 | ||||
| 2018-01-03 | 2017-12-29 | 4 | GUYER DAVID R | OPHT | Restricted Stock Units | D | -30,480 | 0 | ||||||
| 2018-01-03 | 2017-12-29 | 4 | GUYER DAVID R | OPHT | Common Stock | D | 30,480 | 50,494 | ||||||
| 2018-01-03 | 2018-01-02 | 4 | SBLENDORIO GLENN | OPHT | Common Stock | D | 3.1900 | -8,089 | -26 | 36,495 | ||||
| 2018-01-03 | 2017-12-29 | 4 | SBLENDORIO GLENN | OPHT | Restricted Stock Units | D | -20,420 | 0 | ||||||
| 2018-01-03 | 2017-12-29 | 4 | SBLENDORIO GLENN | OPHT | Common Stock | D | 20,420 | 44,584 | ||||||
| 2017-12-21 | 2017-12-19 | 4 | Westby Keith | OPHT | Stock Option (Right to Buy) | D | 2.94 | 150,000 | 150,000 | |||||
| 2017-12-21 | 2017-12-19 | 4 | GUYER DAVID R | OPHT | Stock Option (Right to Buy) | D | 2.94 | 300,000 | 300,000 | |||||
| 2017-12-21 | 2017-12-19 | 4 | SBLENDORIO GLENN | OPHT | Stock Option (Right to Buy) | D | 2.94 | 400,000 | 400,000 | |||||
| 2017-12-21 | 2017-12-19 | 4 | Carroll David Francis | OPHT | Stock Option (Right to Buy) | D | 2.94 | 150,000 | 150,000 | |||||
| 2017-07-05 | 2017-07-05 | 4 | Carroll David Francis | OPHT | Common Stock | D | 2.5800 | -3,284 | -8 | 4,216 | ||||
| 2017-07-05 | 2017-07-01 | 4 | Carroll David Francis | OPHT | Restricted Stock Units | D | -7,500 | 22,500 | ||||||
| 2017-07-05 | 2017-07-01 | 4 | Carroll David Francis | OPHT | Common Stock | D | 7,500 | 7,500 | ||||||
| 2017-07-05 | 2017-07-05 | 4 | SBLENDORIO GLENN | OPHT | Common Stock | D | 2.5800 | -7,828 | -20 | 24,164 | ||||
| 2017-07-05 | 2017-06-30 | 4 | SBLENDORIO GLENN | OPHT | Restricted Stock Units | D | -20,420 | 20,420 | ||||||
| 2017-07-05 | 2017-06-30 | 4 | SBLENDORIO GLENN | OPHT | Common Stock | D | 20,420 | 31,992 | ||||||
| 2017-07-05 | 2017-07-05 | 4 | WOOD BARBARA A | OPHT | Common Stock | D | 2.5800 | -5,119 | -13 | 8,332 | ||||
| 2017-07-05 | 2017-06-30 | 4 | WOOD BARBARA A | OPHT | Restricted Stock Units | D | -12,140 | 12,140 | ||||||
| 2017-07-05 | 2017-06-30 | 4 | WOOD BARBARA A | OPHT | Common Stock | D | 12,140 | 13,451 | ||||||
| 2017-07-05 | 2017-07-05 | 4 | GUYER DAVID R | OPHT | Common Stock | D | 2.5800 | -17,678 | -46 | 20,014 | ||||
| 2017-07-05 | 2017-06-30 | 4 | GUYER DAVID R | OPHT | Restricted Stock Units | D | -30,480 | 30,480 | ||||||
| 2017-07-05 | 2017-06-30 | 4 | GUYER DAVID R | OPHT | Common Stock | D | 30,480 | 37,692 | ||||||
| 2017-06-14 | 2017-06-13 | 4 | Redlick David E | OPHT | Common Stock | D | 2.5200 | -700 | -2 | 1,050 | ||||
| 2017-05-22 | 2017-05-19 | 4 | Redlick David E | OPHT | Stock Option (Right to Buy) | D | 2.46 | 16,000 | 16,000 | |||||
| 2017-05-22 | 2017-05-18 | 4 | Redlick David E | OPHT | Restricted Stock Units | D | -1,750 | 0 | ||||||
| 2017-05-22 | 2017-05-18 | 4 | Redlick David E | OPHT | Common Stock | D | 1,750 | 1,750 | ||||||
| 2017-05-22 | 2017-05-19 | 4 | Bolte Axel | OPHT | Stock Option (Right to Buy) | D | 2.46 | 16,000 | 16,000 | |||||
| 2017-05-22 | 2017-05-19 | 4 | ROSS MICHAEL JAY | OPHT | Stock Option (right to buy) | D | 2.46 | 16,000 | 16,000 | |||||
| 2017-05-22 | 2017-05-18 | 4 | ROSS MICHAEL JAY | OPHT | Restricted Stock Units | D | -1,750 | 0 | ||||||
| 2017-05-22 | 2017-05-18 | 4 | ROSS MICHAEL JAY | OPHT | Common Stock | D | 1,750 | 3,500 | ||||||
| 2017-04-25 | 2017-04-24 | 4 | Carroll David Francis | OPHT | Stock Option (Right To Buy) | D | 2.81 | 63,500 | 63,500 | |||||
| 2017-04-04 | 2017-04-03 | 4 | SBLENDORIO GLENN | OPHT | Common Stock | D | 3.5600 | -7,388 | -26 | 11,572 | ||||
| 2017-04-04 | 2017-04-01 | 4 | SBLENDORIO GLENN | OPHT | Restricted Stock Units | D | -18,750 | 56,250 | ||||||
| 2017-04-04 | 2017-04-01 | 4 | SBLENDORIO GLENN | OPHT | Common Stock | D | 18,750 | 18,960 | ||||||
| 2017-02-14 | 2016-08-11 | 5 | PATEL SAMIR CHANDRAKANT | OPHT | Common Stock | D | -90,000 | 11,531 | ||||||
| 2017-02-14 | 2016-08-10 | 5 | PATEL SAMIR CHANDRAKANT | OPHT | Common Stock | D | -30,000 | 11,531 | ||||||
| 2017-02-01 | 3 | Westby Keith | OPHT | Common Stock | D | 48,350 | ||||||||
| 2017-02-01 | 3 | Westby Keith | OPHT | Common Stock | D | 48,350 | ||||||||
| 2017-02-01 | 2017-01-30 | 4 | SBLENDORIO GLENN | OPHT | Stock Option (Right to Buy) | D | 4.52 | 260,000 | 260,000 | |||||
| 2017-02-01 | 2017-01-30 | 4 | WOOD BARBARA A | OPHT | Stock Option (Right to Buy) | D | 4.52 | 38,000 | 38,000 | |||||
| 2017-02-01 | 2017-01-30 | 4 | GUYER DAVID R | OPHT | Stock Option (Right to Buy) | D | 4.52 | 260,000 | 260,000 | |||||
| 2017-02-01 | 2017-01-30 | 4 | Westby Keith | OPHT | Stock Option (Right to Buy) | D | 4.52 | 60,000 | 60,000 | |||||
| 2017-01-23 | 2016-12-30 | 4 | Bolte Axel | OPHT | Common Stock | D | 4.8300 | -6,000 | -29 | 0 | ||||
| 2017-01-19 | 2017-01-17 | 4 | SBLENDORIO GLENN | OPHT | Restricted Stock Units | D | 40,840 | 40,840 | ||||||
| 2017-01-19 | 2017-01-17 | 4 | GUYER DAVID R | OPHT | Restricted Stock Units | D | 60,960 | 60,960 | ||||||
| 2017-01-19 | 2017-01-17 | 4 | WOOD BARBARA A | OPHT | Restricted Stock Units | D | 24,280 | 24,280 | ||||||
| 2017-01-06 | 2017-01-05 | 4 | PATEL SAMIR CHANDRAKANT | OPHT | Common Stock | D | 4.9600 | -815 | -4 | 15,813 | ||||
| 2017-01-06 | 2017-01-05 | 4 | PATEL SAMIR CHANDRAKANT | OPHT | Common Stock | D | 4.9600 | -3,029 | -15 | 16,628 | ||||
| 2017-01-06 | 2017-01-04 | 4 | PATEL SAMIR CHANDRAKANT | OPHT | Restricted Stock Units | D | 1,325 | 3,975 | ||||||
| 2017-01-06 | 2017-01-04 | 4 | PATEL SAMIR CHANDRAKANT | OPHT | Restricted Stock Units | D | 4,925 | 14,775 | ||||||
| 2017-01-06 | 2017-01-04 | 4 | PATEL SAMIR CHANDRAKANT | OPHT | Common Stock | D | 1,325 | 19,657 | ||||||
| 2017-01-06 | 2017-01-04 | 4 | PATEL SAMIR CHANDRAKANT | OPHT | Common Stock | D | 4,925 | 18,332 | ||||||
| 2017-01-06 | 2017-01-05 | 4 | GUYER DAVID R | OPHT | Common Stock | D | 4.9600 | -3,785 | -19 | 7,212 | ||||
| 2017-01-06 | 2017-01-04 | 4 | GUYER DAVID R | OPHT | Restricted Stock Units | D | -6,250 | 18,750 | ||||||
| 2017-01-06 | 2017-01-04 | 4 | GUYER DAVID R | OPHT | Common Stock | D | 6,250 | 10,997 | ||||||
| 2017-01-06 | 2017-01-05 | 4 | WOOD BARBARA A | OPHT | Common Stock | D | 4.9600 | -589 | -3 | 1,311 | ||||
| 2017-01-06 | 2017-01-04 | 4 | WOOD BARBARA A | OPHT | Restricted Stock Units | D | -1,200 | 3,600 | ||||||
| 2017-01-06 | 2017-01-04 | 4 | WOOD BARBARA A | OPHT | Common Stock | D | 1,200 | 1,900 | ||||||
| 2017-01-06 | 2017-01-05 | 4 | Bjarke Henric Bjorn | OPHT | Common Stock | D | 4.9600 | -316 | -2 | 1,384 | ||||
| 2017-01-06 | 2017-01-04 | 4 | Bjarke Henric Bjorn | OPHT | Restricted Stock Units | D | -700 | 2,100 | ||||||
| 2017-01-06 | 2017-01-04 | 4 | Bjarke Henric Bjorn | OPHT | Common Stock | D | 700 | 1,700 | ||||||
| 2017-01-04 | 2017-01-03 | 4 | WOOD BARBARA A | OPHT | Common Stock | D | 4.9000 | -675 | -3 | 700 | ||||
| 2017-01-04 | 2017-01-02 | 4 | WOOD BARBARA A | OPHT | Restricted Stock Units | D | -1,375 | 2,750 | ||||||
| 2017-01-04 | 2017-01-02 | 4 | WOOD BARBARA A | OPHT | Common Stock | D | 1,375 | 1,375 | ||||||
| 2017-01-04 | 2017-01-03 | 4 | GUYER DAVID R | OPHT | Common Stock | D | 4.9000 | -3,484 | -17 | 4,747 | ||||
| 2017-01-04 | 2017-01-02 | 4 | GUYER DAVID R | OPHT | Restricted Stock Units | D | -5,750 | 11,500 | ||||||
| 2017-01-04 | 2017-01-02 | 4 | GUYER DAVID R | OPHT | Common Stock | D | 5,750 | 8,231 | ||||||
| 2017-01-04 | 2017-01-03 | 4 | PATEL SAMIR CHANDRAKANT | OPHT | Common Stock | D | 4.9000 | -2,999 | -15 | 13,407 | ||||
| 2017-01-04 | 2017-01-02 | 4 | PATEL SAMIR CHANDRAKANT | OPHT | Restricted Stock Units | D | -4,875 | 9,750 | ||||||
| 2017-01-04 | 2017-01-02 | 4 | PATEL SAMIR CHANDRAKANT | OPHT | Common Stock | D | 4,875 | 16,406 | ||||||
| 2016-12-27 | 2016-12-23 | 4 | WOOD BARBARA A | OPHT | Common Stock | D | 4.9200 | -746 | -4 | 0 | ||||
| 2016-12-23 | 2016-12-22 | 4 | SBLENDORIO GLENN | OPHT | Common Stock | D | 4.8531 | -1,079 | -5 | 0 | ||||
| 2016-12-16 | 2016-12-15 | 4 | Novo A/S | OPHT | Common Stock | D | 4.7215 | -1,405,487 | -6,636 | 0 | ||||
| 2016-12-16 | 2016-12-14 | 4 | Novo A/S | OPHT | Common Stock | D | 4.9716 | -2,205,000 | -10,962 | 1,405,487 | ||||
| 2016-11-03 | 2016-11-01 | 4 | GUYER DAVID R | OPHT | Stock Options (Right to Buy) | D | 10.03 | -22,060 | 105,636 | |||||
| 2016-11-03 | 2016-11-01 | 4 | GUYER DAVID R | OPHT | Common Stock | D | 36.8600 | -3,820 | -141 | 2,481 | ||||
| 2016-11-03 | 2016-11-01 | 4 | GUYER DAVID R | OPHT | Common Stock | D | 35.9300 | -7,710 | -277 | 6,301 | ||||
| 2016-11-03 | 2016-11-01 | 4 | GUYER DAVID R | OPHT | Common Stock | D | 34.9300 | -10,530 | -368 | 14,011 | ||||
| 2016-11-03 | 2016-11-01 | 4 | GUYER DAVID R | OPHT | Common Stock | D | 10.0300 | 22,060 | 221 | 24,541 | ||||
| 2016-10-05 | 2016-10-03 | 4 | GUYER DAVID R | OPHT | Stock Options (Right to Buy) | D | 10.03 | -16,210 | 8,334 | |||||
| 2016-10-05 | 2016-10-03 | 4 | GUYER DAVID R | OPHT | Common Stock | D | 45.9700 | -1,600 | -74 | 2,481 | ||||
| 2016-10-05 | 2016-10-03 | 4 | GUYER DAVID R | OPHT | Common Stock | D | 44.7700 | -6,632 | -297 | 4,081 | ||||
| 2016-10-05 | 2016-10-03 | 4 | GUYER DAVID R | OPHT | Common Stock | D | 44.0000 | -13,828 | -608 | 10,713 | ||||
| 2016-10-05 | 2016-10-03 | 4 | GUYER DAVID R | OPHT | Common Stock | D | 10.0300 | 16,210 | 163 | 24,541 | ||||
| 2016-10-03 | 2016-09-29 | 4 | PATEL SAMIR CHANDRAKANT | OPHT | Common Stock | D | 56.9000 | -2,000 | -114 | 11,531 | ||||
| 2016-10-03 | 2016-09-29 | 4 | PATEL SAMIR CHANDRAKANT | OPHT | Common Stock | D | 55.7500 | -8,096 | -451 | 13,531 | ||||
| 2016-10-03 | 2016-09-29 | 4 | PATEL SAMIR CHANDRAKANT | OPHT | Common Stock | D | 54.9300 | -2,612 | -143 | 21,627 | ||||
| 2016-10-03 | 2016-09-29 | 4 | PATEL SAMIR CHANDRAKANT | OPHT | Common Stock | D | 54.1300 | -7,292 | -395 | 24,239 | ||||
| 2016-09-06 | 2016-09-01 | 4 | GUYER DAVID R | OPHT | Common Stock | D | 52.5800 | -24,060 | -1,265 | 8,331 | ||||
| 2016-08-31 | 2016-08-29 | 4 | PATEL SAMIR CHANDRAKANT | OPHT | Common Stock | D | 52.8000 | -20,000 | -1,056 | 31,531 | ||||
| 2016-08-04 | 2016-08-02 | 4 | SMITH IAN F | OPHT | Stock Option (Right to Buy) | D | 62.63 | 20,000 | 20,000 | |||||
| 2016-08-03 | 2016-08-01 | 4 | GUYER DAVID R | OPHT | Stock Options (Right to Buy) | D | 10.03 | -24,060 | 24,544 | |||||
| 2016-08-03 | 2016-08-01 | 4 | GUYER DAVID R | OPHT | Common Stock | D | 65.0600 | -2,805 | -182 | 32,391 | ||||
| 2016-08-03 | 2016-08-01 | 4 | GUYER DAVID R | OPHT | Common Stock | D | 64.3900 | -21,255 | -1,369 | 35,196 | ||||
| 2016-08-03 | 2016-08-01 | 4 | GUYER DAVID R | OPHT | Common Stock | D | 10.0300 | 24,060 | 241 | 56,451 | ||||
| 2016-08-02 | 2016-07-29 | 4 | PATEL SAMIR CHANDRAKANT | OPHT | Common Stock | D | 64.6200 | -4,500 | -291 | 171,531 | ||||
| 2016-08-02 | 2016-07-29 | 4 | PATEL SAMIR CHANDRAKANT | OPHT | Common Stock | D | 64.0900 | -15,500 | -993 | 176,031 | ||||
| 2016-07-06 | 2016-07-01 | 4 | GUYER DAVID R | OPHT | Stock Options (Right to Buy) | D | 10.03 | -24,060 | 48,604 | |||||
| 2016-07-06 | 2016-07-01 | 4 | GUYER DAVID R | OPHT | Common Stock | D | 52.7500 | -800 | -42 | 32,391 | ||||
| 2016-07-06 | 2016-07-01 | 4 | GUYER DAVID R | OPHT | Common Stock | D | 52.3800 | -17,960 | -941 | 33,191 | ||||
| 2016-07-06 | 2016-07-01 | 4 | GUYER DAVID R | OPHT | Common Stock | D | 51.1300 | -5,300 | -271 | 51,151 | ||||
| 2016-07-06 | 2016-07-01 | 4 | GUYER DAVID R | OPHT | Common Stock | D | 10.0300 | 24,060 | 241 | 56,451 | ||||
| 2016-07-01 | 2016-06-30 | 4 | PATEL SAMIR CHANDRAKANT | OPHT | Common Stock | D | 51.8600 | -2,700 | -140 | 191,531 | ||||
| 2016-07-01 | 2016-06-30 | 4 | PATEL SAMIR CHANDRAKANT | OPHT | Common Stock | D | 50.9400 | -19,146 | -975 | 194,231 | ||||
| 2016-07-01 | 2016-06-29 | 4 | PATEL SAMIR CHANDRAKANT | OPHT | Common Stock | D | 40,000 | 213,377 | ||||||
| 2016-07-01 | 2016-06-29 | 4 | PATEL SAMIR CHANDRAKANT | OPHT | Common Stock | D | 51.9400 | -1,615 | -84 | 173,377 | ||||
| 2016-07-01 | 2016-06-29 | 4 | PATEL SAMIR CHANDRAKANT | OPHT | Common Stock | D | 51.3700 | -18,385 | -944 | 174,992 | ||||
| 2016-06-07 | 2016-06-03 | 4 | Bolte Axel | OPHT | Common Stock | D | 56.9700 | 3,500 | 199 | 6,000 | ||||
| 2016-06-03 | 2016-06-02 | 4 | SBLENDORIO GLENN | OPHT | Common Stock | D | 57.2000 | -671 | -38 | 1,079 | ||||
| 2016-06-03 | 2016-06-01 | 4 | SBLENDORIO GLENN | OPHT | Restricted Stock Units | D | -1,750 | 0 | ||||||
| 2016-06-03 | 2016-06-01 | 4 | SBLENDORIO GLENN | OPHT | Common Stock | D | 1,750 | 1,750 | ||||||
| 2016-06-03 | 2016-06-01 | 4 | GUYER DAVID R | OPHT | Stock Options (Right to Buy) | D | 10.03 | -30,060 | 72,664 | |||||
| 2016-06-03 | 2016-06-01 | 4 | GUYER DAVID R | OPHT | Common Stock | D | 53.4400 | -4,294 | -229 | 32,391 | ||||
| 2016-06-03 | 2016-06-01 | 4 | GUYER DAVID R | OPHT | Common Stock | D | 52.5900 | -25,766 | -1,355 | 36,685 | ||||
| 2016-06-03 | 2016-06-01 | 4 | GUYER DAVID R | OPHT | Common Stock | D | 10.0300 | 30,060 | 302 | 62,451 | ||||
| 2016-06-03 | 2016-06-02 | 4 | ROSS MICHAEL JAY | OPHT | Restricted Stock Units | D | 1,750 | 1,750 | ||||||
| 2016-06-03 | 2016-06-02 | 4 | ROSS MICHAEL JAY | OPHT | Stock Option (right to buy) | D | 58.29 | 7,000 | 7,000 | |||||
| 2016-06-03 | 2016-06-01 | 4 | ROSS MICHAEL JAY | OPHT | Common Stock | D | 1,750 | 1,750 | ||||||
| 2016-06-03 | 2016-06-02 | 4 | Redlick David E | OPHT | Restricted Stock Units | D | 1,750 | 1,750 | ||||||
| 2016-06-03 | 2016-06-02 | 4 | Redlick David E | OPHT | Stock Option (Right To Buy) | D | 58.29 | 7,000 | 7,000 | |||||
| 2016-06-02 | 2016-05-31 | 4 | PATEL SAMIR CHANDRAKANT | OPHT | Stock Option (Right To Buy) | D | 13.22 | -1,185 | 14,214 | |||||
| 2016-06-02 | 2016-05-31 | 4 | PATEL SAMIR CHANDRAKANT | OPHT | Common Stock | D | 54.0850 | -300 | -16 | 193,377 | ||||
| 2016-06-02 | 2016-05-31 | 4 | PATEL SAMIR CHANDRAKANT | OPHT | Common Stock | D | 53.8100 | -3,709 | -200 | 193,677 | ||||
| 2016-06-02 | 2016-05-31 | 4 | PATEL SAMIR CHANDRAKANT | OPHT | Common Stock | D | 53.3300 | -14,317 | -764 | 197,386 | ||||
| 2016-06-02 | 2016-05-31 | 4 | PATEL SAMIR CHANDRAKANT | OPHT | Common Stock | D | 52.0300 | -1,674 | -87 | 211,703 | ||||
| 2016-06-02 | 2016-05-31 | 4 | PATEL SAMIR CHANDRAKANT | OPHT | Common Stock | D | 13.2160 | 1,185 | 16 | 213,377 | ||||
| 2016-05-25 | 2016-05-24 | 4 | Novo A/S | OPHT | COMMON STOCK | D | 49.0000 | -1,300,000 | -63,700 | 3,610,489 | ||||
| 2016-05-04 | 2016-05-02 | 4 | GUYER DAVID R | OPHT | Stock Options (Right to Buy) | D | 10.03 | -22,060 | 102,724 | |||||
| 2016-05-04 | 2016-05-02 | 4 | GUYER DAVID R | OPHT | Common Stock | D | 46.8200 | -4,639 | -217 | 32,391 | ||||
| 2016-05-04 | 2016-05-02 | 4 | GUYER DAVID R | OPHT | Common Stock | D | 46.0100 | -17,421 | -802 | 37,030 | ||||
| 2016-05-04 | 2016-05-02 | 4 | GUYER DAVID R | OPHT | Common Stock | D | 10.0300 | 22,060 | 221 | 54,451 | ||||
| 2016-05-03 | 2016-04-29 | 4 | PATEL SAMIR CHANDRAKANT | OPHT | Stock Option (Right To Buy) | D | 13.22 | -1,184 | 15,399 | |||||
| 2016-05-03 | 2016-04-29 | 4 | PATEL SAMIR CHANDRAKANT | OPHT | Stock Option (Right To Buy) | D | 1.65 | -1,413 | 0 | |||||
| 2016-05-03 | 2016-04-29 | 4 | PATEL SAMIR CHANDRAKANT | OPHT | Common Stock | D | 47.7800 | -1,565 | -75 | 212,192 | ||||
| 2016-05-03 | 2016-04-29 | 4 | PATEL SAMIR CHANDRAKANT | OPHT | Common Stock | D | 46.7100 | -18,435 | -861 | 213,757 | ||||
| 2016-05-03 | 2016-04-29 | 4 | PATEL SAMIR CHANDRAKANT | OPHT | Common Stock | D | 13.2160 | 1,184 | 16 | 232,192 | ||||
| 2016-05-03 | 2016-04-29 | 4 | PATEL SAMIR CHANDRAKANT | OPHT | Common Stock | D | 1.6520 | 1,413 | 2 | 231,008 | ||||
| 2016-04-05 | 2016-04-01 | 4 | GUYER DAVID R | OPHT | Stock Options (Right to Buy) | D | 10.03 | 124,784 | ||||||
| 2016-04-05 | 2016-04-01 | 4 | GUYER DAVID R | OPHT | Common Stock | D | 45.0900 | -3,481 | -157 | 32,391 | ||||
| 2016-04-05 | 2016-04-01 | 4 | GUYER DAVID R | OPHT | Common Stock | D | 44.4300 | -12,969 | -576 | 35,872 | ||||
| 2016-04-05 | 2016-04-01 | 4 | GUYER DAVID R | OPHT | Common Stock | D | 43.2100 | -3,500 | -151 | 48,841 | ||||
| 2016-04-05 | 2016-04-01 | 4 | GUYER DAVID R | OPHT | Common Stock | D | 41.9800 | -2,110 | -89 | 52,341 | ||||
| 2016-04-05 | 2016-04-01 | 4 | GUYER DAVID R | OPHT | Common Stock | D | 10.0300 | 22,060 | 221 | 54,451 | ||||
| 2016-04-05 | 2016-04-01 | 4 | SBLENDORIO GLENN | OPHT | Restricted Stock Units | D | 75,000 | 75,000 | ||||||
| 2016-04-05 | 2016-04-01 | 4 | SBLENDORIO GLENN | OPHT | Stock Option (Right To Buy) | D | 44.90 | 150,000 | 150,000 | |||||
| 2016-03-31 | 2016-03-29 | 4 | PATEL SAMIR CHANDRAKANT | OPHT | Stock Option (Right To Buy) | D | 13.22 | -1,185 | 16,583 | |||||
| 2016-03-31 | 2016-03-29 | 4 | PATEL SAMIR CHANDRAKANT | OPHT | Stock Option (Right To Buy) | D | 1.65 | -1,412 | 1,413 | |||||
| 2016-03-31 | 2016-03-29 | 4 | PATEL SAMIR CHANDRAKANT | OPHT | Common Stock | D | 43.0700 | -6,279 | -270 | 229,595 | ||||
| 2016-03-31 | 2016-03-29 | 4 | PATEL SAMIR CHANDRAKANT | OPHT | Common Stock | D | 42.0500 | -5,118 | -215 | 235,874 | ||||
| 2016-03-31 | 2016-03-29 | 4 | PATEL SAMIR CHANDRAKANT | OPHT | Common Stock | D | 40.8300 | -8,603 | -351 | 240,992 | ||||
| 2016-03-31 | 2016-03-29 | 4 | PATEL SAMIR CHANDRAKANT | OPHT | Common Stock | D | 13.2160 | 1,185 | 16 | 249,595 | ||||
| 2016-03-31 | 2016-03-29 | 4 | PATEL SAMIR CHANDRAKANT | OPHT | Common Stock | D | 1.6520 | 1,412 | 2 | 248,410 | ||||
| 2016-03-03 | 2016-03-01 | 4 | GUYER DAVID R | OPHT | Stock Options (Right to Buy) | D | 10.03 | -22,060 | 146,844 | |||||
| 2016-03-03 | 2016-03-01 | 4 | GUYER DAVID R | OPHT | Common Stock | D | 46.2100 | -2,468 | -114 | 32,391 | ||||
| 2016-03-03 | 2016-03-01 | 4 | GUYER DAVID R | OPHT | Common Stock | D | 45.5300 | -16,592 | -755 | 34,859 | ||||
| 2016-03-03 | 2016-03-01 | 4 | GUYER DAVID R | OPHT | Common Stock | D | 44.6100 | -3,000 | -134 | 51,451 | ||||
| 2016-03-03 | 2016-03-01 | 4 | GUYER DAVID R | OPHT | Common Stock | D | 10.0300 | 22,060 | 221 | 54,451 | ||||
| 2016-03-02 | 2016-02-29 | 4 | PATEL SAMIR CHANDRAKANT | OPHT | Stock Option (Right To Buy) | D | 13.22 | -3,262 | 17,768 | |||||
| 2016-03-02 | 2016-02-29 | 4 | PATEL SAMIR CHANDRAKANT | OPHT | Stock Option (Right To Buy) | D | 1.65 | -2,825 | 2,825 | |||||
| 2016-03-02 | 2016-02-29 | 4 | PATEL SAMIR CHANDRAKANT | OPHT | Common Stock | D | 45.9200 | -1,935 | -89 | 246,998 | ||||
| 2016-03-02 | 2016-02-29 | 4 | PATEL SAMIR CHANDRAKANT | OPHT | Common Stock | D | 45.0400 | -18,065 | -814 | 248,933 | ||||
| 2016-03-02 | 2016-02-29 | 4 | PATEL SAMIR CHANDRAKANT | OPHT | Common Stock | D | 13.2160 | 3,262 | 43 | 266,998 | ||||
| 2016-03-02 | 2016-02-29 | 4 | PATEL SAMIR CHANDRAKANT | OPHT | Common Stock | D | 1.6520 | 2,825 | 5 | 263,736 | ||||
| 2016-02-02 | 2016-01-29 | 4 | PATEL SAMIR CHANDRAKANT | OPHT | Common Stock | D | 54.6900 | -100 | -5 | 260,911 | ||||
| 2016-02-02 | 2016-01-29 | 4 | PATEL SAMIR CHANDRAKANT | OPHT | Common Stock | D | 53.9200 | -8,482 | -457 | 261,011 | ||||
| 2016-02-02 | 2016-01-29 | 4 | PATEL SAMIR CHANDRAKANT | OPHT | Common Stock | D | 53.3300 | -11,418 | -609 | 269,493 | ||||
| 2016-02-01 | 2016-01-28 | 4 | GUYER DAVID R | OPHT | Stock Options (Right to Buy) | D | 10.03 | -18,598 | 168,904 | |||||
| 2016-02-01 | 2016-01-28 | 4 | GUYER DAVID R | OPHT | Common Stock | D | 56.2900 | -600 | -34 | 32,391 | ||||
| 2016-02-01 | 2016-01-28 | 4 | GUYER DAVID R | OPHT | Common Stock | D | 55.0300 | -600 | -33 | 32,991 | ||||
| 2016-02-01 | 2016-01-28 | 4 | GUYER DAVID R | OPHT | Common Stock | D | 54.1000 | -3,200 | -173 | 33,591 | ||||
| 2016-02-01 | 2016-01-28 | 4 | GUYER DAVID R | OPHT | Common Stock | D | 53.3500 | -14,198 | -757 | 36,791 | ||||
| 2016-02-01 | 2016-01-28 | 4 | GUYER DAVID R | OPHT | Common Stock | D | 10.0300 | 18,598 | 187 | 50,989 | ||||
| 2016-01-13 | 2016-01-11 | 4 | GALAKATOS NICHOLAS | OPHT | Common Stock | I | 65.3300 | -499 | -33 | 3,945 | ||||
| 2016-01-13 | 2016-01-11 | 4 | GALAKATOS NICHOLAS | OPHT | Common Stock | I | 65.4500 | -501 | -33 | 4,444 | ||||
| 2016-01-13 | 2016-01-11 | 4 | GALAKATOS NICHOLAS | OPHT | Common Stock | D | 66.3300 | -1,001 | -66 | 5,684 | ||||
| 2016-01-13 | 2016-01-11 | 4 | GALAKATOS NICHOLAS | OPHT | Common Stock | D | 65.4500 | -999 | -65 | 6,685 | ||||
| 2016-01-06 | 2016-01-04 | 4 | Redlick David E | OPHT | Stock Option (Right to Buy) | D | 73.22 | 20,000 | 20,000 | |||||
| 2016-01-06 | 2016-01-04 | 4 | Bjarke Henric Bjorn | OPHT | Restricted Stock Units | D | 2,800 | 2,800 | ||||||
| 2016-01-06 | 2016-01-04 | 4 | Bjarke Henric Bjorn | OPHT | Stock Option (Right To Buy) | D | 73.22 | 11,300 | 11,300 | |||||
| 2016-01-06 | 2016-01-04 | 4 | PATEL SAMIR CHANDRAKANT | OPHT | Restricted Stock Units | D | 5,300 | 5,300 | ||||||
| 2016-01-06 | 2016-01-04 | 4 | PATEL SAMIR CHANDRAKANT | OPHT | Stock Option (Right to Buy) | D | 73.22 | 16,300 | 16,300 | |||||
| 2016-01-06 | 2016-01-04 | 4 | PATEL SAMIR CHANDRAKANT | OPHT | Restricted Stock Units | D | 19,700 | 19,700 | ||||||
| 2016-01-06 | 2016-01-04 | 4 | PATEL SAMIR CHANDRAKANT | OPHT | Stock Option (Right to Buy) | D | 73.22 | 78,700 | 78,700 | |||||
| 2016-01-06 | 2016-01-04 | 4 | GUYER DAVID R | OPHT | Restricted Stock Units | D | 25,000 | 25,000 | ||||||
| 2016-01-06 | 2016-01-04 | 4 | GUYER DAVID R | OPHT | Stock Option (Right to Buy) | D | 73.22 | 95,000 | 95,000 | |||||
| 2016-01-06 | 2016-01-04 | 4 | WOOD BARBARA A | OPHT | Restricted Stock Units | D | 4,800 | 4,800 | ||||||
| 2016-01-06 | 2016-01-04 | 4 | WOOD BARBARA A | OPHT | Stock Option (Right to Buy) | D | 73.22 | 19,200 | 19,200 | |||||
| 2016-01-06 | 2016-01-04 | 4 | WOOD BARBARA A | OPHT | Stock Option (Right to Buy) | D | 24.49 | -1,000 | 59,000 | |||||
| 2016-01-06 | 2016-01-04 | 4 | WOOD BARBARA A | OPHT | Common Stock | D | 76.3700 | -1,000 | -76 | 746 | ||||
| 2016-01-06 | 2016-01-04 | 4 | WOOD BARBARA A | OPHT | Common Stock | D | 24.4900 | 1,000 | 24 | 1,746 | ||||
| 2016-01-05 | 2016-01-04 | 4 | PATEL SAMIR CHANDRAKANT | OPHT | Common Stock | D | 74.9600 | -85 | -6 | 280,911 | ||||
| 2016-01-05 | 2016-01-04 | 4 | PATEL SAMIR CHANDRAKANT | OPHT | Common Stock | D | 74.0500 | -454 | -34 | 280,996 | ||||
| 2016-01-05 | 2016-01-04 | 4 | PATEL SAMIR CHANDRAKANT | OPHT | Common Stock | D | 72.9300 | -881 | -64 | 281,450 | ||||
| 2016-01-05 | 2016-01-04 | 4 | PATEL SAMIR CHANDRAKANT | OPHT | Common Stock | D | 71.9300 | -472 | -34 | 282,331 | ||||
| 2016-01-05 | 2016-01-04 | 4 | PATEL SAMIR CHANDRAKANT | OPHT | Common Stock | D | 71.1500 | -677 | -48 | 282,803 | ||||
| 2016-01-05 | 2016-01-02 | 4 | PATEL SAMIR CHANDRAKANT | OPHT | Restricted Stock Units | D | -4,875 | 14,625 | ||||||
| 2016-01-05 | 2016-01-02 | 4 | PATEL SAMIR CHANDRAKANT | OPHT | Common Stock | D | 4,875 | 283,480 | ||||||
| 2016-01-05 | 2016-01-04 | 4 | GUYER DAVID R | OPHT | Common Stock | D | 74.9600 | -108 | -8 | 32,391 | ||||
| 2016-01-05 | 2016-01-04 | 4 | GUYER DAVID R | OPHT | Common Stock | D | 74.0500 | -578 | -43 | 32,499 | ||||
| 2016-01-05 | 2016-01-04 | 4 | GUYER DAVID R | OPHT | Common Stock | D | 72.9300 | -1,121 | -82 | 33,077 | ||||
| 2016-01-05 | 2016-01-04 | 4 | GUYER DAVID R | OPHT | Common Stock | D | 71.9300 | -600 | -43 | 34,198 | ||||
| 2016-01-05 | 2016-01-04 | 4 | GUYER DAVID R | OPHT | Common Stock | D | 71.1500 | -862 | -61 | 34,798 | ||||
| 2016-01-05 | 2016-01-02 | 4 | GUYER DAVID R | OPHT | Restricted Stock Units | D | -5,750 | 17,250 | ||||||
| 2016-01-05 | 2016-01-02 | 4 | GUYER DAVID R | OPHT | Common Stock | D | 5,750 | 35,660 | ||||||
| 2016-01-05 | 2016-01-04 | 4 | WOOD BARBARA A | OPHT | Common Stock | D | 74.9600 | -21 | -2 | 746 | ||||
| 2016-01-05 | 2016-01-04 | 4 | WOOD BARBARA A | OPHT | Common Stock | D | 74.0500 | -111 | -8 | 767 | ||||
| 2016-01-05 | 2016-01-04 | 4 | WOOD BARBARA A | OPHT | Common Stock | D | 72.9300 | -216 | -16 | 878 | ||||
| 2016-01-05 | 2016-01-04 | 4 | WOOD BARBARA A | OPHT | Common Stock | D | 71.9300 | -115 | -8 | 1,094 | ||||
| 2016-01-05 | 2016-01-04 | 4 | WOOD BARBARA A | OPHT | Common Stock | D | 71.1500 | -166 | -12 | 1,209 | ||||
| 2016-01-05 | 2016-01-02 | 4 | WOOD BARBARA A | OPHT | Restricted Stock Units | D | -1,375 | 4,125 | ||||||
| 2016-01-05 | 2016-01-02 | 4 | WOOD BARBARA A | OPHT | Common Stock | D | 1,375 | 1,375 | ||||||
| 2016-01-05 | 2016-01-04 | 4 | ATIEH MICHAEL G | OPHT | Common Stock | D | 74.9600 | -4 | -0 | 295 | ||||
| 2016-01-05 | 2016-01-04 | 4 | ATIEH MICHAEL G | OPHT | Common Stock | D | 74.0500 | -23 | -2 | 299 | ||||
| 2016-01-05 | 2016-01-04 | 4 | ATIEH MICHAEL G | OPHT | Common Stock | D | 72.9300 | -45 | -3 | 322 | ||||
| 2016-01-05 | 2016-01-04 | 4 | ATIEH MICHAEL G | OPHT | Common Stock | D | 71.9300 | -24 | -2 | 367 | ||||
| 2016-01-05 | 2016-01-04 | 4 | ATIEH MICHAEL G | OPHT | Common Stock | D | 71.1500 | -34 | -2 | 391 | ||||
| 2016-01-05 | 2016-01-02 | 4 | ATIEH MICHAEL G | OPHT | Restricted Stock Units | D | -425 | 1,275 | ||||||
| 2016-01-05 | 2016-01-02 | 4 | ATIEH MICHAEL G | OPHT | Common Stock | D | 425 | 425 | ||||||
| 2016-01-04 | 2015-12-30 | 4 | SBLENDORIO GLENN | OPHT | Stock Option (right to buy) | D | 13.22 | -2,000 | 11,084 | |||||
| 2016-01-04 | 2015-12-30 | 4 | SBLENDORIO GLENN | OPHT | Common Stock | D | 80.0000 | -2,000 | -160 | 0 | ||||
| 2016-01-04 | 2015-12-30 | 4 | SBLENDORIO GLENN | OPHT | Common Stock | D | 13.2160 | 2,000 | 26 | 2,000 | ||||
| 2016-01-04 | 2015-12-30 | 4 | GUYER DAVID R | OPHT | Stock Option (Right To Buy) | D | 10.03 | -18,582 | 187,502 | |||||
| 2016-01-04 | 2015-12-30 | 4 | GUYER DAVID R | OPHT | Common Stock | D | 79.3100 | -6,951 | -551 | 29,910 | ||||
| 2016-01-04 | 2015-12-30 | 4 | GUYER DAVID R | OPHT | Common Stock | D | 78.5300 | -11,631 | -913 | 36,861 | ||||
| 2016-01-04 | 2015-12-30 | 4 | GUYER DAVID R | OPHT | Common Stock | D | 10.0300 | 18,582 | 186 | 48,492 | ||||
| 2015-12-31 | 2015-12-29 | 4 | PATEL SAMIR CHANDRAKANT | OPHT | Stock Option (Right To Buy) | D | 13.22 | -1,184 | 21,030 | |||||
| 2015-12-31 | 2015-12-29 | 4 | PATEL SAMIR CHANDRAKANT | OPHT | Common Stock | D | 77.9500 | -624 | -49 | 278,605 | ||||
| 2015-12-31 | 2015-12-29 | 4 | PATEL SAMIR CHANDRAKANT | OPHT | Common Stock | D | 77.0000 | -560 | -43 | 279,229 | ||||
| 2015-12-31 | 2015-12-29 | 4 | PATEL SAMIR CHANDRAKANT | OPHT | Common Stock | D | 13.2160 | 1,184 | 16 | 279,789 | ||||
| 2015-12-28 | 2015-12-24 | 4 | PATEL SAMIR CHANDRAKANT | OPHT | Stock Option (Right To Buy) | D | 31.29 | -14,583 | 72,917 | |||||
| 2015-12-28 | 2015-12-24 | 4 | PATEL SAMIR CHANDRAKANT | OPHT | Stock Option (Right To Buy) | D | 13.22 | -5,923 | 22,214 | |||||
| 2015-12-28 | 2015-12-24 | 4 | PATEL SAMIR CHANDRAKANT | OPHT | Stock Option (Right To Buy) | D | 1.65 | -5,530 | 5,650 | |||||
| 2015-12-28 | 2015-12-24 | 4 | PATEL SAMIR CHANDRAKANT | OPHT | Common Stock | D | 79.0200 | -200 | -16 | 278,605 | ||||
| 2015-12-28 | 2015-12-24 | 4 | PATEL SAMIR CHANDRAKANT | OPHT | Common Stock | D | 78.2000 | -2,100 | -164 | 278,805 | ||||
| 2015-12-28 | 2015-12-24 | 4 | PATEL SAMIR CHANDRAKANT | OPHT | Common Stock | D | 77.3200 | -14,636 | -1,132 | 280,905 | ||||
| 2015-12-28 | 2015-12-24 | 4 | PATEL SAMIR CHANDRAKANT | OPHT | Common Stock | D | 76.4200 | -9,100 | -695 | 295,541 | ||||
| 2015-12-28 | 2015-12-24 | 4 | PATEL SAMIR CHANDRAKANT | OPHT | Common Stock | D | 31.2900 | 14,583 | 456 | 304,641 | ||||
| 2015-12-28 | 2015-12-24 | 4 | PATEL SAMIR CHANDRAKANT | OPHT | Common Stock | D | 13.2160 | 5,923 | 78 | 290,058 | ||||
| 2015-12-28 | 2015-12-24 | 4 | PATEL SAMIR CHANDRAKANT | OPHT | Common Stock | D | 1.6520 | 5,530 | 9 | 284,135 | ||||
| 2015-12-14 | 2015-12-10 | 4 | GALAKATOS NICHOLAS | OPHT | Common Stock | I | 64.6300 | -733 | -47 | 4,945 | ||||
| 2015-12-14 | 2015-12-10 | 4 | GALAKATOS NICHOLAS | OPHT | Common Stock | I | 63.9100 | -267 | -17 | 5,678 | ||||
| 2015-12-14 | 2015-12-10 | 4 | GALAKATOS NICHOLAS | OPHT | Common Stock | D | 64.6300 | -1,467 | -95 | 7,684 | ||||
| 2015-12-14 | 2015-12-10 | 4 | GALAKATOS NICHOLAS | OPHT | Common Stock | D | 63.9000 | -533 | -34 | 9,151 | ||||
| 2015-12-03 | 2015-12-01 | 4 | WOOD BARBARA A | OPHT | Stock Option (Right to Buy) | D | 24.49 | -2,000 | 60,000 | |||||
| 2015-12-03 | 2015-12-01 | 4 | WOOD BARBARA A | OPHT | Common Stock | D | 63.8300 | -100 | -6 | 0 | ||||
| 2015-12-03 | 2015-12-01 | 4 | WOOD BARBARA A | OPHT | Common Stock | D | 63.2100 | -1,900 | -120 | 100 | ||||
| 2015-12-03 | 2015-12-01 | 4 | WOOD BARBARA A | OPHT | Common Stock | D | 24.4900 | 2,000 | 49 | 2,000 | ||||
| 2015-12-02 | 2015-11-30 | 4 | GUYER DAVID R | OPHT | Stock Option (Right To Buy) | D | 10.03 | 18,582 | 206,084 | |||||
| 2015-12-02 | 2015-11-30 | 4 | GUYER DAVID R | OPHT | Common Stock | D | 63.8000 | -2,027 | -129 | 29,910 | ||||
| 2015-12-02 | 2015-11-30 | 4 | GUYER DAVID R | OPHT | Common Stock | D | 63.2300 | -5,049 | -319 | 31,937 | ||||
| 2015-12-02 | 2015-11-30 | 4 | GUYER DAVID R | OPHT | Common Stock | D | 62.1500 | -9,135 | -568 | 36,986 | ||||
| 2015-12-02 | 2015-11-30 | 4 | GUYER DAVID R | OPHT | Common Stock | D | 61.0800 | -2,371 | -145 | 46,121 | ||||
| 2015-12-02 | 2015-11-30 | 4 | GUYER DAVID R | OPHT | Common Stock | D | 10.0300 | 18,582 | 186 | 48,492 | ||||
| 2015-11-25 | 2015-11-24 | 4 | PATEL SAMIR CHANDRAKANT | OPHT | Stock Option (Right To Buy) | D | 31.29 | -25,683 | 87,500 | |||||
| 2015-11-25 | 2015-11-24 | 4 | PATEL SAMIR CHANDRAKANT | OPHT | Stock Option (Right To Buy) | D | 1.65 | -1,532 | 11,180 | |||||
| 2015-11-25 | 2015-11-24 | 4 | PATEL SAMIR CHANDRAKANT | OPHT | Common Stock | D | 60.6000 | -7,844 | -475 | 278,605 | ||||
| 2015-11-25 | 2015-11-24 | 4 | PATEL SAMIR CHANDRAKANT | OPHT | Common Stock | D | 60.1400 | -19,371 | -1,165 | 286,449 | ||||
| 2015-11-25 | 2015-11-24 | 4 | PATEL SAMIR CHANDRAKANT | OPHT | Common Stock | D | 31.2900 | 25,683 | 804 | 305,820 | ||||
| 2015-11-25 | 2015-11-24 | 4 | PATEL SAMIR CHANDRAKANT | OPHT | Common Stock | D | 1.6520 | 1,532 | 3 | 280,137 | ||||
| 2015-11-19 | 2015-11-18 | 4 | GALAKATOS NICHOLAS | OPHT | Common Stock | I | 60.0000 | -500 | -30 | 5,945 | ||||
| 2015-11-19 | 2015-11-18 | 4 | GALAKATOS NICHOLAS | OPHT | Common Stock | D | 60.0000 | -1,000 | -60 | 9,684 | ||||
| 2015-11-12 | 2015-11-10 | 4 | GALAKATOS NICHOLAS | OPHT | Common Stock | I | 58.6900 | -500 | -29 | 6,445 | ||||
| 2015-11-12 | 2015-11-10 | 4 | GALAKATOS NICHOLAS | OPHT | Common Stock | D | 58.6900 | -1,000 | -59 | 10,684 | ||||
| 2015-11-12 | 2015-11-09 | 4 | GALAKATOS NICHOLAS | OPHT | Common Stock | I | 60.0000 | -500 | -30 | 6,945 | ||||
| 2015-11-12 | 2015-11-09 | 4 | GALAKATOS NICHOLAS | OPHT | Common Stock | D | 60.0000 | -1,000 | -60 | 11,684 | ||||
| 2015-11-06 | 2015-11-05 | 4 | PATEL SAMIR CHANDRAKANT | OPHT | Common Stock | D | 54.8000 | -3,665 | -201 | 278,605 | ||||
| 2015-11-06 | 2015-11-05 | 4 | PATEL SAMIR CHANDRAKANT | OPHT | Common Stock | D | 53.9500 | -4,200 | -227 | 282,270 | ||||
| 2015-11-06 | 2015-11-05 | 4 | PATEL SAMIR CHANDRAKANT | OPHT | Common Stock | D | 53.0600 | -12,822 | -680 | 286,470 | ||||
| 2015-11-06 | 2015-11-04 | 4 | PATEL SAMIR CHANDRAKANT | OPHT | Common Stock | D | 40,000 | 299,292 | ||||||
| 2015-11-04 | 2015-11-02 | 4 | GALAKATOS NICHOLAS | OPHT | Common Stock | I | 54.0000 | -500 | -27 | 7,445 | ||||
| 2015-11-04 | 2015-11-02 | 4 | GALAKATOS NICHOLAS | OPHT | Common Stock | D | 54.0000 | -1,000 | -54 | 13,184 | ||||
| 2015-11-03 | 2015-10-30 | 4 | GUYER DAVID R | OPHT | Stock Option (Right To Buy) | D | 10.03 | 18,582 | 224,666 | |||||
| 2015-11-03 | 2015-10-30 | 4 | GUYER DAVID R | OPHT | Common Stock | D | 50.2700 | -100 | -5 | 29,910 | ||||
| 2015-11-03 | 2015-10-30 | 4 | GUYER DAVID R | OPHT | Common Stock | D | 49.8800 | -18,482 | -922 | 30,010 | ||||
| 2015-11-03 | 2015-10-30 | 4 | GUYER DAVID R | OPHT | Common Stock | D | 10.0300 | 18,582 | 186 | 48,492 | ||||
| 2015-10-23 | 2015-10-21 | 4 | PATEL SAMIR CHANDRAKANT | OPHT | Stock Option (Right To Buy) | D | 13.22 | -398 | 28,137 | |||||
| 2015-10-23 | 2015-10-21 | 4 | PATEL SAMIR CHANDRAKANT | OPHT | Stock Option (Right To Buy) | D | 31.29 | -26,817 | 113,183 | |||||
| 2015-10-23 | 2015-10-21 | 4 | PATEL SAMIR CHANDRAKANT | OPHT | Common Stock | D | 45.1900 | -100 | -5 | 259,292 | ||||
| 2015-10-23 | 2015-10-21 | 4 | PATEL SAMIR CHANDRAKANT | OPHT | Common Stock | D | 44.4400 | -5,259 | -234 | 259,392 | ||||
| 2015-10-23 | 2015-10-21 | 4 | PATEL SAMIR CHANDRAKANT | OPHT | Common Stock | D | 43.2700 | -13,556 | -587 | 264,651 | ||||
| 2015-10-23 | 2015-10-21 | 4 | PATEL SAMIR CHANDRAKANT | OPHT | Common Stock | D | 42.5200 | -8,300 | -353 | 278,207 | ||||
| 2015-10-23 | 2015-10-21 | 4 | PATEL SAMIR CHANDRAKANT | OPHT | Common Stock | D | 13.2160 | 398 | 5 | 286,507 | ||||
| 2015-10-23 | 2015-10-21 | 4 | PATEL SAMIR CHANDRAKANT | OPHT | Common Stock | D | 31.2900 | 26,817 | 839 | 286,109 | ||||
| 2015-10-19 | 2015-10-16 | 4 | WOOD BARBARA A | OPHT | Stock Option (Right to Buy) | D | 24.49 | -2,000 | 62,000 | |||||
| 2015-10-19 | 2015-10-16 | 4 | WOOD BARBARA A | OPHT | Common Stock | D | 45.0000 | -2,000 | -90 | 0 | ||||
| 2015-10-19 | 2015-10-16 | 4 | WOOD BARBARA A | OPHT | Common Stock | D | 24.4900 | 2,000 | 49 | 2,000 | ||||
| 2015-09-30 | 2015-09-29 | 4 | GUYER DAVID R | OPHT | Stock Option (Right To Buy) | D | 10.03 | 18,582 | 243,248 | |||||
| 2015-09-30 | 2015-09-29 | 4 | GUYER DAVID R | OPHT | Common Stock | D | 39.1100 | -2,534 | -99 | 29,910 | ||||
| 2015-09-30 | 2015-09-29 | 4 | GUYER DAVID R | OPHT | Common Stock | D | 38.5700 | -6,180 | -238 | 32,444 | ||||
| 2015-09-30 | 2015-09-29 | 4 | GUYER DAVID R | OPHT | Common Stock | D | 37.4000 | -3,953 | -148 | 38,624 | ||||
| 2015-09-30 | 2015-09-29 | 4 | GUYER DAVID R | OPHT | Common Stock | D | 36.3700 | -5,915 | -215 | 42,577 | ||||
| 2015-09-30 | 2015-09-29 | 4 | GUYER DAVID R | OPHT | Common Stock | D | 10.0300 | 18,582 | 186 | 48,492 | ||||
| 2015-09-23 | 2015-09-21 | 4 | PATEL SAMIR CHANDRAKANT | OPHT | Stock Option (Right To Buy) | D | 13.22 | -13,991 | 42,867 | |||||
| 2015-09-23 | 2015-09-21 | 4 | PATEL SAMIR CHANDRAKANT | OPHT | Stock Option (Right To Buy) | D | 1.65 | -13,224 | 0 | |||||
| 2015-09-23 | 2015-09-21 | 4 | PATEL SAMIR CHANDRAKANT | OPHT | Common Stock | D | 49.2400 | -500 | -25 | 259,292 | ||||
| 2015-09-23 | 2015-09-21 | 4 | PATEL SAMIR CHANDRAKANT | OPHT | Common Stock | D | 47.4500 | -10,814 | -513 | 259,792 | ||||
| 2015-09-23 | 2015-09-21 | 4 | PATEL SAMIR CHANDRAKANT | OPHT | Common Stock | D | 46.1400 | -4,300 | -198 | 270,606 | ||||
| 2015-09-23 | 2015-09-21 | 4 | PATEL SAMIR CHANDRAKANT | OPHT | Common Stock | D | 45.2600 | -11,601 | -525 | 274,906 | ||||
| 2015-09-23 | 2015-09-21 | 4 | PATEL SAMIR CHANDRAKANT | OPHT | Common Stock | D | 13.2160 | 13,991 | 185 | 286,507 | ||||
| 2015-09-23 | 2015-09-21 | 4 | PATEL SAMIR CHANDRAKANT | OPHT | Common Stock | D | 1.6520 | 13,224 | 22 | 272,516 | ||||
| 2015-09-02 | 3 | Bjarke Henric Bjorn By wife | OPHT | Common Stock | I | 1,600 | ||||||||
| 2015-09-02 | 3 | Bjarke Henric Bjorn | OPHT | Common Stock | D | 2,300 | ||||||||
| 2015-09-02 | 3 | Bjarke Henric Bjorn | OPHT | Common Stock | D | 2,300 | ||||||||
| 2015-09-02 | 3 | Bjarke Henric Bjorn By wife | OPHT | Common Stock | I | 1,600 | ||||||||
| 2015-09-02 | 2015-08-31 | 4 | Bjarke Henric Bjorn | OPHT | Stock Option (Right To Buy) | D | 44.03 | 120,000 | 120,000 | |||||
| 2015-09-02 | 2015-08-31 | 4 | GUYER DAVID R | OPHT | Stock Option (Right To Buy) | D | 10.03 | 18,582 | 261,830 | |||||
| 2015-09-02 | 2015-08-31 | 4 | GUYER DAVID R | OPHT | Common Stock | D | 45.3000 | -8,498 | -385 | 29,910 | ||||
| 2015-09-02 | 2015-08-31 | 4 | GUYER DAVID R | OPHT | Common Stock | D | 44.5350 | -10,084 | -449 | 38,408 | ||||
| 2015-09-02 | 2015-08-31 | 4 | GUYER DAVID R | OPHT | Common Stock | D | 10.0300 | 18,582 | 186 | 48,492 | ||||
| 2015-08-24 | 2015-08-20 | 4 | PATEL SAMIR CHANDRAKANT | OPHT | Stock Option (Right To Buy) | D | 1.65 | -1,820 | 13,224 | |||||
| 2015-08-24 | 2015-08-20 | 4 | PATEL SAMIR CHANDRAKANT | OPHT | Stock Option (Right To Buy) | D | 1.65 | -25,395 | 12,712 | |||||
| 2015-08-24 | 2015-08-20 | 4 | PATEL SAMIR CHANDRAKANT | OPHT | Common Stock | D | 49.6300 | -7,942 | -394 | 259,292 | ||||
| 2015-08-24 | 2015-08-20 | 4 | PATEL SAMIR CHANDRAKANT | OPHT | Common Stock | D | 48.9600 | -9,643 | -472 | 267,234 | ||||
| 2015-08-24 | 2015-08-20 | 4 | PATEL SAMIR CHANDRAKANT | OPHT | Common Stock | D | 47.8000 | -9,630 | -460 | 276,877 | ||||
| 2015-08-24 | 2015-08-20 | 4 | PATEL SAMIR CHANDRAKANT | OPHT | Common Stock | D | 1.6520 | 1,820 | 3 | 286,507 | ||||
| 2015-08-24 | 2015-08-20 | 4 | PATEL SAMIR CHANDRAKANT | OPHT | Common Stock | D | 1.6520 | 25,395 | 42 | 284,687 | ||||
| 2015-08-11 | 2015-08-07 | 4 | GUYER DAVID R | OPHT | Stock Option (Right To Buy) | D | 10.03 | -29,910 | 280,412 | |||||
| 2015-08-11 | 2015-08-07 | 4 | GUYER DAVID R | OPHT | Common Stock | D | 10.0300 | 29,910 | 300 | 29,910 | ||||
| 2015-08-03 | 2015-07-30 | 4 | GUYER DAVID R | OPHT | Stock Option (Right To Buy) | D | 10.03 | -18,582 | 310,322 | |||||
| 2015-08-03 | 2015-07-30 | 4 | GUYER DAVID R | OPHT | Common Stock | D | 67.1500 | -1,794 | -120 | 0 | ||||
| 2015-08-03 | 2015-07-30 | 4 | GUYER DAVID R | OPHT | Common Stock | D | 66.4400 | -11,488 | -763 | 1,794 | ||||
| 2015-08-03 | 2015-07-30 | 4 | GUYER DAVID R | OPHT | Common Stock | D | 65.7900 | -5,300 | -349 | 13,282 | ||||
| 2015-08-03 | 2015-07-30 | 4 | GUYER DAVID R | OPHT | Common Stock | D | 10.0300 | 18,582 | 186 | 18,582 | ||||
| 2015-07-22 | 2015-07-20 | 4 | PATEL SAMIR CHANDRAKANT | OPHT | Stock Option (Right To Buy) | D | 1.65 | -27,215 | 38,107 | |||||
| 2015-07-22 | 2015-07-20 | 4 | PATEL SAMIR CHANDRAKANT | OPHT | Common Stock | D | 70.1900 | -300 | -21 | 259,292 | ||||
| 2015-07-22 | 2015-07-20 | 4 | PATEL SAMIR CHANDRAKANT | OPHT | Common Stock | D | 68.8000 | -4,954 | -341 | 259,592 | ||||
| 2015-07-22 | 2015-07-20 | 4 | PATEL SAMIR CHANDRAKANT | OPHT | Common Stock | D | 67.9500 | -11,663 | -793 | 264,546 | ||||
| 2015-07-22 | 2015-07-20 | 4 | PATEL SAMIR CHANDRAKANT | OPHT | Common Stock | D | 67.2600 | -10,298 | -693 | 276,209 | ||||
| 2015-07-22 | 2015-07-20 | 4 | PATEL SAMIR CHANDRAKANT | OPHT | Common Stock | D | 1.6520 | 27,215 | 45 | 286,507 | ||||
| 2015-07-20 | 2015-07-17 | 4 | SBLENDORIO GLENN | OPHT | Stock Option (right to buy) | D | 13.22 | -2,000 | 13,084 | |||||
| 2015-07-20 | 2015-07-17 | 4 | SBLENDORIO GLENN | OPHT | Common Stock | D | 70.0000 | -2,000 | -140 | 0 | ||||
| 2015-07-20 | 2015-07-17 | 4 | SBLENDORIO GLENN | OPHT | Common Stock | D | 13.2160 | 2,000 | 26 | 2,000 | ||||
| 2015-07-20 | 2015-07-16 | 4 | SBLENDORIO GLENN | OPHT | Common Stock | D | 62.0000 | -1,000 | -62 | 0 | ||||
| 2015-07-20 | 2013-09-30 | 4 | SBLENDORIO GLENN | OPHT | Common Stock | D | 22.0000 | 1,000 | 22 | 1,000 | ||||
| 2015-07-02 | 2015-07-01 | 4 | WOOD BARBARA A | OPHT | Stock Option (Right to Buy) | D | 24.49 | -2,000 | 64,000 | |||||
| 2015-07-02 | 2015-07-01 | 4 | WOOD BARBARA A | OPHT | Common Stock | D | 51.9400 | -2,000 | -104 | 0 | ||||
| 2015-07-02 | 2015-07-01 | 4 | WOOD BARBARA A | OPHT | Common Stock | D | 24.4900 | 2,000 | 49 | 2,000 | ||||
| 2015-07-01 | 2015-06-29 | 4 | GUYER DAVID R | OPHT | Stock Option (Right To Buy) | D | 10.03 | -18,582 | 328,904 | |||||
| 2015-07-01 | 2015-06-29 | 4 | GUYER DAVID R | OPHT | Common Stock | D | 51.5100 | -8,001 | -412 | 0 | ||||
| 2015-07-01 | 2015-06-29 | 4 | GUYER DAVID R | OPHT | Common Stock | D | 50.7100 | -10,581 | -537 | 8,001 | ||||
| 2015-07-01 | 2015-06-29 | 4 | GUYER DAVID R | OPHT | Common Stock | D | 10.0300 | 18,582 | 186 | 18,582 | ||||
| 2015-06-29 | 2015-06-12 | 4 | GALAKATOS NICHOLAS | OPHT | Common Stock | D | -1,020 | 14,184 | ||||||
| 2015-06-23 | 2015-06-19 | 4/A | PATEL SAMIR CHANDRAKANT | OPHT | Stock Option (Right To Buy) | D | 13.22 | -14,331 | 14,382 | |||||
| 2015-06-23 | 2015-06-19 | 4/A | PATEL SAMIR CHANDRAKANT | OPHT | Stock Option (Right To Buy) | D | 1.65 | -3 | 0 | |||||
| 2015-06-23 | 2015-06-19 | 4/A | PATEL SAMIR CHANDRAKANT | OPHT | Stock Option (Right To Buy) | D | 1.65 | -42,583 | 0 | |||||
| 2015-06-23 | 2015-06-19 | 4/A | PATEL SAMIR CHANDRAKANT | OPHT | Stock Option (Right To Buy) | D | 1.59 | -37,377 | 0 | |||||
| 2015-06-23 | 2015-06-19 | 4/A | PATEL SAMIR CHANDRAKANT | OPHT | Stock Option (Right To Buy) | D | 1.59 | -7,937 | 0 | |||||
| 2015-06-23 | 2015-06-19 | 4/A | PATEL SAMIR CHANDRAKANT | OPHT | Stock Option (Right To Buy) | D | 1.59 | -68,157 | 0 | |||||
| 2015-06-23 | 2015-06-19 | 4/A | PATEL SAMIR CHANDRAKANT | OPHT | Stock Option (Right To Buy) | D | 1.59 | -88,904 | 0 | |||||
| 2015-06-23 | 2015-06-19 | 4/A | PATEL SAMIR CHANDRAKANT | OPHT | Common Stock | D | 13.2200 | 14,331 | 189 | 259,292 | ||||
| 2015-06-23 | 2015-06-19 | 4/A | PATEL SAMIR CHANDRAKANT | OPHT | Common Stock | D | 1.6500 | 3 | 0 | 244,961 | ||||
| 2015-06-23 | 2015-06-19 | 4/A | PATEL SAMIR CHANDRAKANT | OPHT | Common Stock | D | 1.6500 | 42,583 | 70 | 244,958 | ||||
| 2015-06-23 | 2015-06-19 | 4/A | PATEL SAMIR CHANDRAKANT | OPHT | Common Stock | D | 1.5900 | 37,377 | 59 | 202,375 | ||||
| 2015-06-23 | 2015-06-19 | 4/A | PATEL SAMIR CHANDRAKANT | OPHT | Common Stock | D | 1.5900 | 7,937 | 13 | 164,998 | ||||
| 2015-06-23 | 2015-06-19 | 4/A | PATEL SAMIR CHANDRAKANT | OPHT | Common Stock | D | 1.5900 | 68,157 | 108 | 157,061 | ||||
| 2015-06-23 | 2015-06-19 | 4/A | PATEL SAMIR CHANDRAKANT | OPHT | Common Stock | D | 1.5900 | 88,904 | 141 | 88,904 | ||||
| 2015-06-22 | 2015-06-18 | 4 | PATEL SAMIR CHANDRAKANT | OPHT | Stock Option (Right To Buy) | D | 1.65 | -2,471 | 65,322 | |||||
| 2015-06-22 | 2015-06-18 | 4 | PATEL SAMIR CHANDRAKANT | OPHT | Stock Option (Right To Buy) | D | 1.59 | -9,529 | 0 | |||||
| 2015-06-22 | 2015-06-18 | 4 | PATEL SAMIR CHANDRAKANT | OPHT | Common Stock | D | 50.1400 | -3,900 | -196 | 0 | ||||
| 2015-06-22 | 2015-06-18 | 4 | PATEL SAMIR CHANDRAKANT | OPHT | Common Stock | D | 49.6000 | -8,100 | -402 | 3,900 | ||||
| 2015-06-22 | 2015-06-18 | 4 | PATEL SAMIR CHANDRAKANT | OPHT | Common Stock | D | 1.6520 | 2,471 | 4 | 2,471 | ||||
| 2015-06-22 | 2015-06-18 | 4 | PATEL SAMIR CHANDRAKANT | OPHT | Common Stock | D | 1.5930 | 9,529 | 15 | 9,529 | ||||
| 2015-06-22 | 2015-06-19 | 4 | PATEL SAMIR CHANDRAKANT | OPHT | Stock Option (Right To Buy) | D | 13.22 | -14,331 | 14,382 | |||||
| 2015-06-22 | 2015-06-19 | 4 | PATEL SAMIR CHANDRAKANT | OPHT | Stock Option (Right To Buy) | D | 1.65 | -3 | 0 | |||||
| 2015-06-22 | 2015-06-19 | 4 | PATEL SAMIR CHANDRAKANT | OPHT | Stock Option (Right To Buy) | D | 1.65 | -42,583 | 0 | |||||
| 2015-06-22 | 2015-06-19 | 4 | PATEL SAMIR CHANDRAKANT | OPHT | Stock Option (Right To Buy) | D | 1.59 | -37,377 | 0 | |||||
| 2015-06-22 | 2015-06-19 | 4 | PATEL SAMIR CHANDRAKANT | OPHT | Stock Option (Right To Buy) | D | 1.59 | -7,937 | 0 | |||||
| 2015-06-22 | 2015-06-19 | 4 | PATEL SAMIR CHANDRAKANT | OPHT | Stock Option (Right To Buy) | D | 1.59 | -68,157 | 0 | |||||
| 2015-06-22 | 2015-06-19 | 4 | PATEL SAMIR CHANDRAKANT | OPHT | Stock Option (Right To Buy) | D | 1.59 | -88,904 | 0 | |||||
| 2015-06-22 | 2015-06-19 | 4 | PATEL SAMIR CHANDRAKANT | OPHT | Common Stock | D | 13.2200 | 14,331 | 189 | 14,331 | ||||
| 2015-06-22 | 2015-06-19 | 4 | PATEL SAMIR CHANDRAKANT | OPHT | Common Stock | D | 1.6500 | 3 | 0 | 3 | ||||
| 2015-06-22 | 2015-06-19 | 4 | PATEL SAMIR CHANDRAKANT | OPHT | Common Stock | D | 1.6500 | 42,583 | 70 | 42,583 | ||||
| 2015-06-22 | 2015-06-19 | 4 | PATEL SAMIR CHANDRAKANT | OPHT | Common Stock | D | 1.5900 | 37,377 | 59 | 37,377 | ||||
| 2015-06-22 | 2015-06-19 | 4 | PATEL SAMIR CHANDRAKANT | OPHT | Common Stock | D | 1.5900 | 7,937 | 13 | 7,937 | ||||
| 2015-06-22 | 2015-06-19 | 4 | PATEL SAMIR CHANDRAKANT | OPHT | Common Stock | D | 1.5900 | 68,157 | 108 | 68,157 | ||||
| 2015-06-22 | 2015-06-19 | 4 | PATEL SAMIR CHANDRAKANT | OPHT | Common Stock | D | 1.5900 | 88,904 | 141 | 88,904 | ||||
| 2015-06-08 | 2015-06-04 | 4 | GALAKATOS NICHOLAS | OPHT | Restricted Stock Units | D | 1,750 | 1,750 | ||||||
| 2015-06-08 | 2015-06-04 | 4 | GALAKATOS NICHOLAS | OPHT | Stock Option (Right To Buy) | D | 48.30 | 7,000 | 7,000 | |||||
| 2015-06-08 | 2015-06-04 | 4 | SBLENDORIO GLENN | OPHT | Restricted Stock Units | D | 1,750 | 1,750 | ||||||
| 2015-06-08 | 2015-06-04 | 4 | SBLENDORIO GLENN | OPHT | Stock Option (Right To Buy) | D | 48.30 | 7,000 | 7,000 | |||||
| 2015-06-08 | 2015-06-04 | 4 | ROSS MICHAEL JAY | OPHT | Restricted Stock Units | D | 1,750 | 1,750 | ||||||
| 2015-06-08 | 2015-06-04 | 4 | ROSS MICHAEL JAY | OPHT | Stock Option (right to buy) | D | 48.30 | 7,000 | 7,000 | |||||
| 2015-06-01 | 2015-05-28 | 4 | GUYER DAVID R | OPHT | Stock Option (Right To Buy) | D | 10.03 | -18,582 | 347,486 | |||||
| 2015-06-01 | 2015-05-28 | 4 | GUYER DAVID R | OPHT | Common Stock | D | 49.0900 | -5,918 | -291 | 0 | ||||
| 2015-06-01 | 2015-05-28 | 4 | GUYER DAVID R | OPHT | Common Stock | D | 48.6400 | -10,264 | -499 | 5,918 | ||||
| 2015-06-01 | 2015-05-28 | 4 | GUYER DAVID R | OPHT | Common Stock | D | 47.4000 | -2,400 | -114 | 16,182 | ||||
| 2015-06-01 | 2015-05-28 | 4 | GUYER DAVID R | OPHT | Common Stock | D | 10.0300 | 18,582 | 186 | 18,582 | ||||
| 2015-05-28 | 2015-05-26 | 4 | GALAKATOS NICHOLAS | OPHT | Common Stock | I | 3,137 | 7,945 | ||||||
| 2015-05-28 | 2015-05-26 | 4 | GALAKATOS NICHOLAS | OPHT | Common Stock | D | 7,319 | 15,204 | ||||||
| 2015-05-28 | 2015-05-26 | 4 | GALAKATOS NICHOLAS | OPHT | Common Stock | I | -1,554,744 | 0 | ||||||
| 2015-05-28 | 2015-05-26 | 4 | Clarus Lifesciences II, L.P. | OPHT | Common Stock | D | -1,554,744 | 0 | ||||||
| 2015-05-20 | 2015-05-18 | 4 | PATEL SAMIR CHANDRAKANT | OPHT | Stock Option (Right To Buy) | D | 1.59 | -12,000 | 5,802 | |||||
| 2015-05-20 | 2015-05-18 | 4 | PATEL SAMIR CHANDRAKANT | OPHT | Common Stock | D | 52.1900 | -1,300 | -68 | 0 | ||||
| 2015-05-20 | 2015-05-18 | 4 | PATEL SAMIR CHANDRAKANT | OPHT | Common Stock | D | 51.9300 | -10,700 | -556 | 1,300 | ||||
| 2015-05-20 | 2015-05-18 | 4 | PATEL SAMIR CHANDRAKANT | OPHT | Common Stock | D | 1.5930 | 12,000 | 19 | 12,000 | ||||
| 2015-05-05 | 2015-05-01 | 4 | WOOD BARBARA A | OPHT | Stock Option (Right to Buy) | D | 24.49 | -2,000 | 66,000 | |||||
| 2015-05-05 | 2015-05-01 | 4 | WOOD BARBARA A | OPHT | Common Stock | D | 45.8800 | -2,000 | -92 | 0 | ||||
| 2015-05-05 | 2015-05-01 | 4 | WOOD BARBARA A | OPHT | Common Stock | D | 24.4900 | 2,000 | 49 | 2,000 | ||||
| 2015-04-30 | 2015-04-29 | 4 | GUYER DAVID R | OPHT | Stock Option (Right To Buy) | D | 10.03 | -18,582 | 366,068 | |||||
| 2015-04-30 | 2015-04-29 | 4 | GUYER DAVID R | OPHT | Common Stock | D | 49.8500 | -340 | -17 | 0 | ||||
| 2015-04-30 | 2015-04-29 | 4 | GUYER DAVID R | OPHT | Common Stock | D | 49.0900 | -5,582 | -274 | 340 | ||||
| 2015-04-30 | 2015-04-29 | 4 | GUYER DAVID R | OPHT | Common Stock | D | 48.1300 | -12,660 | -609 | 5,922 | ||||
| 2015-04-30 | 2015-04-29 | 4 | GUYER DAVID R | OPHT | Common Stock | D | 10.0300 | 18,582 | 186 | 18,582 | ||||
| 2015-04-21 | 2015-04-17 | 4 | PATEL SAMIR CHANDRAKANT | OPHT | Stock Option (Right To Buy) | D | 1.59 | -12,000 | 459 | |||||
| 2015-04-21 | 2015-04-17 | 4 | PATEL SAMIR CHANDRAKANT | OPHT | Common Stock | D | 51.0900 | -700 | -36 | 0 | ||||
| 2015-04-21 | 2015-04-17 | 4 | PATEL SAMIR CHANDRAKANT | OPHT | Common Stock | D | 50.4300 | -11,300 | -570 | 700 | ||||
| 2015-04-21 | 2015-04-17 | 4 | PATEL SAMIR CHANDRAKANT | OPHT | Common Stock | D | 1.5930 | 12,000 | 19 | 12,000 | ||||
| 2015-04-01 | 2015-03-30 | 4 | Bolte Axel | OPHT | Common Stock | D | 48.2700 | 500 | 24 | 2,500 | ||||
| 2015-03-31 | 2015-03-30 | 4 | GUYER DAVID R | OPHT | Stock Option (Right To Buy) | D | 10.03 | -18,582 | 384,650 | |||||
| 2015-03-31 | 2015-03-30 | 4 | GUYER DAVID R | OPHT | Common Stock | D | 48.9400 | -1,800 | -88 | 0 | ||||
| 2015-03-31 | 2015-03-30 | 4 | GUYER DAVID R | OPHT | Common Stock | D | 48.1900 | -16,782 | -809 | 1,800 | ||||
| 2015-03-31 | 2015-03-30 | 4 | GUYER DAVID R | OPHT | Common Stock | D | 10.0300 | 18,582 | 186 | 18,582 | ||||
| 2015-03-26 | 2015-03-25 | 4 | Novo A/S | OPHT | SERIES A PREFERRED STOCK WARRANT (RIGHT TO BUY) | D | 0.06 | -13,668 | 0 | |||||
| 2015-03-26 | 2015-03-25 | 4 | Novo A/S | OPHT | COMMON STOCK | D | 0.0590 | 13,668 | 1 | 4,910,487 | ||||
| 2015-03-09 | 2015-03-05 | 4 | Novo A/S | OPHT | COMMON STOCK | D | 51.7500 | -1,005,000 | -52,009 | 4,896,819 | ||||
| 2015-03-03 | 2015-03-02 | 4 | GUYER DAVID R | OPHT | Stock Option (Right To Buy) | D | 10.03 | -18,582 | 403,232 | |||||
| 2015-03-03 | 2015-03-02 | 4 | GUYER DAVID R | OPHT | Common Stock | D | 53.8200 | -4,171 | -224 | 0 | ||||
| 2015-03-03 | 2015-03-02 | 4 | GUYER DAVID R | OPHT | Common Stock | D | 53.0500 | -14,411 | -765 | 4,171 | ||||
| 2015-03-03 | 2015-03-02 | 4 | GUYER DAVID R | OPHT | Common Stock | D | 10.0300 | 18,582 | 186 | 18,582 | ||||
| 2015-03-02 | 2015-03-02 | 4 | WOOD BARBARA A | OPHT | Stock Option (Right to Buy) | D | 24.49 | -2,000 | 68,000 | |||||
| 2015-03-02 | 2015-03-02 | 4 | WOOD BARBARA A | OPHT | Common Stock | D | 53.7500 | -100 | -5 | 0 | ||||
| 2015-03-02 | 2015-03-02 | 4 | WOOD BARBARA A | OPHT | Common Stock | D | 53.2300 | -1,900 | -101 | 100 | ||||
| 2015-03-02 | 2015-03-02 | 4 | WOOD BARBARA A | OPHT | Common Stock | D | 24.4900 | 2,000 | 49 | 2,000 | ||||
| 2015-02-04 | 2015-02-02 | 4 | GUYER DAVID R | OPHT | Stock Option (Right To Buy) | D | 10.03 | -15,018 | 421,814 | |||||
| 2015-02-04 | 2015-02-02 | 4 | GUYER DAVID R | OPHT | Common Stock | D | 55.4000 | -1,300 | -72 | 0 | ||||
| 2015-02-04 | 2015-02-02 | 4 | GUYER DAVID R | OPHT | Common Stock | D | 54.3100 | -3,600 | -196 | 1,300 | ||||
| 2015-02-04 | 2015-02-02 | 4 | GUYER DAVID R | OPHT | Common Stock | D | 53.5300 | -4,400 | -236 | 4,900 | ||||
| 2015-02-04 | 2015-02-02 | 4 | GUYER DAVID R | OPHT | Common Stock | D | 52.4300 | -1,000 | -52 | 9,300 | ||||
| 2015-02-04 | 2015-02-02 | 4 | GUYER DAVID R | OPHT | Common Stock | D | 51.5900 | -4,718 | -243 | 10,300 | ||||
| 2015-02-04 | 2015-02-02 | 4 | GUYER DAVID R | OPHT | Common Stock | D | 10.0300 | 15,018 | 151 | 15,018 | ||||
| 2015-01-06 | 2015-01-02 | 4 | WOOD BARBARA A | OPHT | Restricted Stock Units | D | 5,500 | 22,500 | ||||||
| 2015-01-06 | 2015-01-02 | 4 | WOOD BARBARA A | OPHT | Stock Option (Right to Buy) | D | 45.60 | 22,500 | 22,500 | |||||
| 2015-01-06 | 2015-01-02 | 4 | SMITH TODD N | OPHT | Restricted Stock Units | D | 1,400 | 1,400 | ||||||
| 2015-01-06 | 2015-01-02 | 4 | SMITH TODD N | OPHT | Stock Option (Right to Buy) | D | 45.60 | 5,500 | 5,500 | |||||
| 2015-01-06 | 2015-01-02 | 4 | PATEL SAMIR CHANDRAKANT | OPHT | Restricted Stock Units | D | 19,500 | 19,500 | ||||||
| 2015-01-06 | 2015-01-02 | 4 | PATEL SAMIR CHANDRAKANT | OPHT | Stock Option (Right to Buy) | D | 45.60 | 78,000 | 78,000 | |||||
| 2015-01-06 | 2015-01-02 | 4 | ATIEH MICHAEL G | OPHT | Restricted Stock Units | D | 1,700 | 1,700 | ||||||
| 2015-01-06 | 2015-01-02 | 4 | ATIEH MICHAEL G | OPHT | Stock Option (Right to Buy) | D | 45.60 | 6,500 | 6,500 | |||||
| 2015-01-06 | 2015-01-02 | 4 | GUYER DAVID R | OPHT | Restricted Stock Units | D | 23,000 | 23,000 | ||||||
| 2015-01-06 | 2015-01-02 | 4 | GUYER DAVID R | OPHT | Option (Right to Buy) | D | 45.60 | 91,500 | 91,500 | |||||
| 2015-01-06 | 2015-01-02 | 4 | GUYER DAVID R | OPHT | Stock Option (Right To Buy) | D | 10.03 | -15,034 | 436,832 | |||||
| 2015-01-06 | 2015-01-02 | 4 | GUYER DAVID R | OPHT | Common Stock | D | 45.6800 | -8,466 | -387 | 0 | ||||
| 2015-01-06 | 2015-01-02 | 4 | GUYER DAVID R | OPHT | Common Stock | D | 44.9100 | -6,568 | -295 | 8,466 | ||||
| 2015-01-06 | 2015-01-02 | 4 | GUYER DAVID R | OPHT | Common Stock | D | 10.0300 | 15,034 | 151 | 15,034 | ||||
| 2014-12-03 | 2014-12-01 | 4 | GUYER DAVID R | OPHT | Stock Option (Right To Buy) | D | 10.03 | -15,034 | 451,866 | |||||
| 2014-12-03 | 2014-12-01 | 4 | GUYER DAVID R | OPHT | Common Stock | D | 42.8000 | -500 | -21 | 0 | ||||
| 2014-12-03 | 2014-12-01 | 4 | GUYER DAVID R | OPHT | Common Stock | D | 41.9700 | -4,300 | -180 | 500 | ||||
| 2014-12-03 | 2014-12-01 | 4 | GUYER DAVID R | OPHT | Common Stock | D | 41.3500 | -10,234 | -423 | 4,800 | ||||
| 2014-12-03 | 2014-12-01 | 4 | GUYER DAVID R | OPHT | Common Stock | D | 10.0300 | 15,034 | 151 | 15,034 | ||||
| 2014-11-17 | 2014-11-13 | 4 | Novo A/S | OPHT | COMMON STOCK | D | 40.2000 | -995,000 | -39,999 | 5,901,819 | ||||
| 2014-11-04 | 2014-11-03 | 4 | GUYER DAVID R | OPHT | Stock Option (Right To Buy) | D | 10.03 | -15,034 | 19,486 | |||||
| 2014-11-04 | 2014-11-03 | 4 | GUYER DAVID R | OPHT | Common Stock | D | 41.3900 | -800 | -33 | 0 | ||||
| 2014-11-04 | 2014-11-03 | 4 | GUYER DAVID R | OPHT | Common Stock | D | 40.3000 | -1,400 | -56 | 800 | ||||
| 2014-11-04 | 2014-11-03 | 4 | GUYER DAVID R | OPHT | Common Stock | D | 39.5400 | -12,834 | -507 | 2,200 | ||||
| 2014-11-04 | 2014-11-03 | 4 | GUYER DAVID R | OPHT | Common Stock | D | 10.0300 | 15,034 | 151 | 15,034 | ||||
| 2014-10-07 | 2014-10-03 | 4 | SMITH TODD N | OPHT | Stock Option (Right To Buy) | D | 38.41 | 150,000 | 150,000 | |||||
| 2014-10-03 | 2014-09-30 | 4 | ATIEH MICHAEL G | OPHT | Stock Option (Right To Buy) | D | 38.93 | 200,000 | 200,000 | |||||
| 2014-10-03 | 2014-10-01 | 4 | PATEL SAMIR CHANDRAKANT | OPHT | Common Stock | D | 38.6600 | -600 | -23 | 1,965 | ||||
| 2014-10-03 | 2014-10-01 | 4 | PATEL SAMIR CHANDRAKANT | OPHT | Common Stock | D | 37.5800 | -3,647 | -137 | 2,565 | ||||
| 2014-10-03 | 2014-10-01 | 4 | PATEL SAMIR CHANDRAKANT | OPHT | Common Stock | D | 37.1400 | -13,429 | -499 | 6,212 | ||||
| 2014-10-03 | 2014-10-02 | 4 | PATEL SAMIR CHANDRAKANT | OPHT | Common Stock | D | 38.0400 | -1,965 | -75 | 0 | ||||
| 2014-10-03 | 2014-10-02 | 4 | GUYER DAVID R | OPHT | Stock Option (Right To Buy) | D | 10.03 | -2,807 | 34,520 | |||||
| 2014-10-03 | 2014-10-02 | 4 | GUYER DAVID R | OPHT | Common Stock | D | 38.5200 | -2,807 | -108 | 0 | ||||
| 2014-10-03 | 2014-10-02 | 4 | GUYER DAVID R | OPHT | Common Stock | D | 10.0300 | 2,807 | 28 | 2,807 | ||||
| 2014-10-03 | 2014-10-01 | 4 | GUYER DAVID R | OPHT | Stock Option (Right To Buy) | D | 10.03 | -12,227 | 37,327 | |||||
| 2014-10-03 | 2014-10-01 | 4 | GUYER DAVID R | OPHT | Common Stock | D | 38.6500 | -300 | -12 | 0 | ||||
| 2014-10-03 | 2014-10-01 | 4 | GUYER DAVID R | OPHT | Common Stock | D | 37.6100 | -3,572 | -134 | 300 | ||||
| 2014-10-03 | 2014-10-01 | 4 | GUYER DAVID R | OPHT | Common Stock | D | 37.1200 | -8,355 | -310 | 3,872 | ||||
| 2014-10-03 | 2014-10-01 | 4 | GUYER DAVID R | OPHT | Common Stock | D | 10.0300 | 12,277 | 123 | 12,277 | ||||
| 2014-09-08 | 2014-09-04 | 4 | GUYER DAVID R | OPHT | Stock Option (Right To Buy) | D | 10.03 | -1,107 | 49,554 | |||||
| 2014-09-08 | 2014-09-04 | 4 | GUYER DAVID R | OPHT | Common Stock | D | 38.5800 | -1,107 | -43 | 0 | ||||
| 2014-09-08 | 2014-09-04 | 4 | GUYER DAVID R | OPHT | Common Stock | D | 10.0300 | 1,107 | 11 | 1,107 | ||||
| 2014-09-04 | 2014-09-02 | 4 | GUYER DAVID R | OPHT | Stock Option (Right To Buy) | D | 10.03 | -12,727 | 50,661 | |||||
| 2014-09-04 | 2014-09-02 | 4 | GUYER DAVID R | OPHT | Common Stock | D | 38.3400 | -1,718 | -66 | 0 | ||||
| 2014-09-04 | 2014-09-02 | 4 | GUYER DAVID R | OPHT | Common Stock | D | 37.5800 | -11,009 | -414 | 1,718 | ||||
| 2014-09-04 | 2014-09-02 | 4 | GUYER DAVID R | OPHT | Common Stock | D | 10.0300 | 12,727 | 128 | 12,727 | ||||
| 2014-09-04 | 2014-09-02 | 4 | PEACOCK BRUCE | OPHT | Stock Option (Right To Buy) | D | 1.65 | -6,191 | 21,834 | |||||
| 2014-09-04 | 2014-09-02 | 4 | PEACOCK BRUCE | OPHT | Common Stock | D | 38.2500 | -900 | -34 | 0 | ||||
| 2014-09-04 | 2014-09-02 | 4 | PEACOCK BRUCE | OPHT | Common Stock | D | 37.6500 | -5,291 | -199 | 900 | ||||
| 2014-09-04 | 2014-09-02 | 4 | PEACOCK BRUCE | OPHT | Common Stock | D | 1.6520 | 6,191 | 10 | 6,191 | ||||
| 2014-09-04 | 2014-09-02 | 4 | PATEL SAMIR CHANDRAKANT | OPHT | Common Stock | D | 38.3500 | -2,140 | -82 | 19,641 | ||||
| 2014-09-04 | 2014-09-02 | 4 | PATEL SAMIR CHANDRAKANT | OPHT | Common Stock | D | 37.6000 | -16,846 | -633 | 21,781 | ||||
| 2014-08-04 | 2014-08-01 | 4 | PEACOCK BRUCE | OPHT | Stock Option (Right To Buy) | D | 1.65 | -6,191 | 28,025 | |||||
| 2014-08-04 | 2014-08-01 | 4 | PEACOCK BRUCE | OPHT | Common Stock | D | 38.5500 | -100 | -4 | 0 | ||||
| 2014-08-04 | 2014-08-01 | 4 | PEACOCK BRUCE | OPHT | Common Stock | D | 37.7700 | -6,091 | -230 | 100 | ||||
| 2014-08-04 | 2014-08-01 | 4 | PEACOCK BRUCE | OPHT | Common Stock | D | 1.6520 | 6,191 | 10 | 6,191 | ||||
| 2014-08-04 | 2014-08-01 | 4 | GUYER DAVID R | OPHT | Stock Option (Right To Buy) | D | 10.03 | -13,136 | 63,388 | |||||
| 2014-08-04 | 2014-08-01 | 4 | GUYER DAVID R | OPHT | Common Stock | D | 38.6200 | -800 | -31 | 0 | ||||
| 2014-08-04 | 2014-08-01 | 4 | GUYER DAVID R | OPHT | Common Stock | D | 37.8000 | -12,336 | -466 | 800 | ||||
| 2014-08-04 | 2014-08-01 | 4 | GUYER DAVID R | OPHT | Common Stock | D | 10.0300 | 13,136 | 132 | 13,136 | ||||
| 2014-08-04 | 2014-08-01 | 4 | PATEL SAMIR CHANDRAKANT | OPHT | Common Stock | D | 38.6600 | -400 | -15 | 38,627 | ||||
| 2014-08-04 | 2014-08-01 | 4 | PATEL SAMIR CHANDRAKANT | OPHT | Common Stock | D | 37.7800 | -18,586 | -702 | 39,027 | ||||
| 2014-07-03 | 2014-07-01 | 4 | GUYER DAVID R | OPHT | Stock Option (Right To Buy) | D | 10.03 | -15,034 | 76,524 | |||||
| 2014-07-03 | 2014-07-01 | 4 | GUYER DAVID R | OPHT | Common Stock | D | 41.6000 | -3,482 | -145 | 0 | ||||
| 2014-07-03 | 2014-07-01 | 4 | GUYER DAVID R | OPHT | Common Stock | D | 40.9200 | -11,552 | -473 | 3,482 | ||||
| 2014-07-03 | 2014-07-01 | 4 | GUYER DAVID R | OPHT | Common Stock | D | 10.0300 | 15,034 | 151 | 15,034 | ||||
| 2014-07-03 | 2014-07-01 | 4 | PEACOCK BRUCE | OPHT | Stock Option (Right To Buy) | D | 1.65 | -7,739 | 34,216 | |||||
| 2014-07-03 | 2014-07-01 | 4 | PEACOCK BRUCE | OPHT | Common Stock | D | 41.6100 | -2,002 | -83 | 0 | ||||
| 2014-07-03 | 2014-07-01 | 4 | PEACOCK BRUCE | OPHT | Common Stock | D | 40.8800 | -5,737 | -235 | 2,002 | ||||
| 2014-07-03 | 2014-07-01 | 4 | PEACOCK BRUCE | OPHT | Common Stock | D | 1.6520 | 7,739 | 13 | 7,739 | ||||
| 2014-07-03 | 2014-07-01 | 4 | PATEL SAMIR CHANDRAKANT | OPHT | Common Stock | D | 41.6100 | -4,892 | -204 | 57,613 | ||||
| 2014-07-03 | 2014-07-01 | 4 | PATEL SAMIR CHANDRAKANT | OPHT | Common Stock | D | 40.8900 | -14,094 | -576 | 62,505 | ||||
| 2014-06-18 | 2014-06-16 | 4 | GALAKATOS NICHOLAS | OPHT | Common Stock | I | 44.2390 | 2,308 | 102 | 4,808 | ||||
| 2014-06-18 | 2014-06-16 | 4 | GALAKATOS NICHOLAS | OPHT | Common Stock | D | 44.2390 | 5,385 | 238 | 7,885 | ||||
| 2014-06-18 | 2014-06-16 | 4 | GALAKATOS NICHOLAS | OPHT | Common Stock | I | 44.2390 | -1,143,844 | -50,603 | 1,554,744 | ||||
| 2014-06-16 | 2014-06-16 | 4 | GALAKATOS NICHOLAS | OPHT | Common Stock | I | 44.0000 | -15,482 | -681 | 2,698,588 | ||||
| 2014-06-16 | 2014-06-13 | 4 | GALAKATOS NICHOLAS | OPHT | Common Stock | I | 44.0126 | -82,277 | -3,621 | 2,714,070 | ||||
| 2014-06-16 | 2014-06-12 | 4 | GALAKATOS NICHOLAS | OPHT | Common Stock | I | 44.5106 | -47,217 | -2,102 | 2,796,347 | ||||
| 2014-06-11 | 2014-06-11 | 4 | Clarus Lifesciences II, L.P. | OPHT | Common Stock | I | 44.3200 | -500 | -22 | 4,500 | ||||
| 2014-06-11 | 2014-06-11 | 4 | Clarus Lifesciences II, L.P. | OPHT | Common Stock | D | 44.5314 | -29,217 | -1,301 | 2,843,564 | ||||
| 2014-06-11 | 2014-06-10 | 4 | Clarus Lifesciences II, L.P. | OPHT | Common Stock | D | 46.8000 | -200 | -9 | 2,872,781 | ||||
| 2014-06-11 | 2014-06-10 | 4 | Clarus Lifesciences II, L.P. | OPHT | Common Stock | D | 45.8956 | -36,880 | -1,693 | 2,872,981 | ||||
| 2014-06-11 | 2014-06-10 | 4 | Clarus Lifesciences II, L.P. | OPHT | Common Stock | D | 44.6606 | -79,824 | -3,565 | 2,909,861 | ||||
| 2014-06-11 | 2014-06-09 | 4 | Clarus Lifesciences II, L.P. | OPHT | Common Stock | D | 46.7837 | -39,362 | -1,841 | 2,989,685 | ||||
| 2014-06-11 | 2014-06-09 | 4 | Clarus Lifesciences II, L.P. | OPHT | Common Stock | D | 46.0156 | -25,697 | -1,182 | 3,029,047 | ||||
| 2014-06-06 | 2014-06-04 | 4 | PATEL SAMIR CHANDRAKANT See footnote. | OPHT | Common Stock | I | -384,984 | 0 | ||||||
| 2014-06-05 | 2014-06-04 | 4 | SVLSF IV, LLC | OPHT | Common Stock | D | 42.5400 | -18,100 | -770 | 84,325 | ||||
| 2014-06-05 | 2014-06-04 | 4 | SVLSF IV, LLC | OPHT | Common Stock | D | 42.5400 | -637,545 | -27,121 | 2,970,133 | ||||
| 2014-06-05 | 2014-06-04 | 4 | SVLSF IV, LLC | OPHT | Common Stock | I | 42.5400 | -655,645 | -27,891 | 3,054,458 | ||||
| 2014-06-05 | 2014-06-04 | 4 | SVLSF IV, LLC | OPHT | Common Stock | I | 42.5400 | -655,645 | -27,891 | 3,054,458 | ||||
| 2014-06-04 | 2014-06-02 | 4 | GUYER DAVID R | OPHT | Stock Option (Right To Buy) | D | 10.03 | -13,526 | 91,558 | |||||
| 2014-06-04 | 2014-06-02 | 4 | GUYER DAVID R | OPHT | Common Stock | D | 40.8500 | -950 | -39 | 0 | ||||
| 2014-06-04 | 2014-06-02 | 4 | GUYER DAVID R | OPHT | Common Stock | D | 39.8800 | -24,467 | -976 | 950 | ||||
| 2014-06-04 | 2014-06-02 | 4 | GUYER DAVID R | OPHT | Common Stock | D | 10.0300 | 13,526 | 136 | 25,417 | ||||
| 2014-06-04 | 2014-06-02 | 4 | PATEL SAMIR CHANDRAKANT | OPHT | Common Stock | D | 40.7500 | -900 | -37 | 76,599 | ||||
| 2014-06-04 | 2014-06-02 | 4 | PATEL SAMIR CHANDRAKANT | OPHT | Common Stock | D | 39.8800 | -26,973 | -1,076 | 77,499 | ||||
| 2014-06-04 | 2014-06-03 | 4 | PEACOCK BRUCE | OPHT | Stock Option (Right To Buy) | D | 1.65 | -5,094 | 41,955 | |||||
| 2014-06-04 | 2014-06-03 | 4 | PEACOCK BRUCE | OPHT | Common Stock | D | 40.4100 | -5,094 | -206 | 0 | ||||
| 2014-06-04 | 2014-06-03 | 4 | PEACOCK BRUCE | OPHT | Common Stock | D | 1.6520 | 5,094 | 8 | 5,094 | ||||
| 2014-06-04 | 2014-06-02 | 4 | PEACOCK BRUCE | OPHT | Stock Option (Right To Buy) | D | 1.65 | -8,837 | 47,049 | |||||
| 2014-06-04 | 2014-06-02 | 4 | PEACOCK BRUCE | OPHT | Common Stock | D | 40.8000 | -700 | -29 | 0 | ||||
| 2014-06-04 | 2014-06-02 | 4 | PEACOCK BRUCE | OPHT | Common Stock | D | 39.8800 | -8,137 | -325 | 700 | ||||
| 2014-06-04 | 2014-06-02 | 4 | PEACOCK BRUCE | OPHT | Common Stock | D | 1.6520 | 8,837 | 15 | 8,837 | ||||
| 2014-06-04 | 2014-06-03 | 4 | SVLSF IV, LLC | OPHT | Common Stock | D | 40.8100 | -14,022 | -572 | 102,425 | ||||
| 2014-06-04 | 2014-06-03 | 4 | SVLSF IV, LLC | OPHT | Common Stock | D | 40.8100 | -493,901 | -20,156 | 3,607,678 | ||||
| 2014-06-04 | 2014-06-03 | 4 | SVLSF IV, LLC | OPHT | Common Stock | I | 40.8100 | -507,923 | -20,728 | 3,710,103 | ||||
| 2014-06-04 | 2014-06-03 | 4 | SVLSF IV, LLC | OPHT | Common Stock | I | 40.8100 | -507,923 | -20,728 | 3,710,103 | ||||
| 2014-06-04 | 2014-06-02 | 4 | SVLSF IV, LLC | OPHT | Common Stock | D | 39.9100 | -3,146 | -126 | 116,447 | ||||
| 2014-06-04 | 2014-06-02 | 4 | SVLSF IV, LLC | OPHT | Common Stock | D | 39.9100 | -110,804 | -4,422 | 4,101,579 | ||||
| 2014-06-04 | 2014-06-02 | 4 | SVLSF IV, LLC | OPHT | Common Stock | I | 39.9100 | -113,950 | -4,548 | 4,218,026 | ||||
| 2014-06-04 | 2014-06-02 | 4 | SVLSF IV, LLC | OPHT | Common Stock | I | 39.9100 | -113,950 | -4,548 | 4,218,026 | ||||
| 2014-06-02 | 2014-05-30 | 4 | SVLSF IV, LLC | OPHT | Common Stock | D | 41.0100 | -1,983 | -81 | 119,593 | ||||
| 2014-06-02 | 2014-05-30 | 4 | SVLSF IV, LLC | OPHT | Common Stock | D | 41.0100 | -69,853 | -2,865 | 4,212,383 | ||||
| 2014-06-02 | 2014-05-30 | 4 | SVLSF IV, LLC | OPHT | Common Stock | I | 41.0100 | -71,836 | -2,946 | 4,331,976 | ||||
| 2014-06-02 | 2014-05-30 | 4 | SVLSF IV, LLC | OPHT | Common Stock | I | 41.0100 | -71,836 | -2,946 | 4,331,976 | ||||
| 2014-06-02 | 2014-05-29 | 4 | SVLSF IV, LLC | OPHT | Common Stock | D | 40.9900 | -6,592 | -270 | 121,576 | ||||
| 2014-06-02 | 2014-05-29 | 4 | SVLSF IV, LLC | OPHT | Common Stock | D | 40.9900 | -232,195 | -9,518 | 4,282,236 | ||||
| 2014-06-02 | 2014-05-29 | 4 | SVLSF IV, LLC | OPHT | Common Stock | I | 40.9900 | -238,787 | -9,788 | 4,403,812 | ||||
| 2014-06-02 | 2014-05-29 | 4 | SVLSF IV, LLC | OPHT | Common Stock | I | 40.9900 | -238,787 | -9,788 | 4,403,812 | ||||
| 2014-05-29 | 2014-05-28 | 4 | SVLSF IV, LLC | OPHT | Common Stock | D | 40.3300 | -6,321 | -255 | 128,168 | ||||
| 2014-05-29 | 2014-05-28 | 4 | SVLSF IV, LLC | OPHT | Common Stock | D | 40.3300 | -222,651 | -8,980 | 4,514,431 | ||||
| 2014-05-29 | 2014-05-28 | 4 | SVLSF IV, LLC | OPHT | Common Stock | I | 40.3300 | -228,972 | -9,234 | 4,642,599 | ||||
| 2014-05-29 | 2014-05-28 | 4 | SVLSF IV, LLC | OPHT | Common Stock | I | 40.3300 | -228,972 | -9,234 | 4,642,599 | ||||
| 2014-05-29 | 2014-05-27 | 4 | SVLSF IV, LLC | OPHT | Common Stock | D | 39.8700 | -2,698 | -108 | 134,489 | ||||
| 2014-05-29 | 2014-05-27 | 4 | SVLSF IV, LLC | OPHT | Common Stock | D | 39.8700 | -95,039 | -3,789 | 4,737,082 | ||||
| 2014-05-29 | 2014-05-27 | 4 | SVLSF IV, LLC | OPHT | Common Stock | I | 39.8700 | -97,737 | -3,897 | 4,871,571 | ||||
| 2014-05-29 | 2014-05-27 | 4 | SVLSF IV, LLC | OPHT | Common Stock | I | 39.8700 | -97,737 | -3,897 | 4,871,571 | ||||
| 2014-05-27 | 2014-05-23 | 4 | SVLSF IV, LLC | OPHT | Common Stock | D | 38.3400 | -2,102 | -81 | 137,187 | ||||
| 2014-05-27 | 2014-05-23 | 4 | SVLSF IV, LLC | OPHT | Common Stock | D | 38.3400 | -74,048 | -2,839 | 4,832,121 | ||||
| 2014-05-27 | 2014-05-23 | 4 | SVLSF IV, LLC | OPHT | Common Stock | I | 38.3400 | -76,150 | -2,920 | 4,969,308 | ||||
| 2014-05-27 | 2014-05-23 | 4 | SVLSF IV, LLC | OPHT | Common Stock | I | 38.3400 | -76,150 | -2,920 | 4,969,308 | ||||
| 2014-05-27 | 2014-05-22 | 4 | SVLSF IV, LLC | OPHT | Common Stock | D | 37.5700 | -939 | -35 | 139,289 | ||||
| 2014-05-27 | 2014-05-22 | 4 | SVLSF IV, LLC | OPHT | Common Stock | D | 37.5700 | -33,061 | -1,242 | 4,906,169 | ||||
| 2014-05-27 | 2014-05-22 | 4 | SVLSF IV, LLC | OPHT | Common Stock | I | 37.5700 | -34,000 | -1,277 | 5,045,458 | ||||
| 2014-05-27 | 2014-05-22 | 4 | SVLSF IV, LLC | OPHT | Common Stock | I | 37.5700 | -34,000 | -1,277 | 5,045,458 | ||||
| 2014-05-23 | 2014-05-21 | 4 | GALAKATOS NICHOLAS | OPHT | Director Stock Options (Right to Buy) | D | 37.00 | 15,000 | 15,000 | |||||
| 2014-05-23 | 2014-05-21 | 4 | SBLENDORIO GLENN | OPHT | Stock Option (Right To Buy) | D | 37.00 | 15,000 | 15,000 | |||||
| 2014-05-23 | 2014-05-21 | 4 | ROSS MICHAEL JAY | OPHT | Employee Stock Option (right to buy) | D | 37.00 | 15,000 | 15,000 | |||||
| 2014-05-15 | 2014-05-13 | 4 | HBM Healthcare Investments (Cayman) Ltd. | OPHT | Common Stock | D | 29.7500 | -500,000 | -14,875 | 3,139,902 | ||||
| 2014-05-05 | 2014-05-01 | 4 | PEACOCK BRUCE | OPHT | Stock Option (Right To Buy) | D | 1.65 | -4,643 | 55,916 | |||||
| 2014-05-05 | 2014-05-01 | 4 | PEACOCK BRUCE | OPHT | Common Stock | D | 32.7100 | -2,642 | -86 | 0 | ||||
| 2014-05-05 | 2014-05-01 | 4 | PEACOCK BRUCE | OPHT | Common Stock | D | 32.0600 | -2,001 | -64 | 2,642 | ||||
| 2014-05-05 | 2014-05-01 | 4 | PEACOCK BRUCE | OPHT | Common Stock | D | 1.6520 | 4,643 | 8 | 4,643 | ||||
| 2014-05-05 | 2014-05-01 | 4 | PATEL SAMIR CHANDRAKANT | OPHT | Common Stock | D | 33.7700 | -100 | -3 | 104,472 | ||||
| 2014-05-05 | 2014-05-01 | 4 | PATEL SAMIR CHANDRAKANT | OPHT | Common Stock | D | 32.8100 | -4,396 | -144 | 104,572 | ||||
| 2014-05-05 | 2014-05-01 | 4 | PATEL SAMIR CHANDRAKANT | OPHT | Common Stock | D | 32.2700 | -9,823 | -317 | 108,968 | ||||
| 2014-05-05 | 2014-05-01 | 4 | GUYER DAVID R | OPHT | Common Stock | D | 34.7400 | -6,638 | -231 | 11,891 | ||||
| 2014-05-05 | 2014-05-01 | 4 | GUYER DAVID R | OPHT | Common Stock | D | 32.0100 | -4,027 | -129 | 18,529 | ||||
| 2014-04-03 | 2014-04-01 | 4 | GUYER DAVID R | OPHT | Common Stock | D | 34.7900 | -4,181 | -145 | 22,556 | ||||
| 2014-04-03 | 2014-04-01 | 4 | GUYER DAVID R | OPHT | Common Stock | D | 34.0000 | -7,846 | -267 | 26,737 | ||||
| 2014-04-03 | 2014-04-01 | 4 | PEACOCK BRUCE | OPHT | Stock Option (Right To Buy) | D | 1.65 | -6,191 | 60,559 | |||||
| 2014-04-03 | 2014-04-01 | 4 | PEACOCK BRUCE | OPHT | Common Stock | D | 34.7600 | -2,267 | -79 | 0 | ||||
| 2014-04-03 | 2014-04-01 | 4 | PEACOCK BRUCE | OPHT | Common Stock | D | 33.9700 | -3,924 | -133 | 2,267 | ||||
| 2014-04-03 | 2014-04-01 | 4 | PEACOCK BRUCE | OPHT | Common Stock | D | 1.6520 | 6,191 | 10 | 6,191 | ||||
| 2014-04-03 | 2014-04-01 | 4 | PATEL SAMIR CHANDRAKANT | OPHT | Common Stock | D | 35.7000 | -100 | -4 | 118,791 | ||||
| 2014-04-03 | 2014-04-01 | 4 | PATEL SAMIR CHANDRAKANT | OPHT | Common Stock | D | 34.7600 | -6,100 | -212 | 118,891 | ||||
| 2014-04-03 | 2014-04-01 | 4 | PATEL SAMIR CHANDRAKANT | OPHT | Common Stock | D | 33.9800 | -10,676 | -363 | 124,991 | ||||
| 2014-03-26 | 2014-03-24 | 4 | GUYER DAVID R | OPHT | Common Stock | D | 34.9200 | -3,693 | -129 | 34,583 | ||||
| 2014-03-26 | 2014-03-24 | 4 | GUYER DAVID R | OPHT | Common Stock | D | 34.3600 | -8,334 | -286 | 38,276 | ||||
| 2014-03-26 | 2014-03-24 | 4 | PATEL SAMIR CHANDRAKANT | OPHT | Common Stock | D | 35.4600 | -200 | -7 | 135,667 | ||||
| 2014-03-26 | 2014-03-24 | 4 | PATEL SAMIR CHANDRAKANT | OPHT | Common Stock | D | 34.9300 | -4,092 | -143 | 135,867 | ||||
| 2014-03-26 | 2014-03-24 | 4 | PATEL SAMIR CHANDRAKANT | OPHT | Common Stock | D | 34.4000 | -12,584 | -433 | 139,959 | ||||
| 2014-03-26 | 2014-03-24 | 4 | PEACOCK BRUCE | OPHT | Stock Option (Right To Buy) | D | 1.65 | -6,191 | 66,750 | |||||
| 2014-03-26 | 2014-03-24 | 4 | PEACOCK BRUCE | OPHT | Common Stock | D | 35.0300 | -1,106 | -39 | 0 | ||||
| 2014-03-26 | 2014-03-24 | 4 | PEACOCK BRUCE | OPHT | Common Stock | D | 34.7100 | -5,031 | -175 | 1,106 | ||||
| 2014-03-26 | 2014-03-24 | 4 | PEACOCK BRUCE | OPHT | Common Stock | D | 1.6520 | 6,191 | 10 | 6,191 | ||||
| 2014-02-19 | 2014-02-18 | 4 | SVLSF IV, LLC | OPHT | Common Stock | D | 29.6100 | -19,429 | -575 | 140,228 | ||||
| 2014-02-19 | 2014-02-18 | 4 | SVLSF IV, LLC | OPHT | Common Stock | D | 29.6100 | -684,359 | -20,264 | 4,939,230 | ||||
| 2014-02-19 | 2014-02-18 | 4 | SVLSF IV, LLC | OPHT | Common Stock | I | 29.6100 | -703,788 | -20,839 | 5,079,458 | ||||
| 2014-02-19 | 2014-02-18 | 4 | SVLSF IV, LLC | OPHT | Common Stock | I | 29.6100 | -703,788 | -20,839 | 5,079,458 | ||||
| 2014-01-06 | 2014-01-02 | 4 | GUYER DAVID R | OPHT | Stock Option (Right To Buy) | D | 31.29 | 175,000 | 175,000 | |||||
| 2014-01-06 | 2014-01-02 | 4 | PATEL SAMIR CHANDRAKANT | OPHT | Stock Option (Right To Buy) | D | 31.29 | 140,000 | 140,000 | |||||
| 2014-01-06 | 2014-01-02 | 4 | PEACOCK BRUCE | OPHT | Stock Option (Right To Buy) | D | 31.29 | 100,000 | 100,000 | |||||
| 2013-11-20 | 2013-09-30 | 4 | GALAKATOS NICHOLAS | OPHT | Common Stock | D | 22.0000 | 2,500 | 55 | 2,500 | ||||
| 2013-11-20 | 2013-09-30 | 4 | GALAKATOS NICHOLAS | OPHT | Common Stock | I | 22.0000 | 2,500 | 55 | 2,500 | ||||
| 2013-10-25 | 2013-10-23 | 4 | GALAKATOS NICHOLAS | OPHT | Stock Option (Right to Buy) | D | 33.27 | 22,033 | 22,033 | |||||
| 2013-10-25 | 2013-10-23 | 4 | ROSS MICHAEL JAY | OPHT | Employee Stock Option (right to buy) | D | 33.27 | 22,033 | 22,033 | |||||
| 2013-10-25 | 2013-10-23 | 4 | SBLENDORIO GLENN | OPHT | Stock Option (Right To Buy) | D | 33.27 | 6,949 | 22,033 | |||||
| 2013-10-25 | 2013-10-23 | 4 | Dyrberg Thomas | OPHT | STOCK OPTION (RIGHT TO BUY) | D | 33.27 | 22,033 | 22,033 | |||||
| 2013-10-07 | 2013-09-25 | 4 | Bolte Axel | OPHT | Common Stock | D | 22.0000 | -2,000 | -44 | 2,000 | ||||
| 2013-10-03 | 2013-09-30 | 4 | HBM Healthcare Investments (Cayman) Ltd. | OPHT | Common Stock Warrant | D | 0.06 | 13,670 | 13,670 | |||||
| 2013-10-03 | 2013-09-30 | 4 | HBM Healthcare Investments (Cayman) Ltd. | OPHT | Series A Preferred Stock Warrant | D | -13,670 | 0 | ||||||
| 2013-10-03 | 2013-09-30 | 4 | HBM Healthcare Investments (Cayman) Ltd. | OPHT | Series C Preferred Stock | D | -206,756 | 0 | ||||||
| 2013-10-03 | 2013-09-30 | 4 | HBM Healthcare Investments (Cayman) Ltd. | OPHT | Series B Preferred Stock | D | -398,208 | 0 | ||||||
| 2013-10-03 | 2013-09-30 | 4 | HBM Healthcare Investments (Cayman) Ltd. | OPHT | Series A Preferred Stock | D | -2,806,937 | 0 | ||||||
| 2013-10-03 | 2013-09-30 | 4 | HBM Healthcare Investments (Cayman) Ltd. | OPHT | Common Stock | D | 22.0000 | 228,000 | 5,016 | 3,639,902 | ||||
| 2013-10-03 | 2013-09-30 | 4 | HBM Healthcare Investments (Cayman) Ltd. | OPHT | Common Stock | D | 206,756 | 3,411,902 | ||||||
| 2013-10-03 | 2013-09-30 | 4 | HBM Healthcare Investments (Cayman) Ltd. | OPHT | Common Stock | D | 398,208 | 3,205,145 | ||||||
| 2013-10-03 | 2013-09-30 | 4 | HBM Healthcare Investments (Cayman) Ltd. | OPHT | Common Stock | D | 2,806,937 | 2,806,937 | ||||||
| 2013-10-02 | 2013-09-30 | 4 | PATEL SAMIR CHANDRAKANT | OPHT | Series C Preferred Stock | I | -23,081 | 0 | ||||||
| 2013-10-02 | 2013-09-30 | 4 | PATEL SAMIR CHANDRAKANT | OPHT | Series B Preferred Stock | I | -70,621 | 0 | ||||||
| 2013-10-02 | 2013-09-30 | 4 | PATEL SAMIR CHANDRAKANT | OPHT | Series A Preferred Stock | I | -244,821 | 0 | ||||||
| 2013-10-02 | 2013-09-30 | 4 | PATEL SAMIR CHANDRAKANT | OPHT | Common Stock | I | 23,282 | 537,527 | ||||||
| 2013-10-02 | 2013-09-30 | 4 | PATEL SAMIR CHANDRAKANT | OPHT | Common Stock | I | 79,638 | 514,242 | ||||||
| 2013-10-02 | 2013-09-30 | 4 | PATEL SAMIR CHANDRAKANT | OPHT | Common Stock | I | 282,061 | 434,604 | ||||||
| 2013-10-02 | 2013-09-23 | 4 | PATEL SAMIR CHANDRAKANT | OPHT | Common Stock | D | -5,084 | 152,543 | ||||||
| 2013-10-02 | 2013-09-23 | 4 | PATEL SAMIR CHANDRAKANT | OPHT | Common Stock | D | -5,084 | 152,543 | ||||||
| 2013-10-02 | 2013-08-07 | 4 | PATEL SAMIR CHANDRAKANT | OPHT | Series C Preferred Stock | I | 15,388 | 23,081 | ||||||
| 2013-10-02 | 2013-05-28 | 4 | PATEL SAMIR CHANDRAKANT | OPHT | Stock Option (right to buy) | D | 13.22 | 56,858 | 418,185 | |||||
| 2013-10-02 | 2013-05-23 | 4 | PATEL SAMIR CHANDRAKANT | OPHT | Series C Preferred Stock | I | 7,693 | 7,693 | ||||||
| 2013-10-02 | 2013-09-30 | 4 | Dyrberg Thomas | OPHT | COMMON STOCK | D | 22.0000 | 700 | 15 | 700 | ||||
| 2013-10-02 | 2013-09-30 | 4 | Novo A/S | OPHT | SERIES C PREFERRED STOCK | D | -15,438,009 | 0 | ||||||
| 2013-10-02 | 2013-09-30 | 4 | Novo A/S | OPHT | SERIES B PREFERRED STOCK | D | -5,208,334 | 0 | ||||||
| 2013-10-02 | 2013-09-30 | 4 | Novo A/S | OPHT | SERIES A PREFERRED STOCK | D | -14,374,443 | 0 | ||||||
| 2013-10-02 | 2013-09-30 | 4 | Novo A/S | OPHT | COMMON STOCK | D | 22.0000 | 455,000 | 10,010 | 6,896,819 | ||||
| 2013-10-02 | 2013-09-30 | 4 | Novo A/S | OPHT | COMMON STOCK | D | 6,441,819 | 6,441,819 | ||||||
| 2013-10-02 | 2013-09-30 | 4 | SVLSF IV, LLC | OPHT | Series C Preferred Stock | I | -346,733 | 0 | ||||||
| 2013-10-02 | 2013-09-30 | 4 | SVLSF IV, LLC | OPHT | Series C Preferred Stock | I | -346,733 | 0 | ||||||
| 2013-10-02 | 2013-09-30 | 4 | SVLSF IV, LLC | OPHT | Series B Preferred Stock | I | -1,066,383 | 0 | ||||||
| 2013-10-02 | 2013-09-30 | 4 | SVLSF IV, LLC | OPHT | Series B Preferred Stock | I | -1,066,383 | 0 | ||||||
| 2013-10-02 | 2013-09-30 | 4 | SVLSF IV, LLC | OPHT | Warrant to Purchase Shares (Series A Preferred Stock) | I | 0.06 | -11,863 | 0 | |||||
| 2013-10-02 | 2013-09-30 | 4 | SVLSF IV, LLC | OPHT | Warrant to Purchase Shares (Series A Preferred Stock) | I | 0.06 | -11,863 | 0 | |||||
| 2013-10-02 | 2013-09-30 | 4 | SVLSF IV, LLC | OPHT | Series A Preferred Stock | I | -3,660,452 | 0 | ||||||
| 2013-10-02 | 2013-09-30 | 4 | SVLSF IV, LLC | OPHT | Series A Preferred Stock | I | -3,660,452 | 0 | ||||||
| 2013-10-02 | 2013-09-30 | 4 | SVLSF IV, LLC | OPHT | Series C Preferred Stock | D | -9,572 | 0 | ||||||
| 2013-10-02 | 2013-09-30 | 4 | SVLSF IV, LLC | OPHT | Series B Preferred Stock | D | -29,439 | 0 | ||||||
| 2013-10-02 | 2013-09-30 | 4 | SVLSF IV, LLC | OPHT | Warrant to Purchase Shares (Series A Preferred Stock) | D | 0.06 | -327 | 0 | |||||
| 2013-10-02 | 2013-09-30 | 4 | SVLSF IV, LLC | OPHT | Series A Preferred Stock | D | -101,054 | 0 | ||||||
| 2013-10-02 | 2013-09-30 | 4 | SVLSF IV, LLC | OPHT | Series C Preferred Stock | D | -337,161 | 0 | ||||||
| 2013-10-02 | 2013-09-30 | 4 | SVLSF IV, LLC | OPHT | Series B Preferred Stock | D | -1,036,944 | 0 | ||||||
| 2013-10-02 | 2013-09-30 | 4 | SVLSF IV, LLC | OPHT | Warrant to Purchase Shares (Series A Preferred Stock) | D | 0.06 | -11,536 | 0 | |||||
| 2013-10-02 | 2013-09-30 | 4 | SVLSF IV, LLC | OPHT | Series A Preferred Stock | D | -3,559,398 | 0 | ||||||
| 2013-10-02 | 2013-09-30 | 4 | SVLSF IV, LLC | OPHT | Common Stock | D | 159,657 | 159,657 | ||||||
| 2013-10-02 | 2013-09-30 | 4 | SVLSF IV, LLC | OPHT | Common Stock | D | 5,623,587 | 5,623,587 | ||||||
| 2013-10-02 | 2013-09-30 | 4 | SVLSF IV, LLC | OPHT | Common Stock | I | 5,783,244 | 5,783,244 | ||||||
| 2013-10-02 | 2013-09-30 | 4 | SVLSF IV, LLC | OPHT | Common Stock | I | 5,783,244 | 5,783,244 | ||||||
| 2013-10-02 | 2013-09-30 | 4 | Clarus Lifesciences II, L.P. | OPHT | Series C Preferred Stock | D | -186,027 | 0 | ||||||
| 2013-10-02 | 2013-09-30 | 4 | Clarus Lifesciences II, L.P. | OPHT | Series B Preferred Stock | D | -2,542,373 | 0 | ||||||
| 2013-10-02 | 2013-09-30 | 4 | Clarus Lifesciences II, L.P. | OPHT | Common Stock | D | 186,027 | 2,728,390 | ||||||
| 2013-10-02 | 2013-09-30 | 4 | Clarus Lifesciences II, L.P. | OPHT | Common Stock | D | 2,542,373 | 2,542,373 | ||||||
| 2013-09-24 | 3 | PATEL SAMIR CHANDRAKANT | OPHT | Common Stock | D | 152,543 | ||||||||
| 2013-09-24 | 3 | GUYER DAVID R | OPHT | Common Stock | D | 46,610 |
P
非衍生或衍生證券的公開市場或私下買入
S
非衍生或衍生證券的公開市場或私下賣出
A
公司向內部人員授予、獎勵或以其他方式獲取證券（例如股票期權）
C
衍生工具轉換
D
將證券賣出或轉讓回公司
F
使用從公司收到的證券的一部分來支付行使價或稅務負擔。
G
內部人士贈送或接收他人贈送公司股票
K
股權掉期和類似的避險交易
M
行使或轉換從公司獲得的衍生證券（例如期權）
V
內部人士透過Form 4自願報告的一筆交易
J
其他（附有交易描述的腳註）
