| 內部人士股份 | 41,783,886 shares |
內部人士情緒分數
「內部人士情緒分數」用於查找被公司內部人士購入的公司。
它是一個複雜的多因素量化模型的結果，該模型能夠辨識具有最高內部人士累積持有水平的公司。該評分模型結合了內部人士在過去90天內購買的淨數量、總購買股份佔流通股比例，以及內部人士擁有的總股份的指標。該分數的範圍從0到100，數值越高表示相對於同行業而言具有更高程度的內部人士持股水平，50為平均值。
更新頻率：每日
高管情緒分數
「高管情緒分數」用於查找被公司管理層購入的公司。
根據定義，公司高管是公司內部人士，但與其他內部人士（10%的股東和董事會成員）不同，公司高管每天在公司工作，而且他們使用自己的資金進行交易。（10%的股東和董事會成員通常是基金經理，管理著其他人的資金。）因此，公司高管進行的內幕交易更為重要性，應該被適當地重視和關注。
如同「內部人士情緒分數」，「高管情緒分數」也是一個複雜的多因素量化模型的計算結果，該模型能夠辨識具有最高高管累積持有水平的公司。
更新頻率：每日
關鍵內部人士指標
此表格顯示了公司在各種內部人士指標上的排名。百分位數排名顯示了這家公司在美國市場與其他公司相比的表現。排名越高表明公司所處狀況越好。
舉例來說，一般認為內部人士的買入是一個積極的指標，因此具有更多內部人士買入的公司將排名高於那些內部人士買入較少（甚至有內部人士賣出）的公司。
內部人士買入淨數（排名）
N/A
內部人士買入淨數是過去90天內買入的內部人士總數減去賣出的內部人士總數。以百分位排名顯示（範圍從0到100%）。
內部人士買入佔流通股比例（排名）
N/A
內部人士買入佔流通股比例是內部人士在過去90天內購買的股份總數減去賣出的股份總數，除以總流通股數並乘以100。
內幕交易圖表
以下圖表顯示了Aravive, Inc.內部人士交易。內部人士包括公司的高管、董事或重要投資者。一般而言，基於內幕、非公開信息進行交易是非法的。這並不意味著他們在自己的公司進行任何交易都是非法的。但是，他們必須透過Form 4向美國證券交易委員會（SEC）報告所有交易。
內部人員名單及盈利指標
這張表格顯示已知的內部人員名單，從向SEC披露的申報文件中自動生成。除了姓名、最近的職稱和董事、高管或10%擁有人的標誌外，我們還提供了最新披露的持股信息。此外，我們盡可能提供內部人的歷史交易表現。歷史交易表現是內部人士實際進行的公開市場購買交易表現的加權平均值。有關此計算方式的更多資訊，請查看YouTube網絡研討會。
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| 內部人士 | 平均收益（%） | 持股 數量 |
分拆 調整 |
|---|
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追蹤內部人士買入記錄 - 短期收益分析
在這一部分，我們分析了在 ARAV / Aravive, Inc. 中進行的每筆非計劃的公開市場內部人士購買的盈利情況。這種分析有助於了解內部人士是否持續產生異常的回報，以及是否值得跟踪。該分析基於每筆交易後一年的情況， 結果僅為理論值。 .
以下表格顯示了最近的自動交易計劃之外的公開市場購買。
經調整價格 已按拆股調整。 經調整股數 已按拆股調整。
追蹤內部人士賣出記錄 - 短期虧損分析
在這一部分，我們分析了在 ARAV / Aravive, Inc. 中進行的每筆非計劃的公開市場內部人士賣出所達成的短期虧損規避。如果存在持續的虧損規避模式，可能表明未來的內部人士賣出交易預示著價格的下跌。該分析基於每筆交易後一年的情況， 結果僅為理論值。 .
以下表格顯示了最近的自動交易計劃之外的公開市場購買。
經調整價格 已按拆股調整。 經調整股數 已按拆股調整。
交易歷史
點擊連結圖示即可查看完整的交易記錄。作為 10b5-1 自動交易計畫的一部分進行報告的交易，將在標記為 10b-5 的欄位中顯示 X。
| 呈報 日期 |
交易 日期 |
表格 | 內部人士 | 證券代碼 | 證券種類 | 代碼 | 直接 | 行使 價格 |
單位 價格 |
股數 變化 |
價值 變化 (1K) |
剩餘 期權 |
剩餘 股份 |
|
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 2022-10-27 | 2022-10-24 | 4/A | Ho Peter Tai-Ching | ARAV | Common stock | I | 0.9199 | 54,353 | 50 | 55,353 | ||||
| 2022-10-27 | 2022-10-24 | 4/A | Zhang Eric | ARAV | Common stock | I | 0.9199 | 543,537 | 500 | 1,403,303 | ||||
| 2022-10-26 | 2022-10-24 | 4 | Giaccia Amato | ARAV | Common stock | D | 0.9199 | 271,768 | 250 | 1,213,648 | ||||
| 2022-10-26 | 2022-10-24 | 4 | Zhang Eric | ARAV | Common stock | D | 0.9199 | 543,537 | 500 | 1,403,303 | ||||
| 2022-10-26 | 2022-10-24 | 4 | HOWARD RUDY | ARAV | Common stock | D | 0.9199 | 10,870 | 10 | 10,870 | ||||
| 2022-10-26 | 2022-10-24 | 4 | ESHELMAN FREDRIC N | ARAV | Common Stock | I | 0.9199 | 16,306,120 | 15,000 | 25,517,889 | ||||
| 2022-10-26 | 2022-10-24 | 4 | Ho Peter Tai-Ching | ARAV | Common stock | D | 0.9199 | 54,353 | 50 | 55,353 | ||||
| 2022-10-26 | 2022-10-24 | 4 | McIntyre Gail Frances | ARAV | Common stock | D | 0.9199 | 54,353 | 50 | 65,490 | ||||
| 2022-04-04 | 2022-04-01 | 4 | ESHELMAN FREDRIC N | ARAV | Pre-Funded Warrant (right to buy) | I | 0.00 | 4,545,455 | 0 | |||||
| 2022-04-04 | 2022-04-01 | 4 | ESHELMAN FREDRIC N | ARAV | Common Stock | I | 0.0001 | 4,545,455 | 0 | 9,211,769 | ||||
| 2022-03-31 | 2022-03-29 | 4 | ESHELMAN FREDRIC N | ARAV | Warrant (right to buy) | I | 2.20 | 2.2000 | 860,216 | 1,892 | 860,216 | |||
| 2022-03-31 | 2022-03-29 | 4 | ESHELMAN FREDRIC N See Footnote 1 | ARAV | Common Stock | I | 2.3250 | 860,216 | 2,000 | 4,666,314 | ||||
| 2022-03-22 | 2022-03-21 | 4 | Dove Leonard Scott | ARAV | Stock Option (Right to buy) | D | 1.89 | 200,000 | 200,000 | |||||
| 2022-01-25 | 2022-01-24 | 4 | Rangwala Reshma | ARAV | Stock Option (Right to buy) | D | 2.18 | 175,000 | 175,000 | |||||
| 2022-01-25 | 2022-01-24 | 4 | Shah Vinay | ARAV | Stock Option (Right to buy) | D | 2.18 | 175,000 | 175,000 | |||||
| 2022-01-25 | 2022-01-24 | 4 | McIntyre Gail Frances | ARAV | Stock Option (Right to buy) | D | 2.18 | 425,000 | 425,000 | |||||
| 2022-01-05 | 2022-01-03 | 4 | ESHELMAN FREDRIC N | ARAV | Pre-Funded Warrant (right to buy) | I | 0.00 | 2.2000 | 4,545,455 | 10,000 | 4,545,455 | |||
| 2021-12-23 | 2021-12-03 | 4 | Giaccia Amato | ARAV | Common Stock | D | -48,366 | 941,880 | ||||||
| 2021-12-02 | 2021-11-30 | 4 | Giaccia Amato | ARAV | Stock Option | D | 0.24 | -500 | 8,620 | |||||
| 2021-12-02 | 2021-11-30 | 4 | Giaccia Amato | ARAV | Stock Option | D | 0.24 | -38,761 | 0 | |||||
| 2021-12-02 | 2021-11-30 | 4 | Giaccia Amato | ARAV | Stock Option | D | 0.06 | -12,350 | 0 | |||||
| 2021-12-02 | 2021-11-30 | 4 | Giaccia Amato | ARAV | Common Stock | D | 3.2200 | -39 | -0 | 990,246 | ||||
| 2021-12-02 | 2021-11-30 | 4 | Giaccia Amato | ARAV | Common Stock | D | 3.2200 | -2,954 | -10 | 990,285 | ||||
| 2021-12-02 | 2021-11-30 | 4 | Giaccia Amato | ARAV | Common Stock | D | 3.2200 | -252 | -1 | 993,239 | ||||
| 2021-12-02 | 2021-11-30 | 4 | Giaccia Amato | ARAV | Common Stock | D | 0.2400 | 500 | 0 | 993,491 | ||||
| 2021-12-02 | 2021-11-30 | 4 | Giaccia Amato | ARAV | Common Stock | D | 0.2400 | 38,761 | 9 | 992,991 | ||||
| 2021-12-02 | 2021-11-30 | 4 | Giaccia Amato | ARAV | Common Stock | D | 0.0600 | 12,350 | 1 | 954,230 | ||||
| 2021-09-13 | 2021-09-10 | 4 | ESHELMAN FREDRIC N | ARAV | Stock Option | D | 3.97 | 22,812 | 22,812 | |||||
| 2021-09-13 | 2021-09-10 | 4 | Giaccia Amato | ARAV | Stock Option | D | 3.97 | 22,812 | 22,812 | |||||
| 2021-09-13 | 2021-09-10 | 4 | Ho Peter Tai-Ching | ARAV | Stock Option | D | 3.97 | 22,812 | 22,812 | |||||
| 2021-09-13 | 2021-09-10 | 4 | ROGERS MICHAEL W | ARAV | Stock Option | D | 3.97 | 22,812 | 22,812 | |||||
| 2021-09-13 | 2021-09-10 | 4 | Hohneker John | ARAV | Stock Option | D | 3.97 | 22,812 | 22,812 | |||||
| 2021-09-13 | 2021-09-10 | 4 | Zhang Eric | ARAV | Stock Option | D | 3.97 | 22,812 | 22,812 | |||||
| 2021-09-13 | 2021-09-10 | 4 | Kirk Sigurd | ARAV | Stock Option | D | 3.97 | 22,812 | 22,812 | |||||
| 2021-07-02 | 2021-07-01 | 4 | Kirk Sigurd | ARAV | Stock Options | D | 5.80 | 5,245 | 5,245 | |||||
| 2021-07-02 | 2021-07-01 | 4 | Kirk Sigurd | ARAV | Stock Options | D | 5.80 | 15,435 | 15,435 | |||||
| 2021-07-02 | 2021-07-01 | 4 | Ho Peter Tai-Ching | ARAV | Stock Options | D | 5.80 | 5,245 | 5,245 | |||||
| 2021-07-02 | 2021-07-01 | 4 | Ho Peter Tai-Ching | ARAV | Stock Options | D | 5.80 | 15,435 | 15,435 | |||||
| 2021-07-02 | 2021-07-01 | 4 | Hohneker John | ARAV | Stock Options | D | 5.80 | 5,245 | 5,245 | |||||
| 2021-07-02 | 2021-07-01 | 4 | Hohneker John | ARAV | Stock Options | D | 5.80 | 15,435 | 15,435 | |||||
| 2021-06-29 | 2021-06-29 | 4 | McIntyre Gail Frances | ARAV | Common Stock | D | 5.3450 | 1,000 | 5 | 11,137 | ||||
| 2021-06-29 | 2021-06-29 | 4 | Shah Vinay | ARAV | Common Stock | D | 5.3100 | 1,000 | 5 | 190,842 | ||||
| 2021-05-21 | 3 | Ho Peter Tai-Ching Hui Ping Ho Trust, 2016 | ARAV | Common Stock | I | 1,000 | ||||||||
| 2021-03-22 | 2021-03-19 | 4 | Giaccia Amato | ARAV | Stock Option (Right to buy) | D | 0.06 | -4,028 | 0 | |||||
| 2021-03-22 | 2021-03-19 | 4 | Giaccia Amato | ARAV | Stock Option (Right to buy) | D | 0.06 | -8,055 | 0 | |||||
| 2021-03-22 | 2021-03-19 | 4 | Giaccia Amato | ARAV | Common Stock | D | -12,083 | 941,880 | ||||||
| 2021-03-22 | 2021-03-19 | 4 | Giaccia Amato | ARAV | Common Stock | D | 0.0600 | 4,028 | 0 | 953,963 | ||||
| 2021-03-22 | 2021-03-19 | 4 | Giaccia Amato | ARAV | Common Stock | D | 0.0600 | 8,055 | 0 | 949,935 | ||||
| 2021-02-17 | 2021-02-12 | 4 | ESHELMAN FREDRIC N | ARAV | Common stock | I | 7.2900 | 2,875,000 | 20,959 | 3,806,098 | ||||
| 2021-01-26 | 2021-01-25 | 4 | Rangwala Reshma | ARAV | Stock Options | D | 5.95 | 10,000 | 10,000 | |||||
| 2021-01-26 | 2021-01-25 | 4 | McIntyre Gail Frances | ARAV | Stock Options | D | 5.95 | 165,000 | 165,000 | |||||
| 2021-01-26 | 2021-01-25 | 4 | Shah Vinay | ARAV | Stock Options | D | 5.95 | 60,000 | 60,000 | |||||
| 2020-12-07 | 2020-12-04 | 4 | Shah Vinay | ARAV | Common Stock | D | 5.7600 | 8,000 | 46 | 189,842 | ||||
| 2020-12-07 | 2020-12-04 | 4 | McIntyre Gail Frances | ARAV | Common Stock | D | 5.7700 | 8,000 | 46 | 10,137 | ||||
| 2020-09-29 | 2020-09-28 | 4 | Rangwala Reshma | ARAV | Stock Option | D | 4.95 | 75,000 | 75,000 | |||||
| 2020-09-17 | 2020-09-15 | 4 | ROGERS MICHAEL W | ARAV | Stock Option | D | 5.99 | 14,987 | 14,987 | |||||
| 2020-09-17 | 2020-09-15 | 4 | ROGERS MICHAEL W | ARAV | Stock Option | D | 5.99 | 15,024 | 15,024 | |||||
| 2020-09-15 | 2020-09-14 | 4 | ESHELMAN FREDRIC N | ARAV | Stock Option | D | 5.63 | 16,029 | 16,029 | |||||
| 2020-09-15 | 2020-09-14 | 4 | Tabibiazar Raymond | ARAV | Stock Option | D | 5.63 | 16,029 | 16,029 | |||||
| 2020-09-15 | 2020-09-14 | 4 | Zhang Eric | ARAV | Stock Option | D | 5.63 | 16,029 | 16,029 | |||||
| 2020-09-15 | 2020-09-14 | 4 | Giaccia Amato | ARAV | Stock Option | D | 5.63 | 16,029 | 16,029 | |||||
| 2020-06-03 | 2020-06-01 | 4 | ESHELMAN FREDRIC N | ARAV | Stock Option | D | 12.72 | 3,226 | 3,226 | |||||
| 2020-06-03 | 2020-06-01 | 4 | ESHELMAN FREDRIC N | ARAV | Stock Option | D | 12.72 | 7,500 | 7,500 | |||||
| 2020-04-10 | 3 | Eshelman Ventures, LLC | ARAV | Common Stock | I | 1,862,196 | ||||||||
| 2020-04-10 | 3 | Eshelman Ventures, LLC | ARAV | Common Stock | I | 1,862,196 | ||||||||
| 2020-04-10 | 3 | Eshelman Ventures, LLC | ARAV | Common Stock | I | 1,862,196 | ||||||||
| 2020-04-10 | 3 | Eshelman Ventures, LLC | ARAV | Common Stock | I | 1,862,196 | ||||||||
| 2020-04-09 | 2020-04-08 | 4 | McIntyre Gail Frances | ARAV | Stock Option | D | 6.16 | 80,000 | 80,000 | |||||
| 2020-04-09 | 2020-04-08 | 4 | Hemrajani Rekha | ARAV | Common Stock | D | -42,750 | 14,250 | ||||||
| 2020-04-09 | 2020-04-08 | 4 | Shepard Jay | ARAV | Common Stock | D | -9,291 | 61,201 | ||||||
| 2020-01-24 | 2020-01-22 | 4 | McIntyre Gail Frances | ARAV | Stock Option | D | 10.84 | 48,583 | 48,583 | |||||
| 2020-01-24 | 2020-01-22 | 4 | Shah Vinay | ARAV | Stock Option | D | 10.84 | 34,826 | 34,826 | |||||
| 2020-01-09 | 2020-01-09 | 4 | Shepard Jay | ARAV | Stock Option | D | 13.77 | 5,075 | 5,075 | |||||
| 2020-01-09 | 2020-01-09 | 4 | Hemrajani Rekha | ARAV | Stock Options | D | 13.77 | 143,000 | 143,000 | |||||
| 2020-01-09 | 2020-01-09 | 4 | Hemrajani Rekha | ARAV | Common Stock | D | 57,000 | 57,000 | ||||||
| 2019-12-26 | 2019-12-20 | 4 | Shepard Jay | ARAV | Common Stock | D | 11.6700 | -2,262 | -26 | 70,492 | ||||
| 2019-12-02 | 2019-12-02 | 4 | AKKARAJU SRINIVAS | ARAV | Common Stock | I | 7.5000 | 133,333 | 1,000 | 576,066 | ||||
| 2019-10-08 | 2019-10-07 | 4 | Shepard Jay | ARAV | Common Stock | D | 6.8170 | -4,004 | -27 | 72,754 | ||||
| 2019-09-13 | 2019-09-12 | 4 | Malik Shahzad | ARAV | Stock Option | D | 5.77 | 7,500 | 7,500 | |||||
| 2019-09-13 | 2019-09-12 | 4 | AKKARAJU SRINIVAS | ARAV | Stock Option | D | 5.77 | 7,500 | 7,500 | |||||
| 2019-09-13 | 2019-09-12 | 4 | Tabibiazar Raymond | ARAV | Stock Option | D | 5.77 | 7,500 | 7,500 | |||||
| 2019-09-13 | 2019-09-12 | 4 | Giaccia Amato | ARAV | Stock Option | D | 5.77 | 7,500 | 7,500 | |||||
| 2019-09-13 | 2019-09-12 | 4 | HOFFMAN ROBERT | ARAV | Stock Option | D | 5.77 | 7,500 | 7,500 | |||||
| 2019-09-13 | 2019-09-12 | 4 | Zhang Eric | ARAV | Stock Option | D | 5.77 | 7,500 | 7,500 | |||||
| 2019-05-13 | 2019-05-10 | 4 | Shepard Jay | ARAV | Common Stock | D | 6.1100 | -1,192 | -7 | 76,758 | ||||
| 2019-03-04 | 2019-02-28 | 4 | McIntyre Gail Frances | ARAV | Stock Option | D | 5.83 | 53,000 | 53,000 | |||||
| 2019-03-04 | 2019-02-28 | 4 | Shepard Jay | ARAV | Stock Option | D | 5.83 | 116,000 | 116,000 | |||||
| 2019-03-04 | 2019-02-28 | 4 | Haas Kevin | ARAV | Stock Option | D | 5.83 | 18,000 | 18,000 | |||||
| 2019-03-04 | 2019-02-28 | 4 | Shah Vinay | ARAV | Stock Option | D | 5.83 | 38,000 | 38,000 | |||||
| 2019-02-05 | 2019-02-01 | 4 | Haas Kevin | ARAV | Common Stock | D | 4.1400 | -63 | -0 | 10,933 | ||||
| 2019-02-05 | 2019-02-01 | 4 | Haas Kevin | ARAV | Common Stock | D | 4.1400 | -141 | -1 | 10,996 | ||||
| 2019-02-05 | 2019-02-01 | 4 | Shepard Jay | ARAV | Common Stock | D | 4.1400 | -990 | -4 | 81,950 | ||||
| 2019-02-05 | 2019-02-01 | 4 | Shepard Jay | ARAV | Common Stock | D | 4.1400 | -969 | -4 | 82,940 | ||||
| 2019-02-05 | 2019-02-01 | 4 | Shepard Jay | ARAV | Common Stock | D | 4.1400 | -204 | -1 | 83,909 | ||||
| 2019-01-07 | 2019-01-03 | 4/A | Malik Shahzad | ARAV | Stock Option | D | 3.61 | 4,688 | 4,688 | |||||
| 2019-01-07 | 2019-01-03 | 4/A | HOFFMAN ROBERT | ARAV | Stock Option | D | 3.61 | 4,688 | 4,688 | |||||
| 2019-01-07 | 2019-01-03 | 4/A | HOFFMAN ROBERT | ARAV | Stock Option | D | 3.61 | 7,500 | 7,500 | |||||
| 2019-01-07 | 2019-01-03 | 4/A | Giaccia Amato | ARAV | Stock Option | D | 3.61 | 4,688 | 4,688 | |||||
| 2019-01-07 | 2019-01-03 | 4/A | Giaccia Amato | ARAV | Stock Option | D | 3.61 | 7,500 | 7,500 | |||||
| 2019-01-07 | 2019-01-03 | 4/A | AKKARAJU SRINIVAS | ARAV | Stock Option | D | 3.61 | 4,688 | 4,688 | |||||
| 2019-01-07 | 2019-01-03 | 4 | Malik Shahzad | ARAV | Stock Option | D | 3.69 | 4,688 | 4,688 | |||||
| 2019-01-07 | 2019-01-03 | 4 | AKKARAJU SRINIVAS | ARAV | Stock Option | D | 3.69 | 4,688 | 4,688 | |||||
| 2019-01-07 | 2019-01-03 | 4 | Giaccia Amato | ARAV | Stock Option | D | 3.69 | 4,688 | 4,688 | |||||
| 2019-01-07 | 2019-01-03 | 4 | Giaccia Amato | ARAV | Stock Option | D | 3.69 | 7,500 | 7,500 | |||||
| 2019-01-07 | 2019-01-03 | 4 | HOFFMAN ROBERT | ARAV | Stock Option | D | 3.69 | 4,688 | 4,688 | |||||
| 2019-01-07 | 2019-01-03 | 4 | HOFFMAN ROBERT | ARAV | Stock Option | D | 3.69 | 7,500 | 7,500 | |||||
| 2019-01-07 | 2019-01-03 | 4 | Tabibiazar Raymond | ARAV | Stock Option | D | 3.61 | 4,688 | 4,688 | |||||
| 2019-01-07 | 2019-01-03 | 4 | Tabibiazar Raymond | ARAV | Stock Option | D | 3.61 | 7,500 | 7,500 | |||||
| 2019-01-07 | 2019-01-03 | 4 | Zhang Eric | ARAV | Stock Option | D | 3.61 | 4,688 | 4,688 | |||||
| 2019-01-07 | 2019-01-03 | 4 | Zhang Eric | ARAV | Stock Option | D | 3.61 | 7,500 | 7,500 | |||||
| 2018-12-26 | 2018-12-21 | 4 | Haas Kevin | ARAV | Common Stock | D | 3.2300 | -25 | -0 | 11,137 | ||||
| 2018-12-26 | 2018-12-21 | 4 | Haas Kevin | ARAV | Common Stock | D | 3.2170 | -686 | -2 | 11,162 | ||||
| 2018-12-26 | 2018-12-21 | 4 | Shepard Jay | ARAV | Common Stock | D | 3.2240 | -3,484 | -11 | 84,113 | ||||
| 2018-12-19 | 2018-12-17 | 4 | Haas Kevin | ARAV | Common Stock | D | 3.9620 | -1,164 | -5 | 11,848 | ||||
| 2018-12-19 | 2018-12-17 | 4 | Shepard Jay | ARAV | Common Stock | D | 3.9620 | -11,247 | -45 | 87,597 | ||||
| 2018-10-16 | 2018-10-12 | 4 | Zhang Eric | ARAV | Common Stock | I | 859,766 | 859,766 | ||||||
| 2018-10-16 | 2018-10-12 | 4 | Tabibiazar Raymond | ARAV | Stock Option (Right to Buy) | D | 0.90 | 28,501 | 28,501 | |||||
| 2018-10-16 | 2018-10-12 | 4 | Tabibiazar Raymond | ARAV | Stock Option (Right to Buy) | D | 0.90 | 28,501 | 28,501 | |||||
| 2018-10-16 | 2018-10-12 | 4 | Tabibiazar Raymond | ARAV | Stock Option (Right to Buy) | D | 0.66 | 57,002 | 57,002 | |||||
| 2018-10-16 | 2018-10-12 | 4 | Tabibiazar Raymond | ARAV | Stock Option (Right to Buy) | D | 0.24 | 15,200 | 15,200 | |||||
| 2018-10-16 | 2018-10-12 | 4 | Tabibiazar Raymond | ARAV | Stock Option (Right to Buy) | D | 0.24 | 15,200 | 15,200 | |||||
| 2018-10-16 | 2018-10-12 | 4 | Tabibiazar Raymond | ARAV | Stock Option (Right to Buy) | D | 0.24 | 15,200 | 15,200 | |||||
| 2018-10-16 | 2018-10-12 | 4 | Tabibiazar Raymond | ARAV | Stock Option (Right to Buy) | D | 0.24 | 15,200 | 15,200 | |||||
| 2018-10-16 | 2018-10-12 | 4 | Tabibiazar Raymond | ARAV | Stock Option (Right to Buy) | D | 0.24 | 254,177 | 254,177 | |||||
| 2018-10-16 | 2018-10-12 | 4 | Tabibiazar Raymond | ARAV | Stock Option (Right to Buy) | D | 0.24 | 65,365 | 65,365 | |||||
| 2018-10-16 | 2018-10-12 | 4 | Tabibiazar Raymond | ARAV | Stock Option (Right to Buy) | D | 0.24 | 15,200 | 15,200 | |||||
| 2018-10-16 | 2018-10-12 | 4 | Tabibiazar Raymond | ARAV | Stock Option (Right to Buy) | D | 0.24 | 15,200 | 15,200 | |||||
| 2018-10-16 | 2018-10-12 | 4 | Tabibiazar Raymond | ARAV | Stock Option (Right to Buy) | D | 0.24 | 51,682 | 51,682 | |||||
| 2018-10-16 | 2018-10-12 | 4 | Tabibiazar Raymond | ARAV | Stock Option (Right to Buy) | D | 0.06 | 12,084 | 12,084 | |||||
| 2018-10-16 | 2018-10-12 | 4 | Tabibiazar Raymond | ARAV | Stock Option (Right to Buy) | D | 0.06 | 46,322 | 46,322 | |||||
| 2018-10-16 | 2018-10-12 | 4 | Tabibiazar Raymond | ARAV | Common Stock | D | 1,000,751 | 1,000,751 | ||||||
| 2018-10-16 | 2018-10-12 | 4 | Shah Vinay | ARAV | Stock Option (Right to Buy) | D | 0.90 | 19,000 | 19,000 | |||||
| 2018-10-16 | 2018-10-12 | 4 | Shah Vinay | ARAV | Stock Option (Right to Buy) | D | 0.90 | 19,000 | 19,000 | |||||
| 2018-10-16 | 2018-10-12 | 4 | Shah Vinay | ARAV | Stock Option (Right to Buy) | D | 0.66 | 38,001 | 38,001 | |||||
| 2018-10-16 | 2018-10-12 | 4 | Shah Vinay | ARAV | Stock Option (Right to Buy) | D | 0.24 | 19,380 | 19,380 | |||||
| 2018-10-16 | 2018-10-12 | 4 | Shah Vinay | ARAV | Common Stock | D | 178,606 | 178,606 | ||||||
| 2018-10-16 | 2018-10-12 | 4 | Giaccia Amato | ARAV | Stock Option (Right to Buy) | D | 0.90 | 19,000 | 19,000 | |||||
| 2018-10-16 | 2018-10-12 | 4 | Giaccia Amato | ARAV | Stock Option (RIght to Buy) | D | 0.90 | 19,000 | 19,000 | |||||
| 2018-10-16 | 2018-10-12 | 4 | Giaccia Amato | ARAV | Stock Option (Right to Buy) | D | 0.66 | 38,001 | 38,001 | |||||
| 2018-10-16 | 2018-10-12 | 4 | Giaccia Amato | ARAV | Stock Option (Right to Buy) | D | 0.24 | 9,120 | 9,120 | |||||
| 2018-10-16 | 2018-10-12 | 4 | Giaccia Amato | ARAV | Stock Option (Right to Buy) | D | 0.24 | 9,120 | 9,120 | |||||
| 2018-10-16 | 2018-10-12 | 4 | Giaccia Amato | ARAV | Stock Option (Right to Buy) | D | 0.24 | 9,120 | 9,120 | |||||
| 2018-10-16 | 2018-10-12 | 4 | Giaccia Amato | ARAV | Stock Option (Right to Buy) | D | 0.24 | 9,120 | 9,120 | |||||
| 2018-10-16 | 2018-10-12 | 4 | Giaccia Amato | ARAV | Stock Option (Right to Buy) | D | 0.24 | 26,813 | 26,813 | |||||
| 2018-10-16 | 2018-10-12 | 4 | Giaccia Amato | ARAV | Stock Option (Right to Buy) | D | 0.24 | 9,120 | 9,120 | |||||
| 2018-10-16 | 2018-10-12 | 4 | Giaccia Amato | ARAV | Stock Option (Right to Buy) | D | 0.24 | 9,120 | 9,120 | |||||
| 2018-10-16 | 2018-10-12 | 4 | Giaccia Amato | ARAV | Stock Option (Right to Buy) | D | 0.24 | 38,761 | 38,761 | |||||
| 2018-10-16 | 2018-10-12 | 4 | Giaccia Amato | ARAV | Stock Option (Right to Buy) | D | 0.06 | 12,350 | 12,350 | |||||
| 2018-10-16 | 2018-10-12 | 4 | Giaccia Amato | ARAV | Stock Option (Right to Buy) | D | 0.06 | 4,028 | 4,028 | |||||
| 2018-10-16 | 2018-10-12 | 4 | Giaccia Amato | ARAV | Stock Option (Right to Buy) | D | 0.06 | 8,055 | 8,055 | |||||
| 2018-10-16 | 2018-10-12 | 4 | Giaccia Amato | ARAV | Common Stock | D | 941,880 | 941,880 | ||||||
| 2018-10-16 | 3 | Zhang Eric | ARAV | Common Stock | D | 0 | ||||||||
| 2018-10-16 | 3 | Shah Vinay | ARAV | Common Stock | D | 0 | ||||||||
| 2018-10-16 | 3 | Tabibiazar Raymond | ARAV | Common Stock | D | 0 | ||||||||
| 2018-10-16 | 3 | Giaccia Amato | ARAV | Common Stock | D | 0 | ||||||||
| 2018-10-16 | 2018-10-12 | 4 | AKKARAJU SRINIVAS | ARAV | Common Stock | D | 27,456 | 31,815 | ||||||
| 2018-10-16 | 3 | HOFFMAN ROBERT | ARAV | Common Stock | D | 0 | ||||||||
| 2018-06-19 | 2018-06-15 | 4 | Haas Kevin | VSAR | Common Stock | D | 2.3000 | -143 | -0 | 78,075 | ||||
| 2018-06-19 | 2018-06-15 | 4 | Westberg Paul | VSAR | Common Stock | D | 2.3000 | -612 | -1 | 225,124 | ||||
| 2018-06-15 | 2018-06-13 | 4 | AKKARAJU SRINIVAS | VSAR | Common Stock | I | 2.1300 | 53,018 | 113 | 2,682,554 | ||||
| 2018-06-08 | 2018-06-08 | 4 | AKKARAJU SRINIVAS | VSAR | Common Stock | I | 2.0000 | 231,580 | 463 | 2,629,536 | ||||
| 2018-06-08 | 2018-06-07 | 4 | AKKARAJU SRINIVAS | VSAR | Common Stock | I | 1.8500 | 163,224 | 302 | 2,397,956 | ||||
| 2018-06-08 | 2018-06-06 | 4 | AKKARAJU SRINIVAS | VSAR | Common Stock | I | 1.7400 | 660,681 | 1,150 | 2,234,732 | ||||
| 2018-05-23 | 2018-05-22 | 4 | Shepard Jay | VSAR | Common Stock | D | 1.5000 | -9,232 | -14 | 593,066 | ||||
| 2018-04-25 | 2018-04-24 | 4 | Stout Jay S | VSAR | Common Stock | D | 1.5500 | -4,854 | -8 | 185,646 | ||||
| 2018-03-26 | 2018-03-23 | 4 | Woody Tracy M | VSAR | Common Stock | D | 1.7500 | -4,345 | -8 | 215,755 | ||||
| 2018-02-12 | 2018-02-08 | 4 | Westberg Paul | VSAR | Common Stock | D | 1.8000 | -5,355 | -10 | 225,736 | ||||
| 2018-02-12 | 2018-02-08 | 4 | Ward Shane | VSAR | Common Stock | D | 1.8000 | -4,118 | -7 | 201,556 | ||||
| 2018-02-12 | 2018-02-08 | 4 | Shepard Jay | VSAR | Common Stock | D | 1.8000 | -14,446 | -26 | 602,298 | ||||
| 2018-02-12 | 2018-02-08 | 4 | Haas Kevin | VSAR | Common Stock | D | 1.8000 | -1,599 | -3 | 78,218 | ||||
| 2017-12-22 | 2017-12-20 | 4 | GREER R SCOTT | VSAR | Common Stock | D | 11,200 | 44,380 | ||||||
| 2017-12-22 | 2017-12-20 | 4 | Gut Robert | VSAR | Common Stock | D | 91,300 | 227,300 | ||||||
| 2017-12-22 | 2017-12-20 | 4 | Haas Kevin | VSAR | Common Stock | D | 44,700 | 79,817 | ||||||
| 2017-12-22 | 2017-12-20 | 4 | JENNINGS EDMON R | VSAR | Common Stock | D | 11,200 | 22,380 | ||||||
| 2017-12-22 | 2017-12-20 | 4 | Malik Shahzad | VSAR | Common Stock | D | 11,200 | 23,880 | ||||||
| 2017-12-22 | 2017-12-20 | 4 | Shepard Jay | VSAR | Common Stock | D | 223,000 | 616,744 | ||||||
| 2017-12-22 | 2017-12-20 | 4 | Stout Jay S | VSAR | Common Stock | D | 74,500 | 190,500 | ||||||
| 2017-12-22 | 2017-12-20 | 4 | SUN ANTHONY Y | VSAR | Common Stock | D | 11,200 | 23,880 | ||||||
| 2017-12-22 | 2017-12-20 | 4 | Varian John | VSAR | Common Stock | D | 11,200 | 22,280 | ||||||
| 2017-12-22 | 2017-12-20 | 4 | Ward Shane | VSAR | Common Stock | D | 93,100 | 205,674 | ||||||
| 2017-12-22 | 2017-12-20 | 4 | Westberg Paul | VSAR | Common Stock | D | 90,900 | 231,091 | ||||||
| 2017-12-22 | 2017-12-20 | 4 | Woody Tracy M | VSAR | Common Stock | D | 93,100 | 220,100 | ||||||
| 2017-12-22 | 2017-12-20 | 4 | AKKARAJU SRINIVAS | VSAR | Common Stock | D | 11,200 | 26,155 | ||||||
| 2017-12-22 | 2017-12-20 | 4 | DOBMEIER ERIC | VSAR | Common Stock | D | 11,200 | 18,160 | ||||||
| 2017-12-05 | 2017-12-05 | 4 | AKKARAJU SRINIVAS | VSAR | Common Stock | I | 2.0000 | 42,895 | 86 | 1,547,896 | ||||
| 2017-12-05 | 2017-12-04 | 4 | AKKARAJU SRINIVAS | VSAR | Common Stock | I | 2.2100 | 513,872 | 1,136 | 1,505,001 | ||||
| 2017-12-05 | 2017-12-01 | 4 | AKKARAJU SRINIVAS | VSAR | Common Stock | I | 2.1300 | 419,700 | 894 | 991,129 | ||||
| 2017-12-04 | 3 | Haas Kevin | VSAR | Common Stock | D | 70,234 | ||||||||
| 2017-12-04 | 3 | Haas Kevin | VSAR | Common Stock | D | 70,234 | ||||||||
| 2017-11-29 | 2017-11-28 | 4 | Ward Shane | VSAR | Common Stock | D | 20,000 | 112,574 | ||||||
| 2017-11-29 | 2017-11-28 | 4 | Westberg Paul | VSAR | Common Stock | D | 15,000 | 140,191 | ||||||
| 2017-10-23 | 2017-10-19 | 4 | Westberg Paul | VSAR | Common Stock | D | 2.5500 | -1,326 | -3 | 125,191 | ||||
| 2017-10-23 | 2017-10-19 | 4 | Brumm Joshua T | VSAR | Common Stock | D | 2.5500 | -1,326 | -3 | 201,269 | ||||
| 2017-10-23 | 2017-10-19 | 4 | Hislop Colin | VSAR | Common Stock | D | 2.5500 | -667 | -2 | 23,833 | ||||
| 2017-10-23 | 2017-10-19 | 4 | Ward Shane | VSAR | Common Stock | D | 2.5500 | -776 | -2 | 92,574 | ||||
| 2017-10-10 | 2017-10-06 | 4 | Shepard Jay | VSAR | Common Stock | D | 189,000 | 393,744 | ||||||
| 2017-10-10 | 2017-10-06 | 4 | Stout Jay S | VSAR | Common Stock | D | 70,000 | 116,000 | ||||||
| 2017-10-10 | 2017-10-06 | 4 | Ward Shane | VSAR | Common Stock | D | 57,000 | 93,350 | ||||||
| 2017-10-10 | 2017-10-06 | 4 | Westberg Paul | VSAR | Common Stock | D | 59,000 | 126,517 | ||||||
| 2017-10-10 | 2017-10-06 | 4 | Woody Tracy M | VSAR | Common Stock | D | 82,000 | 127,000 | ||||||
| 2017-10-10 | 2017-10-06 | 4 | Brumm Joshua T | VSAR | Common Stock | D | 97,000 | 202,595 | ||||||
| 2017-10-10 | 2017-10-06 | 4 | Gut Robert | VSAR | Common Stock | D | 88,000 | 136,000 | ||||||
| 2017-09-25 | 2017-09-22 | 4 | PERCEPTIVE ADVISORS LLC | VSAR | Common Stock | I | 3.3500 | -350,000 | -1,172 | 2,099,563 | ||||
| 2017-09-25 | 2017-09-22 | 4 | PERCEPTIVE ADVISORS LLC | VSAR | Common Stock | I | 3.2665 | -500,000 | -1,633 | 2,449,563 | ||||
| 2017-09-25 | 2017-09-22 | 4 | PERCEPTIVE ADVISORS LLC | VSAR | Common Stock | I | 3.1700 | -250,000 | -792 | 2,949,563 | ||||
| 2017-09-25 | 2017-09-22 | 4 | PERCEPTIVE ADVISORS LLC | VSAR | Common Stock | I | 3.0290 | -250,000 | -757 | 3,199,563 | ||||
| 2017-09-25 | 2017-09-22 | 4 | PERCEPTIVE ADVISORS LLC | VSAR | Common Stock | I | 3.0875 | -300,000 | -926 | 3,449,563 | ||||
| 2017-09-25 | 2017-09-21 | 4 | PERCEPTIVE ADVISORS LLC | VSAR | Common Stock | I | 3.5599 | -353,421 | -1,258 | 3,749,563 | ||||
| 2017-09-25 | 2017-09-21 | 4 | PERCEPTIVE ADVISORS LLC | VSAR | Common Stock | I | 3.7420 | -126,579 | -474 | 4,102,984 | ||||
| 2017-09-06 | 3 | Gut Robert | VSAR | No securities held. | D | 0 | ||||||||
| 2017-09-06 | 2017-09-05 | 4 | Gut Robert | VSAR | Stock Option (Right to Buy) | D | 19.80 | 107,000 | 107,000 | |||||
| 2017-09-06 | 2017-09-05 | 4 | Gut Robert | VSAR | Common Stock | D | 48,000 | 48,000 | ||||||
| 2017-06-14 | 2017-06-13 | 4 | Brumm Joshua T | VSAR | Common Stock | D | 16.0500 | -1,421 | -23 | 105,595 | ||||
| 2017-06-14 | 2017-06-13 | 4 | Westberg Paul | VSAR | Common Stock | D | 16.0500 | -711 | -11 | 67,517 | ||||
| 2017-06-06 | 3 | DOBMEIER ERIC | VSAR | Common Stock | D | 0 | ||||||||
| 2017-06-06 | 2017-05-25 | 4 | JENNINGS EDMON R | VSAR | Stock Option (Right to Buy) | D | 15.82 | 6,850 | 6,850 | |||||
| 2017-06-06 | 2017-05-25 | 4 | JENNINGS EDMON R | VSAR | Common Stock | D | 3,480 | 11,180 | ||||||
| 2017-06-06 | 2017-05-25 | 4 | GREER R SCOTT | VSAR | Stock Option (Right to Buy) | D | 15.82 | 6,850 | 6,850 | |||||
| 2017-06-06 | 2017-05-25 | 4 | GREER R SCOTT | VSAR | Common Stock | D | 3,480 | 33,180 | ||||||
| 2017-06-06 | 2017-05-25 | 4 | AKKARAJU SRINIVAS | VSAR | Stock Option (Right to Buy) | D | 15.82 | 6,850 | 6,850 | |||||
| 2017-06-06 | 2017-05-25 | 4 | AKKARAJU SRINIVAS | VSAR | Common Stock | D | 3,480 | 14,955 | ||||||
| 2017-06-06 | 2017-05-25 | 4 | DOBMEIER ERIC | VSAR | Stock Option (Right to Buy) | D | 15.82 | 6,850 | 6,850 | |||||
| 2017-06-06 | 2017-05-25 | 4 | DOBMEIER ERIC | VSAR | Stock Option (Right to Buy) | D | 15.82 | 6,850 | 6,850 | |||||
| 2017-06-06 | 2017-05-25 | 4 | DOBMEIER ERIC | VSAR | Common Stock | D | 3,480 | 6,960 | ||||||
| 2017-06-06 | 2017-05-25 | 4 | DOBMEIER ERIC | VSAR | Common Stock | D | 3,480 | 6,960 | ||||||
| 2017-06-06 | 2017-05-25 | 4 | Varian John | VSAR | Stock Option (Right to Buy) | D | 15.82 | 6,850 | 6,850 | |||||
| 2017-06-06 | 2017-05-25 | 4 | Varian John | VSAR | Common Stock | D | 3,480 | 11,080 | ||||||
| 2017-06-06 | 2017-05-25 | 4 | SUN ANTHONY Y | VSAR | Stock Option (Right to Buy) | D | 15.82 | 6,850 | 6,850 | |||||
| 2017-06-06 | 2017-05-25 | 4 | SUN ANTHONY Y | VSAR | Common Stock | D | 3,480 | 12,680 | ||||||
| 2017-06-06 | 2017-05-25 | 4 | Malik Shahzad | VSAR | Stock Option (Right to Buy) | D | 15.82 | 6,850 | 6,850 | |||||
| 2017-06-06 | 2017-05-25 | 4 | Malik Shahzad | VSAR | Common Stock | D | 3,480 | 12,680 | ||||||
| 2017-05-17 | 2017-05-16 | 4 | Brumm Joshua T | VSAR | Common Stock | D | 17.4000 | -1,263 | -22 | 107,016 | ||||
| 2017-05-15 | 2017-05-11 | 4 | Shepard Jay | VSAR | Common Stock | D | 17.5000 | -9,114 | -159 | 204,744 | ||||
| 2017-04-20 | 2017-04-19 | 4 | Westberg Paul | VSAR | Common Stock | D | 19.8500 | -1,316 | -26 | 68,228 | ||||
| 2017-04-05 | 3 | Stout Jay S | VSAR | Common Stock | D | 2,000 | ||||||||
| 2017-04-05 | 3 | Stout Jay S | VSAR | Common Stock | D | 2,000 | ||||||||
| 2017-04-05 | 2017-04-03 | 4 | Stout Jay S | VSAR | Stock Option (Right to Buy) | D | 21.30 | 75,000 | 75,000 | |||||
| 2017-04-05 | 2017-04-03 | 4 | Stout Jay S | VSAR | Common Stock | D | 45,000 | 46,000 | ||||||
| 2017-04-05 | 2017-04-04 | 4 | Hislop Colin | VSAR | Stock Option (Right to Buy) | D | 8.17 | -35,000 | 188,100 | |||||
| 2017-04-05 | 2017-04-04 | 4 | Hislop Colin | VSAR | Common Stock | D | 21.2000 | -35,000 | -742 | 24,500 | ||||
| 2017-04-05 | 2017-04-04 | 4 | Hislop Colin | VSAR | Common Stock | D | 8.1700 | 35,000 | 286 | 59,500 | ||||
| 2017-03-31 | 3 | Woody Tracy M | VSAR | Common Stock | D | 0 | ||||||||
| 2017-03-31 | 2017-03-22 | 4 | Woody Tracy M | VSAR | Stock Option (Right to Buy) | D | 20.15 | 100,000 | 100,000 | |||||
| 2017-03-31 | 2017-03-22 | 4 | Woody Tracy M | VSAR | Common Stock | D | 45,000 | 45,000 | ||||||
| 2017-03-28 | 2017-03-24 | 4 | AKKARAJU SRINIVAS By Partnership | VSAR | Common Stock | I | 12.2500 | 571,429 | 7,000 | 571,429 | ||||
| 2017-03-17 | 2017-03-17 | 4 | Malik Shahzad | VSAR | Common Stock | I | 18.0100 | -386,367 | -6,958 | 1,621,558 | ||||
| 2017-03-17 | 2017-03-16 | 4 | Malik Shahzad | VSAR | Common Stock | I | 18.5000 | -97,303 | -1,800 | 2,007,925 | ||||
| 2017-03-15 | 2017-03-15 | 4 | Malik Shahzad | VSAR | Common Stock | I | 19.0800 | -103,122 | -1,968 | 2,105,228 | ||||
| 2017-03-15 | 2017-03-14 | 4 | Malik Shahzad | VSAR | Common Stock | I | 19.0000 | -46,778 | -889 | 2,208,350 | ||||
| 2017-03-15 | 2017-03-14 | 4 | Malik Shahzad | VSAR | Common Stock | I | 19.0300 | -100 | -2 | 2,255,128 | ||||
| 2017-03-15 | 2017-03-13 | 4 | Malik Shahzad | VSAR | Common Stock | I | 19.4200 | -16,330 | -317 | 2,255,228 | ||||
| 2017-03-15 | 2017-03-15 | 4 | Ward Shane | VSAR | Common Stock | D | 19.0200 | -776 | -15 | 36,350 | ||||
| 2017-03-15 | 2017-03-14 | 4 | Ward Shane | VSAR | Common Stock | D | 19.0000 | -1,265 | -24 | 37,126 | ||||
| 2017-03-14 | 2017-02-13 | 4/A | PERCEPTIVE ADVISORS LLC See Footnotes | VSAR | Common Stock | I | 15.5146 | 59,133 | 917 | 4,229,563 | ||||
| 2017-03-14 | 2017-02-10 | 4/A | PERCEPTIVE ADVISORS LLC See Footnotes | VSAR | Common Stock | I | 14.9437 | 34,883 | 521 | 4,170,430 | ||||
| 2017-02-28 | 2017-02-24 | 4 | Brumm Joshua T | VSAR | Stock Option (Right to Buy) | D | 2.53 | -30,000 | 122,108 | |||||
| 2017-02-28 | 2017-02-24 | 4 | Brumm Joshua T | VSAR | Common Stock | D | 22.0500 | -5,653 | -125 | 105,779 | ||||
| 2017-02-28 | 2017-02-24 | 4 | Brumm Joshua T | VSAR | Common Stock | D | 21.4600 | -6,008 | -129 | 111,432 | ||||
| 2017-02-28 | 2017-02-24 | 4 | Brumm Joshua T | VSAR | Common Stock | D | 20.4200 | -18,339 | -374 | 117,440 | ||||
| 2017-02-28 | 2017-02-24 | 4 | Brumm Joshua T | VSAR | Common Stock | D | 2.5300 | 30,000 | 76 | 135,779 | ||||
| 2017-02-28 | 2017-02-27 | 4 | Shepard Jay | VSAR | Stock Option (Right to Buy) | D | 2.53 | -5,166 | 65,828 | |||||
| 2017-02-28 | 2017-02-27 | 4 | Shepard Jay | VSAR | Common Stock | D | 24.0000 | -5,166 | -124 | 213,858 | ||||
| 2017-02-28 | 2017-02-27 | 4 | Shepard Jay | VSAR | Common Stock | D | 2.5300 | 5,166 | 13 | 219,024 | ||||
| 2017-02-28 | 2017-02-27 | 4 | Westberg Paul | VSAR | Stock Option (Right to Buy) | D | 2.53 | -4,991 | 7,491 | |||||
| 2017-02-28 | 2017-02-27 | 4 | Westberg Paul | VSAR | Stock Option (Right to Buy) | D | 1.61 | -7,509 | 2,975 | |||||
| 2017-02-28 | 2017-02-27 | 4 | Westberg Paul | VSAR | Common Stock | D | 22.5000 | -12,500 | -281 | 69,544 | ||||
| 2017-02-28 | 2017-02-27 | 4 | Westberg Paul | VSAR | Common Stock | D | 2.5300 | 4,991 | 13 | 82,044 | ||||
| 2017-02-28 | 2017-02-27 | 4 | Westberg Paul | VSAR | Common Stock | D | 1.6100 | 7,509 | 12 | 77,053 | ||||
| 2017-02-23 | 2017-02-23 | 4 | Westberg Paul | VSAR | Stock Option (Right to Buy) | D | 1.61 | -6,590 | 10,484 | |||||
| 2017-02-23 | 2017-02-23 | 4 | Westberg Paul | VSAR | Common Stock | D | 20.0000 | -6,590 | -132 | 69,544 | ||||
| 2017-02-23 | 2017-02-23 | 4 | Westberg Paul | VSAR | Common Stock | D | 1.6100 | 6,590 | 11 | 76,134 | ||||
| 2017-02-23 | 2017-02-21 | 4 | Westberg Paul | VSAR | Stock Option (Right to Buy) | D | 1.61 | -3,323 | 17,074 | |||||
| 2017-02-23 | 2017-02-21 | 4 | Westberg Paul | VSAR | Stock Option (Right to Buy) | D | 1.61 | -15,087 | 506 | |||||
| 2017-02-23 | 2017-02-21 | 4 | Westberg Paul | VSAR | Common Stock | D | 20.0000 | -5,910 | -118 | 69,544 | ||||
| 2017-02-23 | 2017-02-21 | 4 | Westberg Paul | VSAR | Common Stock | D | 17.5000 | -12,500 | -219 | 75,454 | ||||
| 2017-02-23 | 2017-02-21 | 4 | Westberg Paul | VSAR | Common Stock | D | 1.6100 | 18,410 | 30 | 87,954 | ||||
| 2017-02-23 | 2017-02-23 | 4 | Shepard Jay | VSAR | Stock Option (Right to Buy) | D | 2.53 | -8,000 | 70,994 | |||||
| 2017-02-23 | 2017-02-23 | 4 | Shepard Jay | VSAR | Common Stock | D | 20.0000 | -8,000 | -160 | 213,858 | ||||
| 2017-02-23 | 2017-02-23 | 4 | Shepard Jay | VSAR | Common Stock | D | 2.5300 | 8,000 | 20 | 221,858 | ||||
| 2017-02-23 | 2017-02-21 | 4 | Shepard Jay | VSAR | Stock Option (Right to Buy) | D | 2.53 | -8,000 | 78,994 | |||||
| 2017-02-23 | 2017-02-21 | 4 | Shepard Jay | VSAR | Common Stock | D | 18.5000 | -8,000 | -148 | 213,858 | ||||
| 2017-02-23 | 2017-02-21 | 4 | Shepard Jay | VSAR | Common Stock | D | 2.5300 | 8,000 | 20 | 221,858 | ||||
| 2017-02-14 | 2017-02-13 | 4 | PERCEPTIVE ADVISORS LLC See Footnotes | VSAR | Common Stock | I | 15.5146 | 59,133 | 917 | 4,228,563 | ||||
| 2017-02-14 | 2017-02-10 | 4 | PERCEPTIVE ADVISORS LLC See Footnotes | VSAR | Common Stock | I | 14.9437 | 34,883 | 521 | 4,169,430 | ||||
| 2017-02-10 | 2017-02-09 | 4 | PERCEPTIVE ADVISORS LLC See Footnotes | VSAR | Common Stock | I | 14.2663 | 41,211 | 588 | 4,134,547 | ||||
| 2017-02-10 | 2017-02-08 | 4 | PERCEPTIVE ADVISORS LLC See Footnotes | VSAR | Common Stock | I | 13.5101 | 104,612 | 1,413 | 4,093,336 | ||||
| 2017-02-06 | 2017-02-03 | 4 | Shepard Jay | VSAR | Common Stock | D | 13.6900 | -6,719 | -92 | 213,858 | ||||
| 2017-02-02 | 2017-02-02 | 4 | Shepard Jay | VSAR | Common Stock | D | 13.5100 | -6,973 | -94 | 220,577 | ||||
| 2017-02-02 | 2017-02-02 | 4 | Shepard Jay | VSAR | Common Stock | D | 2.5300 | 4,166 | 11 | 227,550 | ||||
| 2017-02-02 | 2017-02-01 | 4 | Shepard Jay | VSAR | Stock Option (Right to Buy) | D | 2.53 | -4,166 | 86,994 | |||||
| 2017-02-02 | 2017-02-01 | 4 | Shepard Jay | VSAR | Stock Option (Right to Buy) | D | 2.53 | -6,576 | 91,160 | |||||
| 2017-02-02 | 2017-02-01 | 4 | Shepard Jay | VSAR | Common Stock | D | 13.9500 | -6,576 | -92 | 223,384 | ||||
| 2017-02-02 | 2017-02-01 | 4 | Shepard Jay | VSAR | Common Stock | D | 2.5300 | 6,576 | 17 | 229,960 | ||||
| 2017-02-02 | 2017-01-31 | 4 | Shepard Jay | VSAR | Stock Option (Right to Buy) | D | 2.53 | -10,662 | 97,736 | |||||
| 2017-02-02 | 2017-01-31 | 4 | Shepard Jay | VSAR | Common Stock | D | 14.1600 | -5,940 | -84 | 223,384 | ||||
| 2017-02-02 | 2017-01-31 | 4 | Shepard Jay | VSAR | Common Stock | D | 13.4000 | -4,722 | -63 | 229,324 | ||||
| 2017-02-02 | 2017-01-31 | 4 | Shepard Jay | VSAR | Common Stock | D | 2.5300 | 10,662 | 27 | 234,046 | ||||
| 2017-01-31 | 2017-01-27 | 4 | Hislop Colin | VSAR | Stock Option (Right to Buy) | D | 14.30 | 43,700 | 43,700 | |||||
| 2017-01-31 | 2017-01-27 | 4 | Hislop Colin | VSAR | Common Stock | D | 19,500 | 24,500 | ||||||
| 2017-01-31 | 2017-01-30 | 4 | Brumm Joshua T | VSAR | Common Stock | D | 13.8520 | -2,945 | -41 | 105,779 | ||||
| 2017-01-31 | 2017-01-27 | 4 | Brumm Joshua T | VSAR | Stock Option (Right to Buy) | D | 14.30 | 65,590 | 65,590 | |||||
| 2017-01-31 | 2017-01-27 | 4 | Brumm Joshua T | VSAR | Common Stock | D | 43,900 | 108,724 | ||||||
| 2017-01-31 | 2017-01-30 | 4 | Shepard Jay | VSAR | Stock Option (Right to Buy) | D | 2.53 | -10,596 | 108,398 | |||||
| 2017-01-31 | 2017-01-30 | 4 | Shepard Jay | VSAR | Common Stock | D | 13.3100 | -10,596 | -141 | 223,384 | ||||
| 2017-01-31 | 2017-01-30 | 4 | Shepard Jay | VSAR | Common Stock | D | 2.5300 | 10,596 | 27 | 233,980 | ||||
| 2017-01-31 | 2017-01-30 | 4 | Shepard Jay | VSAR | Common Stock | D | 13.8500 | -6,674 | -92 | 223,384 | ||||
| 2017-01-31 | 2017-01-27 | 4 | Shepard Jay | VSAR | Stock Option (Right to Buy) | D | 14.30 | 144,900 | 144,900 | |||||
| 2017-01-31 | 2017-01-27 | 4 | Shepard Jay | VSAR | Common Stock | D | 10,000 | 230,058 | ||||||
| 2017-01-31 | 2017-01-27 | 4 | Shepard Jay | VSAR | Common Stock | D | 64,700 | 220,058 | ||||||
| 2017-01-31 | 2017-01-30 | 4 | Westberg Paul | VSAR | Common Stock | D | 13.8520 | -1,916 | -27 | 69,544 | ||||
| 2017-01-31 | 2017-01-27 | 4 | Westberg Paul | VSAR | Stock Option (Right to Buy) | D | 14.30 | 40,130 | 40,130 | |||||
| 2017-01-31 | 2017-01-27 | 4 | Westberg Paul | VSAR | Common Stock | D | 26,860 | 71,460 | ||||||
| 2017-01-31 | 2017-01-30 | 4 | Ward Shane | VSAR | Common Stock | D | 13.8520 | -1,474 | -20 | 38,391 | ||||
| 2017-01-31 | 2017-01-27 | 4 | Ward Shane | VSAR | Stock Option (Right to Buy) | D | 14.30 | 46,200 | 46,200 | |||||
| 2017-01-31 | 2017-01-27 | 4 | Ward Shane | VSAR | Common Stock | D | 20,600 | 39,865 | ||||||
| 2017-01-11 | 2017-01-11 | 4 | Westberg Paul | VSAR | Stock Option (Right to Buy) | D | 1.61 | -7,931 | 15,593 | |||||
| 2017-01-11 | 2017-01-11 | 4 | Westberg Paul | VSAR | Common Stock | D | 15.2400 | -7,931 | -121 | 44,600 | ||||
| 2017-01-11 | 2017-01-11 | 4 | Westberg Paul | VSAR | Common Stock | D | 1.6100 | 7,931 | 13 | 52,531 | ||||
| 2017-01-11 | 2017-01-10 | 4 | Westberg Paul | VSAR | Stock Option (Right to Buy) | D | 1.61 | -746 | 23,524 | |||||
| 2017-01-11 | 2017-01-10 | 4 | Westberg Paul | VSAR | Stock Option (Right to Buy) | D | 1.38 | -10,467 | 0 | |||||
| 2017-01-11 | 2017-01-10 | 4 | Westberg Paul | VSAR | Common Stock | D | 15.6600 | -11,213 | -176 | 44,600 | ||||
| 2017-01-11 | 2017-01-10 | 4 | Westberg Paul | VSAR | Common Stock | D | 1.6100 | 746 | 1 | 55,813 | ||||
| 2017-01-11 | 2017-01-10 | 4 | Westberg Paul | VSAR | Common Stock | D | 1.3800 | 10,467 | 14 | 55,067 | ||||
| 2017-01-11 | 2017-01-09 | 4 | Westberg Paul | VSAR | Stock Option (Right to Buy) | D | 1.38 | -11,044 | 10,467 | |||||
| 2017-01-11 | 2017-01-09 | 4 | Westberg Paul | VSAR | Stock Option (Right to Buy) | D | 1.26 | -2,312 | 0 | |||||
| 2017-01-11 | 2017-01-09 | 4 | Westberg Paul | VSAR | Common Stock | D | 15.9300 | -13,356 | -213 | 44,600 | ||||
| 2017-01-11 | 2017-01-09 | 4 | Westberg Paul | VSAR | Common Stock | D | 1.3800 | 11,044 | 15 | 57,956 | ||||
| 2017-01-11 | 2017-01-09 | 4 | Westberg Paul | VSAR | Common Stock | D | 1.2650 | 2,312 | 3 | 46,912 | ||||
| 2017-01-04 | 2016-12-30 | 4/A | PERCEPTIVE ADVISORS LLC See Footnotes | VSAR | Common Stock | I | 14.6580 | 71,063 | 1,042 | 3,989,724 | ||||
| 2017-01-04 | 2016-12-30 | 4 | PERCEPTIVE ADVISORS LLC See Footnotes | VSAR | Common Stock | I | 14.6580 | 94,750 | 1,389 | 4,013,411 | ||||
| 2016-12-30 | 2016-12-29 | 4 | PERCEPTIVE ADVISORS LLC See Footnotes | VSAR | Common Stock | I | 14.3660 | 47,375 | 681 | 3,918,661 | ||||
| 2016-12-29 | 2016-12-27 | 4 | Brumm Joshua T | VSAR | Common Stock | D | 15.8500 | -990 | -16 | 64,824 | ||||
| 2016-12-29 | 2016-12-27 | 4 | Westberg Paul | VSAR | Common Stock | D | 15.8500 | -361 | -6 | 44,600 | ||||
| 2016-12-19 | 2016-12-16 | 4 | Westberg Paul | VSAR | Stock Option (Right to Buy) | D | 1.26 | -5,000 | 2,312 | |||||
| 2016-12-19 | 2016-12-16 | 4 | Westberg Paul | VSAR | Common Stock | D | 15.0000 | -5,000 | -75 | 44,961 | ||||
| 2016-12-19 | 2016-12-16 | 4 | Westberg Paul | VSAR | Common Stock | D | 1.2650 | 5,000 | 6 | 49,961 | ||||
| 2016-12-08 | 2016-12-08 | 4 | JENNINGS EDMON R | VSAR | Common Stock | D | 12.9550 | -1,500 | -19 | 7,700 | ||||
| 2016-12-08 | 2016-12-07 | 4 | Brumm Joshua T | VSAR | Common Stock | D | 13.2500 | -3,021 | -40 | 65,814 | ||||
| 2016-10-13 | 2016-10-11 | 4 | Hislop Colin | VSAR | Common Stock | D | 5,000 | 5,000 | ||||||
| 2016-10-13 | 2016-10-11 | 4 | Brumm Joshua T | VSAR | Common Stock | D | 10,000 | 68,835 | ||||||
| 2016-10-13 | 2016-10-11 | 4 | Westberg Paul | VSAR | Common Stock | D | 10,000 | 44,961 | ||||||
| 2016-10-13 | 2016-10-11 | 4 | Ward Shane | VSAR | Common Stock | D | 5,000 | 19,265 | ||||||
| 2016-10-05 | 3/A | EDELMAN JOSEPH See Footnotes | VSAR | Common Stock | I | 3,871,286 | ||||||||
| 2016-10-04 | 2016-10-03 | 4 | AKKARAJU SRINIVAS | VSAR | Common Stock | I | 12.2500 | 571,429 | 7,000 | 571,429 | ||||
| 2016-09-28 | 3 | EDELMAN JOSEPH See Footnotes | VSAR | Common Stock | I | 7,594,838 | ||||||||
| 2016-09-28 | 3 | EDELMAN JOSEPH See Footnotes | VSAR | Common Stock | I | 7,594,838 | ||||||||
| 2016-09-28 | 3 | EDELMAN JOSEPH See Footnotes | VSAR | Common Stock | I | 7,594,838 | ||||||||
| 2016-09-28 | 3 | EDELMAN JOSEPH See Footnotes | VSAR | Common Stock | I | 7,594,838 | ||||||||
| 2016-08-26 | 2016-08-25 | 4 | Varian John | VSAR | Common Stock | D | 12.9718 | -1,600 | -21 | 7,600 | ||||
| 2016-08-24 | 2016-08-22 | 4 | Shepard Jay | VSAR | Common Stock | D | 12.8800 | -5,442 | -70 | 155,358 | ||||
| 2016-06-20 | 2016-06-14 | 4 | AKKARAJU SRINIVAS | VSAR | Stock Option (Right to Buy) | D | 10.87 | 28,720 | 28,720 | |||||
| 2016-06-20 | 2016-06-14 | 4 | AKKARAJU SRINIVAS | VSAR | Common Stock | D | 6,900 | 11,475 | ||||||
| 2016-06-17 | 2016-06-15 | 4 | Brumm Joshua T | VSAR | Common Stock | D | 10.6300 | -1,448 | -15 | 58,835 | ||||
| 2016-06-17 | 2016-06-15 | 4 | Westberg Paul | VSAR | Common Stock | D | 10.6300 | -725 | -8 | 34,961 | ||||
| 2016-05-20 | 2016-05-18 | 4 | Varian John | VSAR | Stock Option (Right to Buy) | D | 8.12 | 14,625 | 14,625 | |||||
| 2016-05-20 | 2016-05-18 | 4 | Varian John | VSAR | Common Stock | D | 4,625 | 9,200 | ||||||
| 2016-05-20 | 2016-05-18 | 4 | SUN ANTHONY Y | VSAR | Stock Option (Right to Buy) | D | 8.12 | 14,625 | 14,625 | |||||
| 2016-05-20 | 2016-05-18 | 4 | SUN ANTHONY Y | VSAR | Common Stock | D | 4,625 | 9,200 | ||||||
| 2016-05-20 | 2016-05-18 | 4 | JENNINGS EDMON R | VSAR | Stock Option (Right to Buy) | D | 8.12 | 14,625 | 14,625 | |||||
| 2016-05-20 | 2016-05-18 | 4 | JENNINGS EDMON R | VSAR | Common Stock | D | 4,625 | 9,200 | ||||||
| 2016-05-20 | 2016-05-18 | 4 | GREER R SCOTT | VSAR | Stock Option (Right to Buy) | D | 8.12 | 14,625 | 14,625 | |||||
| 2016-05-20 | 2016-05-18 | 4 | GREER R SCOTT | VSAR | Common Stock | D | 4,625 | 29,700 | ||||||
| 2016-05-20 | 2016-05-18 | 4 | Malik Shahzad | VSAR | Stock Option (Right to Buy) | D | 8.12 | 14,625 | 14,625 | |||||
| 2016-05-20 | 2016-05-18 | 4 | Malik Shahzad | VSAR | Common Stock | D | 4,625 | 9,200 | ||||||
| 2016-05-20 | 2016-05-20 | 4 | Brumm Joshua T | VSAR | Common Stock | D | 7.8700 | -1,265 | -10 | 60,283 | ||||
| 2016-05-02 | 3 | Hislop Colin | VSAR | Common Stock | D | 0 | ||||||||
| 2016-05-02 | 2016-04-04 | 4 | Hislop Colin | VSAR | Stock Option (Right to Buy) | D | 8.17 | 223,100 | 223,100 | |||||
| 2016-04-25 | 2016-04-21 | 4 | Westberg Paul | VSAR | Common Stock | D | 9.6800 | -1,430 | -14 | 35,686 | ||||
| 2016-02-01 | 2016-01-28 | 4 | Brumm Joshua T | VSAR | Stock Option (Right to Buy) | D | 10.68 | 83,800 | 83,800 | |||||
| 2016-02-01 | 2016-01-28 | 4 | Brumm Joshua T | VSAR | Common Stock | D | 26,000 | 61,548 | ||||||
| 2016-02-01 | 2016-01-28 | 4 | Westberg Paul | VSAR | Stock Option (Right to Buy) | D | 10.68 | 54,400 | 54,400 | |||||
| 2016-02-01 | 2016-01-28 | 4 | Westberg Paul | VSAR | Common Stock | D | 16,900 | 37,116 | ||||||
| 2016-02-01 | 2016-01-28 | 4 | Shepard Jay | VSAR | Stock Option (Right to Buy) | D | 10.68 | 209,200 | 209,200 | |||||
| 2016-02-01 | 2016-01-28 | 4 | Shepard Jay | VSAR | Common Stock | D | 64,800 | 160,800 | ||||||
| 2016-02-01 | 2016-01-28 | 4 | Ward Shane | VSAR | Stock Option (Right to Buy) | D | 10.68 | 42,000 | 42,000 | |||||
| 2016-02-01 | 2016-01-28 | 4 | Ward Shane | VSAR | Common Stock | D | 13,000 | 14,265 | ||||||
| 2016-01-04 | 2015-12-30 | 4 | Westberg Paul | VSAR | Common Stock | D | 12.4360 | -362 | -5 | 20,216 | ||||
| 2016-01-04 | 2015-12-30 | 4 | Brumm Joshua T | VSAR | Common Stock | D | 12.4360 | -990 | -12 | 35,548 | ||||
| 2015-11-13 | 2015-11-12 | 4 | Brumm Joshua T | VSAR | Common Stock | D | 9.9900 | 2,500 | 25 | 36,538 | ||||
| 2015-11-13 | 2015-11-11 | 4 | GREER R SCOTT | VSAR | Common Stock | D | 10.1700 | 9,500 | 97 | 25,075 | ||||
| 2015-11-13 | 2015-11-11 | 4 | GREER R SCOTT | VSAR | Common Stock | D | 10.1600 | 200 | 2 | 15,575 | ||||
| 2015-11-13 | 2015-11-11 | 4 | GREER R SCOTT | VSAR | Common Stock | D | 10.1500 | 300 | 3 | 15,375 | ||||
| 2015-08-05 | 2015-08-04 | 4 | Westberg Paul | VSAR | Stock Option (Right to Buy) | D | 1.26 | -2,400 | 7,312 | |||||
| 2015-08-05 | 2015-08-04 | 4 | Westberg Paul | VSAR | Common Stock | D | 18.5300 | -142 | -3 | 20,578 | ||||
| 2015-08-05 | 2015-08-04 | 4 | Westberg Paul | VSAR | Common Stock | D | 18.2500 | -2,258 | -41 | 20,720 | ||||
| 2015-08-05 | 2015-08-04 | 4 | Westberg Paul | VSAR | Common Stock | D | 1.2650 | 2,400 | 3 | 22,978 | ||||
| 2015-07-07 | 2015-07-06 | 4 | Westberg Paul | VSAR | Stock Option (Right to Buy) | D | 1.26 | -2,400 | 9,712 | |||||
| 2015-07-07 | 2015-07-06 | 4 | Westberg Paul | VSAR | Common Stock | D | 15.0000 | -2,400 | -36 | 20,578 | ||||
| 2015-07-07 | 2015-07-06 | 4 | Westberg Paul | VSAR | Common Stock | D | 1.2650 | 2,400 | 3 | 22,978 | ||||
| 2015-07-01 | 2015-06-29 | 4 | GREER R SCOTT | VSAR | Stock Option (Right to Buy) | D | 14.73 | 13,100 | 13,100 | |||||
| 2015-07-01 | 2015-06-29 | 4 | GREER R SCOTT | VSAR | Common Stock | D | 4,575 | 15,075 | ||||||
| 2015-07-01 | 2015-06-29 | 4 | JENNINGS EDMON R | VSAR | Stock Option (Right to Buy) | D | 14.73 | 13,100 | 13,100 | |||||
| 2015-07-01 | 2015-06-29 | 4 | JENNINGS EDMON R | VSAR | Common Stock | D | 4,575 | 4,575 | ||||||
| 2015-07-01 | 2015-06-29 | 4 | AKKARAJU SRINIVAS | VSAR | Stock Option (Right to Buy) | D | 14.73 | 13,100 | 13,100 | |||||
| 2015-07-01 | 2015-06-29 | 4 | AKKARAJU SRINIVAS | VSAR | Common Stock | D | 4,575 | 4,575 | ||||||
| 2015-07-01 | 2015-06-29 | 4 | SUN ANTHONY Y | VSAR | Stock Option (Right to Buy) | D | 14.73 | 13,100 | 13,100 | |||||
| 2015-07-01 | 2015-06-29 | 4 | SUN ANTHONY Y | VSAR | Common Stock | D | 4,575 | 4,575 | ||||||
| 2015-07-01 | 2015-06-29 | 4 | Varian John | VSAR | Stock Option (Right to Buy) | D | 14.73 | 13,100 | 13,100 | |||||
| 2015-07-01 | 2015-06-29 | 4 | Varian John | VSAR | Common Stock | D | 4,575 | 4,575 | ||||||
| 2015-07-01 | 2015-06-29 | 4 | Malik Shahzad | VSAR | Stock Option (Right to Buy) | D | 14.73 | 13,100 | 13,100 | |||||
| 2015-07-01 | 2015-06-29 | 4 | Malik Shahzad | VSAR | Common Stock | D | 4,575 | 4,575 | ||||||
| 2015-06-15 | 2015-06-11 | 4 | Brumm Joshua T | VSAR | Common Stock | D | 17.2800 | -1,375 | -24 | 34,038 | ||||
| 2015-06-15 | 2015-06-11 | 4 | Brumm Joshua T | VSAR | Common Stock | D | 19.9000 | -1,222 | -24 | 35,413 | ||||
| 2015-06-15 | 2015-06-11 | 4 | Westberg Paul | VSAR | Common Stock | D | 17.2800 | -687 | -12 | 20,578 | ||||
| 2015-06-15 | 2015-06-11 | 4 | Westberg Paul | VSAR | Common Stock | D | 19.9000 | -1,222 | -24 | 21,265 | ||||
| 2015-06-04 | 2015-06-03 | 4 | Westberg Paul | VSAR | Stock Option (Right to Buy) | D | 1.26 | -2,400 | 12,112 | |||||
| 2015-06-04 | 2015-06-03 | 4 | Westberg Paul | VSAR | Common Stock | D | 16.7259 | -2,400 | -40 | 22,487 | ||||
| 2015-06-04 | 2015-06-03 | 4 | Westberg Paul | VSAR | Common Stock | D | 1.2650 | 2,400 | 3 | 24,887 | ||||
| 2015-05-13 | 2015-05-11 | 4 | Shepard Jay | VSAR | Stock Option (Right to Buy) | D | 15.19 | 309,000 | 309,000 | |||||
| 2015-05-13 | 2015-05-11 | 4 | Shepard Jay | VSAR | Common Stock | D | 96,000 | 96,000 | ||||||
| 2015-05-06 | 2015-05-04 | 4 | Westberg Paul | VSAR | Stock Option (Right to Buy) | D | 1.26 | -2,400 | 14,512 | |||||
| 2015-05-06 | 2015-05-04 | 4 | Westberg Paul | VSAR | Common Stock | D | 17.4706 | -2,400 | -42 | 22,487 | ||||
| 2015-05-06 | 2015-05-04 | 4 | Westberg Paul | VSAR | Common Stock | D | 1.2650 | 2,400 | 3 | 24,887 | ||||
| 2015-04-16 | 2014-12-22 | 4/A | Cleland Jeffrey L | VSAR | Common Stock | D | 21.3561 | -5,870 | -125 | 133,388 | ||||
| 2015-04-16 | 2014-12-22 | 4/A | Cleland Jeffrey L | VSAR | Common Stock | D | 20.5364 | -2,110 | -43 | 139,258 | ||||
| 2015-04-16 | 2014-12-19 | 4/A | Cleland Jeffrey L | VSAR | Common Stock | D | 20.0000 | -20 | -0 | 141,368 | ||||
| 2015-04-16 | 2014-11-14 | 4/A | Cleland Jeffrey L | VSAR | Common Stock | D | -1,900 | 141,388 | ||||||
| 2015-04-16 | 2014-12-15 | 4 | Cleland Jeffrey L | VSAR | Common Stock | D | 496 | 142,396 | ||||||
| 2015-04-16 | 2015-04-14 | 4 | Cleland Jeffrey L | VSAR | Common Stock | D | 20.1300 | -8,000 | -161 | 121,548 | ||||
| 2015-04-08 | 3 | Ward Shane | VSAR | Common Stock | D | 0 | ||||||||
| 2015-04-08 | 2015-04-06 | 4 | Westberg Paul | VSAR | Stock Option (Right to Buy) | D | 1.26 | -2,041 | 16,912 | |||||
| 2015-04-08 | 2015-04-06 | 4 | Westberg Paul | VSAR | Stock Option (Right to Buy) | D | 1.26 | -359 | 0 | |||||
| 2015-04-08 | 2015-04-06 | 4 | Westberg Paul | VSAR | Common Stock | D | 17.4884 | -2,400 | -42 | 22,487 | ||||
| 2015-04-08 | 2015-04-06 | 4 | Westberg Paul | VSAR | Common Stock | D | 1.2650 | 2,400 | 3 | 24,887 | ||||
| 2015-04-08 | 2015-04-06 | 4 | Ward Shane | VSAR | Stock Option (Right to Buy) | D | 17.47 | 50,000 | 50,000 | |||||
| 2015-03-24 | 2015-03-23 | 4 | Cleland Jeffrey L | VSAR | Common Stock | D | 20.2573 | -4,000 | -81 | 93,432 | ||||
| 2015-03-20 | 2015-03-20 | 4 | Cleland Jeffrey L | VSAR | Common Stock | D | 20.0670 | -740 | -15 | 97,432 | ||||
| 2015-03-20 | 2015-03-19 | 4 | Cleland Jeffrey L | VSAR | Common Stock | D | 20.0086 | -1,315 | -26 | 98,172 | ||||
| 2015-03-20 | 2015-03-18 | 4 | Cleland Jeffrey L | VSAR | Common Stock | D | 20.0309 | -1,124 | -23 | 99,487 | ||||
| 2015-03-17 | 2015-03-17 | 4 | Cleland Jeffrey L | VSAR | Common Stock | D | 20.0908 | -738 | -15 | 100,611 | ||||
| 2015-03-17 | 2015-03-16 | 4 | Cleland Jeffrey L | VSAR | Common Stock | D | 20.0300 | -3 | -0 | 101,349 | ||||
| 2015-03-17 | 2015-03-16 | 4 | Cleland Jeffrey L | VSAR | Common Stock | D | 20.0100 | -80 | -2 | 101,352 | ||||
| 2015-03-11 | 2015-03-10 | 4 | Cleland Jeffrey L | VSAR | Common Stock | D | 20.3003 | -2,537 | -52 | 101,432 | ||||
| 2015-03-11 | 2015-03-09 | 4 | Cleland Jeffrey L | VSAR | Common Stock | D | 20.1034 | -1,463 | -29 | 103,969 | ||||
| 2015-03-05 | 2015-03-03 | 4 | Westberg Paul | VSAR | Stock Option (Right to Buy) | D | 1.26 | -2,041 | 18,953 | |||||
| 2015-03-05 | 2015-03-03 | 4 | Westberg Paul | VSAR | Stock Option (Right to Buy) | D | 1.26 | -359 | 359 | |||||
| 2015-03-05 | 2015-03-03 | 4 | Westberg Paul | VSAR | Common Stock | D | 20.0292 | -2,400 | -48 | 22,487 | ||||
| 2015-03-05 | 2015-03-03 | 4 | Westberg Paul | VSAR | Common Stock | D | 1.2650 | 2,400 | 3 | 24,887 | ||||
| 2015-03-05 | 2015-03-03 | 4 | Cleland Jeffrey L | VSAR | Common Stock | D | 20.0689 | -1,129 | -23 | 105,432 | ||||
| 2015-03-02 | 2015-03-02 | 4 | Cleland Jeffrey L | VSAR | Common Stock | D | 20.1144 | -2,871 | -58 | 106,561 | ||||
| 2015-02-27 | 2015-02-25 | 4 | Cleland Jeffrey L | VSAR | Common Stock | D | 20.2471 | -8,000 | -162 | 109,432 | ||||
| 2015-02-04 | 2015-02-03 | 4 | Westberg Paul | VSAR | Stock Option (Right to Buy) | D | 1.26 | -3,501 | 20,994 | |||||
| 2015-02-04 | 2015-02-03 | 4 | Westberg Paul | VSAR | Stock Option (Right to Buy) | D | 1.26 | -1,499 | 718 | |||||
| 2015-02-04 | 2015-02-03 | 4 | Westberg Paul | VSAR | Common Stock | D | 18.0984 | -371 | -7 | 22,487 | ||||
| 2015-02-04 | 2015-02-03 | 4 | Westberg Paul | VSAR | Common Stock | D | 17.3408 | -4,629 | -80 | 22,858 | ||||
| 2015-02-04 | 2015-02-03 | 4 | Westberg Paul | VSAR | Common Stock | D | 1.2650 | 5,000 | 6 | 27,487 | ||||
| 2015-01-29 | 2015-01-27 | 4 | SUN ANTHONY Y See FN | VSAR | Common Stock | I | 17.2500 | 145,000 | 2,501 | 2,139,568 | ||||
| 2015-01-29 | 2015-01-27 | 4 | AISLING CAPITAL III LP See FN | VSAR | Common Stock | I | 17.2500 | 145,000 | 2,501 | 2,139,568 | ||||
| 2015-01-27 | 2015-01-27 | 4 | GREER R SCOTT | VSAR | Common Stock | D | 17.2500 | 5,500 | 95 | 10,500 | ||||
| 2015-01-26 | 2015-01-22 | 4/A | Advent Life Sciences LLP See FN | VSAR | Common Stock | I | 17.2500 | 55,000 | 949 | 2,271,558 | ||||
| 2015-01-26 | 2015-01-22 | 4 | Malik Shahzad See FN | VSAR | Common Stock | I | 17.2500 | 55,000 | 949 | 2,271,558 | ||||
| 2015-01-26 | 2015-01-22 | 4 | Advent Life Sciences LLP See FN | VSAR | Common Stock | I | 17.2500 | 55,000 | 949 | 2,271,558 | ||||
| 2015-01-13 | 2015-01-12 | 4 | Cleland Jeffrey L | VSAR | Common Stock | D | 22.8545 | -4,000 | -91 | 117,432 | ||||
| 2015-01-07 | 2015-01-05 | 4 | Westberg Paul | VSAR | Stock Option (Right to Buy) | D | 1.26 | -5,000 | 2,217 | |||||
| 2015-01-07 | 2015-01-05 | 4 | Westberg Paul | VSAR | Common Stock | D | 23.3347 | -1,270 | -30 | 22,487 | ||||
| 2015-01-07 | 2015-01-05 | 4 | Westberg Paul | VSAR | Common Stock | D | 22.1893 | -3,730 | -83 | 23,757 | ||||
| 2015-01-07 | 2015-01-05 | 4 | Westberg Paul | VSAR | Common Stock | D | 1.2650 | 5,000 | 6 | 27,487 | ||||
| 2015-01-07 | 2015-01-05 | 4 | Cleland Jeffrey L | VSAR | Common Stock | D | 21.9692 | -3,800 | -83 | 121,432 | ||||
| 2015-01-07 | 2015-01-05 | 4 | Cleland Jeffrey L | VSAR | Common Stock | D | 21.2900 | -200 | -4 | 125,232 | ||||
| 2014-12-30 | 2014-12-26 | 4 | Westberg Paul | VSAR | Stock Option (Right to Buy) | D | 22.24 | 8,860 | 8,860 | |||||
| 2014-12-30 | 2014-12-26 | 4 | Westberg Paul | VSAR | Common Stock | D | 3,797 | 22,487 | ||||||
| 2014-12-30 | 2014-12-26 | 4 | Brumm Joshua T | VSAR | Stock Option (Right to Buy) | D | 22.24 | 24,373 | 24,373 | |||||
| 2014-12-30 | 2014-12-26 | 4 | Brumm Joshua T | VSAR | Common Stock | D | 10,445 | 36,635 | ||||||
| 2014-12-30 | 2014-12-29 | 4 | Cleland Jeffrey L | VSAR | Common Stock | D | 22.1054 | -4,000 | -88 | 125,432 | ||||
| 2014-12-30 | 2014-12-26 | 4 | Cleland Jeffrey L | VSAR | Stock Option (Right to Buy) | D | 22.24 | 75,041 | 75,041 | |||||
| 2014-12-30 | 2014-12-26 | 4 | Cleland Jeffrey L | VSAR | Common Stock | D | 32,160 | 129,432 | ||||||
| 2014-12-22 | 2014-12-22 | 4 | Cleland Jeffrey L | VSAR | Common Stock | D | 21.3561 | -5,870 | -125 | 97,272 | ||||
| 2014-12-22 | 2014-12-22 | 4 | Cleland Jeffrey L | VSAR | Common Stock | D | 20.5364 | -2,110 | -43 | 103,142 | ||||
| 2014-12-22 | 2014-12-19 | 4 | Cleland Jeffrey L | VSAR | Common Stock | D | 20.0000 | -20 | -0 | 105,252 | ||||
| 2014-12-22 | 2014-11-14 | 4 | Cleland Jeffrey L | VSAR | Common Stock | D | -1,900 | 105,272 | ||||||
| 2014-12-22 | 2014-12-18 | 4 | New Leaf Ventures II, L.P. | VSAR | Common Stock | D | 19.0123 | -150,000 | -2,852 | 2,409,374 | ||||
| 2014-12-15 | 2014-12-12 | 4 | Westberg Paul | VSAR | Stock Option (Right to Buy) | D | 1.26 | -3,054 | 7,217 | |||||
| 2014-12-15 | 2014-12-12 | 4 | Westberg Paul | VSAR | Common Stock | D | 18.6542 | -3,054 | -57 | 18,690 | ||||
| 2014-12-15 | 2014-12-12 | 4 | Westberg Paul | VSAR | Common Stock | D | 1.2650 | 3,054 | 4 | 21,744 | ||||
| 2014-12-15 | 2014-12-11 | 4 | Westberg Paul | VSAR | Stock Option (Right to Buy) | D | 1.26 | -6,946 | 10,271 | |||||
| 2014-12-15 | 2014-12-11 | 4 | Westberg Paul | VSAR | Common Stock | D | 18.5100 | -6,946 | -129 | 18,690 | ||||
| 2014-12-15 | 2014-12-11 | 4 | Westberg Paul | VSAR | Common Stock | D | 1.2650 | 6,946 | 9 | 25,636 | ||||
| 2014-12-11 | 3 | GREER R SCOTT | VSAR | Common Stock | D | 10,000 | ||||||||
| 2014-12-11 | 3 | GREER R SCOTT | VSAR | Common Stock | D | 10,000 | ||||||||
| 2014-12-11 | 2014-12-09 | 4 | GREER R SCOTT | VSAR | Stock Option (right to Buy) | D | 18.66 | 35,000 | 35,000 | |||||
| 2014-11-25 | 2014-11-24 | 4 | Index Ventures IV (Jersey) LP | VSAR | Common Stock | D | 18.0164 | -138 | -2 | 19,161 | ||||
| 2014-11-25 | 2014-11-24 | 4 | Index Ventures IV (Jersey) LP | VSAR | Common Stock | D | 18.0164 | -1,480 | -27 | 205,968 | ||||
| 2014-11-25 | 2014-11-24 | 4 | Index Ventures IV (Jersey) LP | VSAR | Common Stock | D | 18.0164 | -15,589 | -281 | 2,169,931 | ||||
| 2014-11-24 | 2014-11-21 | 4 | Index Ventures IV (Jersey) LP | VSAR | Common Stock | D | 18.0388 | -214 | -4 | 19,299 | ||||
| 2014-11-24 | 2014-11-21 | 4 | Index Ventures IV (Jersey) LP | VSAR | Common Stock | D | 18.0388 | -2,304 | -42 | 207,448 | ||||
| 2014-11-24 | 2014-11-21 | 4 | Index Ventures IV (Jersey) LP | VSAR | Common Stock | D | 18.0388 | -24,275 | -438 | 2,185,520 | ||||
| 2014-11-21 | 2014-11-20 | 4 | Index Ventures IV (Jersey) LP | VSAR | Common Stock | D | 18.3205 | -72 | -1 | 19,513 | ||||
| 2014-11-21 | 2014-11-20 | 4 | Index Ventures IV (Jersey) LP | VSAR | Common Stock | D | 18.3205 | -774 | -14 | 209,752 | ||||
| 2014-11-21 | 2014-11-20 | 4 | Index Ventures IV (Jersey) LP | VSAR | Common Stock | D | 18.3205 | -8,154 | -149 | 2,209,795 | ||||
| 2014-11-20 | 2014-11-18 | 4 | Index Ventures IV (Jersey) LP | VSAR | Common Stock | D | 19.3823 | -1,531 | -30 | 19,585 | ||||
| 2014-11-20 | 2014-11-18 | 4 | Index Ventures IV (Jersey) LP | VSAR | Common Stock | D | 19.3823 | -16,456 | -319 | 210,526 | ||||
| 2014-11-20 | 2014-11-18 | 4 | Index Ventures IV (Jersey) LP | VSAR | Common Stock | D | 19.3823 | -173,375 | -3,360 | 2,217,949 | ||||
| 2014-11-17 | 2014-11-13 | 4 | Index Ventures IV (Jersey) LP | VSAR | Common Stock | D | 19.4322 | -99 | -2 | 21,116 | ||||
| 2014-11-17 | 2014-11-13 | 4 | Index Ventures IV (Jersey) LP | VSAR | Common Stock | D | 19.4322 | -1,070 | -21 | 226,982 | ||||
| 2014-11-17 | 2014-11-13 | 4 | Index Ventures IV (Jersey) LP | VSAR | Common Stock | D | 19.4322 | -11,269 | -219 | 2,391,324 | ||||
| 2014-11-14 | 2014-11-12 | 4 | Index Ventures IV (Jersey) LP | VSAR | Common Stock | D | 19.4210 | -290 | -6 | 21,215 | ||||
| 2014-11-14 | 2014-11-12 | 4 | Index Ventures IV (Jersey) LP | VSAR | Common Stock | D | 19.4210 | -3,113 | -60 | 228,052 | ||||
| 2014-11-14 | 2014-11-12 | 4 | Index Ventures IV (Jersey) LP | VSAR | Common Stock | D | 19.4210 | -32,797 | -637 | 2,402,593 | ||||
| 2014-11-13 | 2014-11-11 | 4 | New Leaf Ventures II, L.P. | VSAR | Common Stock | D | 19.3700 | -800,000 | -15,496 | 2,559,374 | ||||
| 2014-10-01 | 2014-09-29 | 4 | New Leaf Ventures II, L.P. | VSAR | Common Stock | D | 20.0168 | -12,556 | -251 | 3,359,374 | ||||
| 2014-06-13 | 2014-06-11 | 4 | Brumm Joshua T | VSAR | Stock Option (Right to Buy) | D | 31.96 | 32,000 | 32,000 | |||||
| 2014-06-13 | 2014-06-11 | 4 | Brumm Joshua T | VSAR | Common Stock | D | 15,000 | 25,000 | ||||||
| 2014-06-13 | 2014-06-11 | 4 | Cleland Jeffrey L | VSAR | Stock Option (Right to Buy) | D | 31.96 | 100,000 | 100,000 | |||||
| 2014-06-13 | 2014-06-11 | 4 | Cleland Jeffrey L | VSAR | Common Stock | D | 30,000 | 146,280 | ||||||
| 2014-06-13 | 2014-06-11 | 4 | Westberg Paul | VSAR | Stock Option (Right to Buy) | D | 31.96 | 25,000 | 25,000 | |||||
| 2014-06-13 | 2014-06-11 | 4 | Westberg Paul | VSAR | Common Stock | D | 7,500 | 17,500 | ||||||
| 2014-04-17 | 2014-04-15 | 4 | Brumm Joshua T | VSAR | Common Stock | D | 10,000 | 10,000 | ||||||
| 2014-04-17 | 2014-04-15 | 4 | Cleland Jeffrey L | VSAR | Common Stock | D | 10,000 | 116,280 | ||||||
| 2014-04-17 | 2014-04-15 | 4 | Westberg Paul | VSAR | Common Stock | D | 10,000 | 10,000 | ||||||
| 2014-03-28 | 2014-03-27 | 4 | New Leaf Ventures II, L.P. | VSAR | Series B Convertible Preferred Stock | D | 0.00 | -759,565 | 0 | |||||
| 2014-03-28 | 2014-03-27 | 4 | New Leaf Ventures II, L.P. | VSAR | Warrant | D | 0.45 | -759,565 | 0 | |||||
| 2014-03-28 | 2014-03-27 | 4 | New Leaf Ventures II, L.P. | VSAR | Series E Convertible Preferred Stock | D | 0.00 | -3,546,094 | 0 | |||||
| 2014-03-28 | 2014-03-27 | 4 | New Leaf Ventures II, L.P. | VSAR | Series D2 Convertible Preferred Stock | D | 0.00 | -1,349,433 | 0 | |||||
| 2014-03-28 | 2014-03-27 | 4 | New Leaf Ventures II, L.P. | VSAR | Series D1 Convertible Preferred Stock | D | 0.00 | -3,050,019 | 0 | |||||
| 2014-03-28 | 2014-03-27 | 4 | New Leaf Ventures II, L.P. | VSAR | Series C Convertible Preferred Stock | D | 0.00 | -8,439,620 | 0 | |||||
| 2014-03-28 | 2014-03-27 | 4 | New Leaf Ventures II, L.P. | VSAR | Series B Convertible Preferred Stock | D | 0.00 | -20,942,466 | 0 | |||||
| 2014-03-28 | 2014-03-27 | 4 | New Leaf Ventures II, L.P. | VSAR | Common Stock | D | 21.0200 | 60,000 | 1,261 | 3,371,930 | ||||
| 2014-03-28 | 2014-03-27 | 4 | New Leaf Ventures II, L.P. | VSAR | Common Stock | D | 66,049 | 3,311,930 | ||||||
| 2014-03-28 | 2014-03-27 | 4 | New Leaf Ventures II, L.P. | VSAR | Common Stock | D | 308,356 | 3,245,881 | ||||||
| 2014-03-28 | 2014-03-27 | 4 | New Leaf Ventures II, L.P. | VSAR | Common Stock | D | 117,342 | 2,937,525 | ||||||
| 2014-03-28 | 2014-03-27 | 4 | New Leaf Ventures II, L.P. | VSAR | Common Stock | D | 265,219 | 2,820,183 | ||||||
| 2014-03-28 | 2014-03-27 | 4 | New Leaf Ventures II, L.P. | VSAR | Common Stock | D | 733,880 | 2,554,964 | ||||||
| 2014-03-28 | 2014-03-27 | 4 | New Leaf Ventures II, L.P. | VSAR | Common Stock | D | 1,821,084 | 1,821,084 | ||||||
| 2014-03-28 | 2014-03-26 | 4 | AKKARAJU SRINIVAS | VSAR | Series E Convertible Preferred Stock | D | -485,664 | 0 | ||||||
| 2014-03-28 | 2014-03-26 | 4 | AKKARAJU SRINIVAS | VSAR | Series D-2 Convertible Preferred Stock | D | -802,596 | 0 | ||||||
| 2014-03-28 | 2014-03-26 | 4 | AKKARAJU SRINIVAS | VSAR | Series D-1 Convertible Preferred Stock | D | -775,315 | 0 | ||||||
| 2014-03-28 | 2014-03-26 | 4 | AKKARAJU SRINIVAS | VSAR | Series B Convertible Preferred Stock | D | -23,403 | 0 | ||||||
| 2014-03-28 | 2014-03-26 | 4 | AKKARAJU SRINIVAS | VSAR | Common Stock | D | 21.0000 | 60,000 | 1,260 | 2,146,978 | ||||
| 2014-03-28 | 2014-03-26 | 4 | AKKARAJU SRINIVAS | VSAR | Common Stock | D | 485,664 | 2,086,978 | ||||||
| 2014-03-28 | 2014-03-26 | 4 | AKKARAJU SRINIVAS | VSAR | Common Stock | D | 802,596 | 1,601,314 | ||||||
| 2014-03-28 | 2014-03-26 | 4 | AKKARAJU SRINIVAS | VSAR | Common Stock | D | 775,315 | 798,718 | ||||||
| 2014-03-28 | 2014-03-26 | 4 | AKKARAJU SRINIVAS | VSAR | Common Stock | D | 23,403 | 23,403 | ||||||
| 2014-03-27 | 2014-03-26 | 4 | Malik Shahzad See FN | VSAR | Series E Convertible Preferred Stock | I | -1,773,049 | 0 | ||||||
| 2014-03-27 | 2014-03-26 | 4 | Malik Shahzad See FN | VSAR | Series D-2 Convertible Preferred Stock | I | -899,619 | 0 | ||||||
| 2014-03-27 | 2014-03-26 | 4 | Malik Shahzad See FN | VSAR | Series D-1 Convertible Preferred Stock | I | -2,033,350 | 0 | ||||||
| 2014-03-27 | 2014-03-26 | 4 | Malik Shahzad See FN | VSAR | Series C Convertible Preferred Stock | I | -5,626,413 | 0 | ||||||
| 2014-03-27 | 2014-03-26 | 4 | Malik Shahzad See FN | VSAR | Series B Convertible Preferred Stock | I | -14,468,020 | 0 | ||||||
| 2014-03-27 | 2014-03-26 | 4 | Malik Shahzad See FN | VSAR | Series B Convertible Preferred Stock | I | 506,376 | 14,468,020 | ||||||
| 2014-03-27 | 2014-03-26 | 4 | Malik Shahzad See FN | VSAR | Warrants to Purchase Series B Preferred Stock | I | 0.45 | -506,376 | 0 | |||||
| 2014-03-27 | 2014-03-26 | 4 | Malik Shahzad See FN | VSAR | Common Stock | I | 21.0000 | 60,000 | 1,260 | 2,216,558 | ||||
| 2014-03-27 | 2014-03-26 | 4 | Malik Shahzad See FN | VSAR | Common Stock | I | 154,178 | 2,156,558 | ||||||
| 2014-03-27 | 2014-03-26 | 4 | Malik Shahzad See FN | VSAR | Common Stock | I | 78,228 | 2,002,380 | ||||||
| 2014-03-27 | 2014-03-26 | 4 | Malik Shahzad See FN | VSAR | Common Stock | I | 176,813 | 1,924,152 | ||||||
| 2014-03-27 | 2014-03-26 | 4 | Malik Shahzad See FN | VSAR | Common Stock | I | 489,253 | 1,747,339 | ||||||
| 2014-03-27 | 2014-03-26 | 4 | Malik Shahzad See FN | VSAR | Common Stock | I | 1,258,086 | 1,258,086 | ||||||
| 2014-03-27 | 2014-03-26 | 4 | SUN ANTHONY Y See FN | VSAR | Series E Convertible Preferred Stock | I | -5,486,820 | 0 | ||||||
| 2014-03-27 | 2014-03-26 | 4 | SUN ANTHONY Y See FN | VSAR | Series D-2 Convertible Preferred Stock | I | -654,796 | 0 | ||||||
| 2014-03-27 | 2014-03-26 | 4 | SUN ANTHONY Y See FN | VSAR | Series D-1 Convertible Preferred Stock | I | -1,479,993 | 0 | ||||||
| 2014-03-27 | 2014-03-26 | 4 | SUN ANTHONY Y See FN | VSAR | Series C Convertible Preferred Stock | I | -14,222,222 | 0 | ||||||
| 2014-03-27 | 2014-03-26 | 4 | SUN ANTHONY Y See FN | VSAR | Series B Convertible Preferred Stock | I | -403,704 | 0 | ||||||
| 2014-03-27 | 2014-03-26 | 4 | SUN ANTHONY Y See FN | VSAR | Common Stock | I | 21.0000 | 60,000 | 1,260 | 1,994,568 | ||||
| 2014-03-27 | 2014-03-26 | 4 | SUN ANTHONY Y See FN | VSAR | Common Stock | I | 477,115 | 1,934,568 | ||||||
| 2014-03-27 | 2014-03-26 | 4 | SUN ANTHONY Y See FN | VSAR | Common Stock | I | 56,939 | 1,457,453 | ||||||
| 2014-03-27 | 2014-03-26 | 4 | SUN ANTHONY Y See FN | VSAR | Common Stock | I | 128,695 | 1,400,514 | ||||||
| 2014-03-27 | 2014-03-26 | 4 | SUN ANTHONY Y See FN | VSAR | Common Stock | I | 1,236,715 | 1,271,819 | ||||||
| 2014-03-27 | 2014-03-26 | 4 | SUN ANTHONY Y See FN | VSAR | Common Stock | I | 35,104 | 35,104 | ||||||
| 2014-03-27 | 2014-03-26 | 4 | AISLING CAPITAL III LP See FN | VSAR | Series E Convertible Preferred Stock | I | -5,486,820 | 0 | ||||||
| 2014-03-27 | 2014-03-26 | 4 | AISLING CAPITAL III LP See FN | VSAR | Series D-2 Convertible Preferred Stock | I | -654,796 | 0 | ||||||
| 2014-03-27 | 2014-03-26 | 4 | AISLING CAPITAL III LP See FN | VSAR | Series D-1 Convertible Preferred Stock | I | -1,479,993 | 0 | ||||||
| 2014-03-27 | 2014-03-26 | 4 | AISLING CAPITAL III LP See FN | VSAR | Series C Convertible Preferred Stock | I | -14,222,222 | 0 | ||||||
| 2014-03-27 | 2014-03-26 | 4 | AISLING CAPITAL III LP See FN | VSAR | Series B Convertible Preferred Stock | I | -403,704 | 0 | ||||||
| 2014-03-27 | 2014-03-26 | 4 | AISLING CAPITAL III LP See FN | VSAR | Common Stock | I | 21.0000 | 60,000 | 1,260 | 1,994,568 | ||||
| 2014-03-27 | 2014-03-26 | 4 | AISLING CAPITAL III LP See FN | VSAR | Common Stock | I | 477,115 | 1,934,568 | ||||||
| 2014-03-27 | 2014-03-26 | 4 | AISLING CAPITAL III LP See FN | VSAR | Common Stock | I | 56,939 | 1,457,453 | ||||||
| 2014-03-27 | 2014-03-26 | 4 | AISLING CAPITAL III LP See FN | VSAR | Common Stock | I | 128,695 | 1,400,514 | ||||||
| 2014-03-27 | 2014-03-26 | 4 | AISLING CAPITAL III LP See FN | VSAR | Common Stock | I | 1,236,715 | 1,271,819 | ||||||
| 2014-03-27 | 2014-03-26 | 4 | AISLING CAPITAL III LP See FN | VSAR | Common Stock | I | 35,104 | 35,104 | ||||||
| 2014-03-27 | 2014-03-26 | 4 | Index Ventures IV (Jersey) LP | VSAR | Warrant to Purchase Common Stock | D | 5.18 | -510 | 0 | |||||
| 2014-03-27 | 2014-03-26 | 4 | Index Ventures IV (Jersey) LP | VSAR | Warrant to Purchase Common Stock | D | 5.18 | 510 | 510 | |||||
| 2014-03-27 | 2014-03-26 | 4 | Index Ventures IV (Jersey) LP | VSAR | Warrant to Purchase Series B Convertible Preferred Stock | D | 0.45 | -5,872 | 0 | |||||
| 2014-03-27 | 2014-03-26 | 4 | Index Ventures IV (Jersey) LP | VSAR | Series D-2 Convertible Preferred Stock | D | -5,796 | 0 | ||||||
| 2014-03-27 | 2014-03-26 | 4 | Index Ventures IV (Jersey) LP | VSAR | Series D-1 Convertible Preferred Stock | D | -13,040 | 0 | ||||||
| 2014-03-27 | 2014-03-26 | 4 | Index Ventures IV (Jersey) LP | VSAR | Series C Convertible Preferred Stock | D | -65,250 | 0 | ||||||
| 2014-03-27 | 2014-03-26 | 4 | Index Ventures IV (Jersey) LP | VSAR | Seires B Convertible Preferred Stock | D | -70,792 | 0 | ||||||
| 2014-03-27 | 2014-03-26 | 4 | Index Ventures IV (Jersey) LP | VSAR | Series A Convertible Preferred Stock | D | -88,000 | 0 | ||||||
| 2014-03-27 | 2014-03-26 | 4 | Index Ventures IV (Jersey) LP | VSAR | Warrant to Purchase Common Stock | D | 5.18 | -5,489 | 0 | |||||
| 2014-03-27 | 2014-03-26 | 4 | Index Ventures IV (Jersey) LP | VSAR | Warrant to Purchase Common Stock | D | 5.18 | 5,489 | 5,489 | |||||
| 2014-03-27 | 2014-03-26 | 4 | Index Ventures IV (Jersey) LP | VSAR | Warrant to Purchase Series B Convertible Preferred Stock | D | 0.45 | -63,127 | 0 | |||||
| 2014-03-27 | 2014-03-26 | 4 | Index Ventures IV (Jersey) LP | VSAR | Series D-2 Convertible Preferred Stock | D | -62,297 | 0 | ||||||
| 2014-03-27 | 2014-03-26 | 4 | Index Ventures IV (Jersey) LP | VSAR | Series D-1 Convertible Preferred Stock | D | -140,174 | 0 | ||||||
| 2014-03-27 | 2014-03-26 | 4 | Index Ventures IV (Jersey) LP | VSAR | Series C Convertible Preferred Stock | D | -701,432 | 0 | ||||||
| 2014-03-27 | 2014-03-26 | 4 | Index Ventures IV (Jersey) LP | VSAR | Series B Convertible Prefered Stock | D | -760,994 | 0 | ||||||
| 2014-03-27 | 2014-03-26 | 4 | Index Ventures IV (Jersey) LP | VSAR | Series A Convertible Preferred Stock | D | -945,973 | 0 | ||||||
| 2014-03-27 | 2014-03-26 | 4 | Index Ventures IV (Jersey) LP | VSAR | Warrant to Purchase Common Stock | D | 5.18 | -57,831 | 0 | |||||
| 2014-03-27 | 2014-03-26 | 4 | Index Ventures IV (Jersey) LP | VSAR | Warrant to Purchase Common Stock | D | 5.18 | 57,831 | 57,831 | |||||
| 2014-03-27 | 2014-03-26 | 4 | Index Ventures IV (Jersey) LP | VSAR | Warrant to Purchase Series B Convertible Preferred Stock | D | 0.45 | -665,057 | 0 | |||||
| 2014-03-27 | 2014-03-26 | 4 | Index Ventures IV (Jersey) LP | VSAR | Series D-2 Convertible Preferred Stock | D | -656,313 | 0 | ||||||
| 2014-03-27 | 2014-03-26 | 4 | Index Ventures IV (Jersey) LP | VSAR | Series D-1 Convertible Preferred Stock | D | -1,476,754 | 0 | ||||||
| 2014-03-27 | 2014-03-26 | 4 | Index Ventures IV (Jersey) LP | VSAR | Series C Convertible Preferred Stock | D | -7,389,507 | 0 | ||||||
| 2014-03-27 | 2014-03-26 | 4 | Index Ventures IV (Jersey) LP | VSAR | Series B Convertible Preferred Stock | D | -8,017,215 | 0 | ||||||
| 2014-03-27 | 2014-03-26 | 4 | Index Ventures IV (Jersey) LP | VSAR | Series A Convertible Preferred Stock | D | -9,966,027 | 0 | ||||||
| 2014-03-27 | 2014-03-26 | 4 | Index Ventures IV (Jersey) LP | VSAR | Common Stock | D | 384 | 21,503 | ||||||
| 2014-03-27 | 2014-03-26 | 4 | Index Ventures IV (Jersey) LP | VSAR | Common Stock | D | 21,119 | 21,119 | ||||||
| 2014-03-27 | 2014-03-26 | 4 | Index Ventures IV (Jersey) LP | VSAR | Common Stock | D | 4,136 | 231,168 | ||||||
| 2014-03-27 | 2014-03-26 | 4 | Index Ventures IV (Jersey) LP | VSAR | Common Stock | D | 227,032 | 227,032 | ||||||
| 2014-03-27 | 2014-03-26 | 4 | Index Ventures IV (Jersey) LP | VSAR | Common Stock | D | 43,579 | 2,435,389 | ||||||
| 2014-03-27 | 2014-03-26 | 4 | Index Ventures IV (Jersey) LP | VSAR | Common Stock | D | 2,391,810 | 2,391,810 | ||||||
| 2014-03-27 | 2014-03-26 | 4 | Advent Life Sciences LLP See FN | VSAR | Series E Convertible Preferred Stock | I | -1,773,049 | 0 | ||||||
| 2014-03-27 | 2014-03-26 | 4 | Advent Life Sciences LLP See FN | VSAR | Series D-2 Convertible Preferred Stock | I | -899,619 | 0 | ||||||
| 2014-03-27 | 2014-03-26 | 4 | Advent Life Sciences LLP See FN | VSAR | Series D-1 Convertible Preferred Stock | I | -2,033,350 | 0 | ||||||
| 2014-03-27 | 2014-03-26 | 4 | Advent Life Sciences LLP See FN | VSAR | Series C Convertible Preferred Stock | I | -5,626,413 | 0 | ||||||
| 2014-03-27 | 2014-03-26 | 4 | Advent Life Sciences LLP See FN | VSAR | Series B Convertible Preferred Stock | I | -14,468,020 | 0 | ||||||
| 2014-03-27 | 2014-03-26 | 4 | Advent Life Sciences LLP See FN | VSAR | Series B Convertible Preferred Stock | I | 506,376 | 14,468,020 | ||||||
| 2014-03-27 | 2014-03-26 | 4 | Advent Life Sciences LLP See FN | VSAR | Warrants to Purchase Series B Preferred Stock | I | 0.45 | -506,376 | 0 | |||||
| 2014-03-27 | 2014-03-26 | 4 | Advent Life Sciences LLP See FN | VSAR | Common Stock | I | 21.0000 | 60,000 | 1,260 | 2,216,558 | ||||
| 2014-03-27 | 2014-03-26 | 4 | Advent Life Sciences LLP See FN | VSAR | Common Stock | I | 154,178 | 2,156,558 | ||||||
| 2014-03-27 | 2014-03-26 | 4 | Advent Life Sciences LLP See FN | VSAR | Common Stock | I | 78,228 | 2,002,380 | ||||||
| 2014-03-27 | 2014-03-26 | 4 | Advent Life Sciences LLP See FN | VSAR | Common Stock | I | 176,813 | 1,924,152 | ||||||
| 2014-03-27 | 2014-03-26 | 4 | Advent Life Sciences LLP See FN | VSAR | Common Stock | I | 489,253 | 1,747,339 | ||||||
| 2014-03-27 | 2014-03-26 | 4 | Advent Life Sciences LLP See FN | VSAR | Common Stock | I | 1,258,086 | 1,258,086 | ||||||
| 2014-03-24 | 2014-03-20 | 4 | AKKARAJU SRINIVAS | VSAR | Stock Option (Right to Buy) | D | 21.00 | 35,000 | 35,000 | |||||
| 2014-03-24 | 2014-03-20 | 4 | Malik Shahzad | VSAR | Stock Option (Right to Buy) | D | 21.00 | 35,000 | 35,000 | |||||
| 2014-03-24 | 2014-03-20 | 4 | JENNINGS EDMON R | VSAR | Stock Option (Right to Buy) | D | 21.00 | 35,000 | 35,000 | |||||
| 2014-03-24 | 2014-03-20 | 4 | SUN ANTHONY Y | VSAR | Stock Option (Right to Buy) | D | 21.00 | 35,000 | 35,000 | |||||
| 2014-03-24 | 2014-03-20 | 4 | Varian John | VSAR | Stock Option (Right to Buy) | D | 21.00 | 35,000 | 35,000 | |||||
| 2014-03-24 | 2014-03-20 | 4 | Dybbs Michael | VSAR | Stock Option (Right to Buy) | D | 21.00 | 35,000 | 35,000 | |||||
| 2014-03-24 | 2014-03-20 | 4 | De Rubertis Francesco | VSAR | Stock Option (Right to Buy) | D | 21.00 | 35,000 | 35,000 | |||||
| 2014-03-20 | 3 | Varian John | VSAR | Common Stock | D | 0 | ||||||||
| 2014-03-20 | 3 | De Rubertis Francesco | VSAR | Common Stock | D | 0 | ||||||||
| 2014-03-20 | 3 | Cleland Jeffrey L | VSAR | Common Stock | D | 212,560 | ||||||||
| 2014-03-20 | 3 | Cleland Jeffrey L | VSAR | Common Stock | D | 212,560 |
P
非衍生或衍生證券的公開市場或私下買入
S
非衍生或衍生證券的公開市場或私下賣出
A
公司向內部人員授予、獎勵或以其他方式獲取證券（例如股票期權）
C
衍生工具轉換
D
將證券賣出或轉讓回公司
F
使用從公司收到的證券的一部分來支付行使價或稅務負擔。
G
內部人士贈送或接收他人贈送公司股票
K
股權掉期和類似的避險交易
M
行使或轉換從公司獲得的衍生證券（例如期權）
V
內部人士透過Form 4自願報告的一筆交易
J
其他（附有交易描述的腳註）
