共晶製藥股份有限公司
US ˙ NasdaqCM ˙ US19188J4094

簡介

本頁面提供了有關 Jane Ph D Hsiao 已知的內部交易歷史的全面分析。內部人士包括公司的高管、董事或重要投資者。一般而言，基於內幕、非公開信息進行交易是非法的。這並不意味著他們在自己的公司進行任何交易都是非法的。但是，他們必須透過Form 4向美國證券交易委員會（SEC）報告所有交易。盡管存在這些限制，學術研究表明，內部人士 - 整體而言 - 在自己公司中的投資表現往往優於市場。

平均交易盈利能力

「平均交易盈利能力」衡量了內部人士在過去三年中所有非計劃性的公開市場購買交易的平均回報率。計算過程包括檢查每筆交易，排除了作為10b5-1交易計劃的一部分的交易。然後，對每筆交易在3、6和12個月的表現進行平均，以生成該筆交易最終的表現指標。最終，將所有交易的表現指標進行平均，計算出內部人士的總體平均表現指標。列表僅包含在過去兩年中進行過至少三筆交易的內部人士。

如果內部人士的交易盈利能力顯示為"N/A"，則可能是因為該內部人士在過去三年內沒有進行任何公開市場購買交易，或者他們進行的交易距離現在太近，無法計算出可靠的表現指標。

更新頻率：每日

查看收益最高的的內幕交易者列表。

查看排名最高的內部人士。
報告內部持倉的公司

SEC文件顯示Jane Ph D Hsiao已報告在以下公司擁有持倉或進行了交易：

證券 職位 最新報告的持倉
US:OPK / OPKO Health, Inc. Vice Chairman & CTO, Director 28,499,880
US:ASXC / Asensus Surgical, Inc. Director 336,895
US:NIMU / Non-Invasive Monitoring Systems, Inc. Interim CEO, Director, 10% Owner 20,883,660
US:COCP / Cocrystal Pharma, Inc. Director 50,000
US:PBTH / Prolor Biotech, Inc. Director 0
US:SRNE / Sorrento Therapeutics, Inc. Director 75,000
如何解讀這些圖表

以下圖表顯示了在Jane Ph D Hsiao進行的每筆公開市場非計劃交易後證券的股價表現。非計劃交易是指沒有作為10b5-1交易計劃的一部分而進行的交易。股價表現以累積百分比變化的方式繪製。例如，如果一筆內部人士交易是在2019年1月1日進行的，該圖表將顯示該證券的每日百分比變化直至當前日期。如果在此期間股價從10美元漲至15美元，則股價的累積百分比變化將為50%。從10美元漲至20美元的價格變化將為100%，而從10美元跌至5美元的價格變化將為-50%。

最終，我們將評估內部人士的交易與股價的超額回報（正向或負向）之間的相關性，以判斷內部人士是否在交易中利用內部信息獲利。如果內部人士有這樣的行為，我們預期看到（a）購買後的正回報，或者（b）賣出後的負回報。對於情況（a），購買圖表將顯示一系列向上傾斜的曲線，表示每次購買後都有正回報。對於情況（b），賣出圖表將顯示一系列向下傾斜的曲線，表示每次賣出後都有負回報。

然而，僅憑這一點還不足以得出結論。例如，如果公司的股價在多年內呈現非周期性上升，我們會預期所有購買後的圖表都呈現向上傾斜。同樣地，多年來呈現非周期性下降的股價會導致賣出後的圖表也呈現向下傾斜。這兩種情況的圖表都不能表示內部人士在進行內幕交易。

最有力的指標是在公司股價呈極度循環波動的情況下，「購買」圖表顯示正向信號，而「賣出」圖表顯示負向趨勢。這種情況強烈暗示內部人士可能根據內幕信息精確地計時進行交易，以獲得財務優勢。

COCP / Cocrystal Pharma, Inc.內部人士買入 - 短期收益分析

在這一部分，我們分析了在 COCP / Cocrystal Pharma, Inc. 中進行的每筆非計劃的公開市場內部人士購買的盈利情況。這種分析有助於了解內部人士是否持續產生異常的回報，以及是否值得跟踪。該分析基於每筆交易後一年的情況，結果僅為理論值。

以下表格顯示了最近的自動交易計劃之外的公開市場購買。

交易日期 證券代碼 內部人士 報告
股數		 Reported
價格		 經調整
股數		 經調整
價格		 成本基礎 達到最高利潤的
天數		 達到最高利潤時的
價格		 最高
淨利 ($)		 最高回報率（%）
2016-03-15 COCP HSIAO JANE PH D 1,235,294 0.5100 58,824 10.7100 630,000 23 0.79 -583,529 -92.62
2015-03-25 COCP HSIAO JANE PH D 2,200,000 0.9200 104,762 19.3200 2,024,000

經調整價格 已按拆股調整。經調整股數 已按拆股調整。

COCP / Cocrystal Pharma, Inc. Insider Trades
COCP / Cocrystal Pharma, Inc.內部人士賣出 - 短期虧損分析

在這一部分，我們分析了在 COCP / Cocrystal Pharma, Inc. 中進行的每筆非計劃的公開市場內部人士賣出所達成的短期虧損規避。如果存在持續的虧損規避模式，可能表明未來的內部人士賣出交易預示著價格的下跌。該分析基於每筆交易後一年的情況，

以下表格顯示了最近的自動交易計劃之外的公開市場購買。

交易日期 證券代碼 內部人士 報告
股數		 Reported
價格		 經調整
股數		 經調整
價格		 成本基礎 達到最低利潤的
天數		 達到最低利潤時的
價格		 避免的
最高損失金額($)		 避免的
最高損失率($)
當前未知該內部人士及證券組合進行過任何未預先計劃的公開市場交易。

經調整價格 已按拆股調整。經調整股數 已按拆股調整。

COCP / Cocrystal Pharma, Inc. Insider Trades
NIMU / Non-Invasive Monitoring Systems, Inc.內部人士買入 - 短期收益分析

在這一部分，我們分析了在 COCP / Cocrystal Pharma, Inc. 中進行的每筆非計劃的公開市場內部人士購買的盈利情況。這種分析有助於了解內部人士是否持續產生異常的回報，以及是否值得跟踪。該分析基於每筆交易後一年的情況，結果僅為理論值。

以下表格顯示了最近的自動交易計劃之外的公開市場購買。

交易日期 證券代碼 內部人士 報告
股數		 Reported
價格		 經調整
股數		 經調整
價格		 成本基礎 達到最高利潤的
天數		 達到最高利潤時的
價格		 最高
淨利 ($)		 最高回報率（%）
2018-12-21 NIMU HSIAO JANE PH D 1,428,571 0.0700 1,428,571 0.0700 100,000 12 0.1400 100,001 100.00
2018-12-21 NIMU HSIAO JANE PH D 4,923,503 0.0700 4,923,503 0.0700 344,645
2018-12-21 NIMU HSIAO JANE PH D 20,883,660 0.0700 20,883,660 0.0700 1,461,856
2013-04-08 NIMU HSIAO JANE PH D 2,000,000 0.0500 2,000,000 0.0500 100,000
2012-02-28 NIMU HSIAO JANE PH D 6,000,000 0.0500 6,000,000 0.0500 300,000

經調整價格 已按拆股調整。經調整股數 已按拆股調整。

NIMU / Non-Invasive Monitoring Systems, Inc. Insider Trades
NIMU / Non-Invasive Monitoring Systems, Inc.內部人士賣出 - 短期虧損分析

在這一部分，我們分析了在 COCP / Cocrystal Pharma, Inc. 中進行的每筆非計劃的公開市場內部人士賣出所達成的短期虧損規避。如果存在持續的虧損規避模式，可能表明未來的內部人士賣出交易預示著價格的下跌。該分析基於每筆交易後一年的情況，

以下表格顯示了最近的自動交易計劃之外的公開市場購買。

交易日期 證券代碼 內部人士 報告
股數		 Reported
價格		 經調整
股數		 經調整
價格		 成本基礎 達到最低利潤的
天數		 達到最低利潤時的
價格		 避免的
最高損失金額($)		 避免的
最高損失率($)
當前未知該內部人士及證券組合進行過任何未預先計劃的公開市場交易。

經調整價格 已按拆股調整。經調整股數 已按拆股調整。

NIMU / Non-Invasive Monitoring Systems, Inc. Insider Trades
OPK / OPKO Health, Inc.內部人士買入 - 短期收益分析

在這一部分，我們分析了在 COCP / Cocrystal Pharma, Inc. 中進行的每筆非計劃的公開市場內部人士購買的盈利情況。這種分析有助於了解內部人士是否持續產生異常的回報，以及是否值得跟踪。該分析基於每筆交易後一年的情況，結果僅為理論值。

以下表格顯示了最近的自動交易計劃之外的公開市場購買。

交易日期 證券代碼 內部人士 報告
股數		 Reported
價格		 經調整
股數		 經調整
價格		 成本基礎 達到最高利潤的
天數		 達到最高利潤時的
價格		 最高
淨利 ($)		 最高回報率（%）
2024-01-17 OPK HSIAO JANE PH D 150,000 0.9500 150,000 0.9500 142,500 226 1.6800 109,500 76.84
2024-01-05 OPK HSIAO JANE PH D 150,010 0.8726 150,010 0.8726 130,899
2023-11-10 OPK HSIAO JANE PH D 34,058 1.2600 34,058 1.2600 42,913
2023-11-10 OPK HSIAO JANE PH D 65,942 1.2700 65,942 1.2700 83,746
2021-08-09 OPK HSIAO JANE PH D 10 3.7300 10 3.7300 37
2019-10-25 OPK HSIAO JANE PH D 400,000 1.5000 400,000 1.5000 600,000
2019-05-09 OPK HSIAO JANE PH D 6,717 2.0250 6,717 2.0250 13,602
2019-05-09 OPK HSIAO JANE PH D 500 2.0350 500 2.0350 1,018
2019-05-09 OPK HSIAO JANE PH D 2,783 2.0400 2,783 2.0400 5,677
2017-05-11 OPK HSIAO JANE PH D 10,000 6.9200 10,000 6.9200 69,200
2017-05-11 OPK HSIAO JANE PH D 10,000 6.9300 10,000 6.9300 69,300
2017-05-11 OPK HSIAO JANE PH D 10,000 6.9200 10,000 6.9200 69,200
2017-05-11 OPK HSIAO JANE PH D 10,000 6.9300 10,000 6.9300 69,300
2017-05-10 OPK HSIAO JANE PH D 10,000 6.9400 10,000 6.9400 69,400
2017-05-10 OPK HSIAO JANE PH D 2,600 6.9500 2,600 6.9500 18,070
2017-05-10 OPK HSIAO JANE PH D 11,735 6.9700 11,735 6.9700 81,793
2017-05-10 OPK HSIAO JANE PH D 5,665 6.9800 5,665 6.9800 39,542
2017-05-10 OPK HSIAO JANE PH D 10,000 6.9900 10,000 6.9900 69,900
2017-05-10 OPK HSIAO JANE PH D 10,000 6.9400 10,000 6.9400 69,400
2017-05-10 OPK HSIAO JANE PH D 2,600 6.9500 2,600 6.9500 18,070
2017-05-10 OPK HSIAO JANE PH D 11,735 6.9700 11,735 6.9700 81,793
2017-05-10 OPK HSIAO JANE PH D 5,665 6.9800 5,665 6.9800 39,542
2017-05-10 OPK HSIAO JANE PH D 10,000 6.9900 10,000 6.9900 69,900
2016-03-17 OPK HSIAO JANE PH D 500 10.5900 500 10.5900 5,295
2016-03-17 OPK HSIAO JANE PH D 700 10.7000 700 10.7000 7,490
2016-03-16 OPK HSIAO JANE PH D 1,200 9.9900 1,200 9.9900 11,988
2016-03-15 OPK HSIAO JANE PH D 1,200 10.0000 1,200 10.0000 12,000
2016-03-14 OPK HSIAO JANE PH D 200 10.1150 200 10.1150 2,023
2016-03-14 OPK HSIAO JANE PH D 1,000 10.1200 1,000 10.1200 10,120
2016-03-11 OPK HSIAO JANE PH D 100 10.2050 100 10.2050 1,020
2016-03-11 OPK HSIAO JANE PH D 1,100 10.2100 1,100 10.2100 11,231
2016-03-10 OPK HSIAO JANE PH D 300 9.8000 300 9.8000 2,940
2016-03-10 OPK HSIAO JANE PH D 900 9.8300 900 9.8300 8,847
2016-03-09 OPK HSIAO JANE PH D 1,200 9.9900 1,200 9.9900 11,988
2016-03-08 OPK HSIAO JANE PH D 1,200 10.0100 1,200 10.0100 12,012
2015-08-25 OPK HSIAO JANE PH D 4,200 10.8050 4,200 10.8050 45,381
2015-08-25 OPK HSIAO JANE PH D 3,800 10.8100 3,800 10.8100 41,078
2015-08-25 OPK HSIAO JANE PH D 1,500 10.8150 1,500 10.8150 16,222
2015-08-25 OPK HSIAO JANE PH D 8,500 10.8200 8,500 10.8200 91,970
2015-08-25 OPK HSIAO JANE PH D 1,300 10.8350 1,300 10.8350 14,086
2015-08-25 OPK HSIAO JANE PH D 200 10.8375 200 10.8375 2,168
2015-08-25 OPK HSIAO JANE PH D 500 10.8400 500 10.8400 5,420
2014-04-15 OPK HSIAO JANE PH D 10,000 8.0300 10,000 8.0300 80,300
2014-01-31 OPK HSIAO JANE PH D 10,000 7.9600 10,000 7.9600 79,600
2014-01-30 OPK HSIAO JANE PH D 2,000 8.0800 2,000 8.0800 16,160
2014-01-30 OPK HSIAO JANE PH D 2,000 8.1300 2,000 8.1300 16,260
2014-01-30 OPK HSIAO JANE PH D 4,000 8.1500 4,000 8.1500 32,600
2014-01-30 OPK HSIAO JANE PH D 2,000 8.1800 2,000 8.1800 16,360
2014-01-28 OPK HSIAO JANE PH D 200 8.1900 200 8.1900 1,638
2014-01-28 OPK HSIAO JANE PH D 100 8.1950 100 8.1950 820
2014-01-28 OPK HSIAO JANE PH D 9,700 8.2000 9,700 8.2000 79,540
2013-04-03 OPK HSIAO JANE PH D 5,000 6.9900 5,000 6.9900 34,950
2012-10-09 OPK HSIAO JANE PH D 100 4.3150 100 4.3150 432
2012-10-09 OPK HSIAO JANE PH D 1,400 4.3200 1,400 4.3200 6,048
2012-10-09 OPK HSIAO JANE PH D 700 4.3250 700 4.3250 3,028
2012-10-09 OPK HSIAO JANE PH D 2,750 4.3300 2,750 4.3300 11,908
2012-10-09 OPK HSIAO JANE PH D 400 4.3350 400 4.3350 1,734
2012-10-09 OPK HSIAO JANE PH D 1,650 4.3400 1,650 4.3400 7,161
2012-10-09 OPK HSIAO JANE PH D 400 4.3450 400 4.3450 1,738
2012-10-09 OPK HSIAO JANE PH D 2,600 4.3500 2,600 4.3500 11,310
2012-07-30 OPK HSIAO JANE PH D 30,000 4.3500 30,000 4.3500 130,500
2012-07-27 OPK HSIAO JANE PH D 20,000 4.3000 20,000 4.3000 86,000
2012-03-29 OPK HSIAO JANE PH D 6,504 4.6800 6,504 4.6800 30,439
2012-03-29 OPK HSIAO JANE PH D 2,300 4.7221 2,300 4.7221 10,861
2012-03-29 OPK HSIAO JANE PH D 1,196 4.7300 1,196 4.7300 5,657
2008-05-08 OPK HSIAO JANE PH D 500,000 1.2500 500,000 1.2500 625,000

經調整價格 已按拆股調整。經調整股數 已按拆股調整。

OPK / OPKO Health, Inc. Insider Trades
OPK / OPKO Health, Inc.內部人士賣出 - 短期虧損分析

在這一部分，我們分析了在 COCP / Cocrystal Pharma, Inc. 中進行的每筆非計劃的公開市場內部人士賣出所達成的短期虧損規避。如果存在持續的虧損規避模式，可能表明未來的內部人士賣出交易預示著價格的下跌。該分析基於每筆交易後一年的情況，

以下表格顯示了最近的自動交易計劃之外的公開市場購買。

交易日期 證券代碼 內部人士 報告
股數		 Reported
價格		 經調整
股數		 經調整
價格		 成本基礎 達到最低利潤的
天數		 達到最低利潤時的
價格		 避免的
最高損失金額($)		 避免的
最高損失率($)
當前未知該內部人士及證券組合進行過任何未預先計劃的公開市場交易。

經調整價格 已按拆股調整。經調整股數 已按拆股調整。

OPK / OPKO Health, Inc. Insider Trades
SRNE / Sorrento Therapeutics, Inc.內部人士買入 - 短期收益分析

在這一部分，我們分析了在 COCP / Cocrystal Pharma, Inc. 中進行的每筆非計劃的公開市場內部人士購買的盈利情況。這種分析有助於了解內部人士是否持續產生異常的回報，以及是否值得跟踪。該分析基於每筆交易後一年的情況，結果僅為理論值。

以下表格顯示了最近的自動交易計劃之外的公開市場購買。

交易日期 證券代碼 內部人士 報告
股數		 Reported
價格		 經調整
股數		 經調整
價格		 成本基礎 達到最高利潤的
天數		 達到最高利潤時的
價格		 最高
淨利 ($)		 最高回報率（%）
當前未知該內部人士及證券組合進行過任何未預先計劃的公開市場交易。

經調整價格 已按拆股調整。經調整股數 已按拆股調整。

SRNE / Sorrento Therapeutics, Inc. Insider Trades
SRNE / Sorrento Therapeutics, Inc.內部人士賣出 - 短期虧損分析

在這一部分，我們分析了在 COCP / Cocrystal Pharma, Inc. 中進行的每筆非計劃的公開市場內部人士賣出所達成的短期虧損規避。如果存在持續的虧損規避模式，可能表明未來的內部人士賣出交易預示著價格的下跌。該分析基於每筆交易後一年的情況，

以下表格顯示了最近的自動交易計劃之外的公開市場購買。

交易日期 證券代碼 內部人士 報告
股數		 Reported
價格		 經調整
股數		 經調整
價格		 成本基礎 達到最低利潤的
天數		 達到最低利潤時的
價格		 避免的
最高損失金額($)		 避免的
最高損失率($)
當前未知該內部人士及證券組合進行過任何未預先計劃的公開市場交易。

經調整價格 已按拆股調整。經調整股數 已按拆股調整。

SRNE / Sorrento Therapeutics, Inc. Insider Trades
歷史內部人交易

該表格顯示了由 Jane Ph D Hsiao 進行的所有內幕交易的完整列表，這些交易已向美國證券交易委員會（SEC）披露。

呈報日期 交易日期 表格 證券代碼 證券 代碼 10b5-1 股份 剩餘股份 %
變化		 每股
股價		 交易
金額		 剩餘
金額
2024-07-26 2024-07-24 4 OPK OPKO HEALTH, INC.
Common Stock 		A - Award 500,000 28,499,880 1.79
2024-01-17 2024-01-17 4 OPK OPKO HEALTH, INC.
Common Stock 		P - Purchase 150,000 27,999,880 0.54 0.95 142,500 26,599,886
2024-01-08 2024-01-05 4 OPK OPKO HEALTH, INC.
Common Stock 		P - Purchase 150,010 27,849,880 0.54 0.87 130,899 24,301,805
2023-11-13 2023-11-10 4 OPK OPKO HEALTH, INC.
Common Stock 		P - Purchase 65,942 27,699,870 0.24 1.27 83,746 35,178,835
2023-11-13 2023-11-10 4 OPK OPKO HEALTH, INC.
Common Stock 		P - Purchase 34,058 27,633,928 0.12 1.26 42,913 34,818,749
2021-08-10 2021-08-09 4 OPK OPKO HEALTH, INC.
Common Stock 		P - Purchase 10 27,599,870 0.00 3.73 37 102,947,515
2021-07-02 2021-07-01 4 ASXC ASENSUS SURGICAL, INC.
Common Stock 		A - Award 29,231 336,895 9.50
2021-07-02 2021-06-30 4 ASXC ASENSUS SURGICAL, INC.
Stock Option 		A - Award 3,748 3,748
2021-04-02 2021-03-31 4 ASXC ASENSUS SURGICAL, INC.
Stock Option 		A - Award 3,155 3,155
2021-02-22 2021-02-19 4 OPK OPKO HEALTH, INC.
Stock Option (Right to Buy) 		A - Award 400,000 400,000
2021-01-05 2020-12-31 4 TRXC TRANSENTERIX, INC.
Stock Option 		A - Award 12,831 12,831
2020-10-02 2020-09-30 4 TRXC TRANSENTERIX, INC.
Stock Option 		A - Award 12,915 12,915
2020-06-10 2020-06-08 4 TRXC TRANSENTERIX, INC.
Stock Option 		A - Award 31,250 31,250
2020-06-10 2020-06-08 4 TRXC TRANSENTERIX, INC.
Common Stock 		A - Award 22,500 307,664 7.89
2020-06-10 2020-06-08 4 TRXC TRANSENTERIX, INC.
Common Stock 		A - Award 7,988 285,164 2.88
2020-06-08 2020-06-04 4 OPK Opko Health, Inc.
Stock Option (Right to Buy) 		A - Award 450,000 450,000
2019-10-25 2019-10-25 4 OPK Opko Health, Inc.
Common Stock 		P - Purchase 400,000 5,127,404 8.46 1.50 600,000 7,691,106
2019-07-03 2019-07-01 4 OPK Opko Health, Inc.
Stock Option (Right to Buy) 		A - Award 350,000 350,000
2019-05-10 2019-05-09 4 OPK Opko Health, Inc.
Common Stock 		P - Purchase 2,783 24,475,147 0.01 2.04 5,677 49,929,300
2019-05-10 2019-05-09 4 OPK Opko Health, Inc.
Common Stock 		P - Purchase 500 24,472,364 0.00 2.04 1,018 49,801,261
2019-05-10 2019-05-09 4 OPK Opko Health, Inc.
Common Stock 		P - Purchase 6,717 24,471,864 0.03 2.02 13,602 49,555,525
2019-04-26 2019-04-25 4 TRXC TRANSENTERIX INC.
Stock Option Award 		A - Award 29,104 29,104
2019-04-26 2019-04-25 4 TRXC TRANSENTERIX INC.
Common Stock 		A - Award 20,380 3,603,278 0.57
2019-02-05 2018-12-13 4 OPK Opko Health, Inc.
Common Stock 		G - Gift -1,000,000 0 -100.00
2019-02-05 2018-12-13 4 OPK Opko Health, Inc.
Common Stock 		G - Gift -1,000,000 0 -100.00
2019-02-05 2014-01-31 4 OPK Opko Health, Inc.
Common Stock 		P - Purchase 10,000 24,465,147 0.04 7.96 79,600 194,742,570
2019-02-05 2012-07-30 4 OPK Opko Health, Inc.
Common Stock 		P - Purchase 30,000 4,727,404 0.64 4.35 130,500 20,564,207
2019-02-05 2012-07-27 4 OPK Opko Health, Inc.
Common Stock 		P - Purchase 20,000 4,697,404 0.43 4.30 86,000 20,198,837
2019-02-05 2011-12-21 4 OPK Opko Health, Inc.
Common Stock 		G - Gift -831,052 24,455,147 -3.29
2019-02-05 2017-05-11 4/A OPK Opko Health, Inc.
Common Stock 		P - Purchase 10,000 4,677,404 0.21 6.93 69,300 32,414,410
2019-02-05 2017-05-11 4/A OPK Opko Health, Inc.
Common Stock 		P - Purchase 10,000 4,667,404 0.21 6.92 69,200 32,298,436
2019-02-05 2017-05-10 4/A OPK Opko Health, Inc.
Common Stock 		P - Purchase 10,000 4,657,404 0.22 6.99 69,900 32,555,254
2019-02-05 2017-05-10 4/A OPK Opko Health, Inc.
Common Stock 		P - Purchase 5,665 4,647,404 0.12 6.98 39,542 32,438,880
2019-02-05 2017-05-10 4/A OPK Opko Health, Inc.
Common Stock 		P - Purchase 11,735 4,641,739 0.25 6.97 81,793 32,352,921
2019-02-05 2017-05-10 4/A OPK Opko Health, Inc.
Common Stock 		P - Purchase 2,600 4,630,004 0.06 6.95 18,070 32,178,528
2019-02-05 2017-05-10 4/A OPK Opko Health, Inc.
Common Stock 		P - Purchase 10,000 4,627,404 0.22 6.94 69,400 32,114,184
2018-12-27 2018-12-21 4 NIMU NON INVASIVE MONITORING SYSTEMS INC /FL/
Common Stock, $0.01 par value per share 		P - Purchase 20,883,660 20,883,660 0.07 1,461,856 1,461,856
2018-12-27 2018-12-21 4 NIMU NON INVASIVE MONITORING SYSTEMS INC /FL/
Common Stock, $0.01 par value per share 		P - Purchase 4,923,503 16,752,074 41.62 0.07 344,645 1,172,645
2018-12-27 2018-12-21 4 NIMU NON INVASIVE MONITORING SYSTEMS INC /FL/
Common Stock, $0.01 par value per share 		P - Purchase 1,428,571 11,828,571 13.74 0.07 100,000 828,000
2018-11-13 2018-11-08 4 OPK Opko Health, Inc.
Common Stock 		A - Award 573,066 25,346,199 2.31 3.49 2,000,000 88,458,235
2018-09-24 2018-09-21 4 COCP Cocrystal Pharma, Inc.
Stock Options (Right to Buy) 		A - Award 50,000 50,000
2018-06-22 2018-06-21 4 OPK Opko Health, Inc.
Stock Option (Right to Buy) 		A - Award 500,000 500,000
2018-05-29 2018-05-24 4 TRXC TRANSENTERIX INC.
Stock Option Award 		A - Award 35,592 35,592
2018-05-29 2018-05-24 4 TRXC TRANSENTERIX INC.
Common Stock 		A - Award 20,362 3,582,898 0.57
2018-03-26 2018-03-22 4 TRXC TRANSENTERIX INC.
Warrants 		X - Other -400,000 0 -100.00
2018-03-26 2018-03-22 4 TRXC TRANSENTERIX INC.
Common Stock 		X - Other 400,000 3,562,536 12.65 1.65 660,000 5,878,184
2018-03-01 2018-02-27 4 OPK Opko Health, Inc.
5% Convertible Promissory Note 		A - Award 5,000,000.00
2017-05-26 2017-05-25 4 TRXC TRANSENTERIX INC.
Stock Option Award 		A - Award 20,000 20,000
2017-05-12 2017-05-11 4 OPK Opko Health, Inc.
Common Stock 		P - Purchase 10,000 24,773,133 0.04 6.93 69,300 171,677,812
2017-05-12 2017-05-11 4 OPK Opko Health, Inc.
Common Stock 		P - Purchase 10,000 24,763,133 0.04 6.92 69,200 171,360,880
2017-05-11 2017-05-10 4 OPK Opko Health, Inc.
Common Stock 		P - Purchase 10,000 24,753,133 0.04 6.99 69,900 173,024,400
2017-05-11 2017-05-10 4 OPK Opko Health, Inc.
Common Stock 		P - Purchase 5,665 24,743,133 0.02 6.98 39,542 172,707,068
2017-05-11 2017-05-10 4 OPK Opko Health, Inc.
Common Stock 		P - Purchase 11,735 24,737,468 0.05 6.97 81,793 172,420,152
2017-05-11 2017-05-10 4 OPK Opko Health, Inc.
Common Stock 		P - Purchase 2,600 24,725,733 0.01 6.95 18,070 171,843,844
2017-05-11 2017-05-10 4 OPK Opko Health, Inc.
Common Stock 		P - Purchase 10,000 24,723,133 0.04 6.94 69,400 171,578,543
2017-01-05 2017-01-04 4 OPK Opko Health, Inc.
Stock Option (Right to Buy) 		M - Exercise -112,500 112,500 -50.00
2017-01-05 2017-01-04 4 OPK Opko Health, Inc.
Common Stock 		M - Exercise 112,500 24,713,133 0.46 7.61 856,125 188,066,942
2016-06-10 2016-06-08 4 TRXC TRANSENTERIX INC.
Stock Option Award 		A - Award 20,000 20,000
2016-04-01 2016-04-01 4 OPK Opko Health, Inc.
Stock Option (Right to Buy) 		A - Award 450,000 450,000
2016-03-18 2016-03-17 4 OPK Opko Health, Inc.
Common Stock 		P - Purchase 700 24,600,633 0.00 10.70 7,490 263,226,773
2016-03-18 2016-03-17 4 OPK Opko Health, Inc.
Common Stock 		P - Purchase 500 24,599,933 0.00 10.59 5,295 260,513,290
2016-03-17 2016-03-16 4 OPK Opko Health, Inc.
Common Stock 		P - Purchase 1,200 24,599,433 0.00 9.99 11,988 245,748,336
2016-03-17 2016-03-15 4 COCP Cocrystal Pharma, Inc.
Common Stock 		P - Purchase 1,235,294 3,435,294 56.15 0.51 630,000 1,752,000
2016-03-16 2016-03-15 4 OPK Opko Health, Inc.
Common Stock 		P - Purchase 1,200 24,598,233 0.00 10.00 12,000 245,982,330
2016-03-16 2016-03-14 4 OPK Opko Health, Inc.
Common Stock 		P - Purchase 1,000 24,597,033 0.00 10.12 10,120 248,921,974
2016-03-16 2016-03-14 4 OPK Opko Health, Inc.
Common Stock 		P - Purchase 200 24,596,033 0.00 10.12 2,023 248,788,874
2016-03-15 2016-03-11 4 OPK Opko Health, Inc.
Common Stock 		P - Purchase 1,100 24,595,833 0.00 10.21 11,231 251,123,455
2016-03-15 2016-03-11 4 OPK Opko Health, Inc.
Common Stock 		P - Purchase 100 24,594,733 0.00 10.20 1,020 250,989,250
2016-03-15 2016-03-10 4 OPK Opko Health, Inc.
Common Stock 		P - Purchase 900 24,594,633 0.00 9.83 8,847 241,765,242
2016-03-15 2016-03-10 4 OPK Opko Health, Inc.
Common Stock 		P - Purchase 300 24,593,733 0.00 9.80 2,940 241,018,583
2016-03-15 2016-03-09 4 OPK Opko Health, Inc.
Common Stock 		P - Purchase 1,200 24,593,433 0.00 9.99 11,988 245,688,396
2016-03-15 2016-03-08 4 OPK Opko Health, Inc.
Common Stock 		P - Purchase 1,200 24,592,233 0.00 10.01 12,012 246,168,252
2015-08-26 2015-08-25 4 OPK Opko Health, Inc.
Common Stock 		P - Purchase 500 24,591,033 0.00 10.84 5,420 266,566,798
2015-08-26 2015-08-25 4 OPK Opko Health, Inc.
Common Stock 		P - Purchase 200 24,590,533 0.00 10.84 2,168 266,499,901
2015-08-26 2015-08-25 4 OPK Opko Health, Inc.
Common Stock 		P - Purchase 1,300 24,590,333 0.01 10.84 14,086 266,436,258
2015-08-26 2015-08-25 4 OPK Opko Health, Inc.
Common Stock 		P - Purchase 8,500 24,589,033 0.03 10.82 91,970 266,053,337
2015-08-26 2015-08-25 4 OPK Opko Health, Inc.
Common Stock 		P - Purchase 1,500 24,580,533 0.01 10.82 16,222 265,838,464
2015-08-26 2015-08-25 4 OPK Opko Health, Inc.
Common Stock 		P - Purchase 3,800 24,579,033 0.02 10.81 41,078 265,699,347
2015-08-26 2015-08-25 4 OPK Opko Health, Inc.
Common Stock 		P - Purchase 4,200 24,575,233 0.02 10.80 45,381 265,535,393
2015-08-10 2015-08-07 4 OPK Opko Health, Inc.
Stock Option (Right to Buy) 		M - Exercise -87,500 262,500 -25.00
2015-08-10 2015-08-07 4 OPK Opko Health, Inc.
Stock Option (Right to Buy) 		M - Exercise -112,500 225,000 -33.33
2015-08-10 2015-08-07 4 OPK Opko Health, Inc.
Common Stock 		M - Exercise 87,500 24,571,033 0.36 8.37 732,375 205,659,546
2015-08-10 2015-08-07 4 OPK Opko Health, Inc.
Common Stock 		M - Exercise 112,500 24,483,533 0.46 7.61 856,125 186,319,686
2015-08-07 2015-08-06 4 OPK Opko Health, Inc.
3% Convertible Senior Notes due 2033 		C - Conversion 0
2015-08-07 2015-08-06 4 OPK Opko Health, Inc.
Common Stock 		C - Conversion 144,823 4,617,404 3.24 7.07 1,023,899 32,645,046
2015-05-08 2015-05-07 4 TRXC TRANSENTERIX INC.
Stock Option 		A - Award 25,000 20,000 -500.00
2015-04-15 2015-04-13 4 COCP Cocrystal Pharma, Inc.
Stock options (Right to buy) 		A - Award 350,000 350,000
2015-03-27 2015-03-25 4 COCP Cocrystal Pharma, Inc.
Common Stock 		P - Purchase 2,200,000 2,200,000 0.92 2,024,000 2,024,000
2015-03-19 2015-03-18 4 OPK Opko Health, Inc.
Stock Option (Right to Buy) 		A - Award 450,000 450,000
2015-03-05 2015-03-03 4 COCP Cocrystal Pharma, Inc.
Series B Convertible Preferred Stock 		M - Exercise -53,626,802 0 -100.00
2015-03-05 2015-03-03 4 COCP Cocrystal Pharma, Inc.
Common Stock 		M - Exercise 5,496,654 5,496,654
2015-02-02 2015-01-31 4 OPK Opko Health, Inc.
Warrant (Right to Buy) 		M - Exercise -22,125 0 -100.00
2015-02-02 2015-01-31 4 OPK Opko Health, Inc.
Warrant (Right to Buy) 		M - Exercise -22,124 0 -100.00
2015-02-02 2015-01-31 4 OPK Opko Health, Inc.
Warrant (Right to Buy) 		M - Exercise -22,124 0 -100.00
2015-02-02 2015-01-31 4 OPK Opko Health, Inc.
Warrant (Right to Buy) 		M - Exercise -6,487 0 -100.00
2015-02-02 2015-01-31 4 OPK Opko Health, Inc.
Warrant (Right to Buy) 		M - Exercise -81,085 0 -100.00
2015-02-02 2015-01-31 4 OPK Opko Health, Inc.
Warrant (Right to Buy) 		M - Exercise -4,000,000 0 -100.00
2015-02-02 2015-01-31 4 OPK Opko Health, Inc.
Warrant (Right to Buy) 		M - Exercise -978,860 0 -100.00
2015-02-02 2015-01-31 4 OPK Opko Health, Inc.
Warrant (Right to Buy) 		M - Exercise -978,860 0 -100.00
2015-02-02 2015-01-31 4 OPK Opko Health, Inc.
Warrant (Right to Buy) 		M - Exercise -978,860 0 -100.00
2015-02-02 2015-01-31 4 OPK Opko Health, Inc.
Common Stock 		F - Taxes -21,523 20,091,062 -0.11 11.62 -250,011 233,377,776
2015-02-02 2015-01-31 4 OPK Opko Health, Inc.
Common Stock 		F - Taxes -174,119 20,112,585 -0.86 11.78 -2,050,599 236,865,914
2015-02-02 2015-01-31 4 OPK Opko Health, Inc.
Common Stock 		M - Exercise 22,125 20,286,704 0.11 1.05 23,156 21,232,064
2015-02-02 2015-01-31 4 OPK Opko Health, Inc.
Common Stock 		M - Exercise 22,124 20,264,579 0.11 0.85 18,746 17,170,178
2015-02-02 2015-01-31 4 OPK Opko Health, Inc.
Common Stock 		M - Exercise 22,124 20,242,455 0.11 0.67 14,885 13,619,124
2015-02-02 2015-01-31 4 OPK Opko Health, Inc.
Common Stock 		M - Exercise 4,000,000 20,220,331 24.66 0.50 1,993,600 10,077,813
2015-02-02 2015-01-31 4 OPK Opko Health, Inc.
Common Stock 		M - Exercise 648,700 16,220,331 4.17 0.39 250,009 6,251,316
2015-02-02 2015-01-31 4 OPK Opko Health, Inc.
Common Stock 		M - Exercise 81,085 15,571,631 0.52 0.00 154 29,586
2015-02-02 2015-01-31 4 OPK Opko Health, Inc.
Common Stock 		F - Taxes -213,342 24,371,033 -0.87 11.78 -2,512,529 287,017,656
2015-02-02 2015-01-31 4 OPK Opko Health, Inc.
Common Stock 		M - Exercise 978,860 24,584,375 4.15 1.05 1,024,475 25,730,007
2015-02-02 2015-01-31 4 OPK Opko Health, Inc.
Common Stock 		M - Exercise 978,860 23,605,515 4.33 0.85 829,388 20,000,953
2015-02-02 2015-01-31 4 OPK Opko Health, Inc.
Common Stock 		M - Exercise 978,860 22,626,655 4.52 0.67 658,577 15,223,213
2014-09-25 2014-09-24 4 OPK Opko Health, Inc.
Warrant (Right to Buy) 		M - Exercise -201,613 0 -100.00
2014-09-25 2014-09-24 4 OPK Opko Health, Inc.
Common Stock 		M - Exercise 201,613 4,472,581 4.72 2.48 500,000 11,092,001
2014-08-04 2014-08-01 4 OPK Opko Health, Inc.
Stock Option (Right to Buy) 		M - Exercise -14,926 0 -100.00
2014-08-04 2014-08-01 4 OPK Opko Health, Inc.
Stock Option (Right to Buy) 		M - Exercise -112,500 0 -100.00
2014-08-04 2014-08-01 4 OPK Opko Health, Inc.
Stock Option (Right to Buy) 		M - Exercise -112,500 0 -100.00
2014-08-04 2014-08-01 4 OPK Opko Health, Inc.
Stock Option (Right to Buy) 		M - Exercise -29,853 0 -100.00
2014-08-04 2014-08-01 4 OPK Opko Health, Inc.
Stock Option (Right to Buy) 		M - Exercise -39,804 0 -100.00
2014-08-04 2014-08-01 4 OPK Opko Health, Inc.
Common Stock 		M - Exercise 112,500 21,647,795 0.52 7.61 856,125 164,739,720
2014-08-04 2014-08-01 4 OPK Opko Health, Inc.
Common Stock 		M - Exercise 39,804 21,535,295 0.19 4.77 189,865 102,723,357
2014-08-04 2014-08-01 4 OPK Opko Health, Inc.
Common Stock 		M - Exercise 29,853 21,495,491 0.14 5.50 164,192 118,225,200
2014-08-04 2014-08-01 4 OPK Opko Health, Inc.
Common Stock 		M - Exercise 112,500 21,465,638 0.53 2.36 265,500 50,658,906
2014-08-04 2014-08-01 4 OPK Opko Health, Inc.
Common Stock 		M - Exercise 14,926 21,353,138 0.07 0.66 9,851 14,093,071
2014-05-30 2014-05-28 4 TRXC TRANSENTERIX INC.
Stock Option 		A - Award 25,000 20,000 -500.00
2014-04-15 2014-04-15 4 OPK Opko Health, Inc.
Common Stock 		P - Purchase 10,000 21,338,212 0.05 8.03 80,300 171,345,842
2014-04-15 2014-04-14 4 OPK Opko Health, Inc.
Stock Option (Right to Buy) 		A - Award 350,000 350,000
2014-03-17 3 BZNE BIOZONE PHARMACEUTICALS, INC.
Common Stock 		9,091,986
2014-03-17 3 BZNE BIOZONE PHARMACEUTICALS, INC.
Common Stock 		9,091,986
2014-01-31 2014-01-30 4 OPK Opko Health, Inc.
Common Stock 		P - Purchase 2,000 21,328,212 0.01 8.18 16,360 174,464,774
2014-01-31 2014-01-30 4 OPK Opko Health, Inc.
Common Stock 		P - Purchase 4,000 21,326,212 0.02 8.15 32,600 173,808,628
2014-01-31 2014-01-30 4 OPK Opko Health, Inc.
Common Stock 		P - Purchase 2,000 21,322,212 0.01 8.13 16,260 173,349,584
2014-01-31 2014-01-30 4 OPK Opko Health, Inc.
Common Stock 		P - Purchase 2,000 21,320,212 0.01 8.08 16,160 172,267,313
2014-01-30 2014-01-28 4 OPK Opko Health, Inc.
Common Stock 		P - Purchase 9,700 21,318,212 0.05 8.20 79,540 174,809,338
2014-01-30 2014-01-28 4 OPK Opko Health, Inc.
Common Stock 		P - Purchase 100 21,308,512 0.00 8.20 820 174,623,256
2014-01-30 2014-01-28 4 OPK Opko Health, Inc.
Common Stock 		P - Purchase 200 21,308,412 0.00 8.19 1,638 174,515,894
2013-12-16 2013-12-13 4 OPK Opko Health, Inc.
Stock Option (Right to Buy) 		M - Exercise -337,500 112,500 -75.00
2013-12-16 2013-12-13 4 OPK Opko Health, Inc.
Stock Option (Right to Buy) 		M - Exercise -300,000 0 -100.00
2013-12-16 2013-12-13 4 OPK Opko Health, Inc.
Stock Option (Right to Buy) 		M - Exercise -250,000 0 -100.00
2013-12-16 2013-12-13 4 OPK Opko Health, Inc.
Stock Option (Right to Buy) 		M - Exercise -650,000 0 -100.00
2013-12-16 2013-12-13 4 OPK Opko Health, Inc.
Common Stock 		M - Exercise 337,500 21,308,212 1.61 2.36 796,500 50,287,380
2013-12-16 2013-12-13 4 OPK Opko Health, Inc.
Common Stock 		M - Exercise 300,000 20,970,712 1.45 1.16 348,000 24,326,026
2013-12-16 2013-12-13 4 OPK Opko Health, Inc.
Common Stock 		M - Exercise 250,000 20,670,712 1.22 1.65 412,500 34,106,675
2013-12-16 2013-12-13 4 OPK Opko Health, Inc.
Common Stock 		M - Exercise 650,000 20,420,712 3.29 4.88 3,172,000 99,653,075
2013-12-10 2013-12-06 4 TRXC.OB TRANSENTERIX INC.
Series B Convertible Preferred Stock 		C - Conversion -437,500 0 -100.00
2013-12-10 2013-12-06 4 TRXC.OB TRANSENTERIX INC.
Series B Convertible Preferred Stock 		C - Conversion -437,500 0 -100.00
2013-12-10 2013-12-06 4 TRXC.OB TRANSENTERIX INC.
Common Stock 		C - Conversion 4,375,000 6,288,470 228.64 0.40 1,750,000 2,515,388
2013-12-10 2013-12-06 4 TRXC.OB TRANSENTERIX INC.
Common Stock 		C - Conversion 4,375,000 6,288,470 228.64 0.40 1,750,000 2,515,388
2013-09-05 2013-09-03 4 SFES.OB SafeStitch Medical, Inc.
Series B Convertible Preferred Stock 		P - Purchase 437,500 437,500 4.00 1,750,000 1,750,000
2013-09-05 2013-09-03 4 SFES.OB SafeStitch Medical, Inc.
Series B Convertible Preferred Stock 		P - Purchase 437,500 437,500 4.00 1,750,000 1,750,000
2013-09-03 2013-08-29 4 OPK Opko Health, Inc.
Stock Option (Right to Buy) 		A - Award 14,926 14,926
2013-09-03 2013-08-29 4 OPK Opko Health, Inc.
Stock Option (Right to Buy) 		A - Award 29,853 29,853
2013-09-03 2013-08-29 4 OPK Opko Health, Inc.
Stock Option (Right to Buy) 		A - Award 39,804 39,804
2013-09-03 2013-08-29 4 OPK Opko Health, Inc.
Common Stock 		A - Award 366,718 4,270,968 9.39
2013-09-03 2013-08-29 4 OPK Opko Health, Inc.
Common Stock 		A - Award 1,865,481 19,770,712 10.42
2013-09-03 2013-08-29 4 PBTH PROLOR Biotech, Inc.
Stock Option (right to buy) 		D - Sale to Issuer -40,000 0 -100.00
2013-09-03 2013-08-29 4 PBTH PROLOR Biotech, Inc.
Stock Option (right to buy) 		D - Sale to Issuer -30,000 0 -100.00
2013-09-03 2013-08-29 4 PBTH PROLOR Biotech, Inc.
Stock Option (right to buy) 		D - Sale to Issuer -15,000 0 -100.00
2013-09-03 2013-08-29 4 PBTH PROLOR Biotech, Inc.
Common Stock 		D - Sale to Issuer -368,523 0 -100.00
2013-09-03 2013-08-29 4 PBTH PROLOR Biotech, Inc.
Common Stock 		D - Sale to Issuer -1,874,666 0 -100.00
2013-06-06 2013-06-04 4 PBTH PROLOR Biotech, Inc.
Stock Option (right to buy) 		A - Award 40,000 40,000
2013-04-25 2013-04-23 4 SFES.OB SafeStitch Medical, Inc.
Stock Option (Right to Buy) 		A - Award 200,000 200,000
2013-04-10 2013-04-08 4 NIMU NON INVASIVE MONITORING SYSTEMS INC /FL/
Common Stock, $0.01 par value 		P - Purchase 20,000,000 10,400,000 -208.33 0.05 1,000,000 520,000
2013-04-10 2013-04-08 4/A NIMU NON INVASIVE MONITORING SYSTEMS INC /FL/
Common Stock, $0.01 par value 		P - Purchase 2,000,000 10,400,000 23.81 0.05 100,000 520,000
2013-04-04 2013-04-03 4 OPK Opko Health, Inc.
Common Stock 		P - Purchase 5,000 17,905,231 0.03 6.99 34,950 125,157,565
2013-03-26 2013-03-22 4 SFES.OB SafeStitch Medical, Inc.
Warrants 		P - Purchase 2,000,000 2,000,000
2013-03-26 2013-03-22 4 SFES.OB SafeStitch Medical, Inc.
Common Stock 		P - Purchase 4,000,000 11,437,681 53.78 0.25 1,000,000 2,859,420
2013-03-20 2013-03-18 4 OPK Opko Health, Inc.
Stock Option (Right to Buy) 		A - Award 450,000 450,000
2013-03-12 2013-03-08 4 OPK Opko Health, Inc.
Series D Cumulative Convertible Preferred Stock 		M - Exercise -80,645 0 -100.00 24.80 -1,999,996
2013-03-12 2013-03-08 4 OPK Opko Health, Inc.
Common Stock 		M - Exercise 806,450 3,904,250 26.03
2013-01-31 2013-01-30 4 OPK Opko Health, Inc.
3% Convertible Senior Notes due 2033 		A - Award 1,000 1,000 1,000.00 1,000,000 1,000,000
2012-10-29 2012-10-25 4 SFES SafeStitch Medical, Inc.
Warrants 		X - Other -785,383 0 -100.00
2012-10-29 2012-10-25 4 SFES SafeStitch Medical, Inc.
Common Stock 		X - Other 785,383 785,383 0.25 196,346 196,346
2012-10-10 2012-10-09 4 OPK Opko Health, Inc.
Common Stock 		P - Purchase 2,600 17,900,231 0.01 4.35 11,310 77,866,005
2012-10-10 2012-10-09 4 OPK Opko Health, Inc.
Common Stock 		P - Purchase 400 17,897,631 0.00 4.34 1,738 77,765,207
2012-10-10 2012-10-09 4 OPK Opko Health, Inc.
Common Stock 		P - Purchase 1,650 17,897,231 0.01 4.34 7,161 77,673,983
2012-10-10 2012-10-09 4 OPK Opko Health, Inc.
Common Stock 		P - Purchase 400 17,895,581 0.00 4.34 1,734 77,577,344
2012-10-10 2012-10-09 4 OPK Opko Health, Inc.
Common Stock 		P - Purchase 2,750 17,895,181 0.02 4.33 11,908 77,486,134
2012-10-10 2012-10-09 4 OPK Opko Health, Inc.
Common Stock 		P - Purchase 700 17,892,431 0.00 4.32 3,028 77,384,764
2012-10-10 2012-10-09 4 OPK Opko Health, Inc.
Common Stock 		P - Purchase 1,400 17,891,731 0.01 4.32 6,048 77,292,278
2012-10-10 2012-10-09 4 OPK Opko Health, Inc.
Common Stock 		P - Purchase 100 17,890,331 0.00 4.32 432 77,196,778
2012-04-13 2012-04-12 4 PBTH PROLOR Biotech, Inc.
Common Stock Warrants (right to buy) 		X - Other -63,333 0 -100.00
2012-04-13 2012-04-12 4 PBTH PROLOR Biotech, Inc.
Common Stock 		X - Other 63,333 1,874,666 3.50 2.50 158,332 4,686,665
2012-03-30 2012-03-29 4 OPK Opko Health, Inc.
Common Stock 		P - Purchase 1,196 17,890,231 0.01 4.73 5,657 84,620,793
2012-03-30 2012-03-29 4 OPK Opko Health, Inc.
Common Stock 		P - Purchase 2,300 17,889,035 0.01 4.72 10,861 84,473,812
2012-03-30 2012-03-29 4 OPK Opko Health, Inc.
Common Stock 		P - Purchase 6,504 17,886,735 0.04 4.68 30,439 83,709,920
2012-03-01 2012-02-28 4 NIMU NON INVASIVE MONITORING SYSTEMS INC /FL/
Common Stock, $0.01 par value 		P - Purchase 6,000,000 8,400,000 250.00 0.05 300,000 420,000
2012-02-22 2012-02-17 4 SFES SafeStitch Medical, Inc.
Common Stock 		P - Purchase 4,500,000 7,303,965 160.49 0.40 1,800,000 2,921,586
2012-02-17 2012-02-16 4 SFES SafeStitch Medical, Inc.
Stock Option (Right to Buy) 		A - Award 100,000 100,000
2012-02-07 2012-02-06 4 SRNE Sorrento Therapeutics, Inc.
Non-qualified stock options 		A - Award 75,000 75,000
2010-01-27 3 SRNE Sorrento Therapeutics, Inc.
Common Stock 		2,231,719
2008-05-12 2008-05-08 4 OPK Opko Health, Inc.
Common Stock 		P - Purchase 500,000 500,000 1.25 625,000 625,000
P
非衍生或衍生證券的公開市場或私下買入
S
非衍生或衍生證券的公開市場或私下賣出
A
公司向內部人員授予、獎勵或以其他方式獲取證券（例如股票期權）
C
衍生工具轉換
D
將證券賣出或轉讓回公司
F
使用從公司收到的證券的一部分來支付行使價或稅務負擔。
G
內部人士贈送或接收他人贈送公司股票
K
股權掉期和類似的避險交易
M
行使或轉換從公司獲得的衍生證券（例如期權）
V
內部人士透過Form 4自願報告的一筆交易
J
其他（附有交易描述的腳註）