O'neil Patrick R. - Insider Trading Tracker

伊奧尼斯製藥公司

US ˙ NasdaqGS ˙ US4622221004

簡介

本頁面提供了有關 O'neil Patrick R. 已知的內部交易歷史的全面分析。內部人士包括公司的高管、董事或重要投資者。一般而言，基於內幕、非公開信息進行交易是非法的。這並不意味著他們在自己的公司進行任何交易都是非法的。但是，他們必須透過Form 4向美國證券交易委員會（SEC）報告所有交易。盡管存在這些限制，學術研究表明，內部人士 - 整體而言 - 在自己公司中的投資表現往往優於市場。

平均交易盈利能力

「平均交易盈利能力」衡量了內部人士在過去三年中所有非計劃性的公開市場購買交易的平均回報率。計算過程包括檢查每筆交易，排除了作為10b5-1交易計劃的一部分的交易。然後，對每筆交易在3、6和12個月的表現進行平均，以生成該筆交易最終的表現指標。最終，將所有交易的表現指標進行平均，計算出內部人士的總體平均表現指標。列表僅包含在過去兩年中進行過至少三筆交易的內部人士。

如果內部人士的交易盈利能力顯示為"N/A"，則可能是因為該內部人士在過去三年內沒有進行任何公開市場購買交易，或者他們進行的交易距離現在太近，無法計算出可靠的表現指標。

更新頻率：每日

查看收益最高的的內幕交易者列表。

查看排名最高的內部人士。

報告內部持倉的公司

SEC文件顯示O'neil Patrick R.已報告在以下公司擁有持倉或進行了交易：

證券	職位	最新報告的持倉
US:IONS / Ionis Pharmaceuticals, Inc.	EVP CLO & General Counsel	62,211

如何解讀這些圖表

以下圖表顯示了在O'neil Patrick R.進行的每筆公開市場非計劃交易後證券的股價表現。非計劃交易是指沒有作為10b5-1交易計劃的一部分而進行的交易。股價表現以累積百分比變化的方式繪製。例如，如果一筆內部人士交易是在2019年1月1日進行的，該圖表將顯示該證券的每日百分比變化直至當前日期。如果在此期間股價從10美元漲至15美元，則股價的累積百分比變化將為50%。從10美元漲至20美元的價格變化將為100%，而從10美元跌至5美元的價格變化將為-50%。

最終，我們將評估內部人士的交易與股價的超額回報（正向或負向）之間的相關性，以判斷內部人士是否在交易中利用內部信息獲利。如果內部人士有這樣的行為，我們預期看到（a）購買後的正回報，或者（b）賣出後的負回報。對於情況（a），購買圖表將顯示一系列向上傾斜的曲線，表示每次購買後都有正回報。對於情況（b），賣出圖表將顯示一系列向下傾斜的曲線，表示每次賣出後都有負回報。

然而，僅憑這一點還不足以得出結論。例如，如果公司的股價在多年內呈現非周期性上升，我們會預期所有購買後的圖表都呈現向上傾斜。同樣地，多年來呈現非周期性下降的股價會導致賣出後的圖表也呈現向下傾斜。這兩種情況的圖表都不能表示內部人士在進行內幕交易。

最有力的指標是在公司股價呈極度循環波動的情況下，「購買」圖表顯示正向信號，而「賣出」圖表顯示負向趨勢。這種情況強烈暗示內部人士可能根據內幕信息精確地計時進行交易，以獲得財務優勢。

IONS / Ionis Pharmaceuticals, Inc.內部人士買入 - 短期收益分析

在這一部分，我們分析了在 IONS / Ionis Pharmaceuticals, Inc. 中進行的每筆非計劃的公開市場內部人士購買的盈利情況。這種分析有助於了解內部人士是否持續產生異常的回報，以及是否值得跟踪。該分析基於每筆交易後一年的情況，結果僅為理論值。

以下表格顯示了最近的自動交易計劃之外的公開市場購買。

交易日期	證券代碼	內部人士	報告股數	Reported 價格	經調整股數	經調整價格	成本基礎	達到最高利潤的天數	達到最高利潤時的價格	最高淨利 ($)	最高回報率（%）
當前未知該內部人士及證券組合進行過任何未預先計劃的公開市場交易。

經調整價格 已按拆股調整。經調整股數 已按拆股調整。

IONS / Ionis Pharmaceuticals, Inc. Insider Trades

IONS / Ionis Pharmaceuticals, Inc.內部人士賣出 - 短期虧損分析

在這一部分，我們分析了在 IONS / Ionis Pharmaceuticals, Inc. 中進行的每筆非計劃的公開市場內部人士賣出所達成的短期虧損規避。如果存在持續的虧損規避模式，可能表明未來的內部人士賣出交易預示著價格的下跌。該分析基於每筆交易後一年的情況，

以下表格顯示了最近的自動交易計劃之外的公開市場購買。

交易日期	證券代碼	內部人士	報告股數	Reported 價格	經調整股數	經調整價格	成本基礎	達到最低利潤的天數	達到最低利潤時的價格	避免的最高損失金額($)	避免的最高損失率($)
2026-01-30	IONS	O'NEIL PATRICK R.	6,179	83.5335	6,179	83.5335	516,153	53	69.6800	-85,600	-16.58
2026-01-16	IONS	O'NEIL PATRICK R.	9,191	75.8400	9,191	75.8400	697,045
2025-01-31	IONS	O'NEIL PATRICK R.	1,406	32.4926	1,406	32.4926	45,685
2025-01-16	IONS	O'NEIL PATRICK R.	7,360	32.8300	7,360	32.8300	241,629
2024-02-02	IONS	O'NEIL PATRICK R.	1,961	49.6738	1,961	49.6738	97,410
2024-02-02	IONS	O'NEIL PATRICK R.	1,995	49.6738	1,995	49.6738	99,099
2024-01-25	IONS	O'NEIL PATRICK R.	6,450	51.7500	6,450	51.7500	333,788
2024-01-17	IONS	O'NEIL PATRICK R.	7,744	50.4170	7,744	50.4170	390,429
2023-12-26	IONS	O'NEIL PATRICK R.	20,825	51.4630	20,825	51.4630	1,071,717
2023-02-06	IONS	O'NEIL PATRICK R.	1,920	40.8648	1,920	40.8648	78,460
2023-01-18	IONS	O'NEIL PATRICK R.	7,836	39.4946	7,836	39.4946	309,480
2019-04-04	IONS	O'NEIL PATRICK R.	1,122	82.0100	1,122	82.0100	92,015
2019-04-04	IONS	O'NEIL PATRICK R.	1,878	84.2500	1,878	84.2500	158,222
2018-01-16	IONS	O'NEIL PATRICK R.	2,697	51.7600	2,697	51.7600	139,597
2017-01-17	IONS	O'NEIL PATRICK R.	122	46.2930	122	46.2930	5,648
2017-01-17	IONS	O'NEIL PATRICK R.	256	46.2900	256	46.2900	11,850
2017-01-17	IONS	O'NEIL PATRICK R.	733	46.2900	733	46.2900	33,931
2017-01-17	IONS	O'NEIL PATRICK R.	512	46.2910	512	46.2910	23,701
2017-01-17	IONS	O'NEIL PATRICK R.	623	46.2900	623	46.2900	28,839
2016-01-19	IONS	O'NEIL PATRICK R.	216	41.4563	216	41.4563	8,955
2016-01-19	IONS	O'NEIL PATRICK R.	125	41.4589	125	41.4589	5,182
2016-01-19	IONS	O'NEIL PATRICK R.	261	41.4592	261	41.4592	10,821
2016-01-19	IONS	O'NEIL PATRICK R.	747	41.4653	747	41.4653	30,975
2016-01-19	IONS	O'NEIL PATRICK R.	522	41.4588	522	41.4588	21,641
2015-01-16	ISIS	O'NEIL PATRICK R.	207	67.9640	207	67.9640	14,069
2015-01-16	ISIS	O'NEIL PATRICK R.	120	67.9640	120	67.9640	8,156
2015-01-16	ISIS	O'NEIL PATRICK R.	250	67.9640	250	67.9640	16,991
2015-01-16	ISIS	O'NEIL PATRICK R.	714	67.9640	714	67.9640	48,526
2014-11-03	ISIS	O'NEIL PATRICK R.	1,500	46.1700	1,500	46.1700	69,255
2014-01-16	ISIS	O'NEIL PATRICK R.	250	47.0812	250	47.0812	11,770
2014-01-16	ISIS	O'NEIL PATRICK R.	207	47.0810	207	47.0810	9,746
2014-01-16	ISIS	O'NEIL PATRICK R.	120	47.0812	120	47.0812	5,650
2013-01-17	ISIS	O'NEIL PATRICK R.	242	14.1600	242	14.1600	3,427

經調整價格 已按拆股調整。經調整股數 已按拆股調整。

歷史內部人交易

該表格顯示了由 O'neil Patrick R. 進行的所有內幕交易的完整列表，這些交易已向美國證券交易委員會（SEC）披露。

呈報日期	交易日期	表格	證券代碼	證券	代碼	10b5-1	股份	剩餘股份	% 變化	每股股價	交易金額	剩餘金額
2026-03-11	2026-03-09	4	IONS	IONIS PHARMACEUTICALS INC Common Stock	S - Sale	X	-10,148	62,211	-14.02	75.25	-763,662	4,681,533
2026-03-03	2026-02-27	4	IONS	IONIS PHARMACEUTICALS INC Common Stock	J - Other		376	72,359	0.52	48.87	18,374	3,535,931
2026-02-02	2026-01-30	4	IONS	IONIS PHARMACEUTICALS INC Common Stock	S - Sale		-6,179	71,983	-7.91	83.53	-516,153	6,012,992
2026-02-02	2026-01-29	4	IONS	IONIS PHARMACEUTICALS INC Common Stock	A - Award		11,991	78,162	18.12
2026-01-20	2026-01-16	4	IONS	IONIS PHARMACEUTICALS INC Common Stock	S - Sale		-9,191	66,171	-12.20	75.84	-697,045	5,018,409
2026-01-20	2026-01-15	4	IONS	IONIS PHARMACEUTICALS INC Common Stock	M - Exercise		21,473	75,362	39.85
2025-10-08	2025-10-06	4	IONS	IONIS PHARMACEUTICALS INC Common Stock	S - Sale	X	-3,241	53,889	-5.67	69.27	-224,488	3,732,627
2025-10-08	2025-10-06	4	IONS	IONIS PHARMACEUTICALS INC Common Stock	S - Sale	X	-10,200	57,130	-15.15	69.89	-712,849	3,992,656
2025-10-08	2025-10-06	4	IONS	IONIS PHARMACEUTICALS INC Common Stock	M - Exercise		10,200	67,330	17.85	52.87	539,274	3,559,737
2025-10-02	2025-10-02	4	IONS	IONIS PHARMACEUTICALS INC Common Stock	S - Sale	X	-34,461	57,130	-37.62	67.69	-2,332,638	3,867,084
2025-10-02	2025-10-02	4	IONS	IONIS PHARMACEUTICALS INC Common Stock	M - Exercise		34,461	91,591	60.32	60.89	2,098,330	5,576,976
2025-10-02	2025-10-02	4	IONS	IONIS PHARMACEUTICALS INC Common Stock	S - Sale	X	-30,203	57,130	-34.58	67.69	-2,044,417	3,867,084
2025-10-02	2025-10-02	4	IONS	IONIS PHARMACEUTICALS INC Common Stock	M - Exercise		30,203	87,333	52.87	56.78	1,714,926	4,958,768
2025-10-01	2025-09-30	4	IONS	IONIS PHARMACEUTICALS INC Common Stock	S - Sale	X	-14,827	57,130	-20.61	64.68	-958,976	3,695,037
2025-10-01	2025-09-30	4	IONS	IONIS PHARMACEUTICALS INC Common Stock	M - Exercise		14,827	71,957	25.95	56.78	841,877	4,085,718
2025-10-01	2025-09-29	4	IONS	IONIS PHARMACEUTICALS INC Common Stock	S - Sale	X	-10,473	57,130	-15.49	64.54	-675,945	3,687,267
2025-10-01	2025-09-29	4	IONS	IONIS PHARMACEUTICALS INC Common Stock	M - Exercise		10,473	67,603	18.33	56.78	594,657	3,838,498
2025-09-16	2025-09-12	4	IONS	IONIS PHARMACEUTICALS INC Common Stock	S - Sale	X	-1,700	57,130	-2.89	64.58	-109,787	3,689,495
2025-09-16	2025-09-12	4	IONS	IONIS PHARMACEUTICALS INC Common Stock	M - Exercise		1,700	58,830	2.98	56.78	96,526	3,340,367
2025-09-11	2025-09-09	4	IONS	IONIS PHARMACEUTICALS INC Common Stock	S - Sale	X	-1,000	57,130	-1.72	64.56	-64,555	3,688,044
2025-09-11	2025-09-09	4	IONS	IONIS PHARMACEUTICALS INC Common Stock	M - Exercise		1,000	58,130	1.75	56.78	56,780	3,300,621
2025-09-11	2025-09-09	4	IONS	IONIS PHARMACEUTICALS INC Common Stock	S - Sale	X	-20,000	57,130	-25.93	64.56	-1,291,106	3,688,044
2025-09-11	2025-09-09	4	IONS	IONIS PHARMACEUTICALS INC Common Stock	M - Exercise		20,000	77,130	35.01	60.89	1,217,800	4,696,446
2025-09-04	2025-09-03	4	IONS	IONIS PHARMACEUTICALS INC Common Stock	M - Exercise		49,800	57,130	679.40	53.77	2,677,746	3,071,880
2025-09-04	2025-09-03	4	IONS	IONIS PHARMACEUTICALS INC Common Stock	S - Sale	X	-11,375	7,330	-60.81	61.42	-698,652	450,209
2025-09-04	2025-09-03	4	IONS	IONIS PHARMACEUTICALS INC Common Stock	M - Exercise		13,050	18,705	230.77	32.60	425,430	609,783
2025-09-04	2025-09-03	4	IONS	IONIS PHARMACEUTICALS INC Common Stock	S - Sale	X	-65,475	5,655	-92.05	60.89	-3,986,773	344,333
2025-09-04	2025-09-03	4	IONS	IONIS PHARMACEUTICALS INC Common Stock	M - Exercise		14,000	71,130	24.51	37.58	526,120	2,673,065
2025-09-04	2025-09-02	4	IONS	IONIS PHARMACEUTICALS INC Common Stock	S - Sale	X	-13,050	57,130	-18.60	54.51	-711,418	3,114,431
2025-09-04	2025-09-02	4	IONS	IONIS PHARMACEUTICALS INC Common Stock	M - Exercise		13,050	70,180	22.84	32.60	425,430	2,287,868
2025-09-03	2025-08-29	4	IONS	IONIS PHARMACEUTICALS INC Common Stock	J - Other		331	57,130	0.58	27.71	9,172	1,583,072
2025-03-04	2025-02-28	4	IONS	IONIS PHARMACEUTICALS INC Common Stock	J - Other		554	56,799	0.98	28.21	15,629	1,602,385
2025-02-24	2025-02-20	4	IONS	IONIS PHARMACEUTICALS INC Common Stock	S - Sale	X	-1,207	56,245	-2.10	32.35	-39,046	1,819,526
2025-02-06	2025-02-04	4	IONS	IONIS PHARMACEUTICALS INC Common Stock	S - Sale	X	-6,165	57,452	-9.69	31.62	-194,939	1,816,649
2025-02-03	2025-01-31	4	IONS	IONIS PHARMACEUTICALS INC Common Stock	S - Sale		-1,406	63,617	-2.16	32.49	-45,685	2,067,082
2025-02-03	2025-01-30	4	IONS	IONIS PHARMACEUTICALS INC Common Stock	A - Award		3,820	65,023	6.24
2025-01-17	2025-01-16	4	IONS	IONIS PHARMACEUTICALS INC Common Stock	S - Sale		-7,360	61,203	-10.73	32.83	-241,629	2,009,294
2025-01-17	2025-01-15	4	IONS	IONIS PHARMACEUTICALS INC Common Stock	M - Exercise		19,690	68,563	40.29
2024-09-04	2024-02-02	4/A	IONS	IONIS PHARMACEUTICALS INC Common Stock	S - Sale		-1,995	48,627	-3.94	49.67	-99,099	2,415,488
2024-09-04	2024-08-30	4	IONS	IONIS PHARMACEUTICALS INC Common Stock	J - Other		246	48,873	0.51	38.64	9,506	1,888,502
2024-02-02	2024-02-02	4	IONS	IONIS PHARMACEUTICALS INC Common Stock	S - Sale		-1,961	48,661	-3.87	49.67	-97,410	2,417,177
2024-02-02	2024-02-01	4	IONS	IONIS PHARMACEUTICALS INC Common Stock	A - Award		3,820	50,622	8.16
2024-01-29	2024-01-25	4	IONS	IONIS PHARMACEUTICALS INC Common Stock	S - Sale		-6,450	46,802	-12.11	51.75	-333,788	2,422,004
2024-01-18	2024-01-17	4	IONS	IONIS PHARMACEUTICALS INC Common Stock	S - Sale		-7,744	53,252	-12.70	50.42	-390,429	2,684,806
2024-01-18	2024-01-16	4	IONS	IONIS PHARMACEUTICALS INC Common Stock	M - Exercise		20,641	60,996	51.15
2023-12-28	2023-12-26	4	IONS	IONIS PHARMACEUTICALS INC Common Stock	S - Sale		-20,825	40,355	-34.04	51.46	-1,071,717	2,076,789
2023-12-28	2023-12-26	4	IONS	IONIS PHARMACEUTICALS INC Common Stock	M - Exercise		20,825	61,180	51.60	47.34	985,856	2,896,261
2023-05-24	2023-05-24	4	IONS	IONIS PHARMACEUTICALS INC Common Stock	S - Sale	X	-1,527	40,355	-3.65	41.70	-63,676	1,682,804
2023-03-02	2023-02-28	4	IONS	IONIS PHARMACEUTICALS INC Common Stock	J - Other		301	41,882	0.72	30.52	9,185	1,278,029
2023-02-07	2023-02-06	4	IONS	IONIS PHARMACEUTICALS INC Common Stock	S - Sale		-1,920	41,581	-4.41	40.86	-78,460	1,699,199
2023-02-07	2023-02-03	4	IONS	IONIS PHARMACEUTICALS INC Common Stock	A - Award		3,822	43,501	9.63
2023-02-02	2023-01-31	4	IONS	IONIS PHARMACEUTICALS INC Common Stock	S - Sale	X	-4,500	39,679	-10.19	39.71	-178,700	1,575,697
2023-02-02	2023-01-30	4	IONS	IONIS PHARMACEUTICALS INC Common Stock	S - Sale	X	-4,500	44,179	-9.24	39.42	-177,372	1,741,359
2023-01-19	2023-01-18	4	IONS	IONIS PHARMACEUTICALS INC Common Stock	S - Sale		-7,836	48,679	-13.87	39.49	-309,480	1,922,558
2023-01-19	2023-01-17	4	IONS	IONIS PHARMACEUTICALS INC Common Stock	M - Exercise		21,871	56,515	63.13
2022-09-01	2022-08-31	4	IONS	IONIS PHARMACEUTICALS INC Common Stock	J - Other		108	34,644	0.31	28.97	3,129	1,003,567
2022-04-14	2022-04-12	4	IONS	IONIS PHARMACEUTICALS INC Common Stock	S - Sale	X	-6,792	34,536	-16.43	40.06	-272,057	1,383,357
2022-03-02	2022-02-28	4	IONS	IONIS PHARMACEUTICALS INC Common Stock	J - Other		735	41,328	1.81	28.37	20,854	1,172,599
2022-01-20	2022-01-18	4	IONS	IONIS PHARMACEUTICALS INC Restricted Stock Unit	M - Exercise		-21,086	52,319	-28.73
2022-01-20	2022-01-18	4	IONS	IONIS PHARMACEUTICALS INC Common Stock	F - Taxes		-7,501	40,593	-15.60	30.12	-225,930	1,222,661
2022-01-20	2022-01-18	4	IONS	IONIS PHARMACEUTICALS INC Common Stock	M - Exercise		21,086	48,094	78.07
2022-01-19	2022-01-15	4	IONS	IONIS PHARMACEUTICALS INC Restricted Stock Unit	A - Award		15,284	73,405	26.30
2022-01-19	2022-01-15	4	IONS	IONIS PHARMACEUTICALS INC Performance Restricted Stock Units	A - Award		11,463	11,463
2022-01-05	2022-01-03	4	IONS	IONIS PHARMACEUTICALS INC Non-Qualified Stock Option (right to buy)	A - Award		30,567	30,567
2021-09-02	2021-08-31	4	IONS	IONIS PHARMACEUTICALS INC Common Stock	J - Other		309	27,008	1.16	33.80	10,443	912,762
2021-03-02	2021-02-26	4	IONS	IONIS PHARMACEUTICALS INC Common Stock	J - Other		197	26,699	0.74	44.54	8,774	1,189,173
2021-01-27	2021-01-25	4	IONS	IONIS PHARMACEUTICALS INC Common Stock	S - Sale	X	-5,324	26,502	-16.73	63.50	-338,074	1,682,877
2021-01-20	2021-01-15	4	IONS	IONIS PHARMACEUTICALS INC Restricted Stock Units	M - Exercise		-16,504	32,253	-33.85
2021-01-20	2021-01-15	4	IONS	IONIS PHARMACEUTICALS INC Restricted Stock Units	A - Award		25,868	25,868
2021-01-20	2021-01-15	4	IONS	IONIS PHARMACEUTICALS INC Common Stock	F - Taxes		-5,856	31,826	-15.54	61.28	-358,856	1,950,297
2021-01-20	2021-01-15	4	IONS	IONIS PHARMACEUTICALS INC Common Stock	M - Exercise		16,504	37,682	77.93
2021-01-06	2021-01-04	4	IONS	IONIS PHARMACEUTICALS INC Employee Stock Option (right to buy)	A - Award		58,203	58,203
2020-09-02	2020-08-31	4	IONS	IONIS PHARMACEUTICALS INC Common Stock	J - Other		169	21,178	0.80	44.46	7,513	941,468
2020-03-03	2020-02-29	4	IONS	IONIS PHARMACEUTICALS INC Common Stock	J - Other		289	21,009	1.39	43.16	12,474	906,811
2020-02-11	2020-02-10	4	IONS	IONIS PHARMACEUTICALS INC Common Stock	S - Sale	X	-3,882	20,720	-15.78	59.60	-231,367	1,234,912
2020-01-17	2020-01-15	4	IONS	IONIS PHARMACEUTICALS INC Restricted Stock Units	M - Exercise		-12,045	24,552	-32.91
2020-01-17	2020-01-15	4	IONS	IONIS PHARMACEUTICALS INC Restricted Stock Units	A - Award		24,205	24,205
2020-01-17	2020-01-15	4	IONS	IONIS PHARMACEUTICALS INC Common Stock	F - Taxes		-4,277	24,602	-14.81	62.06	-265,431	1,526,800
2020-01-17	2020-01-15	4	IONS	IONIS PHARMACEUTICALS INC Common Stock	M - Exercise		12,045	28,879	71.55
2020-01-03	2020-01-02	4	IONS	IONIS PHARMACEUTICALS INC Employee Stock Option (Right to Buy)	A - Award		54,461	54,461
2019-07-02	2019-07-01	4	IONS	IONIS PHARMACEUTICALS INC Common Stock	J - Other		161	16,834	0.97	45.70	7,358	769,390
2019-04-05	2019-04-05	4	IONS	IONIS PHARMACEUTICALS INC Employee Stock Option (right to buy)	M - Exercise		2,252	7,969	39.39
2019-04-05	2019-04-05	4	IONS	IONIS PHARMACEUTICALS INC Common Stock	S - Sale	X	-2,252	16,673	-11.90	84.75	-190,857	1,413,037
2019-04-05	2019-04-05	4	IONS	IONIS PHARMACEUTICALS INC Common Stock	M - Exercise	X	2,252	18,925	13.51	61.68	138,903	1,167,294
2019-04-05	2019-04-04	4	IONS	IONIS PHARMACEUTICALS INC Employee Stock Option (right to buy)	M - Exercise		8,000	46,638	20.71
2019-04-05	2019-04-04	4	IONS	IONIS PHARMACEUTICALS INC Employee Stock Option (right to buy)	M - Exercise		5,600	20,825	36.78
2019-04-05	2019-04-04	4	IONS	IONIS PHARMACEUTICALS INC Employee Stock Option (right to buy)	M - Exercise		2,657	0	-100.00
2019-04-05	2019-04-04	4	IONS	IONIS PHARMACEUTICALS INC Employee Stock Option (right to buy)	M - Exercise		20,365	10,221	-200.76
2019-04-05	2019-04-04	4	IONS	IONIS PHARMACEUTICALS INC Common Stock	S - Sale		-1,878	16,673	-10.12	84.25	-158,222	1,404,700
2019-04-05	2019-04-04	4	IONS	IONIS PHARMACEUTICALS INC Common Stock	S - Sale		-1,122	18,551	-5.70	82.01	-92,015	1,521,368
2019-04-05	2019-04-04	4	IONS	IONIS PHARMACEUTICALS INC Common Stock	S - Sale	X	-8,000	19,673	-28.91	84.29	-674,320	1,658,237
2019-04-05	2019-04-04	4	IONS	IONIS PHARMACEUTICALS INC Common Stock	M - Exercise	X	8,000	27,673	40.66	49.25	394,000	1,362,895
2019-04-05	2019-04-04	4	IONS	IONIS PHARMACEUTICALS INC Common Stock	S - Sale	X	-3,600	19,673	-15.47	82.10	-295,560	1,615,153
2019-04-05	2019-04-04	4	IONS	IONIS PHARMACEUTICALS INC Common Stock	M - Exercise	X	3,600	23,273	18.30	47.34	170,424	1,101,744
2019-04-05	2019-04-04	4	IONS	IONIS PHARMACEUTICALS INC Common Stock	S - Sale	X	-2,000	19,673	-9.23	84.20	-168,400	1,656,467
2019-04-05	2019-04-04	4	IONS	IONIS PHARMACEUTICALS INC Common Stock	M - Exercise	X	2,000	21,673	10.17	47.34	94,680	1,026,000
2019-04-05	2019-04-04	4	IONS	IONIS PHARMACEUTICALS INC Common Stock	S - Sale	X	-2,657	19,673	-11.90	82.03	-217,954	1,613,776
2019-04-05	2019-04-04	4	IONS	IONIS PHARMACEUTICALS INC Common Stock	M - Exercise	X	2,657	22,330	13.51	61.57	163,591	1,374,858
2019-04-05	2019-04-04	4	IONS	IONIS PHARMACEUTICALS INC Common Stock	S - Sale	X	-4,873	19,673	-19.85	82.19	-400,512	1,616,924
2019-04-05	2019-04-04	4	IONS	IONIS PHARMACEUTICALS INC Common Stock	M - Exercise	X	4,873	24,546	24.77	61.68	300,567	1,513,997
2019-04-05	2019-04-04	4	IONS	IONIS PHARMACEUTICALS INC Common Stock	S - Sale	X	-15,492	19,673	-44.06	84.75	-1,312,947	1,667,287
2019-04-05	2019-04-04	4	IONS	IONIS PHARMACEUTICALS INC Common Stock	M - Exercise	X	15,492	35,165	78.75	61.68	955,547	2,168,977
2019-04-05	2019-04-03	4	IONS	IONIS PHARMACEUTICALS INC Employee Stock Option (right to buy)	M - Exercise		7,654	30,586	33.38
2019-04-05	2019-04-03	4	IONS	IONIS PHARMACEUTICALS INC Common Stock	S - Sale	X	-7,654	19,673	-28.01	84.83	-649,289	1,668,861
2019-04-05	2019-04-03	4	IONS	IONIS PHARMACEUTICALS INC Common Stock	M - Exercise	X	7,654	27,327	38.91	61.68	472,099	1,685,529
2019-03-20	2019-03-18	4	IONS	IONIS PHARMACEUTICALS INC Employee Stock Option (right to buy)	M - Exercise		28,800	2,657	-110.16
2019-03-20	2019-03-18	4	IONS	IONIS PHARMACEUTICALS INC Common Stock	S - Sale	X	-28,800	19,673	-59.41	78.79	-2,269,187	1,550,059
2019-03-20	2019-03-18	4	IONS	IONIS PHARMACEUTICALS INC Common Stock	M - Exercise	X	28,800	48,473	146.39	61.57	1,773,216	2,984,483
2019-03-01	2019-02-27	4	IONS	IONIS PHARMACEUTICALS INC Employee Stock Option (right to buy)	M - Exercise		8,000	0	-100.00
2019-03-01	2019-02-27	4	IONS	IONIS PHARMACEUTICALS INC Employee Stock Option (right to buy)	M - Exercise		18,800	4,755	-133.86
2019-03-01	2019-02-27	4	IONS	IONIS PHARMACEUTICALS INC Common Stock	S - Sale	X	-8,000	19,673	-28.91	68.75	-550,000	1,352,519
2019-03-01	2019-02-27	4	IONS	IONIS PHARMACEUTICALS INC Common Stock	M - Exercise	X	8,000	27,673	40.66	39.87	318,960	1,103,323
2019-03-01	2019-02-27	4	IONS	IONIS PHARMACEUTICALS INC Common Stock	S - Sale	X	-14,100	19,673	-41.75	68.75	-969,375	1,352,519
2019-03-01	2019-02-27	4	IONS	IONIS PHARMACEUTICALS INC Common Stock	M - Exercise	X	14,100	33,773	71.67	47.34	667,494	1,598,814
2019-03-01	2019-02-27	4	IONS	IONIS PHARMACEUTICALS INC Common Stock	S - Sale	X	-4,700	19,673	-19.28	64.51	-303,205	1,269,137
2019-03-01	2019-02-27	4	IONS	IONIS PHARMACEUTICALS INC Common Stock	M - Exercise	X	4,700	24,373	23.89	47.34	222,498	1,153,818
2019-02-14	2019-02-12	4	IONS	IONIS PHARMACEUTICALS INC Employee Stock Option (right to buy)	M - Exercise		275	8,000	3.56
2019-02-14	2019-02-12	4	IONS	IONIS PHARMACEUTICALS INC Common Stock	S - Sale	X	-275	19,673	-1.38	59.50	-16,362	1,170,544
2019-02-14	2019-02-12	4	IONS	IONIS PHARMACEUTICALS INC Common Stock	M - Exercise	X	275	19,948	1.40	39.87	10,964	795,327
2019-02-05	2019-02-05	4	IONS	IONIS PHARMACEUTICALS INC Employee Stock Option (right to buy)	M - Exercise		15,600	8,275	-212.97
2019-02-05	2019-02-05	4	IONS	IONIS PHARMACEUTICALS INC Common Stock	S - Sale	X	-15,600	19,673	-44.23	59.50	-928,200	1,170,544
2019-02-05	2019-02-05	4	IONS	IONIS PHARMACEUTICALS INC Common Stock	M - Exercise	X	15,600	35,273	79.30	39.87	621,972	1,406,335
2019-02-05	2019-02-01	4	IONS	IONIS PHARMACEUTICALS INC Employee Stock Option (right to buy)	M - Exercise		4,000	23,875	20.13
2019-02-05	2019-02-01	4	IONS	IONIS PHARMACEUTICALS INC Common Stock	S - Sale	X	-4,000	19,673	-16.90	58.29	-233,160	1,146,739
2019-02-05	2019-02-01	4	IONS	IONIS PHARMACEUTICALS INC Common Stock	M - Exercise	X	4,000	23,673	20.33	39.87	159,480	943,843
2019-01-17	2019-01-15	4	IONS	IONIS PHARMACEUTICALS INC Restricted Stock Units	M - Exercise		-7,823	14,466	-35.10
2019-01-17	2019-01-15	4	IONS	IONIS PHARMACEUTICALS INC Restricted Stock Units	A - Award		22,131	22,131
2019-01-17	2019-01-15	4	IONS	IONIS PHARMACEUTICALS INC Common Stock	F - Taxes		-2,734	19,607	-12.24	58.26	-159,283	1,142,304
2019-01-17	2019-01-15	4	IONS	IONIS PHARMACEUTICALS INC Common Stock	M - Exercise		7,823	22,341	53.88
2019-01-03	2019-01-03	4	IONS	IONIS PHARMACEUTICALS INC Employee Stock Option (right to buy)	M - Exercise		-4,000	27,875	-12.55
2019-01-03	2019-01-03	4	IONS	IONIS PHARMACEUTICALS INC Empoyee Stock Option (right to buy)	M - Exercise		-400	0	-100.00
2019-01-03	2019-01-03	4	IONS	IONIS PHARMACEUTICALS INC Common Stock	S - Sale	X	-4,000	14,584	-21.52	54.80	-219,200	799,203
2019-01-03	2019-01-03	4	IONS	IONIS PHARMACEUTICALS INC Common Stock	M - Exercise	X	4,000	18,584	27.43	39.87	159,480	740,944
2019-01-03	2019-01-03	4	IONS	IONIS PHARMACEUTICALS INC Common Stock	S - Sale	X	-400	14,584	-2.67	54.80	-21,920	799,203
2019-01-03	2019-01-03	4	IONS	IONIS PHARMACEUTICALS INC Common Stock	M - Exercise	X	400	14,984	2.74	10.82	4,328	162,127
2019-01-03	2019-01-02	4	IONS	IONIS PHARMACEUTICALS INC Employee Stock Option (right to buy)	A - Award		49,800	49,800
2019-01-03	2019-01-01	4	IONS	IONIS PHARMACEUTICALS INC Common Stock	J - Other		66	14,584	0.45	36.45	2,406	531,558
2018-07-03	2018-07-01	4	IONS	IONIS PHARMACEUTICALS INC Common Stock	J - Other		66	14,518	0.46	35.42	2,338	514,220
2018-03-13	2018-03-12	4	IONS	IONIS PHARMACEUTICALS INC Employee Stock Option (right to buy)	M - Exercise		-1,000	400	-71.43
2018-03-13	2018-03-12	4	IONS	IONIS PHARMACEUTICALS INC Common Stock	S - Sale	X	-1,000	14,452	-6.47	55.00	-55,000	794,860
2018-03-13	2018-03-12	4	IONS	IONIS PHARMACEUTICALS INC Common Stock	M - Exercise	X	1,000	15,452	6.92	10.82	10,820	167,191
2018-01-31	2018-01-29	4	IONS	IONIS PHARMACEUTICALS INC Employee Stock Option (right to buy)	M - Exercise		-300	1,400	-17.65
2018-01-31	2018-01-29	4	IONS	IONIS PHARMACEUTICALS INC Employee Stock Option (right to buy)	M - Exercise		-55	0	-100.00
2018-01-31	2018-01-29	4	IONS	IONIS PHARMACEUTICALS INC Common Stock	S - Sale	X	-300	14,452	-2.03	55.00	-16,500	794,860
2018-01-31	2018-01-29	4	IONS	IONIS PHARMACEUTICALS INC Common Stock	M - Exercise	X	300	14,752	2.08	10.82	3,246	159,617
2018-01-31	2018-01-29	4	IONS	IONIS PHARMACEUTICALS INC Common Stock	S - Sale	X	-55	14,452	-0.38	55.00	-3,025	794,860
2018-01-31	2018-01-29	4	IONS	IONIS PHARMACEUTICALS INC Common Stock	M - Exercise	X	55	14,507	0.38	10.82	595	156,966
2018-01-29	2018-01-25	4	IONS	IONIS PHARMACEUTICALS INC Employee Stock Option (right to buy)	M - Exercise		-645	55	-92.14
2018-01-29	2018-01-25	4	IONS	IONIS PHARMACEUTICALS INC Common Stock	S - Sale	X	-645	14,452	-4.27	55.00	-35,475	794,860
2018-01-29	2018-01-25	4	IONS	IONIS PHARMACEUTICALS INC Common Stock	M - Exercise	X	645	15,097	4.46	10.82	6,979	163,350
2018-01-17	2018-01-16	4	IONS	IONIS PHARMACEUTICALS INC Common Stock	S - Sale		-2,697	14,452	-15.73	51.76	-139,597	748,036
2018-01-17	2018-01-15	4	IONS	IONIS PHARMACEUTICALS INC Restricted Stock Units	M - Exercise		-6,663	10,148	-39.63
2018-01-17	2018-01-15	4	IONS	IONIS PHARMACEUTICALS INC Restricted Stock Units	A - Award		12,141	12,141
2018-01-17	2018-01-15	4	IONS	IONIS PHARMACEUTICALS INC Common Stock	M - Exercise		6,663	17,149	63.54
2018-01-02	2018-01-02	4	IONS	IONIS PHARMACEUTICALS INC Employee Stock Option (right to buy)	A - Award		54,638	54,638
2018-01-02	2018-01-01	4	IONS	IONIS PHARMACEUTICALS INC Common Stock	J - Other		53	10,486	0.51	42.76	2,266	448,329
2017-12-01	2017-12-01	4	IONS	IONIS PHARMACEUTICALS INC Employee Stock Option (right to buy)	M - Exercise		-1,000	700	-58.82
2017-12-01	2017-12-01	4	IONS	IONIS PHARMACEUTICALS INC Common Stock	S - Sale	X	-1,000	10,433	-8.75	55.50	-55,500	579,032
2017-12-01	2017-12-01	4	IONS	IONIS PHARMACEUTICALS INC Common Stock	M - Exercise	X	1,000	11,433	9.58	10.82	10,820	123,705
2017-11-03	2017-11-01	4	IONS	IONIS PHARMACEUTICALS INC Employee Stock Option (right to buy)	M - Exercise		-1,000	1,700	-37.04
2017-11-03	2017-11-01	4	IONS	IONIS PHARMACEUTICALS INC Common Stock	S - Sale	X	-1,000	10,433	-8.75	58.35	-58,350	608,766
2017-11-03	2017-11-01	4	IONS	IONIS PHARMACEUTICALS INC Common Stock	M - Exercise	X	1,000	11,433	9.58	10.82	10,820	123,705
2017-10-06	2017-10-05	4	IONS	IONIS PHARMACEUTICALS INC Employee Stock Option (right to buy)	M - Exercise		-800	2,700	-22.86
2017-10-06	2017-10-05	4	IONS	IONIS PHARMACEUTICALS INC Employee Stock Option (right to buy)	M - Exercise		-200	0	-100.00
2017-10-06	2017-10-05	4	IONS	IONIS PHARMACEUTICALS INC Common Stock	S - Sale	X	-800	10,433	-7.12	55.00	-44,000	573,815
2017-10-06	2017-10-05	4	IONS	IONIS PHARMACEUTICALS INC Common Stock	M - Exercise	X	800	11,233	7.67	10.82	8,656	121,541
2017-10-06	2017-10-05	4	IONS	IONIS PHARMACEUTICALS INC Common Stock	S - Sale	X	-200	10,433	-1.88	55.00	-11,000	573,815
2017-10-06	2017-10-05	4	IONS	IONIS PHARMACEUTICALS INC Common Stock	M - Exercise	X	200	10,633	1.92	7.25	1,450	77,089
2017-09-07	2017-09-06	4	IONS	IONIS PHARMACEUTICALS INC Employee Stock Option (right to buy)	M - Exercise		-800	200	-80.00
2017-09-07	2017-09-06	4	IONS	IONIS PHARMACEUTICALS INC Common Stock	S - Sale	X	-800	10,433	-7.12	55.00	-44,000	573,815
2017-09-07	2017-09-06	4	IONS	IONIS PHARMACEUTICALS INC Common Stock	M - Exercise	X	800	11,233	7.67	7.25	5,800	81,439
2017-09-07	2017-09-05	4	IONS	IONIS PHARMACEUTICALS INC Employee Stock Option (right to buy)	M - Exercise		-200	1,000	-16.67
2017-09-07	2017-09-05	4	IONS	IONIS PHARMACEUTICALS INC Common Stock	S - Sale	X	-200	10,433	-1.88	55.00	-11,000	573,815
2017-09-07	2017-09-05	4	IONS	IONIS PHARMACEUTICALS INC Common Stock	M - Exercise	X	200	10,633	1.92	7.25	1,450	77,089
2017-07-03	2017-07-01	4	IONS	IONIS PHARMACEUTICALS INC Common Stock	J - Other		134	10,433	1.30	40.66	5,448	424,159
2017-06-02	2017-06-01	4	IONS	IONIS PHARMACEUTICALS INC Employee Stock Option (right to buy)	M - Exercise		-70	1,700	-3.95
2017-06-02	2017-06-01	4	IONS	IONIS PHARMACEUTICALS INC Common Stock	S - Sale	X	-70	10,299	-0.68	48.00	-3,360	494,352
2017-06-02	2017-06-01	4	IONS	IONIS PHARMACEUTICALS INC Common Stock	M - Exercise	X	70	10,369	0.68	10.82	757	112,193
2017-05-03	2017-05-01	4	IONS	IONIS PHARMACEUTICALS INC Employee Stock Option (right to buy)	M - Exercise		-500	1,770	-22.03
2017-05-03	2017-05-01	4	IONS	IONIS PHARMACEUTICALS INC Common Stock	S - Sale	X	-500	10,299	-4.63	48.75	-24,375	502,076
2017-05-03	2017-05-01	4	IONS	IONIS PHARMACEUTICALS INC Common Stock	M - Exercise	X	500	10,799	4.85	10.82	5,410	116,845
2017-05-03	2017-05-01	4	IONS	IONIS PHARMACEUTICALS INC Common Stock	S - Sale	X	-150	10,299	-1.44	48.75	-7,312	502,076
2017-04-26	2017-04-24	4	IONS	IONIS PHARMACEUTICALS INC Employee Stock Option (right to buy)	M - Exercise		-426	3,500	-10.85
2017-04-26	2017-04-24	4	IONS	IONIS PHARMACEUTICALS INC Employee Stock Option (right to buy)	M - Exercise		-74	2,270	-3.16
2017-04-26	2017-04-24	4	IONS	IONIS PHARMACEUTICALS INC Common Stock	S - Sale	X	-426	10,449	-3.92	45.00	-19,170	470,205
2017-04-26	2017-04-24	4	IONS	IONIS PHARMACEUTICALS INC Common Stock	M - Exercise	X	426	10,875	4.08	10.82	4,609	117,668
2017-04-26	2017-04-24	4	IONS	IONIS PHARMACEUTICALS INC Common Stock	S - Sale	X	-74	10,449	-0.70	45.00	-3,330	470,205
2017-04-26	2017-04-24	4	IONS	IONIS PHARMACEUTICALS INC Common Stock	M - Exercise	X	74	10,523	0.71	10.82	801	113,859
2017-04-13	2017-04-12	4	IONS	IONIS PHARMACEUTICALS INC Common Stock	S - Sale	X	-1,000	10,449	-8.73	40.07	-40,070	418,691
2017-03-02	2017-03-01	4	IONS	IONIS PHARMACEUTICALS INC Employee Stock Option (right to buy)	M - Exercise		-500	3,926	-11.30
2017-03-02	2017-03-01	4	IONS	IONIS PHARMACEUTICALS INC Common Stock	S - Sale	X	-1,000	11,449	-8.03	49.29	-49,290	564,321
2017-03-02	2017-03-01	4	IONS	IONIS PHARMACEUTICALS INC Common Stock	S - Sale	X	-500	12,449	-3.86	49.29	-24,645	613,611
2017-03-02	2017-03-01	4	IONS	IONIS PHARMACEUTICALS INC Common Stock	M - Exercise	X	500	12,949	4.02	10.82	5,410	140,108
2017-02-08	2017-02-06	4	IONS	IONIS PHARMACEUTICALS INC Employee Stock Option (right to buy)	M - Exercise		-481	4,426	-9.80
2017-02-08	2017-02-06	4	IONS	IONIS PHARMACEUTICALS INC Employee Stock Option (right to buy)	M - Exercise		-19	1,200	-1.56
2017-02-08	2017-02-06	4	IONS	IONIS PHARMACEUTICALS INC Common Stock	S - Sale	X	-481	12,449	-3.72	46.50	-22,366	578,878
2017-02-08	2017-02-06	4	IONS	IONIS PHARMACEUTICALS INC Common Stock	M - Exercise	X	481	12,930	3.86	10.82	5,204	139,903
2017-02-08	2017-02-06	4	IONS	IONIS PHARMACEUTICALS INC Common Stock	S - Sale	X	-19	12,449	-0.15	46.50	-884	578,878
2017-02-08	2017-02-06	4	IONS	IONIS PHARMACEUTICALS INC Common Stock	M - Exercise	X	19	12,468	0.15	7.25	138	90,393
2017-02-08	2017-02-06	4	IONS	IONIS PHARMACEUTICALS INC Common Stock	S - Sale	X	-1,000	12,449	-7.44	46.00	-46,004	572,704
2017-01-18	2017-01-17	4	IONS	IONIS PHARMACEUTICALS INC Common Stock	S - Sale		-623	13,449	-4.43	46.29	-28,839	622,554
2017-01-18	2017-01-17	4	IONS	IONIS PHARMACEUTICALS INC Common Stock	S - Sale		-512	12,478	-3.94	46.29	-23,701	577,619
2017-01-18	2017-01-17	4	IONS	IONIS PHARMACEUTICALS INC Common Stock	S - Sale		-733	11,679	-5.91	46.29	-33,931	540,621
2017-01-18	2017-01-17	4	IONS	IONIS PHARMACEUTICALS INC Common Stock	S - Sale		-256	10,537	-2.37	46.29	-11,850	487,758
2017-01-18	2017-01-17	4	IONS	IONIS PHARMACEUTICALS INC Common Stock	S - Sale		-122	10,140	-1.19	46.29	-5,648	469,411
2017-01-18	2017-01-15	4	IONS	IONIS PHARMACEUTICALS INC Restricted Stock Units	M - Exercise		-1,594	4,779	-25.01
2017-01-18	2017-01-15	4	IONS	IONIS PHARMACEUTICALS INC Restricted Stock Units	M - Exercise		-1,311	2,620	-33.35
2017-01-18	2017-01-15	4	IONS	IONIS PHARMACEUTICALS INC Restricted Stock Units	M - Exercise		-1,875	1,875	-50.00
2017-01-18	2017-01-15	4	IONS	IONIS PHARMACEUTICALS INC Restricted Stock Units	M - Exercise		-653	0	-100.00
2017-01-18	2017-01-15	4	IONS	IONIS PHARMACEUTICALS INC Restricted Stock Units	M - Exercise		-312	0	-100.00
2017-01-18	2017-01-15	4	IONS	IONIS PHARMACEUTICALS INC Restricted Stock Units	A - Award		7,537	7,537
2017-01-18	2017-01-15	4	IONS	IONIS PHARMACEUTICALS INC Common Stock	M - Exercise		1,594	14,072	12.77
2017-01-18	2017-01-15	4	IONS	IONIS PHARMACEUTICALS INC Common Stock	M - Exercise		1,311	12,990	11.23
2017-01-18	2017-01-15	4	IONS	IONIS PHARMACEUTICALS INC Common Stock	M - Exercise		1,875	12,412	17.79
2017-01-18	2017-01-15	4	IONS	IONIS PHARMACEUTICALS INC Common Stock	M - Exercise		653	10,793	6.44
2017-01-18	2017-01-15	4	IONS	IONIS PHARMACEUTICALS INC Common Stock	M - Exercise		312	10,262	3.14
2017-01-04	2017-01-03	4	IONS	IONIS PHARMACEUTICALS INC Employee Stock Option (right to buy)	A - Award		45,225	45,225
2017-01-04	2017-01-01	4	IONS	IONIS PHARMACEUTICALS INC Common Stock	J - Other		424	9,950	4.45	20.76	8,801	206,532
2016-12-07	2016-12-05	4	IONS	IONIS PHARMACEUTICALS INC Employee Stock Option (right to buy)	M - Exercise		-350	2,344	-12.99
2016-12-07	2016-12-05	4	IONS	IONIS PHARMACEUTICALS INC Common Stock	S - Sale	X	-350	9,526	-3.54	45.00	-15,750	428,670
2016-12-07	2016-12-05	4	IONS	IONIS PHARMACEUTICALS INC Common Stock	M - Exercise	X	350	9,876	3.67	10.82	3,787	106,858
2016-11-14	2016-11-14	4	IONS	IONIS PHARMACEUTICALS INC Employee Stock Option (right to buy)	M - Exercise		-806	2,694	-23.03
2016-11-14	2016-11-14	4	IONS	IONIS PHARMACEUTICALS INC Employee Stock Option (right to buy)	M - Exercise		-194	4,907	-3.80
2016-11-14	2016-11-14	4	IONS	IONIS PHARMACEUTICALS INC Common Stock	S - Sale	X	-806	9,526	-7.80	45.00	-36,270	428,670
2016-11-14	2016-11-14	4	IONS	IONIS PHARMACEUTICALS INC Common Stock	M - Exercise	X	806	10,332	8.46	10.82	8,721	111,792
2016-11-14	2016-11-14	4	IONS	IONIS PHARMACEUTICALS INC Common Stock	S - Sale	X	-194	9,526	-2.00	45.00	-8,730	428,670
2016-11-14	2016-11-14	4	IONS	IONIS PHARMACEUTICALS INC Common Stock	M - Exercise	X	194	9,720	2.04	10.82	2,099	105,170
2016-07-01	2016-07-01	4	IONS	IONIS PHARMACEUTICALS INC Common Stock	J - Other		402	9,526	4.41	20.76	8,344	197,731
2016-04-07	2016-04-06	4	IONS	IONIS PHARMACEUTICALS INC Employee Stock Option (right to buy)	M - Exercise		-1,000	5,101	-16.39
2016-04-07	2016-04-06	4	IONS	IONIS PHARMACEUTICALS INC Common Stock	S - Sale	X	-1,000	9,124	-9.88	45.00	-45,000	410,580
2016-04-07	2016-04-06	4	IONS	IONIS PHARMACEUTICALS INC Common Stock	M - Exercise	X	1,000	10,124	10.96	10.82	10,820	109,542
2016-03-24	2016-03-23	4	IONS	IONIS PHARMACEUTICALS INC Employee Stock Option (right to buy)	M - Exercise		-1,000	6,101	-14.08
2016-03-24	2016-03-23	4	IONS	IONIS PHARMACEUTICALS INC Common Stock	S - Sale	X	-1,000	9,124	-9.88	45.40	-45,400	414,230
2016-03-24	2016-03-23	4	IONS	IONIS PHARMACEUTICALS INC Common Stock	M - Exercise	X	1,000	10,124	10.96	10.82	10,820	109,542
2016-01-19	2016-01-19	4	IONS	IONIS PHARMACEUTICALS INC Common Stock	S - Sale		-522	9,124	-5.41	41.46	-21,641	378,270
2016-01-19	2016-01-19	4	IONS	IONIS PHARMACEUTICALS INC Common Stock	S - Sale		-747	8,335	-8.23	41.47	-30,975	345,613
2016-01-19	2016-01-19	4	IONS	IONIS PHARMACEUTICALS INC Common Stock	S - Sale		-261	7,207	-3.49	41.46	-10,821	298,796
2016-01-19	2016-01-19	4	IONS	IONIS PHARMACEUTICALS INC Common Stock	S - Sale		-125	6,814	-1.80	41.46	-5,182	282,501
2016-01-19	2016-01-19	4	IONS	IONIS PHARMACEUTICALS INC Common Stock	S - Sale		-216	6,627	-3.16	41.46	-8,955	274,731
2016-01-19	2016-01-15	4	IONS	IONIS PHARMACEUTICALS INC Restricted Stock Units	M - Exercise		-1,311	3,931	-25.01
2016-01-19	2016-01-15	4	IONS	IONIS PHARMACEUTICALS INC Restricted Stock Units	M - Exercise		-1,875	3,750	-33.33
2016-01-19	2016-01-15	4	IONS	IONIS PHARMACEUTICALS INC Restricted Stock Units	M - Exercise		-654	653	-50.04
2016-01-19	2016-01-15	4	IONS	IONIS PHARMACEUTICALS INC Restricted Stock Units	M - Exercise		-312	312	-50.00
2016-01-19	2016-01-15	4	IONS	IONIS PHARMACEUTICALS INC Restricted Stock Units	M - Exercise		-541	0	-100.00
2016-01-19	2016-01-15	4	IONS	IONIS PHARMACEUTICALS INC Restricted Stock Units	A - Award		6,373	6,373
2016-01-19	2016-01-15	4	IONS	IONIS PHARMACEUTICALS INC Common Stock	M - Exercise		1,311	9,646	15.73
2016-01-19	2016-01-15	4	IONS	IONIS PHARMACEUTICALS INC Common Stock	M - Exercise		1,875	9,082	26.02
2016-01-19	2016-01-15	4	IONS	IONIS PHARMACEUTICALS INC Common Stock	M - Exercise		654	7,468	9.60
2016-01-19	2016-01-15	4	IONS	IONIS PHARMACEUTICALS INC Common Stock	M - Exercise		312	6,939	4.71
2016-01-19	2016-01-15	4	IONS	IONIS PHARMACEUTICALS INC Common Stock	M - Exercise		541	6,843	8.58
2016-01-04	2016-01-04	4	IONS	IONIS PHARMACEUTICALS INC Employee Stock Option (right to buy)	M - Exercise		-848	1,219	-41.03
2016-01-04	2016-01-04	4	IONS	IONIS PHARMACEUTICALS INC Employee Stock Option (right to buy)	M - Exercise		-152	7,101	-2.10
2016-01-04	2016-01-04	4	IONS	IONIS PHARMACEUTICALS INC Employee Stock Option (right to buy)	A - Award		38,240	38,240
2016-01-04	2016-01-04	4	IONS	IONIS PHARMACEUTICALS INC Common Stock	S - Sale	X	-848	6,302	-11.86	61.10	-51,813	385,052
2016-01-04	2016-01-04	4	IONS	IONIS PHARMACEUTICALS INC Common Stock	M - Exercise	X	848	7,150	13.46	7.25	6,148	51,838
2016-01-04	2016-01-04	4	IONS	IONIS PHARMACEUTICALS INC Common Stock	S - Sale	X	-152	6,302	-2.36	61.10	-9,287	385,052
2016-01-04	2016-01-04	4	IONS	IONIS PHARMACEUTICALS INC Common Stock	M - Exercise	X	152	6,454	2.41	10.82	1,645	69,832
2016-01-04	2016-01-01	4	IONS	IONIS PHARMACEUTICALS INC Common Stock	J - Other		43	6,302	0.69	47.71	2,052	300,672
2015-12-02	2015-12-01	4	ISIS	ISIS PHARMACEUTICALS INC Employee Stock Option (right to buy)	M - Exercise		-1,000	2,067	-32.61
2015-12-02	2015-12-01	4	ISIS	ISIS PHARMACEUTICALS INC Common Stock	S - Sale	X	-1,000	6,259	-13.78	61.50	-61,500	384,928
2015-12-02	2015-12-01	4	ISIS	ISIS PHARMACEUTICALS INC Common Stock	M - Exercise	X	1,000	7,259	15.98	7.25	7,250	52,628
2015-11-04	2015-11-03	4	ISIS	ISIS PHARMACEUTICALS INC Employee Stock Option (right to buy)	M - Exercise		-1,000	3,067	-24.59
2015-11-04	2015-11-03	4	ISIS	ISIS PHARMACEUTICALS INC Common Stock	S - Sale	X	-1,000	6,259	-13.78	51.95	-51,950	325,155
2015-11-04	2015-11-03	4	ISIS	ISIS PHARMACEUTICALS INC Common Stock	M - Exercise	X	1,000	7,259	15.98	7.25	7,250	52,628
2015-07-02	2015-07-01	4	ISIS	ISIS PHARMACEUTICALS INC Common Stock	J - Other		85	6,259	1.38	48.59	4,130	304,100
2015-03-20	2015-03-19	4	ISIS	ISIS PHARMACEUTICALS INC Employee Stock Option (right to buy)	M - Exercise		-13,125	31,875	-29.17
2015-03-20	2015-03-19	4	ISIS	ISIS PHARMACEUTICALS INC Employee Stock Option (right to buy)	M - Exercise		-4,000	3,500	-53.33
2015-03-20	2015-03-19	4	ISIS	ISIS PHARMACEUTICALS INC Employee Stock Option (right to buy)	M - Exercise		-6,100	7,253	-45.68
2015-03-20	2015-03-19	4	ISIS	ISIS PHARMACEUTICALS INC Employee Stock Option (right to buy)	M - Exercise		-5,683	4,067	-58.29
2015-03-20	2015-03-19	4	ISIS	ISIS PHARMACEUTICALS INC Employee Stock Option (right to buy)	M - Exercise		-1,617	0	-100.00
2015-03-20	2015-03-19	4	ISIS	ISIS PHARMACEUTICALS INC Common Stock	S - Sale	X	-10,525	6,174	-63.03	75.00	-789,417	463,075
2015-03-20	2015-03-19	4	ISIS	ISIS PHARMACEUTICALS INC Common Stock	M - Exercise	X	10,525	16,699	170.47	39.87	419,632	665,789
2015-03-20	2015-03-19	4	ISIS	ISIS PHARMACEUTICALS INC Common Stock	S - Sale	X	-2,600	6,174	-29.63	74.77	-194,394	461,611
2015-03-20	2015-03-19	4	ISIS	ISIS PHARMACEUTICALS INC Common Stock	M - Exercise	X	2,600	8,774	42.11	39.87	103,662	349,819
2015-03-20	2015-03-19	4	ISIS	ISIS PHARMACEUTICALS INC Common Stock	S - Sale	X	-4,000	6,174	-39.32	74.77	-299,068	461,611
2015-03-20	2015-03-19	4	ISIS	ISIS PHARMACEUTICALS INC Common Stock	M - Exercise	X	4,000	10,174	64.79	10.82	43,280	110,083
2015-03-20	2015-03-19	4	ISIS	ISIS PHARMACEUTICALS INC Common Stock	S - Sale	X	-6,100	6,174	-49.70	74.77	-456,079	461,611
2015-03-20	2015-03-19	4	ISIS	ISIS PHARMACEUTICALS INC Common Stock	M - Exercise	X	6,100	12,274	98.80	10.82	66,002	132,805
2015-03-20	2015-03-19	4	ISIS	ISIS PHARMACEUTICALS INC Common Stock	S - Sale	X	-5,683	6,174	-47.93	74.77	-424,901	461,611
2015-03-20	2015-03-19	4	ISIS	ISIS PHARMACEUTICALS INC Common Stock	M - Exercise	X	5,683	11,857	92.05	7.25	41,202	85,963
2015-03-20	2015-03-19	4	ISIS	ISIS PHARMACEUTICALS INC Common Stock	S - Sale	X	-1,617	6,174	-20.75	74.77	-120,898	461,611
2015-03-20	2015-03-19	4	ISIS	ISIS PHARMACEUTICALS INC Common Stock	M - Exercise	X	1,617	7,791	26.19	10.29	16,639	80,169
2015-03-09	2015-03-05	4	ISIS	ISIS PHARMACEUTICALS INC Employee Stock Option (right to buy)	M - Exercise		-4,133	1,617	-71.88
2015-03-09	2015-03-05	4	ISIS	ISIS PHARMACEUTICALS INC Employee Stock Option (right to buy)	M - Exercise		-1,667	0	-100.00
2015-03-09	2015-03-05	4	ISIS	ISIS PHARMACEUTICALS INC Common Stock	S - Sale	X	-4,133	6,174	-40.10	71.67	-296,204	442,478
2015-03-09	2015-03-05	4	ISIS	ISIS PHARMACEUTICALS INC Common Stock	M - Exercise	X	4,133	10,307	66.94	10.29	42,529	106,059
2015-03-09	2015-03-05	4	ISIS	ISIS PHARMACEUTICALS INC Common Stock	S - Sale	X	-1,667	6,174	-21.26	71.67	-119,471	442,478
2015-03-09	2015-03-05	4	ISIS	ISIS PHARMACEUTICALS INC Common Stock	M - Exercise	X	1,667	7,841	27.00	8.00	13,336	62,728
2015-01-20	2015-01-16	4	ISIS	ISIS PHARMACEUTICALS INC Common Stock	S - Sale		-714	6,174	-10.37	67.96	-48,526	419,610
2015-01-20	2015-01-16	4	ISIS	ISIS PHARMACEUTICALS INC Common Stock	S - Sale		-250	5,013	-4.75	67.96	-16,991	340,704
2015-01-20	2015-01-16	4	ISIS	ISIS PHARMACEUTICALS INC Common Stock	S - Sale		-120	4,609	-2.54	67.96	-8,156	313,246
2015-01-20	2015-01-16	4	ISIS	ISIS PHARMACEUTICALS INC Common Stock	S - Sale		-207	4,416	-4.48	67.96	-14,069	300,129
2015-01-20	2015-01-15	4	ISIS	ISIS PHARMACEUTICALS INC Restricted Stock Units	M - Exercise		-1,875	5,625	-25.00
2015-01-20	2015-01-15	4	ISIS	ISIS PHARMACEUTICALS INC Restricted Stock Units	M - Exercise		-654	1,307	-33.35
2015-01-20	2015-01-15	4	ISIS	ISIS PHARMACEUTICALS INC Restricted Stock Units	M - Exercise		-313	624	-33.40
2015-01-20	2015-01-15	4	ISIS	ISIS PHARMACEUTICALS INC Restricted Stock Units	M - Exercise		-541	541	-50.00
2015-01-20	2015-01-15	4	ISIS	ISIS PHARMACEUTICALS INC Restricted Stock Units	A - Award		5,242	5,242
2015-01-20	2015-01-15	4	ISIS	ISIS PHARMACEUTICALS INC Common Stock	M - Exercise		1,875	6,888	37.40
2015-01-20	2015-01-15	4	ISIS	ISIS PHARMACEUTICALS INC Common Stock	M - Exercise		654	5,263	14.19
2015-01-20	2015-01-15	4	ISIS	ISIS PHARMACEUTICALS INC Common Stock	M - Exercise		313	4,729	7.09
2015-01-20	2015-01-15	4	ISIS	ISIS PHARMACEUTICALS INC Common Stock	M - Exercise		541	4,623	13.25
2015-01-05	2015-01-02	4	ISIS	ISIS PHARMACEUTICALS INC Employee Stock Option (right to buy)	M - Exercise		-283	9,750	-2.82
2015-01-05	2015-01-02	4	ISIS	ISIS PHARMACEUTICALS INC Employee Stock Option (right to buy)	M - Exercise		-1,217	13,353	-8.35
2015-01-05	2015-01-02	4	ISIS	ISIS PHARMACEUTICALS INC Employee Stock Option (right to buy)	A - Award		31,457	31,457
2015-01-05	2015-01-02	4	ISIS	ISIS PHARMACEUTICALS INC Common Stock	S - Sale	X	-283	4,082	-6.48	62.12	-17,579	253,553
2015-01-05	2015-01-02	4	ISIS	ISIS PHARMACEUTICALS INC Common Stock	M - Exercise	X	283	4,365	6.93	7.25	2,052	31,646
2015-01-05	2015-01-02	4	ISIS	ISIS PHARMACEUTICALS INC Common Stock	S - Sale	X	-1,217	4,082	-22.97	62.12	-75,594	253,553
2015-01-05	2015-01-02	4	ISIS	ISIS PHARMACEUTICALS INC Common Stock	M - Exercise	X	1,217	5,299	29.81	10.82	13,168	57,335
2015-01-05	2015-01-01	4	ISIS	ISIS PHARMACEUTICALS INC Common Stock	J - Other		329	4,082	8.77	30.05	9,886	122,654
2014-12-03	2014-12-01	4	ISIS	ISIS PHARMACEUTICALS INC Employee Stock Option (right to buy)	M - Exercise		-1,500	10,033	-13.01
2014-12-03	2014-12-01	4	ISIS	ISIS PHARMACEUTICALS INC Common Stock	S - Sale	X	-500	3,753	-11.76	50.37	-25,185	189,039
2014-12-03	2014-12-01	4	ISIS	ISIS PHARMACEUTICALS INC Common Stock	M - Exercise	X	500	4,253	13.32	7.25	3,625	30,834
2014-12-03	2014-12-01	4	ISIS	ISIS PHARMACEUTICALS INC Common Stock	M - Exercise	X	500	4,253	13.32	7.25	3,625	30,834
2014-12-03	2014-12-01	4	ISIS	ISIS PHARMACEUTICALS INC Common Stock	M - Exercise	X	500	4,253	13.32	7.25	3,625	30,834
2014-12-03	2014-12-01	4	ISIS	ISIS PHARMACEUTICALS INC Common Stock	S - Sale	X	-500	3,753	-11.76	51.05	-25,525	191,591
2014-12-03	2014-12-01	4	ISIS	ISIS PHARMACEUTICALS INC Common Stock	S - Sale	X	-500	3,753	-11.76	52.21	-26,105	195,944
2014-11-05	2014-11-03	4	ISIS	ISIS PHARMACEUTICALS INC Employee Stock Option (right to buy)	M - Exercise		-1,500	11,533	-11.51
2014-11-05	2014-11-03	4	ISIS	ISIS PHARMACEUTICALS INC Common Stock	S - Sale		-1,500	3,753	-28.56	46.17	-69,255	173,276
2014-11-05	2014-11-03	4	ISIS	ISIS PHARMACEUTICALS INC Common Stock	M - Exercise	X	1,500	5,253	39.97	7.25	10,875	38,084
2014-10-03	2014-10-01	4	ISIS	ISIS PHARMACEUTICALS INC Employee Stock Option (right to buy)	M - Exercise		-1,267	13,033	-8.86
2014-10-03	2014-10-01	4	ISIS	ISIS PHARMACEUTICALS INC Employee Stock Option (right to buy)	M - Exercise		-233	5,750	-3.89
2014-10-03	2014-10-01	4	ISIS	ISIS PHARMACEUTICALS INC Common Stock	S - Sale	X	-800	3,753	-17.57	37.90	-30,320	142,239
2014-10-03	2014-10-01	4	ISIS	ISIS PHARMACEUTICALS INC Common Stock	M - Exercise	X	800	4,553	21.32	7.25	5,800	33,009
2014-10-03	2014-10-01	4	ISIS	ISIS PHARMACEUTICALS INC Common Stock	S - Sale	X	-467	3,753	-11.07	38.20	-17,839	143,365
2014-10-03	2014-10-01	4	ISIS	ISIS PHARMACEUTICALS INC Common Stock	M - Exercise	X	467	4,220	12.44	7.25	3,386	30,595
2014-10-03	2014-10-01	4	ISIS	ISIS PHARMACEUTICALS INC Common Stock	S - Sale	X	-233	3,753	-5.85	38.20	-8,901	143,365
2014-10-03	2014-10-01	4	ISIS	ISIS PHARMACEUTICALS INC Common Stock	M - Exercise	X	233	3,986	6.21	10.29	2,398	41,016
2014-09-04	2014-09-02	4	ISIS	ISIS PHARMACEUTICALS INC Employee Stock Option (right to buy)	M - Exercise		-1,500	5,983	-20.05
2014-09-04	2014-09-02	4	ISIS	ISIS PHARMACEUTICALS INC Common Stock	S - Sale	X	-700	3,753	-15.72	40.60	-28,420	152,372
2014-09-04	2014-09-02	4	ISIS	ISIS PHARMACEUTICALS INC Common Stock	M - Exercise	X	700	4,453	18.65	10.29	7,203	45,821
2014-09-04	2014-09-02	4	ISIS	ISIS PHARMACEUTICALS INC Common Stock	S - Sale	X	-800	3,753	-17.57	40.30	-32,240	151,246
2014-09-04	2014-09-02	4	ISIS	ISIS PHARMACEUTICALS INC Common Stock	M - Exercise	X	800	4,553	21.32	10.29	8,232	46,850
2014-08-12	2014-08-12	4	ISIS	ISIS PHARMACEUTICALS INC Employee Stock Option (right to buy)	M - Exercise		-800	7,483	-9.66
2014-08-12	2014-08-12	4	ISIS	ISIS PHARMACEUTICALS INC Common Stock	S - Sale	X	-800	3,753	-17.57	35.00	-28,000	131,355
2014-08-12	2014-08-12	4	ISIS	ISIS PHARMACEUTICALS INC Common Stock	M - Exercise	X	800	4,553	21.32	10.29	8,232	46,850
2014-08-12	2014-08-11	4	ISIS	ISIS PHARMACEUTICALS INC Employee Stock Option (right to buy)	M - Exercise		-700	8,983	-7.23
2014-08-12	2014-08-11	4	ISIS	ISIS PHARMACEUTICALS INC Common Stock	S - Sale	X	-700	3,753	-15.72	35.00	-24,500	131,355
2014-08-12	2014-08-11	4	ISIS	ISIS PHARMACEUTICALS INC Common Stock	M - Exercise	X	700	4,453	18.65	10.29	7,203	45,821
2014-07-02	2014-07-01	4	ISIS	ISIS PHARMACEUTICALS INC Employee Stock Option (right to buy)	M - Exercise		-1,500	8,983	-14.31
2014-07-02	2014-07-01	4	ISIS	ISIS PHARMACEUTICALS INC Common Stock	S - Sale	X	-1,500	3,753	-28.56	35.33	-53,000	132,606
2014-07-02	2014-07-01	4	ISIS	ISIS PHARMACEUTICALS INC Common Stock	M - Exercise	X	1,500	5,253	39.97	10.29	15,435	54,053
2014-07-02	2014-07-01	4	ISIS	ISIS PHARMACEUTICALS INC Common Stock	J - Other		403	3,753	12.03	30.20	12,171	113,342
2014-06-20	2014-06-19	4	ISIS	ISIS PHARMACEUTICALS INC Employee Stock Option (right to buy)	M - Exercise		-667	10,483	-5.98
2014-06-20	2014-06-19	4	ISIS	ISIS PHARMACEUTICALS INC Employee Stock Option (right to buy)	M - Exercise		-33	1,667	-1.94
2014-06-20	2014-06-19	4	ISIS	ISIS PHARMACEUTICALS INC Common Stock	S - Sale	X	-67	3,350	-1.96	35.27	-2,363	118,154
2014-06-20	2014-06-19	4	ISIS	ISIS PHARMACEUTICALS INC Common Stock	M - Exercise	X	67	3,417	2.00	10.29	689	35,161
2014-06-20	2014-06-19	4	ISIS	ISIS PHARMACEUTICALS INC Common Stock	S - Sale	X	-100	3,350	-2.90	35.28	-3,528	118,171
2014-06-20	2014-06-19	4	ISIS	ISIS PHARMACEUTICALS INC Common Stock	M - Exercise	X	100	3,450	2.99	10.29	1,029	35,500
2014-06-20	2014-06-19	4	ISIS	ISIS PHARMACEUTICALS INC Common Stock	S - Sale	X	-200	3,350	-5.63	35.29	-7,058	118,222
2014-06-20	2014-06-19	4	ISIS	ISIS PHARMACEUTICALS INC Common Stock	M - Exercise	X	200	3,550	5.97	10.29	2,058	36,530
2014-06-20	2014-06-19	4	ISIS	ISIS PHARMACEUTICALS INC Common Stock	S - Sale	X	-300	3,350	-8.22	35.45	-10,635	118,758
2014-06-20	2014-06-19	4	ISIS	ISIS PHARMACEUTICALS INC Common Stock	M - Exercise	X	300	3,650	8.96	10.29	3,087	37,558
2014-06-20	2014-06-19	4	ISIS	ISIS PHARMACEUTICALS INC Common Stock	S - Sale	X	-33	3,350	-0.98	35.27	-1,164	118,154
2014-06-20	2014-06-19	4	ISIS	ISIS PHARMACEUTICALS INC Common Stock	M - Exercise	X	33	3,383	0.99	8.00	264	27,064
2014-06-18	2014-06-16	4	ISIS	ISIS PHARMACEUTICALS INC Employee Stock Option (right to buy)	M - Exercise		-800	1,700	-32.00
2014-06-18	2014-06-16	4	ISIS	ISIS PHARMACEUTICALS INC Common Stock	S - Sale	X	-100	3,350	-2.90	35.27	-3,527	118,154
2014-06-18	2014-06-16	4	ISIS	ISIS PHARMACEUTICALS INC Common Stock	M - Exercise	X	100	3,450	2.99	8.00	800	27,600
2014-06-18	2014-06-16	4	ISIS	ISIS PHARMACEUTICALS INC Common Stock	M - Exercise	X	100	3,450	2.99	8.00	800	27,600
2014-06-18	2014-06-16	4	ISIS	ISIS PHARMACEUTICALS INC Common Stock	S - Sale	X	-100	3,350	-2.90	35.25	-3,525	118,096
2014-06-18	2014-06-16	4	ISIS	ISIS PHARMACEUTICALS INC Common Stock	S - Sale	X	-400	3,350	-10.67	35.02	-14,008	117,317
2014-06-18	2014-06-16	4	ISIS	ISIS PHARMACEUTICALS INC Common Stock	M - Exercise	X	400	3,750	11.94	8.00	3,200	30,000
2014-06-18	2014-06-16	4	ISIS	ISIS PHARMACEUTICALS INC Common Stock	S - Sale	X	-200	3,350	-5.63	35.25	-7,050	118,088
2014-06-18	2014-06-16	4	ISIS	ISIS PHARMACEUTICALS INC Common Stock	M - Exercise	X	200	3,550	5.97	8.00	1,600	28,400
2014-04-03	2014-04-01	4	ISIS	ISIS PHARMACEUTICALS INC Employee Stock Option (right to buy)	M - Exercise		-1,500	1,458	-50.71
2014-04-03	2014-04-01	4	ISIS	ISIS PHARMACEUTICALS INC Common Stock	S - Sale	X	-500	3,350	-12.99	44.02	-22,010	147,467
2014-04-03	2014-04-01	4	ISIS	ISIS PHARMACEUTICALS INC Common Stock	M - Exercise	X	500	3,850	14.93	8.00	4,000	30,800
2014-04-03	2014-04-01	4	ISIS	ISIS PHARMACEUTICALS INC Common Stock	M - Exercise	X	500	3,850	14.93	8.00	4,000	30,800
2014-04-03	2014-04-01	4	ISIS	ISIS PHARMACEUTICALS INC Common Stock	M - Exercise	X	500	3,850	14.93	8.00	4,000	30,800
2014-04-03	2014-04-01	4	ISIS	ISIS PHARMACEUTICALS INC Common Stock	S - Sale	X	-500	3,350	-12.99	44.30	-22,150	148,405
2014-04-03	2014-04-01	4	ISIS	ISIS PHARMACEUTICALS INC Common Stock	S - Sale	X	-500	3,350	-12.99	44.88	-22,440	150,348
2014-03-05	2014-03-03	4	ISIS	ISIS PHARMACEUTICALS INC Employee Stock Option (right to buy)	M - Exercise		-1,130	14,570	-7.20
2014-03-05	2014-03-03	4	ISIS	ISIS PHARMACEUTICALS INC Employee Stock Option (right to buy)	M - Exercise		-370	0	-100.00
2014-03-05	2014-03-03	4	ISIS	ISIS PHARMACEUTICALS INC Common Stock	S - Sale	X	-800	3,350	-19.28	50.70	-40,560	169,845
2014-03-05	2014-03-03	4	ISIS	ISIS PHARMACEUTICALS INC Common Stock	M - Exercise	X	800	4,150	23.88	10.82	8,656	44,903
2014-03-05	2014-03-03	4	ISIS	ISIS PHARMACEUTICALS INC Common Stock	S - Sale	X	-330	3,350	-8.97	49.20	-16,236	164,820
2014-03-05	2014-03-03	4	ISIS	ISIS PHARMACEUTICALS INC Common Stock	M - Exercise	X	330	3,680	9.85	10.82	3,571	39,818
2014-03-05	2014-03-03	4	ISIS	ISIS PHARMACEUTICALS INC Common Stock	S - Sale	X	-370	3,350	-9.95	49.20	-18,204	164,820
2014-03-05	2014-03-03	4	ISIS	ISIS PHARMACEUTICALS INC Common Stock	M - Exercise	X	370	3,720	11.04	11.27	4,170	41,924
2014-02-05	2014-02-03	4	ISIS	ISIS PHARMACEUTICALS INC Employee Stock Option (right to buy)	M - Exercise		-1,500	370	-80.21
2014-02-05	2014-02-03	4	ISIS	ISIS PHARMACEUTICALS INC Common Stock	S - Sale	X	-1,500	3,350	-30.93	50.45	-75,676	169,011
2014-02-05	2014-02-03	4	ISIS	ISIS PHARMACEUTICALS INC Common Stock	M - Exercise	X	1,500	4,850	44.78	11.27	16,905	54,660
2014-01-17	2014-01-16	4	ISIS	ISIS PHARMACEUTICALS INC Common Stock	S - Sale		-120	3,350	-3.46	47.08	-5,650	157,722
2014-01-17	2014-01-16	4	ISIS	ISIS PHARMACEUTICALS INC Common Stock	S - Sale		-207	3,157	-6.15	47.08	-9,746	148,635
2014-01-17	2014-01-16	4	ISIS	ISIS PHARMACEUTICALS INC Common Stock	S - Sale		-250	2,822	-8.14	47.08	-11,770	132,863
2014-01-17	2014-01-15	4	ISIS	ISIS PHARMACEUTICALS INC Restricted Stock Units	M - Exercise		-313	937	-25.04
2014-01-17	2014-01-15	4	ISIS	ISIS PHARMACEUTICALS INC Restricted Stock Units	M - Exercise		-542	1,082	-33.37
2014-01-17	2014-01-15	4	ISIS	ISIS PHARMACEUTICALS INC Restricted Stock Units	M - Exercise		-654	1,961	-25.01
2014-01-17	2014-01-15	4	ISIS	ISIS PHARMACEUTICALS INC Restricted Stock Units	A - Award		7,500	7,500
2014-01-17	2014-01-15	4	ISIS	ISIS PHARMACEUTICALS INC Common Stock	M - Exercise		313	3,470	9.91
2014-01-17	2014-01-15	4	ISIS	ISIS PHARMACEUTICALS INC Common Stock	M - Exercise		542	3,364	19.21
2014-01-17	2014-01-15	4	ISIS	ISIS PHARMACEUTICALS INC Common Stock	M - Exercise		654	3,072	27.05
2014-01-03	2014-01-02	4	ISIS	ISIS PHARMACEUTICALS INC Employee Stock Option (right to buy)	A - Award		45,000	45,000
2014-01-03	2014-01-01	4	ISIS	ISIS PHARMACEUTICALS INC Common Stock	J - Other		395	2,418	19.53	24.20	9,559	58,514
2013-09-06	2013-09-04	4	ISIS	ISIS PHARMACEUTICALS INC Employee Stock Option (right to buy)	M - Exercise		-10	0	-100.00
2013-09-06	2013-09-04	4	ISIS	ISIS PHARMACEUTICALS INC Common Stock	M - Exercise		-10	0	-100.00
2013-09-06	2013-09-04	4	ISIS	ISIS PHARMACEUTICALS INC Employee Stock Option (right to buy)	M - Exercise		-2,480	1,870	-57.01
2013-09-06	2013-09-04	4	ISIS	ISIS PHARMACEUTICALS INC Common Stock	S - Sale	X	-10	2,023	-0.49	26.85	-268	54,318
2013-09-06	2013-09-04	4	ISIS	ISIS PHARMACEUTICALS INC Common Stock	S - Sale	X	-10	2,023	-0.49	26.85	-268	54,318
2013-09-06	2013-09-04	4	ISIS	ISIS PHARMACEUTICALS INC Common Stock	M - Exercise	X	10	2,033	0.49	14.47	145	29,418
2013-09-06	2013-09-04	4	ISIS	ISIS PHARMACEUTICALS INC Common Stock	M - Exercise	X	10	2,033	0.49	14.18	142	28,828
2013-09-06	2013-09-04	4	ISIS	ISIS PHARMACEUTICALS INC Common Stock	S - Sale	X	-637	2,023	-23.95	26.85	-17,103	54,318
2013-09-06	2013-09-04	4	ISIS	ISIS PHARMACEUTICALS INC Common Stock	M - Exercise	X	637	2,660	31.49	11.27	7,179	29,978
2013-09-06	2013-09-04	4	ISIS	ISIS PHARMACEUTICALS INC Common Stock	S - Sale	X	-526	2,023	-20.64	27.00	-14,202	54,621
2013-09-06	2013-09-04	4	ISIS	ISIS PHARMACEUTICALS INC Common Stock	M - Exercise	X	526	2,549	26.00	11.27	5,928	28,727
2013-09-06	2013-09-04	4	ISIS	ISIS PHARMACEUTICALS INC Common Stock	S - Sale	X	-1,317	2,023	-39.43	27.25	-35,888	55,127
2013-09-06	2013-09-04	4	ISIS	ISIS PHARMACEUTICALS INC Common Stock	M - Exercise	X	1,317	3,340	65.10	11.27	14,843	37,642
2013-07-05	2013-07-05	4	ISIS	ISIS PHARMACEUTICALS INC Common Stock	S - Sale	X	-277	2,023	-12.04	29.25	-8,102	59,173
2013-07-05	2013-07-01	4	ISIS	ISIS PHARMACEUTICALS INC Common Stock	J - Other		976	2,300	73.72	9.20	8,976	21,153
2013-04-23	2013-04-23	4	ISIS	ISIS PHARMACEUTICALS INC Employee Stock Option (right to buy)	M - Exercise		-3,900	11,150	-25.91
2013-04-23	2013-04-23	4	ISIS	ISIS PHARMACEUTICALS INC Employee Stock Option (right to buy)	M - Exercise		-1,800	4,000	-31.03
2013-04-23	2013-04-23	4	ISIS	ISIS PHARMACEUTICALS INC Employee Stock Option (right to buy)	M - Exercise		-2,700	4,350	-38.30
2013-04-23	2013-04-23	4	ISIS	ISIS PHARMACEUTICALS INC Employee Stock Option (right to buy)	M - Exercise		-2,260	10	-99.56
2013-04-23	2013-04-23	4	ISIS	ISIS PHARMACEUTICALS INC Employee Stock Option (right to buy)	M - Exercise		-10,660	10	-99.91
2013-04-23	2013-04-23	4	ISIS	ISIS PHARMACEUTICALS INC Employee Stock Option (right to buy)	M - Exercise		-6,000	0	-100.00
2013-04-23	2013-04-23	4	ISIS	ISIS PHARMACEUTICALS INC Common Stock	S - Sale	X	-3,900	1,324	-74.66	22.13	-86,307	29,300
2013-04-23	2013-04-23	4	ISIS	ISIS PHARMACEUTICALS INC Common Stock	M - Exercise	X	3,900	5,224	294.56	10.29	40,131	53,755
2013-04-23	2013-04-23	4	ISIS	ISIS PHARMACEUTICALS INC Common Stock	S - Sale	X	-1,800	1,324	-57.62	22.13	-39,834	29,300
2013-04-23	2013-04-23	4	ISIS	ISIS PHARMACEUTICALS INC Common Stock	M - Exercise	X	1,800	3,124	135.95	8.00	14,400	24,992
2013-04-23	2013-04-23	4	ISIS	ISIS PHARMACEUTICALS INC Common Stock	S - Sale	X	-2,700	1,324	-67.10	22.13	-59,751	29,300
2013-04-23	2013-04-23	4	ISIS	ISIS PHARMACEUTICALS INC Common Stock	M - Exercise	X	2,700	4,024	203.93	11.27	30,429	45,350
2013-04-23	2013-04-23	4	ISIS	ISIS PHARMACEUTICALS INC Common Stock	S - Sale	X	-2,260	1,324	-63.06	22.13	-50,014	29,300
2013-04-23	2013-04-23	4	ISIS	ISIS PHARMACEUTICALS INC Common Stock	M - Exercise	X	2,260	3,584	170.69	14.47	32,702	51,860
2013-04-23	2013-04-23	4	ISIS	ISIS PHARMACEUTICALS INC Common Stock	S - Sale	X	-10,660	1,324	-88.95	22.13	-235,906	29,300
2013-04-23	2013-04-23	4	ISIS	ISIS PHARMACEUTICALS INC Common Stock	M - Exercise	X	10,660	11,984	805.14	14.18	151,159	169,933
2013-04-23	2013-04-23	4	ISIS	ISIS PHARMACEUTICALS INC Common Stock	S - Sale	X	-6,000	1,324	-81.92	22.13	-132,780	29,300
2013-04-23	2013-04-23	4	ISIS	ISIS PHARMACEUTICALS INC Common Stock	M - Exercise	X	6,000	7,324	453.17	15.38	92,280	112,643
2013-04-23	2013-04-19	4	ISIS	ISIS PHARMACEUTICALS INC Employee Stock Option (right to buy)	M - Exercise		-6,000	2,270	-72.55
2013-04-23	2013-04-19	4	ISIS	ISIS PHARMACEUTICALS INC Employee Stock Option (right to buy)	M - Exercise		-1,000	10,670	-8.57
2013-04-23	2013-04-19	4	ISIS	ISIS PHARMACEUTICALS INC Employee Stock Option (right to buy)	M - Exercise		-8,000	6,000	-57.14
2013-04-23	2013-04-19	4	ISIS	ISIS PHARMACEUTICALS INC Common Stock	S - Sale	X	-5,000	1,324	-79.06	21.01	-105,050	27,817
2013-04-23	2013-04-19	4	ISIS	ISIS PHARMACEUTICALS INC Common Stock	M - Exercise	X	5,000	6,324	377.64	15.38	76,900	97,263
2013-04-23	2013-04-19	4	ISIS	ISIS PHARMACEUTICALS INC Common Stock	S - Sale	X	-6,000	1,324	-81.92	20.01	-120,036	26,488
2013-04-23	2013-04-19	4	ISIS	ISIS PHARMACEUTICALS INC Common Stock	M - Exercise	X	6,000	7,324	453.17	14.47	86,820	105,978
2013-04-23	2013-04-19	4	ISIS	ISIS PHARMACEUTICALS INC Common Stock	S - Sale	X	-1,000	1,324	-43.03	19.60	-19,600	25,950
2013-04-23	2013-04-19	4	ISIS	ISIS PHARMACEUTICALS INC Common Stock	M - Exercise	X	1,000	2,324	75.53	14.18	14,180	32,954
2013-04-23	2013-04-19	4	ISIS	ISIS PHARMACEUTICALS INC Common Stock	S - Sale	X	-3,000	1,324	-69.38	20.25	-60,750	26,811
2013-04-23	2013-04-19	4	ISIS	ISIS PHARMACEUTICALS INC Common Stock	M - Exercise	X	3,000	4,324	226.59	15.38	46,140	66,503
2013-04-15	2013-04-12	4	ISIS	ISIS PHARMACEUTICALS INC Employee Stock Option (right to buy)	M - Exercise		-4,330	11,670	-27.06
2013-04-15	2013-04-12	4	ISIS	ISIS PHARMACEUTICALS INC Employee Stock Option (right to buy)	M - Exercise		-1,130	8,270	-12.02
2013-04-15	2013-04-12	4	ISIS	ISIS PHARMACEUTICALS INC Common Stock	S - Sale	X	-4,330	1,324	-76.58	19.62	-84,948	25,975
2013-04-15	2013-04-12	4	ISIS	ISIS PHARMACEUTICALS INC Common Stock	M - Exercise	X	4,330	5,654	327.04	14.18	61,399	80,174
2013-04-15	2013-04-12	4	ISIS	ISIS PHARMACEUTICALS INC Common Stock	S - Sale	X	-1,130	1,324	-46.05	19.60	-22,148	25,950
2013-04-15	2013-04-12	4	ISIS	ISIS PHARMACEUTICALS INC Common Stock	M - Exercise	X	1,130	2,454	85.35	14.47	16,351	35,509
2013-03-22	2013-03-21	4	ISIS	ISIS PHARMACEUTICALS INC Employee Stock Option (right to buy)	M - Exercise		-9,000	16,000	-36.00
2013-03-22	2013-03-21	4	ISIS	ISIS PHARMACEUTICALS INC Common Stock	S - Sale	X	-9,000	1,324	-87.18	19.26	-173,340	25,500
2013-03-22	2013-03-21	4	ISIS	ISIS PHARMACEUTICALS INC Common Stock	M - Exercise	X	9,000	10,324	679.76	14.18	127,620	146,394
2013-03-04	2013-03-04	4	ISIS	ISIS PHARMACEUTICALS INC Employee Stock Option (right to buy)	M - Exercise		-1,350	0	-100.00
2013-03-04	2013-03-04	4	ISIS	ISIS PHARMACEUTICALS INC Employee Stock Option (right to buy)	M - Exercise		-10,351	7,050	-59.49
2013-03-04	2013-03-04	4	ISIS	ISIS PHARMACEUTICALS INC Common Stock	S - Sale	X	-1,350	1,324	-50.49	15.82	-21,353	20,942
2013-03-04	2013-03-04	4	ISIS	ISIS PHARMACEUTICALS INC Common Stock	M - Exercise	X	1,350	2,674	101.96	11.12	15,012	29,735
2013-03-04	2013-03-04	4	ISIS	ISIS PHARMACEUTICALS INC Common Stock	S - Sale	X	-10,350	1,324	-88.66	15.82	-163,706	20,942
2013-03-04	2013-03-04	4	ISIS	ISIS PHARMACEUTICALS INC Common Stock	M - Exercise	X	10,350	11,674	781.72	11.27	116,644	131,566
2013-02-20	2013-02-19	4	ISIS	ISIS PHARMACEUTICALS INC Employee Stock Option (right to buy)	M - Exercise		-1,600	15,050	-9.61
2013-02-20	2013-02-19	4	ISIS	ISIS PHARMACEUTICALS INC Common Stock	S - Sale	X	-1,600	1,324	-54.72	14.80	-23,680	19,595
2013-02-20	2013-02-19	4	ISIS	ISIS PHARMACEUTICALS INC Common Stock	M - Exercise	X	1,600	2,924	120.85	10.29	16,464	30,088
2013-02-20	2013-02-15	4	ISIS	ISIS PHARMACEUTICALS INC Employee Stock Option (right to buy)	M - Exercise		-250	16,650	-1.48
2013-02-20	2013-02-15	4	ISIS	ISIS PHARMACEUTICALS INC Employee Stock Option (right to buy)	M - Exercise		-100	16,900	-0.59
2013-02-20	2013-02-15	4	ISIS	ISIS PHARMACEUTICALS INC Common Stock	S - Sale	X	-250	1,324	-15.88	14.82	-3,705	19,622
2013-02-20	2013-02-15	4	ISIS	ISIS PHARMACEUTICALS INC Common Stock	M - Exercise	X	250	1,574	18.88	10.29	2,572	16,196
2013-02-20	2013-02-15	4	ISIS	ISIS PHARMACEUTICALS INC Common Stock	S - Sale	X	-100	1,324	-7.02	14.80	-1,480	19,595
2013-02-20	2013-02-15	4	ISIS	ISIS PHARMACEUTICALS INC Common Stock	M - Exercise	X	100	1,424	7.55	10.29	1,029	14,653
2013-02-14	2013-02-13	4	ISIS	ISIS PHARMACEUTICALS INC Employee Stock Option (right to buy)	M - Exercise		-5,200	14,300	-26.67
2013-02-14	2013-02-13	4	ISIS	ISIS PHARMACEUTICALS INC Employee Stock Option (right to buy)	M - Exercise		-900	5,800	-13.43
2013-02-14	2013-02-13	4	ISIS	ISIS PHARMACEUTICALS INC Common Stock	S - Sale	X	-139	1,324	-9.50	14.17	-1,970	18,761
2013-02-14	2013-02-13	4	ISIS	ISIS PHARMACEUTICALS INC Common Stock	S - Sale	X	-5,200	1,463	-78.04	14.17	-73,684	20,731
2013-02-14	2013-02-13	4	ISIS	ISIS PHARMACEUTICALS INC Common Stock	M - Exercise	X	5,200	6,663	355.43	7.25	37,700	48,307
2013-02-14	2013-02-13	4	ISIS	ISIS PHARMACEUTICALS INC Common Stock	S - Sale	X	-900	1,463	-38.09	14.17	-12,753	20,731
2013-02-14	2013-02-13	4	ISIS	ISIS PHARMACEUTICALS INC Common Stock	M - Exercise	X	900	2,363	61.52	8.00	7,200	18,904
2013-01-31	2013-01-30	4	ISIS	ISIS PHARMACEUTICALS INC Employee Stock Option (right to buy)	M - Exercise		-2,000	17,000	-10.53
2013-01-31	2013-01-30	4	ISIS	ISIS PHARMACEUTICALS INC Common Stock	S - Sale	X	-2,000	1,463	-57.75	14.82	-29,640	21,682
2013-01-31	2013-01-30	4	ISIS	ISIS PHARMACEUTICALS INC Common Stock	M - Exercise	X	2,000	3,463	136.71	10.29	20,580	35,634
2013-01-31	2013-01-29	4	ISIS	ISIS PHARMACEUTICALS INC Common Stock	S - Sale	X	-300	1,463	-17.02	13.40	-4,020	19,604
2013-01-17	2013-01-17	4	ISIS	ISIS PHARMACEUTICALS INC Common Stock	S - Sale		-242	1,763	-12.07	14.16	-3,427	24,964
2013-01-17	2013-01-15	4	ISIS	ISIS PHARMACEUTICALS INC Restricted Stock Units	A - Award		2,615	2,615
2013-01-17	2013-01-15	4	ISIS	ISIS PHARMACEUTICALS INC Restricted Stock Units	A - Award		1,250	1,250
2013-01-17	2013-01-15	4	ISIS	ISIS PHARMACEUTICALS INC Restricted Stock Units	M - Exercise		-542	1,624	-25.02
2013-01-17	2013-01-15	4	ISIS	ISIS PHARMACEUTICALS INC Common Stock	M - Exercise		542	2,005	37.05
2013-01-04	2013-01-04	4	ISIS	ISIS PHARMACEUTICALS INC Common Stock	S - Sale	X	-1,296	1,463	-46.97	10.76	-13,945	15,742
2013-01-03	2013-01-02	4	ISIS	ISIS PHARMACEUTICALS INC Employee Stock Option (right to buy)	A - Award		15,700	15,700
2013-01-03	2013-01-02	4	ISIS	ISIS PHARMACEUTICALS INC Employee Stock Option (right to buy)	A - Award		7,500	7,500
2013-01-03	2013-01-01	4	ISIS	ISIS PHARMACEUTICALS INC Common Stock	J - Other		431	2,759	18.51	8.87	3,825	24,483
2013-01-03		3	ISIS	ISIS PHARMACEUTICALS INC Common Stock				2,328

非衍生或衍生證券的公開市場或私下買入

非衍生或衍生證券的公開市場或私下賣出

公司向內部人員授予、獎勵或以其他方式獲取證券（例如股票期權）

衍生工具轉換

將證券賣出或轉讓回公司

使用從公司收到的證券的一部分來支付行使價或稅務負擔。

內部人士贈送或接收他人贈送公司股票

股權掉期和類似的避險交易

行使或轉換從公司獲得的衍生證券（例如期權）

內部人士透過Form 4自願報告的一筆交易

其他（附有交易描述的腳註）