| 內部人士股份 | 10,007,540 shares |
內部人士情緒分數
「內部人士情緒分數」用於查找被公司內部人士購入的公司。
它是一個複雜的多因素量化模型的結果，該模型能夠辨識具有最高內部人士累積持有水平的公司。該評分模型結合了內部人士在過去90天內購買的淨數量、總購買股份佔流通股比例，以及內部人士擁有的總股份的指標。該分數的範圍從0到100，數值越高表示相對於同行業而言具有更高程度的內部人士持股水平，50為平均值。
更新頻率：每日
高管情緒分數
「高管情緒分數」用於查找被公司管理層購入的公司。
根據定義，公司高管是公司內部人士，但與其他內部人士（10%的股東和董事會成員）不同，公司高管每天在公司工作，而且他們使用自己的資金進行交易。（10%的股東和董事會成員通常是基金經理，管理著其他人的資金。）因此，公司高管進行的內幕交易更為重要性，應該被適當地重視和關注。
如同「內部人士情緒分數」，「高管情緒分數」也是一個複雜的多因素量化模型的計算結果，該模型能夠辨識具有最高高管累積持有水平的公司。
更新頻率：每日
關鍵內部人士指標
此表格顯示了公司在各種內部人士指標上的排名。百分位數排名顯示了這家公司在美國市場與其他公司相比的表現。排名越高表明公司所處狀況越好。
舉例來說，一般認為內部人士的買入是一個積極的指標，因此具有更多內部人士買入的公司將排名高於那些內部人士買入較少（甚至有內部人士賣出）的公司。
內部人士買入淨數（排名）
N/A
內部人士買入淨數是過去90天內買入的內部人士總數減去賣出的內部人士總數。以百分位排名顯示（範圍從0到100%）。
內部人士買入佔流通股比例（排名）
N/A
內部人士買入佔流通股比例是內部人士在過去90天內購買的股份總數減去賣出的股份總數，除以總流通股數並乘以100。
內幕交易圖表
以下圖表顯示了Alpine Immune Sciences, Inc.內部人士交易。內部人士包括公司的高管、董事或重要投資者。一般而言，基於內幕、非公開信息進行交易是非法的。這並不意味著他們在自己的公司進行任何交易都是非法的。但是，他們必須透過Form 4向美國證券交易委員會（SEC）報告所有交易。
內部人員名單及盈利指標
這張表格顯示已知的內部人員名單，從向SEC披露的申報文件中自動生成。除了姓名、最近的職稱和董事、高管或10%擁有人的標誌外，我們還提供了最新披露的持股信息。此外，我們盡可能提供內部人的歷史交易表現。歷史交易表現是內部人士實際進行的公開市場購買交易表現的加權平均值。有關此計算方式的更多資訊，請查看YouTube網絡研討會。
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| 內部人士 | 平均收益（%） | 持股 數量 |
分拆 調整 |
|---|
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追蹤內部人士買入記錄 - 短期收益分析
在這一部分，我們分析了在 ALPN / Alpine Immune Sciences, Inc. 中進行的每筆非計劃的公開市場內部人士購買的盈利情況。這種分析有助於了解內部人士是否持續產生異常的回報，以及是否值得跟踪。該分析基於每筆交易後一年的情況， 結果僅為理論值。 .
以下表格顯示了最近的自動交易計劃之外的公開市場購買。
經調整價格 已按拆股調整。 經調整股數 已按拆股調整。
追蹤內部人士賣出記錄 - 短期虧損分析
在這一部分，我們分析了在 ALPN / Alpine Immune Sciences, Inc. 中進行的每筆非計劃的公開市場內部人士賣出所達成的短期虧損規避。如果存在持續的虧損規避模式，可能表明未來的內部人士賣出交易預示著價格的下跌。該分析基於每筆交易後一年的情況， 結果僅為理論值。 .
以下表格顯示了最近的自動交易計劃之外的公開市場購買。
經調整價格 已按拆股調整。 經調整股數 已按拆股調整。
交易歷史
點擊連結圖示即可查看完整的交易記錄。作為 10b5-1 自動交易計畫的一部分進行報告的交易，將在標記為 10b-5 的欄位中顯示 X。
| 呈報 日期 |
交易 日期 |
表格 | 內部人士 | 證券代碼 | 證券種類 | 代碼 | 直接 | 行使 價格 |
單位 價格 |
股數 變化 |
價值 變化 (1K) |
剩餘 期權 |
剩餘 股份 |
|
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 2024-05-20 | 2024-05-20 | 4 | Peetz Christopher Christopher Peetz & Christine Peetz TR UA 02/15/2017 The Peetz Living Trust | ALPN | Common Stock | I | -1,900 | 0 | ||||||
| 2024-05-20 | 2024-05-20 | 4 | CONWAY ROBERT E By Robert E. Conway Rev Trust and Carolyn J. Conway Rev Trust | ALPN | Common Stock | I | -50,000 | 0 | ||||||
| 2024-05-20 | 2024-05-18 | 4 | Topper James N By Frazier Life Sciences VIII, L.P. | ALPN | Common Stock | I | -2,829,347 | 0 | ||||||
| 2024-05-20 | 2024-05-18 | 4 | Thompson Peter A. See Footnotes | ALPN | Common Stock | I | -264,315 | 0 | ||||||
| 2024-05-20 | 2024-05-18 | 4 | Thompson Peter A. See Footnotes | ALPN | Common Stock | I | -2,416,181 | 0 | ||||||
| 2024-05-20 | 2024-05-18 | 4 | Cui Xiangmin | ALPN | Common Stock | I | -1,735,544 | 0 | ||||||
| 2024-05-20 | 2024-05-18 | 4 | Cui Xiangmin | ALPN | Common Stock | I | -6,582,380 | 0 | ||||||
| 2024-05-20 | 2024-05-20 | 4 | Rickey James Paul | ALPN | Common Stock | D | -31,200 | 0 | ||||||
| 2024-05-20 | 2024-05-20 | 4 | Rickey James Paul | ALPN | Common Stock | D | -26,761 | 31,200 | ||||||
| 2024-05-20 | 2024-05-20 | 4 | PENG STANFORD L | ALPN | Common Stock | D | -48,000 | 0 | ||||||
| 2024-05-20 | 2024-05-20 | 4 | PENG STANFORD L | ALPN | Common Stock | D | -296,163 | 48,000 | ||||||
| 2024-05-20 | 2024-05-20 | 4 | GOLD MITCHELL | ALPN | Common Stock | D | -96,000 | 0 | ||||||
| 2024-05-20 | 2024-05-20 | 4 | GOLD MITCHELL | ALPN | Common Stock | D | -13,245 | 96,000 | ||||||
| 2024-05-20 | 2024-05-18 | 4 | GOLD MITCHELL Alpine ImmunoSciences, L.P. | ALPN | Common Stock | I | -2,627,157 | 0 | ||||||
| 2024-05-20 | 2024-05-20 | 4 | FUHS ULRICH MARTIN | ALPN | Common Stock | D | -7,300 | 0 | ||||||
| 2024-05-20 | 2024-05-20 | 4 | FUHS ULRICH MARTIN | ALPN | Common Stock | D | -22,820 | 7,300 | ||||||
| 2024-05-20 | 2024-05-20 | 4 | DURAND REMY | ALPN | Common Stock | D | -31,200 | 0 | ||||||
| 2024-05-20 | 2024-05-20 | 4 | DURAND REMY | ALPN | Common Stock | D | -102,192 | 31,200 | ||||||
| 2024-05-20 | 2024-05-18 | 4 | ORBIMED ADVISORS LLC See footnotes | ALPN | Common Stock | I | -264,315 | 0 | ||||||
| 2024-05-20 | 2024-05-18 | 4 | ORBIMED ADVISORS LLC See footnotes | ALPN | Common Stock | I | -2,416,181 | 0 | ||||||
| 2024-05-10 | 2024-05-08 | 4 | PENG STANFORD L | ALPN | Common Stock | D | 6.3300 | 13,377 | 85 | 344,163 | ||||
| 2024-05-10 | 2024-05-08 | 4 | PENG STANFORD L | ALPN | Common Stock | D | 3.2300 | 26,912 | 87 | 330,786 | ||||
| 2024-05-10 | 2024-05-08 | 4 | PENG STANFORD L | ALPN | Common Stock | D | 11.3100 | 22,593 | 256 | 303,874 | ||||
| 2024-05-10 | 2024-05-08 | 4 | PENG STANFORD L | ALPN | Common Stock | D | 0.6500 | 161,492 | 105 | 281,281 | ||||
| 2024-05-10 | 2024-05-08 | 4 | PENG STANFORD L | ALPN | Common Stock | D | 0.6500 | 37,267 | 24 | 119,789 | ||||
| 2024-05-10 | 2024-05-08 | 4 | PENG STANFORD L | ALPN | Common Stock | D | 6.5100 | 3,126 | 20 | 82,522 | ||||
| 2024-05-10 | 2024-05-08 | 4 | PENG STANFORD L | ALPN | Common Stock | D | 13.2000 | 7,025 | 93 | 79,396 | ||||
| 2024-05-10 | 2024-05-08 | 4 | DURAND REMY | ALPN | Common Stock | D | 4.7600 | 10,000 | 48 | 133,392 | ||||
| 2024-05-10 | 2024-05-08 | 4 | DURAND REMY | ALPN | Common Stock | D | 3.2300 | 38,078 | 123 | 123,392 | ||||
| 2024-05-10 | 2024-05-08 | 4 | DURAND REMY | ALPN | Common Stock | D | 4.0900 | 12,365 | 51 | 85,314 | ||||
| 2024-05-10 | 2024-05-08 | 4 | DURAND REMY | ALPN | Common Stock | D | 6.5100 | 25,000 | 163 | 72,949 | ||||
| 2024-05-10 | 2024-05-08 | 4 | DURAND REMY | ALPN | Common Stock | D | 13.2000 | 9,845 | 130 | 47,949 | ||||
| 2024-05-10 | 2024-05-08 | 4 | GOLD MITCHELL | ALPN | Common Stock | D | 7.5500 | 13,245 | 100 | 109,245 | ||||
| 2024-05-10 | 2024-05-08 | 4 | FUHS ULRICH MARTIN | ALPN | Common Stock | D | 12.0700 | 22,820 | 275 | 30,120 | ||||
| 2024-05-09 | 2024-05-07 | 4 | Rickey James Paul | ALPN | Common Stock | D | 5.0200 | 398 | 2 | 57,961 | ||||
| 2024-05-09 | 2024-05-07 | 4 | Rickey James Paul | ALPN | Common Stock | D | 3.2300 | 18,286 | 59 | 57,563 | ||||
| 2024-05-09 | 2024-05-07 | 4 | Rickey James Paul | ALPN | Common Stock | D | 11.3100 | 164 | 2 | 39,277 | ||||
| 2024-05-09 | 2024-05-07 | 4 | Rickey James Paul | ALPN | Common Stock | D | 6.5100 | 857 | 6 | 39,113 | ||||
| 2024-05-09 | 2024-05-07 | 4 | Rickey James Paul | ALPN | Common Stock | D | 13.2000 | 7,055 | 93 | 38,256 | ||||
| 2024-05-09 | 2024-05-07 | 4 | Rickey James Paul | ALPN | Common Stock | D | 7.5500 | 1 | 0 | 31,201 | ||||
| 2024-04-29 | 2024-04-25 | 4 | Topper James N By: Frazier Life Sciences VIII, L.P. | ALPN | Common Stock | I | 64.5700 | -19 | -1 | 2,829,347 | ||||
| 2024-04-29 | 2024-04-25 | 4 | Topper James N By: Frazier Life Sciences VIII, L.P. | ALPN | Common Stock | I | 0.0010 | 1,200,000 | 1 | 2,829,366 | ||||
| 2024-04-05 | 3 | FUHS ULRICH MARTIN | ALPN | Common Stock | D | 7,300 | ||||||||
| 2024-01-29 | 2024-01-26 | 4 | Rickey James Paul | ALPN | Common Stock | D | 25.0000 | -44,000 | -1,100 | 0 | ||||
| 2024-01-29 | 2024-01-26 | 4 | Rickey James Paul | ALPN | Common Stock | D | 11.3100 | 44,000 | 498 | 44,000 | ||||
| 2024-01-29 | 2024-01-26 | 4 | Rickey James Paul | ALPN | Common Stock | D | 22.3121 | -73,764 | -1,646 | 0 | ||||
| 2024-01-29 | 2024-01-26 | 4 | Rickey James Paul | ALPN | Common Stock | D | 6.5100 | 73,764 | 480 | 73,764 | ||||
| 2024-01-29 | 2024-01-25 | 4 | Rickey James Paul | ALPN | Common Stock | D | 22.0000 | -236 | -5 | 0 | ||||
| 2024-01-29 | 2024-01-25 | 4 | Rickey James Paul | ALPN | Common Stock | D | 6.5100 | 236 | 2 | 236 | ||||
| 2024-01-22 | 2024-01-18 | 4 | Decheng Capital China Life Sciences USD Fund III, L.P. | ALPN | Common Stock | D | 12.7400 | 1,234,636 | 15,729 | 6,582,380 | ||||
| 2024-01-22 | 2024-01-18 | 4 | Cui Xiangmin | ALPN | Common Stock | I | 12.7400 | 1,234,636 | 15,729 | 6,582,380 | ||||
| 2024-01-16 | 2024-01-11 | 4 | ORBIMED ADVISORS LLC See footnotes | ALPN | Common Stock | I | 12.7400 | 145,251 | 1,850 | 2,416,181 | ||||
| 2024-01-16 | 2024-01-11 | 4 | Thompson Peter A. See footnotes | ALPN | Common Stock | I | 12.7400 | 145,251 | 1,850 | 2,416,181 | ||||
| 2024-01-05 | 2024-01-04 | 4 | PENG STANFORD L | ALPN | Common Stock | D | 48,000 | 72,371 | ||||||
| 2024-01-05 | 2024-01-04 | 4 | GOLD MITCHELL | ALPN | Common Stock | D | 96,000 | 96,000 | ||||||
| 2024-01-05 | 2024-01-04 | 4 | Rickey James Paul | ALPN | Common Stock | D | 31,200 | 31,200 | ||||||
| 2024-01-05 | 2024-01-04 | 4 | DURAND REMY | ALPN | Common Stock | D | 31,200 | 38,104 | ||||||
| 2023-12-29 | 2023-12-28 | 4 | GOLD MITCHELL Alpine ImmunoSciences, L.P. | ALPN | Common Stock | I | 19.6500 | -48,264 | -948 | 2,627,157 | ||||
| 2023-12-29 | 2023-12-28 | 4 | GOLD MITCHELL Alpine ImmunoSciences, L.P. | ALPN | Common Stock | I | 12.7400 | 74,441 | 948 | 2,675,421 | ||||
| 2023-12-29 | 2023-12-28 | 4 | GOLD MITCHELL | ALPN | Common Stock | D | 20.0413 | -1,016 | -20 | 0 | ||||
| 2023-12-29 | 2023-12-28 | 4 | GOLD MITCHELL | ALPN | Common Stock | D | 0.6500 | 1,016 | 1 | 1,016 | ||||
| 2023-12-29 | 2023-12-28 | 4 | Thompson Peter A. See footnotes | ALPN | Common Stock | I | 18.3200 | -139,166 | -2,550 | 264,315 | ||||
| 2023-12-29 | 2023-12-28 | 4 | Thompson Peter A. See footnotes | ALPN | Common Stock | I | 18.3200 | -1,195,683 | -21,905 | 2,270,930 | ||||
| 2023-12-29 | 2023-12-28 | 4 | Thompson Peter A. See footnotes | ALPN | Common Stock | I | 19.8200 | -3,128 | -62 | 403,481 | ||||
| 2023-12-29 | 2023-12-28 | 4 | Thompson Peter A. See footnotes | ALPN | Common Stock | I | 19.8200 | -26,872 | -533 | 3,466,613 | ||||
| 2023-12-29 | 2023-12-27 | 4 | Thompson Peter A. See footnotes | ALPN | Common Stock | I | 19.9600 | -18,922 | -378 | 406,609 | ||||
| 2023-12-29 | 2023-12-27 | 4 | Thompson Peter A. See footnotes | ALPN | Common Stock | I | 19.9600 | -162,576 | -3,245 | 3,493,485 | ||||
| 2023-12-29 | 2023-12-28 | 4 | ORBIMED ADVISORS LLC See footnotes | ALPN | Common Stock | I | 18.3200 | -139,166 | -2,550 | 264,315 | ||||
| 2023-12-29 | 2023-12-28 | 4 | ORBIMED ADVISORS LLC See footnotes | ALPN | Common Stock | I | 18.3200 | -1,195,683 | -21,905 | 2,270,930 | ||||
| 2023-12-29 | 2023-12-28 | 4 | ORBIMED ADVISORS LLC See footnotes | ALPN | Common Stock | I | 19.8200 | -3,128 | -62 | 403,481 | ||||
| 2023-12-29 | 2023-12-28 | 4 | ORBIMED ADVISORS LLC See footnotes | ALPN | Common Stock | I | 19.8200 | -26,872 | -533 | 3,466,613 | ||||
| 2023-12-29 | 2023-12-27 | 4 | ORBIMED ADVISORS LLC See footnotes | ALPN | Common Stock | I | 19.9600 | -18,922 | -378 | 406,609 | ||||
| 2023-12-29 | 2023-12-27 | 4 | ORBIMED ADVISORS LLC See footnotes | ALPN | Common Stock | I | 19.9600 | -162,576 | -3,245 | 3,493,485 | ||||
| 2023-12-27 | 2023-12-27 | 4 | GOLD MITCHELL | ALPN | Common Stock | D | 20.0425 | -29,573 | -593 | 0 | ||||
| 2023-12-27 | 2023-12-27 | 4 | GOLD MITCHELL | ALPN | Common Stock | D | 0.6500 | 29,573 | 19 | 29,573 | ||||
| 2023-12-27 | 2023-12-26 | 4 | GOLD MITCHELL | ALPN | Common Stock | D | 20.2245 | -24,486 | -495 | 0 | ||||
| 2023-12-27 | 2023-12-26 | 4 | GOLD MITCHELL | ALPN | Common Stock | D | 0.6500 | 22,084 | 14 | 24,486 | ||||
| 2023-12-27 | 2023-12-26 | 4 | GOLD MITCHELL | ALPN | Common Stock | D | 0.4500 | 2,402 | 1 | 2,402 | ||||
| 2023-12-27 | 2023-12-22 | 4 | GOLD MITCHELL | ALPN | Common Stock | D | 20.4255 | -37,825 | -773 | 0 | ||||
| 2023-12-27 | 2023-12-22 | 4 | GOLD MITCHELL | ALPN | Common Stock | D | 0.4500 | 37,825 | 17 | 37,825 | ||||
| 2023-12-21 | 2023-12-19 | 4 | Rickey James Paul | ALPN | Common Stock | D | 19.2087 | -15,213 | -292 | 0 | ||||
| 2023-12-21 | 2023-12-19 | 4 | Rickey James Paul | ALPN | Common Stock | D | 5.0200 | 15,213 | 76 | 15,213 | ||||
| 2023-12-21 | 2023-12-19 | 4 | GOLD MITCHELL | ALPN | Common Stock | D | 20.0099 | -2,402 | -48 | 0 | ||||
| 2023-12-21 | 2023-12-19 | 4 | GOLD MITCHELL | ALPN | Common Stock | D | 0.4500 | 2,402 | 1 | 2,402 | ||||
| 2023-12-18 | 2023-12-18 | 4 | Rickey James Paul | ALPN | Common Stock | D | 19.0017 | -1,800 | -34 | 0 | ||||
| 2023-12-18 | 2023-12-18 | 4 | Rickey James Paul | ALPN | Common Stock | D | 5.0200 | 1,800 | 9 | 1,800 | ||||
| 2023-12-18 | 2023-12-15 | 4 | Rickey James Paul | ALPN | Common Stock | D | 19.0888 | -45,387 | -866 | 0 | ||||
| 2023-12-18 | 2023-12-15 | 4 | Rickey James Paul | ALPN | Common Stock | D | 5.0200 | 45,387 | 228 | 45,387 | ||||
| 2023-12-18 | 2023-12-14 | 4 | Rickey James Paul | ALPN | Common Stock | D | 19.0005 | -11,600 | -220 | 0 | ||||
| 2023-12-18 | 2023-12-14 | 4 | Rickey James Paul | ALPN | Common Stock | D | 5.0200 | 11,600 | 58 | 11,600 | ||||
| 2023-12-13 | 2023-12-11 | 4 | Topper James N By: Frazier Life Sciences VIII, L.P. | ALPN | Common Stock | I | 12.7400 | 145,251 | 1,850 | 1,629,366 | ||||
| 2023-12-12 | 2023-12-12 | 4 | GOLD MITCHELL | ALPN | Common Stock | D | 17.3155 | -8,613 | -149 | 0 | ||||
| 2023-12-12 | 2023-12-12 | 4 | GOLD MITCHELL | ALPN | Common Stock | D | 0.4500 | 8,613 | 4 | 8,613 | ||||
| 2023-12-12 | 2023-12-12 | 4 | GOLD MITCHELL | ALPN | Common Stock | D | 17.3155 | -32,450 | -562 | 0 | ||||
| 2023-12-12 | 2023-12-11 | 4 | GOLD MITCHELL | ALPN | Common Stock | D | 17.2648 | -68,870 | -1,189 | 32,450 | ||||
| 2023-12-12 | 2023-12-08 | 4 | GOLD MITCHELL | ALPN | Common Stock | D | 17.0799 | -8,067 | -138 | 101,320 | ||||
| 2023-12-06 | 2023-12-06 | 4 | Rickey James Paul | ALPN | Common Stock | D | 16.0797 | -6,446 | -104 | 0 | ||||
| 2023-12-06 | 2023-12-06 | 4 | Rickey James Paul | ALPN | Common Stock | D | 3.2300 | 6,446 | 21 | 6,446 | ||||
| 2023-12-06 | 2023-12-05 | 4 | Rickey James Paul | ALPN | Common Stock | D | 16.0139 | -418 | -7 | 0 | ||||
| 2023-12-06 | 2023-12-05 | 4 | Rickey James Paul | ALPN | Common Stock | D | 3.2300 | 418 | 1 | 418 | ||||
| 2023-12-06 | 2023-12-04 | 4 | Rickey James Paul | ALPN | Common Stock | D | 16.0584 | -63,947 | -1,027 | 0 | ||||
| 2023-12-06 | 2023-12-04 | 4 | Rickey James Paul | ALPN | Common Stock | D | 3.2300 | 63,947 | 207 | 63,947 | ||||
| 2023-12-01 | 2023-11-30 | 4 | Rickey James Paul | ALPN | Common Stock | D | 16.0000 | -700 | -11 | 0 | ||||
| 2023-12-01 | 2023-11-30 | 4 | Rickey James Paul | ALPN | Common Stock | D | 3.2300 | 700 | 2 | 700 | ||||
| 2023-11-14 | 2023-11-09 | 4 | Cui Xiangmin | ALPN | Common Stock | I | 12.5000 | 375,000 | 4,688 | 1,735,544 | ||||
| 2023-11-14 | 2023-11-09 | 4 | Decheng Capital Global Healthcare Fund (Master), LP | ALPN | Common Stock | D | 12.5000 | 375,000 | 4,688 | 1,735,544 | ||||
| 2023-11-08 | 2023-11-06 | 4 | Rickey James Paul | ALPN | Common Stock | D | 16.0281 | -18,003 | -289 | 0 | ||||
| 2023-11-08 | 2023-11-06 | 4 | Rickey James Paul | ALPN | Common Stock | D | 3.2300 | 10,989 | 35 | 18,003 | ||||
| 2023-04-27 | 3 | DURAND REMY | ALPN | Common Stock | D | 6,904 | ||||||||
| 2022-09-27 | 2022-09-23 | 4 | Cui Xiangmin | ALPN | Common Stock | I | 7.3500 | 1,360,544 | 10,000 | 1,360,544 | ||||
| 2022-09-27 | 2022-09-23 | 4 | Cui Xiangmin | ALPN | Common Stock | I | 7.3500 | 639,456 | 4,700 | 5,347,744 | ||||
| 2022-09-27 | 2022-09-23 | 4 | Decheng Capital China Life Sciences USD Fund III, L.P. | ALPN | Common Stock | I | 7.3500 | 1,360,544 | 10,000 | 1,360,544 | ||||
| 2022-09-27 | 2022-09-23 | 4 | Decheng Capital China Life Sciences USD Fund III, L.P. | ALPN | Common Stock | D | 7.3500 | 639,456 | 4,700 | 5,347,744 | ||||
| 2022-07-19 | 2022-07-15 | 4 | Venkatesan Jay | ALPN | Common Stock | D | 0.4500 | 20,063 | 9 | 238,126 | ||||
| 2022-02-15 | 2022-02-11 | 4 | Frazier Life Sciences VIII, L.P. | ALPN | Common Stock | D | 7.1006 | 112,665 | 800 | 1,484,115 | ||||
| 2022-01-06 | 2022-01-04 | 4 | PENG STANFORD L | ALPN | Stock Option (Right to buy) | D | 13.30 | 215,000 | 215,000 | |||||
| 2022-01-06 | 2022-01-04 | 4 | GOLD MITCHELL | ALPN | Stock Option (Right to buy) | D | 13.30 | 215,000 | 215,000 | |||||
| 2022-01-06 | 2022-01-04 | 4 | Rickey James Paul | ALPN | Stock Option (Right to buy) | D | 13.30 | 112,500 | 112,500 | |||||
| 2022-01-04 | 2022-01-03 | 4 | Hernday Natasha | ALPN | Stock Option (Right to buy) | D | 13.89 | 10,000 | 10,000 | |||||
| 2022-01-04 | 2021-12-31 | 4 | Rickey James Paul | ALPN | Common Stock | D | 13.9162 | -17,013 | -237 | 7,014 | ||||
| 2022-01-04 | 2022-01-03 | 4 | Peetz Christopher | ALPN | Stock Option (Right to buy) | D | 13.89 | 10,000 | 10,000 | |||||
| 2022-01-04 | 2022-01-03 | 4 | Venkatesan Jay | ALPN | Stock Option (Right to buy) | D | 13.89 | 10,000 | 10,000 | |||||
| 2022-01-04 | 2022-01-03 | 4 | Topper James N | ALPN | Stock Option (Right to buy) | D | 13.89 | 10,000 | 10,000 | |||||
| 2022-01-04 | 2022-01-03 | 4 | CONWAY ROBERT E | ALPN | Stock Option (Right to buy) | D | 13.89 | 10,000 | 10,000 | |||||
| 2022-01-04 | 2022-01-03 | 4 | Thompson Peter A. | ALPN | Stock Option (Right to buy) | D | 13.89 | 10,000 | 10,000 | |||||
| 2022-01-04 | 2022-01-03 | 4 | Cui Xiangmin | ALPN | Stock Option (Right to buy) | D | 13.89 | 10,000 | 10,000 | |||||
| 2021-09-27 | 2021-09-23 | 4/A | Peetz Christopher Christopher Peetz and Christine Peetz TR UA 02/15/2017 The Peetz Living Trust | ALPN | Common Stock | I | 10.1700 | 1,900 | 19 | 1,900 | ||||
| 2021-09-27 | 2021-09-23 | 4/A | CONWAY ROBERT E By Robert E. Conway Rev Trust and Carolyn J. Conway Rev Trust | ALPN | Common Stock | I | 10.0769 | 15,000 | 151 | 50,000 | ||||
| 2021-09-24 | 2021-09-23 | 4 | Peetz Christopher Christopher Peetz & Christine Peetz TR UA 02/15/2017 The Peetz Living Trust | ALPN | Common Stock | I | 10.1700 | 1,900 | 19 | 1,900 | ||||
| 2021-09-24 | 2021-09-23 | 4 | CONWAY ROBERT E By Robert E. Conway Rev Trust and Carolyn J. Conway Rev Trust | ALPN | Common Stock | I | 10.0769 | 15,000 | 151 | 50,000 | ||||
| 2021-09-23 | 2021-09-21 | 4 | CONWAY ROBERT E By Robert E. Conway Rev Trust and Carolyn J. Conway Rev Trust | ALPN | Common Stock | I | 9.7966 | 10,000 | 98 | 35,000 | ||||
| 2021-09-21 | 2021-09-17 | 4 | ORBIMED ADVISORS LLC See Footnotes | ALPN | Common Stock | I | 9.4000 | 425,531 | 4,000 | 425,531 | ||||
| 2021-09-21 | 2021-09-17 | 4 | ORBIMED ADVISORS LLC See Footnotes | ALPN | Common Stock | I | 9.4000 | 585,106 | 5,500 | 3,656,061 | ||||
| 2021-09-21 | 2021-09-17 | 4 | Decheng Capital China Life Sciences USD Fund III, L.P. | ALPN | Common Stock | D | 9.4000 | 1,542,553 | 14,500 | 4,708,288 | ||||
| 2021-09-21 | 2021-09-17 | 4 | Thompson Peter A. See Footnotes | ALPN | Common Stock | I | 9.4000 | 425,531 | 4,000 | 425,531 | ||||
| 2021-09-21 | 2021-09-17 | 4 | Thompson Peter A. See Footnotes | ALPN | Common Stock | I | 9.4000 | 585,106 | 5,500 | 3,656,061 | ||||
| 2021-09-21 | 2021-09-17 | 4 | Alpine ImmunoSciences, L.P. | ALPN | Common Stock | D | 9.4000 | -400,000 | -3,760 | 2,600,980 | ||||
| 2021-09-21 | 2021-09-17 | 4 | GOLD MITCHELL | ALPN | Common Stock | D | 10.0076 | -45,262 | -453 | 109,387 | ||||
| 2021-09-21 | 2021-09-17 | 4 | GOLD MITCHELL By Alpine ImmunoSciences, L.P. | ALPN | Common Stock | I | 9.4000 | -400,000 | -3,760 | 2,600,980 | ||||
| 2021-09-21 | 2021-09-17 | 4 | Venkatesan Jay By Alpine ImmunoSciences, L.P. | ALPN | Common Stock | I | 9.4000 | -400,000 | -3,760 | 2,600,980 | ||||
| 2021-09-21 | 2021-09-17 | 4 | Cui Xiangmin | ALPN | Common Stock | I | 9.4000 | 1,542,553 | 14,500 | 4,708,288 | ||||
| 2021-09-21 | 2021-09-17 | 4 | Frazier Life Sciences VIII, L.P. | ALPN | Warrant (Right to Buy) | D | 0.00 | 1,200,000 | 1,200,000 | |||||
| 2021-09-21 | 2021-09-17 | 4 | Frazier Life Sciences VIII, L.P. | ALPN | Common Stock | D | -1,200,000 | 1,371,450 | ||||||
| 2021-09-17 | 2021-09-16 | 4 | GOLD MITCHELL | ALPN | Common Stock | D | 10.0024 | -6,768 | -68 | 154,649 | ||||
| 2021-09-17 | 2021-09-15 | 4 | GOLD MITCHELL | ALPN | Common Stock | D | 10.0000 | -3,484 | -35 | 161,417 | ||||
| 2021-06-29 | 2021-06-28 | 4 | GOLD MITCHELL | ALPN | Common Stock | D | 10.0005 | -3,479 | -35 | 164,901 | ||||
| 2021-06-29 | 2021-06-25 | 4 | GOLD MITCHELL | ALPN | Common Stock | D | 10.0143 | -9,473 | -95 | 168,380 | ||||
| 2021-06-02 | 2021-06-01 | 4 | Goldberg Zelanna | ALPN | Stock Option (Right to buy) | D | 10.29 | 160,000 | 160,000 | |||||
| 2021-05-21 | 2021-05-20 | 4 | GOLD MITCHELL | ALPN | Common Stock | D | 15.0006 | -1,221 | -18 | 177,853 | ||||
| 2021-05-21 | 2021-05-19 | 4 | GOLD MITCHELL | ALPN | Common Stock | D | 15.0283 | -50,965 | -766 | 179,074 | ||||
| 2021-05-14 | 2021-05-13 | 4 | GOLD MITCHELL | ALPN | Common Stock | D | 11.5169 | -10,000 | -115 | 230,039 | ||||
| 2021-05-14 | 2021-05-12 | 4 | GOLD MITCHELL | ALPN | Common Stock | D | 11.6842 | -10,000 | -117 | 240,039 | ||||
| 2021-04-23 | 2021-03-31 | 4 | Venkatesan Jay | ALPN | Stock Option (Right to buy) | D | 3.62 | -7,650 | 0 | |||||
| 2021-04-23 | 2021-03-31 | 4 | Venkatesan Jay | ALPN | Common Stock | D | 3.6233 | 7,650 | 28 | 218,063 | ||||
| 2021-04-23 | 2021-03-30 | 4 | Venkatesan Jay | ALPN | Stock Option (Right to buy) | D | 4.09 | -7,650 | 0 | |||||
| 2021-04-23 | 2021-03-30 | 4 | Venkatesan Jay | ALPN | Common Stock | D | 4.0900 | 7,650 | 31 | 210,413 | ||||
| 2021-04-15 | 2021-04-14 | 4 | GOLD MITCHELL | ALPN | Common Stock | D | 10.5200 | -10,000 | -105 | 250,039 | ||||
| 2021-04-15 | 2021-04-13 | 4 | GOLD MITCHELL | ALPN | Common Stock | D | 10.0714 | -10,000 | -101 | 260,039 | ||||
| 2021-03-08 | 2021-03-05 | 4 | GOLD MITCHELL | ALPN | Common Stock | D | 12.9875 | -10,000 | -130 | 270,039 | ||||
| 2021-03-08 | 2021-03-04 | 4 | GOLD MITCHELL | ALPN | Common Stock | D | 13.0108 | -10,000 | -130 | 280,039 | ||||
| 2021-02-03 | 2021-02-02 | 4 | GOLD MITCHELL | ALPN | Common Stock | D | 11.7381 | -10,000 | -117 | 290,039 | ||||
| 2021-02-03 | 2021-02-01 | 4 | GOLD MITCHELL | ALPN | Common Stock | D | 13.2029 | -7,021 | -93 | 300,039 | ||||
| 2021-02-03 | 2021-02-01 | 4 | GOLD MITCHELL | ALPN | Common Stock | D | 12.0738 | -2,979 | -36 | 307,060 | ||||
| 2021-01-06 | 2021-01-05 | 4 | PENG STANFORD L | ALPN | Stock Option (Right to buy) | D | 13.20 | 150,000 | 150,000 | |||||
| 2021-01-06 | 2021-01-05 | 4 | GOLD MITCHELL | ALPN | Stock Option (Right to buy) | D | 13.20 | 255,000 | 255,000 | |||||
| 2021-01-06 | 2021-01-05 | 4 | Rickey James Paul | ALPN | Stock Option (Right to buy) | D | 13.20 | 120,000 | 120,000 | |||||
| 2021-01-05 | 2021-01-04 | 4 | Hernday Natasha | ALPN | Stock Option (Right to buy) | D | 13.45 | 7,650 | 7,650 | |||||
| 2021-01-05 | 2021-01-04 | 4 | Peetz Christopher | ALPN | Stock Option (Right to buy) | D | 13.45 | 7,650 | 7,650 | |||||
| 2021-01-05 | 2021-01-04 | 4 | Cui Xiangmin | ALPN | Stock Option (Right to buy) | D | 13.45 | 7,650 | 7,650 | |||||
| 2021-01-05 | 2021-01-04 | 4 | Topper James N | ALPN | Stock Option (Right to buy) | D | 13.45 | 7,650 | 7,650 | |||||
| 2021-01-05 | 2021-01-04 | 4 | Venkatesan Jay | ALPN | Stock Option (Right to buy) | D | 13.45 | 7,650 | 7,650 | |||||
| 2021-01-05 | 2021-01-04 | 4 | CONWAY ROBERT E | ALPN | Stock Option (Right to buy) | D | 13.45 | 7,650 | 7,650 | |||||
| 2021-01-05 | 2021-01-04 | 4 | Thompson Peter A. | ALPN | Stock Option (Right to buy) | D | 13.45 | 7,650 | 7,650 | |||||
| 2021-01-04 | 2020-12-31 | 4 | PENG STANFORD L | ALPN | Common Stock | D | 12.6000 | -3,923 | -49 | 24,371 | ||||
| 2021-01-04 | 2020-12-31 | 4 | GOLD MITCHELL | ALPN | Common Stock | D | 12.6000 | -11,123 | -140 | 310,039 | ||||
| 2021-01-04 | 2020-12-31 | 4 | Rickey James Paul | ALPN | Common Stock | D | 12.6000 | -2,258 | -28 | 24,027 | ||||
| 2020-12-30 | 2020-12-28 | 4 | ORBIMED ADVISORS LLC See Footnotes | ALPN | Common Stock | I | 14.2500 | -600,000 | -8,550 | 3,070,955 | ||||
| 2020-12-30 | 2020-12-28 | 4 | Thompson Peter A. See Footnotes | ALPN | Common Stock | I | 14.2500 | -600,000 | -8,550 | 3,070,955 | ||||
| 2020-12-22 | 2020-12-22 | 4 | GOLD MITCHELL | ALPN | Common Stock | D | 260,528 | 321,162 | ||||||
| 2020-12-22 | 2020-12-22 | 4 | GOLD MITCHELL By Alpine ImmunoSciences, L.P. | ALPN | Common Stock | I | -993,801 | 3,000,980 | ||||||
| 2020-12-22 | 2020-12-22 | 4 | Venkatesan Jay | ALPN | Common Stock | D | 181,024 | 202,763 | ||||||
| 2020-12-22 | 2020-12-22 | 4 | Venkatesan Jay By Alpine ImmunoSciences, L.P. | ALPN | Common Stock | I | -993,801 | 3,000,980 | ||||||
| 2020-12-22 | 2020-12-22 | 4 | Alpine ImmunoSciences, L.P. | ALPN | Common Stock | D | -993,801 | 3,000,980 | ||||||
| 2020-12-11 | 2020-12-10 | 4 | Hernday Natasha | ALPN | Stock Option (right to buy) | D | 11.07 | 15,000 | 15,000 | |||||
| 2020-11-23 | 2020-11-19 | 4 | CONWAY ROBERT E By Robert E. Conway Rev Trust and Carolyn J. Conway Rev Trust | ALPN | Common Stock | I | 8.0300 | 10,000 | 80 | 25,000 | ||||
| 2020-07-09 | 2020-07-08 | 4 | PENG STANFORD L | ALPN | Stock Option (right to buy) | D | 7.20 | 50,000 | 50,000 | |||||
| 2020-07-01 | 2020-06-30 | 4 | PENG STANFORD L | ALPN | Common Stock | D | 9.7100 | -3,923 | -38 | 28,294 | ||||
| 2020-07-01 | 2020-06-30 | 4 | GOLD MITCHELL | ALPN | Common Stock | D | 9.7100 | -8,227 | -80 | 60,634 | ||||
| 2020-07-01 | 2020-06-30 | 4 | Rickey James Paul | ALPN | Common Stock | D | 9.7100 | -2,258 | -22 | 26,285 | ||||
| 2020-01-27 | 2020-01-23 | 4 | GOLD MITCHELL | ALPN | Stock Option (right to buy) | D | 3.23 | 270,000 | 270,000 | |||||
| 2020-01-27 | 2020-01-23 | 4 | GOLD MITCHELL | ALPN | Common Stock | D | 67,569 | 68,861 | ||||||
| 2020-01-27 | 2019-12-23 | 4 | GOLD MITCHELL | ALPN | Common Stock | D | -5,000 | 1,292 | ||||||
| 2020-01-27 | 2019-12-11 | 4 | GOLD MITCHELL | ALPN | Common Stock | D | -5,000 | 6,292 | ||||||
| 2020-01-27 | 2020-01-23 | 4 | PENG STANFORD L | ALPN | Stock Option (right to buy) | D | 3.23 | 108,000 | 108,000 | |||||
| 2020-01-27 | 2020-01-23 | 4 | PENG STANFORD L | ALPN | Common Stock | D | 32,217 | 32,217 | ||||||
| 2020-01-27 | 2020-01-23 | 4 | Rickey James Paul | ALPN | Stock Option (right to buy) | D | 3.23 | 102,000 | 102,000 | |||||
| 2020-01-27 | 2020-01-23 | 4 | Rickey James Paul | ALPN | Common Stock | D | 18,543 | 28,543 | ||||||
| 2020-01-06 | 2020-01-02 | 4 | Topper James N | ALPN | Stock Option (Right to buy) | D | 3.62 | 7,650 | 7,650 | |||||
| 2020-01-06 | 2020-01-02 | 4 | Thompson Peter A. | ALPN | Stock Option (Right to buy) | D | 3.62 | 7,650 | 7,650 | |||||
| 2020-01-06 | 2020-01-02 | 4 | Cui Xiangmin | ALPN | Stock Option (Right to buy) | D | 3.62 | 7,650 | 7,650 | |||||
| 2020-01-06 | 2020-01-02 | 4 | CONWAY ROBERT E | ALPN | Stock Option (Right to buy) | D | 3.62 | 7,650 | 7,650 | |||||
| 2020-01-06 | 2020-01-02 | 4 | Venkatesan Jay | ALPN | Stock Option (Right to buy) | D | 3.62 | 7,650 | 7,650 | |||||
| 2020-01-06 | 2020-01-02 | 4 | Peetz Christopher | ALPN | Stock Option (Right to buy) | D | 3.62 | 7,650 | 7,650 | |||||
| 2020-01-06 | 2020-01-02 | 4 | SEKHRI PAUL J | ALPN | Stock Option (Right to buy) | D | 3.62 | 7,650 | 7,650 | |||||
| 2019-06-03 | 2019-05-30 | 4 | Rickey James Paul | ALPN | Common Stock | D | 4.9500 | 10,000 | 50 | 10,000 | ||||
| 2019-02-12 | 2019-02-08 | 4 | TIGER MANAGEMENT L.L.C. | ALPN | Common Stock | I | 5.8498 | -25,000 | -146 | 137,728 | ||||
| 2019-02-08 | 2019-02-06 | 4 | PENG STANFORD L | ALPN | Stock Option (right to buy) | D | 6.51 | 75,000 | 75,000 | |||||
| 2019-02-08 | 2019-02-06 | 4 | Litton Mark James | ALPN | Stock Option (right to buy) | D | 6.51 | 75,000 | 75,000 | |||||
| 2019-02-08 | 2019-02-06 | 4 | Litton Mark James | ALPN | Stock Option (right to buy) | D | 6.81 | 25,000 | 25,000 | |||||
| 2019-02-08 | 2019-02-06 | 4 | GOLD MITCHELL | ALPN | Stock Option (right to buy) | D | 6.51 | 200,000 | 200,000 | |||||
| 2019-02-08 | 2019-02-06 | 4 | Rickey James Paul | ALPN | Stock Option (right to buy) | D | 6.51 | 75,000 | 75,000 | |||||
| 2019-01-23 | 3 | Decheng Capital Management III (Cayman), LLC | ALPN | Common Stock | I | 6,331,470 | ||||||||
| 2019-01-23 | 3 | Decheng Capital Management III (Cayman), LLC | ALPN | Common Stock | I | 6,331,470 | ||||||||
| 2019-01-23 | 3 | Decheng Capital Management III (Cayman), LLC | ALPN | Common Stock | I | 6,331,470 | ||||||||
| 2019-01-23 | 3 | Decheng Capital Management III (Cayman), LLC | ALPN | Common Stock | I | 6,331,470 | ||||||||
| 2019-01-23 | 2019-01-18 | 4 | Cui Xiangmin | ALPN | Stock Option (right to buy) | D | 5.70 | 7,650 | 7,650 | |||||
| 2019-01-23 | 2019-01-18 | 4 | Cui Xiangmin | ALPN | Warrant (right to buy) | I | 12.74 | 5.3700 | 1,234,636 | 6,630 | 1,234,636 | |||
| 2019-01-23 | 2019-01-18 | 4 | Cui Xiangmin | ALPN | Common Stock | I | 5.3700 | 3,165,735 | 17,000 | 3,165,735 | ||||
| 2019-01-23 | 2019-01-18 | 4 | Thompson Peter A. See Footnotes | ALPN | Warrants to Purchase Common Stock | I | 145,251 | 145,251 | ||||||
| 2019-01-23 | 2019-01-18 | 4 | Thompson Peter A. See Footnotes | ALPN | Common Stock | I | 5.3700 | 372,439 | 2,000 | 3,670,955 | ||||
| 2019-01-23 | 2019-01-18 | 4 | ORBIMED ADVISORS LLC See Footnotes | ALPN | Warrants to Purchase Common Stock | I | 145,251 | 145,251 | ||||||
| 2019-01-23 | 2019-01-18 | 4 | ORBIMED ADVISORS LLC See Footnotes | ALPN | Common Stock | I | 5.3700 | 372,439 | 2,000 | 3,670,955 | ||||
| 2019-01-22 | 2019-01-18 | 4 | Venkatesan Jay Alpine ImmunoSciences, L.P. | ALPN | Warrant (right to buy) | I | 12.74 | 74,441 | 74,441 | |||||
| 2019-01-22 | 2019-01-18 | 4 | Venkatesan Jay Alpine ImmunoSciences, L.P. | ALPN | Common Stock | I | 5.3700 | 190,875 | 1,025 | 3,994,781 | ||||
| 2019-01-22 | 2019-01-18 | 4 | GOLD MITCHELL Alpine ImmunoSciences, L.P. | ALPN | Warrant (right to buy) | I | 12.74 | 74,441 | 74,441 | |||||
| 2019-01-22 | 2019-01-18 | 4 | GOLD MITCHELL Alpine ImmunoSciences, L.P. | ALPN | Common Stock | I | 5.3700 | 190,875 | 1,025 | 3,994,781 | ||||
| 2019-01-22 | 2018-05-21 | 4 | GOLD MITCHELL | ALPN | Common Stock | D | -6,000 | 11,292 | ||||||
| 2019-01-22 | 2018-05-15 | 4 | GOLD MITCHELL | ALPN | Common Stock | D | -3,000 | 17,292 | ||||||
| 2019-01-22 | 2018-05-14 | 4 | GOLD MITCHELL | ALPN | Common Stock | D | -3,000 | 20,292 | ||||||
| 2019-01-22 | 2019-01-18 | 4 | Alpine ImmunoSciences, L.P. | ALPN | Warrant (right to buy) | D | 12.74 | 74,441 | 74,441 | |||||
| 2019-01-22 | 2019-01-18 | 4 | Alpine ImmunoSciences, L.P. | ALPN | Common Stock | D | 5.3700 | 190,875 | 1,025 | 3,994,781 | ||||
| 2019-01-22 | 2019-01-18 | 4 | Topper James N By Frazier Life Sciences VIII, L.P. | ALPN | Warrant (Right to Buy) | I | 12.74 | 145,251 | 145,251 | |||||
| 2019-01-22 | 2019-01-18 | 4 | Topper James N By Frazier Life Sciences VIII, L.P. | ALPN | Common Stock | I | 5.3700 | 372,439 | 2,000 | 2,571,450 | ||||
| 2019-01-22 | 2019-01-18 | 4 | Frazier Life Sciences VIII, L.P. | ALPN | Warrant (Right to Buy) | D | 12.74 | 145,251 | 145,251 | |||||
| 2019-01-22 | 2019-01-18 | 4 | Frazier Life Sciences VIII, L.P. | ALPN | Common Stock | D | 5.3700 | 372,439 | 2,000 | 2,571,450 | ||||
| 2019-01-04 | 2019-01-02 | 4 | Peetz Christopher | ALPN | Stock Option (Right to buy) | D | 4.09 | 7,650 | 7,650 | |||||
| 2019-01-04 | 2019-01-02 | 4 | Thompson Peter A. | ALPN | Stock Option (Right to buy) | D | 4.09 | 7,650 | 7,650 | |||||
| 2019-01-04 | 2019-01-02 | 4 | Venkatesan Jay | ALPN | Stock Option (Right to buy) | D | 4.09 | 7,650 | 7,650 | |||||
| 2019-01-04 | 2019-01-02 | 4 | CONWAY ROBERT E | ALPN | Stock Option (Right to buy) | D | 4.09 | 7,650 | 7,650 | |||||
| 2019-01-04 | 2019-01-02 | 4 | Topper James N | ALPN | Stock Option (Right to buy) | D | 4.09 | 7,650 | 7,650 | |||||
| 2019-01-04 | 2019-01-02 | 4 | SEKHRI PAUL J | ALPN | Stock Option (Right to buy) | D | 4.09 | 7,650 | 7,650 | |||||
| 2018-10-02 | 2018-09-28 | 4 | PENG STANFORD L | ALPN | Stock Option (Right to buy) | D | 6.33 | 250,000 | 250,000 | |||||
| 2018-08-08 | 2018-08-06 | 4 | Litton Mark James | ALPN | Stock Option (right to buy) | D | 6.81 | 150,000 | 150,000 | |||||
| 2018-04-24 | 2018-04-20 | 4 | Peetz Christopher | ALPN | Stock Option (right to buy) | D | 7.91 | 7,650 | 7,650 | |||||
| 2018-01-04 | 2018-01-02 | 4 | GOLD MITCHELL | ALPN | Stock Option (Right to buy) | D | 11.31 | 70,000 | 70,000 | |||||
| 2018-01-04 | 2018-01-02 | 4 | Rickey James Paul | ALPN | Stock Option (Right to buy) | D | 11.31 | 45,000 | 45,000 | |||||
| 2018-01-04 | 2018-01-02 | 4 | SEKHRI PAUL J | ALPN | Stock Option (Right to buy) | D | 11.31 | 7,650 | 7,650 | |||||
| 2018-01-04 | 2018-01-02 | 4 | Topper James N | ALPN | Stock Option (Right to buy) | D | 11.31 | 7,650 | 7,650 | |||||
| 2018-01-04 | 2018-01-02 | 4 | Thompson Peter A. | ALPN | Stock Option (Right to buy) | D | 11.31 | 7,650 | 7,650 | |||||
| 2018-01-04 | 2018-01-02 | 4 | PENG STANFORD L | ALPN | Stock Option (Right to buy) | D | 11.31 | 65,000 | 65,000 | |||||
| 2018-01-04 | 2018-01-02 | 4 | Venkatesan Jay | ALPN | Stock Option (Right to buy) | D | 11.31 | 25,000 | 25,000 | |||||
| 2018-01-04 | 2018-01-02 | 4 | CONWAY ROBERT E | ALPN | Stock Option (Right to buy) | D | 11.31 | 7,650 | 7,650 | |||||
| 2017-07-28 | 3 | Frazier Life Sciences VIII, L.P. | ALPN | Common Stock | D | 4,398,022 | ||||||||
| 2017-07-28 | 3 | Frazier Life Sciences VIII, L.P. | ALPN | Common Stock | D | 4,398,022 | ||||||||
| 2017-07-28 | 3 | Frazier Life Sciences VIII, L.P. | ALPN | Common Stock | D | 4,398,022 | ||||||||
| 2017-07-28 | 3 | Frazier Life Sciences VIII, L.P. | ALPN | Common Stock | D | 4,398,022 | ||||||||
| 2017-07-28 | 3 | Frazier Life Sciences VIII, L.P. | ALPN | Common Stock | D | 4,398,022 | ||||||||
| 2017-07-26 | 3 | Alpine ImmunoSciences, L.P. | ALPN | Common Stock | D | 7,607,812 | ||||||||
| 2017-07-26 | 3 | Alpine ImmunoSciences, L.P. | ALPN | Common Stock | D | 7,607,812 | ||||||||
| 2017-07-26 | 3 | Alpine ImmunoSciences, L.P. | ALPN | Common Stock | D | 7,607,812 | ||||||||
| 2017-07-26 | 2017-07-24 | 4 | Thompson Peter A. See Footnotes | ALPN | Common Stock | I | 3,298,516 | 3,298,516 | ||||||
| 2017-07-26 | 2017-07-24 | 4 | GOLD MITCHELL | ALPN | Employee Stock Option (right to buy) | D | 5.02 | 208,916 | 208,916 | |||||
| 2017-07-26 | 2017-07-24 | 4 | GOLD MITCHELL | ALPN | Employee Stock Option (right to buy) | D | 0.65 | 300,624 | 300,624 | |||||
| 2017-07-26 | 2017-07-24 | 4 | GOLD MITCHELL | ALPN | Employee Stock Option (right to buy) | D | 0.45 | 51,242 | 51,242 | |||||
| 2017-07-26 | 2017-07-24 | 4 | GOLD MITCHELL Alpine Immunosciences, L.P. | ALPN | Common Stock | I | 3,803,906 | 3,803,906 | ||||||
| 2017-07-26 | 2017-07-24 | 4 | GOLD MITCHELL | ALPN | Common Stock | D | 23,292 | 23,292 | ||||||
| 2017-07-26 | 2017-07-24 | 4 | GOLD MITCHELL By The Mitch & Dawn Gold Irrevocable Trust fbo Aidan J. Gold | ALPN | Common Stock | I | 24,845 | 24,845 | ||||||
| 2017-07-26 | 2017-07-24 | 4 | GOLD MITCHELL By The Mitch & Dawn Gold Irrevocable Trust fbo Simon P. Gold | ALPN | Common Stock | I | 24,845 | 24,845 | ||||||
| 2017-07-26 | 2017-07-24 | 4 | GOLD MITCHELL By The Mitch & Dawn Gold Irrevocable Trust fbo Noah M. Gold | ALPN | Common Stock | I | 24,845 | 24,845 | ||||||
| 2017-07-26 | 2017-07-24 | 4 | Venkatesan Jay | ALPN | Employee Stock Option (right to buy) | D | 0.45 | 90,063 | 90,063 | |||||
| 2017-07-26 | 2017-07-24 | 4 | Venkatesan Jay Alpine Immunosciences, L.P. | ALPN | Common Stock | I | 3,803,906 | 3,803,906 | ||||||
| 2017-07-26 | 2017-07-24 | 4 | Venkatesan Jay | ALPN | Common Stock | D | 21,739 | 21,739 | ||||||
| 2017-07-26 | 2017-07-24 | 4 | Venkatesan Jay By Raj Venkatesan as UTMA custodian for Nathaniel Graham Venkatesan | ALPN | Common Stock | I | 18,633 | 18,633 | ||||||
| 2017-07-26 | 2017-07-24 | 4 | Venkatesan Jay By Raj Venkatesan as UTMA custodian for Reid Coleman Venkatesan | ALPN | Common Stock | I | 18,633 | 18,633 | ||||||
| 2017-07-26 | 2017-07-24 | 4 | Rickey James Paul | ALPN | Employee Stock Option (right to buy) | D | 5.02 | 74,535 | 74,535 | |||||
| 2017-07-26 | 2017-07-24 | 4 | Topper James N See Footnotes | ALPN | Common Stock | I | 2,199,011 | 2,199,011 | ||||||
| 2017-07-26 | 2017-07-24 | 4 | ORBIMED ADVISORS LLC See Footnotes | ALPN | Common Stock | I | 3,298,516 | 3,298,516 | ||||||
| 2017-07-26 | 2017-07-24 | 4 | PENG STANFORD L | ALPN | Employee Stock Option (right to buy) | D | 0.65 | 37,267 | 37,267 | |||||
| 2017-07-26 | 2017-07-24 | 4 | PENG STANFORD L | ALPN | Employee Stock Option (right to buy) | D | 0.65 | 161,492 | 161,492 | |||||
| 2017-06-22 | 2017-06-20 | 4 | BVF PARTNERS L P/IL | NVLS | Common Stock, $0.001 par value | D | 2.2500 | 1,715 | 4 | 201,811 | ||||
| 2017-06-22 | 2017-06-20 | 4 | BVF PARTNERS L P/IL | NVLS | Common Stock, $0.001 par value | D | 2.2500 | 6,359 | 14 | 717,089 | ||||
| 2017-06-22 | 2017-06-20 | 4 | BVF PARTNERS L P/IL | NVLS | Common Stock, $0.001 par value | D | 2.2500 | 9,732 | 22 | 1,109,258 | ||||
| 2017-06-07 | 2017-06-07 | 4 | BVF PARTNERS L P/IL | NVLS | Common Stock, $0.001 par value | D | 2.2813 | 3,673 | 8 | 200,096 | ||||
| 2017-06-07 | 2017-06-07 | 4 | BVF PARTNERS L P/IL | NVLS | Common Stock, $0.001 par value | D | 2.2813 | 13,046 | 30 | 710,730 | ||||
| 2017-06-07 | 2017-06-07 | 4 | BVF PARTNERS L P/IL | NVLS | Common Stock, $0.001 par value | D | 2.2813 | 20,181 | 46 | 1,099,526 | ||||
| 2017-06-07 | 2017-06-05 | 4 | BVF PARTNERS L P/IL | NVLS | Common Stock, $0.001 par value | D | 2.2906 | 3,920 | 9 | 196,423 | ||||
| 2017-06-07 | 2017-06-05 | 4 | BVF PARTNERS L P/IL | NVLS | Common Stock, $0.001 par value | D | 2.2906 | 12,624 | 29 | 697,684 | ||||
| 2017-06-07 | 2017-06-05 | 4 | BVF PARTNERS L P/IL | NVLS | Common Stock, $0.001 par value | D | 2.2906 | 19,206 | 44 | 1,079,345 | ||||
| 2017-06-01 | 2017-05-31 | 4 | BVF PARTNERS L P/IL | NVLS | Common Stock, $0.001 par value | D | 2.2470 | 2,727 | 6 | 192,503 | ||||
| 2017-06-01 | 2017-05-31 | 4 | BVF PARTNERS L P/IL | NVLS | Common Stock, $0.001 par value | D | 2.2470 | 10,023 | 23 | 685,060 | ||||
| 2017-06-01 | 2017-05-31 | 4 | BVF PARTNERS L P/IL | NVLS | Common Stock, $0.001 par value | D | 2.2470 | 15,350 | 34 | 1,060,139 | ||||
| 2017-06-01 | 2017-05-30 | 4 | BVF PARTNERS L P/IL | NVLS | Common Stock, $0.001 par value | D | 2.2957 | 1,805 | 4 | 189,776 | ||||
| 2017-06-01 | 2017-05-30 | 4 | BVF PARTNERS L P/IL | NVLS | Common Stock, $0.001 par value | D | 2.2957 | 6,903 | 16 | 675,037 | ||||
| 2017-06-01 | 2017-05-30 | 4 | BVF PARTNERS L P/IL | NVLS | Common Stock, $0.001 par value | D | 2.2957 | 10,192 | 23 | 1,044,789 | ||||
| 2017-05-19 | 2017-05-19 | 4 | BVF PARTNERS L P/IL | NVLS | Common Stock, $0.001 par value | D | 2.3000 | 1,124 | 3 | 187,971 | ||||
| 2017-05-19 | 2017-05-19 | 4 | BVF PARTNERS L P/IL | NVLS | Common Stock, $0.001 par value | D | 2.3000 | 4,223 | 10 | 668,134 | ||||
| 2017-05-19 | 2017-05-19 | 4 | BVF PARTNERS L P/IL | NVLS | Common Stock, $0.001 par value | D | 2.3000 | 6,253 | 14 | 1,034,597 | ||||
| 2017-05-19 | 2017-05-18 | 4 | BVF PARTNERS L P/IL | NVLS | Common Stock, $0.001 par value | D | 2.2998 | 2,909 | 7 | 186,847 | ||||
| 2017-05-19 | 2017-05-18 | 4 | BVF PARTNERS L P/IL | NVLS | Common Stock, $0.001 par value | D | 2.2998 | 10,541 | 24 | 663,911 | ||||
| 2017-05-19 | 2017-05-18 | 4 | BVF PARTNERS L P/IL | NVLS | Common Stock, $0.001 par value | D | 2.2998 | 16,436 | 38 | 1,028,344 | ||||
| 2017-05-19 | 2017-05-17 | 4 | BVF PARTNERS L P/IL | NVLS | Common Stock, $0.001 par value | D | 2.2987 | 5,510 | 13 | 183,938 | ||||
| 2017-05-19 | 2017-05-17 | 4 | BVF PARTNERS L P/IL | NVLS | Common Stock, $0.001 par value | D | 2.2987 | 6,897 | 16 | 653,370 | ||||
| 2017-05-19 | 2017-05-17 | 4 | BVF PARTNERS L P/IL | NVLS | Common Stock, $0.001 par value | D | 2.2987 | 24,965 | 57 | 1,011,908 | ||||
| 2017-05-11 | 3 | BVF PARTNERS L P/IL | NVLS | Common Stock, $0.001 par value per share | D | 1,870,417 | ||||||||
| 2017-05-11 | 3 | BVF PARTNERS L P/IL | NVLS | Common Stock, $0.001 par value per share | D | 2,630,471 | ||||||||
| 2017-05-11 | 3 | BVF PARTNERS L P/IL | NVLS | Common Stock, $0.001 par value per share | D | 2,310,352 | ||||||||
| 2017-05-11 | 3 | BVF PARTNERS L P/IL | NVLS | Common Stock, $0.001 par value per share | D | 2,630,471 | ||||||||
| 2017-05-11 | 3 | BVF PARTNERS L P/IL | NVLS | Common Stock, $0.001 par value per share | D | 2,310,352 | ||||||||
| 2017-05-11 | 3 | BVF PARTNERS L P/IL | NVLS | Common Stock, $0.001 par value per share | D | 1,870,417 | ||||||||
| 2017-05-11 | 3 | BVF PARTNERS L P/IL | NVLS | Common Stock, $0.001 par value per share | D | 2,630,471 | ||||||||
| 2017-05-11 | 3 | BVF PARTNERS L P/IL | NVLS | Common Stock, $0.001 par value per share | D | 2,310,352 | ||||||||
| 2017-05-11 | 3 | BVF PARTNERS L P/IL | NVLS | Common Stock, $0.001 par value per share | D | 1,870,417 | ||||||||
| 2017-05-11 | 3 | BVF PARTNERS L P/IL | NVLS | Common Stock, $0.001 par value per share | D | 2,630,471 | ||||||||
| 2017-05-11 | 3 | BVF PARTNERS L P/IL | NVLS | Common Stock, $0.001 par value per share | D | 2,310,352 | ||||||||
| 2017-05-11 | 3 | BVF PARTNERS L P/IL | NVLS | Common Stock, $0.001 par value per share | D | 1,870,417 | ||||||||
| 2017-05-11 | 3 | BVF PARTNERS L P/IL | NVLS | Common Stock, $0.001 par value per share | D | 2,630,471 | ||||||||
| 2017-05-11 | 3 | BVF PARTNERS L P/IL | NVLS | Common Stock, $0.001 par value per share | D | 2,310,352 | ||||||||
| 2017-05-11 | 3 | BVF PARTNERS L P/IL | NVLS | Common Stock, $0.001 par value per share | D | 1,870,417 | ||||||||
| 2017-05-11 | 3 | BVF PARTNERS L P/IL | NVLS | Common Stock, $0.001 par value per share | D | 2,630,471 | ||||||||
| 2017-05-11 | 3 | BVF PARTNERS L P/IL | NVLS | Common Stock, $0.001 par value per share | D | 2,310,352 | ||||||||
| 2017-05-11 | 3 | BVF PARTNERS L P/IL | NVLS | Common Stock, $0.001 par value per share | D | 1,870,417 | ||||||||
| 2017-05-11 | 3 | BVF PARTNERS L P/IL | NVLS | Common Stock, $0.001 par value per share | D | 2,630,471 | ||||||||
| 2017-05-11 | 3 | BVF PARTNERS L P/IL | NVLS | Common Stock, $0.001 par value per share | D | 2,310,352 | ||||||||
| 2017-05-11 | 3 | BVF PARTNERS L P/IL | NVLS | Common Stock, $0.001 par value per share | D | 1,870,417 | ||||||||
| 2017-05-11 | 3 | BVF PARTNERS L P/IL | NVLS | Common Stock, $0.001 par value per share | D | 2,630,471 | ||||||||
| 2017-05-11 | 3 | BVF PARTNERS L P/IL | NVLS | Common Stock, $0.001 par value per share | D | 2,310,352 | ||||||||
| 2017-05-11 | 3 | BVF PARTNERS L P/IL | NVLS | Common Stock, $0.001 par value per share | D | 1,870,417 | ||||||||
| 2017-05-11 | 2017-05-11 | 4 | BVF PARTNERS L P/IL | NVLS | Common Stock, $0.001 par value | D | 2.3429 | 675 | 2 | 178,428 | ||||
| 2017-05-11 | 2017-05-11 | 4 | BVF PARTNERS L P/IL | NVLS | Common Stock, $0.001 par value | D | 2.3429 | 2,565 | 6 | 646,473 | ||||
| 2017-05-11 | 2017-05-11 | 4 | BVF PARTNERS L P/IL | NVLS | Common Stock, $0.001 par value | D | 2.3429 | 3,794 | 9 | 986,943 | ||||
| 2017-05-11 | 2017-05-10 | 4 | BVF PARTNERS L P/IL | NVLS | Common Stock, $0.001 par value | D | 2.3457 | 6,217 | 15 | 177,753 | ||||
| 2017-05-11 | 2017-05-10 | 4 | BVF PARTNERS L P/IL | NVLS | Common Stock, $0.001 par value | D | 2.3457 | 22,092 | 52 | 643,908 | ||||
| 2017-05-11 | 2017-05-10 | 4 | BVF PARTNERS L P/IL | NVLS | Common Stock, $0.001 par value | D | 2.3457 | 33,691 | 79 | 983,149 | ||||
| 2017-05-11 | 2017-05-09 | 4 | BVF PARTNERS L P/IL | NVLS | Common Stock, $0.001 par value | D | 2.2879 | 3,929 | 9 | 171,536 | ||||
| 2017-05-11 | 2017-05-09 | 4 | BVF PARTNERS L P/IL | NVLS | Common Stock, $0.001 par value | D | 2.2879 | 14,274 | 33 | 621,816 | ||||
| 2017-05-11 | 2017-05-09 | 4 | BVF PARTNERS L P/IL | NVLS | Common Stock, $0.001 par value | D | 2.2879 | 21,797 | 50 | 949,458 | ||||
| 2017-05-11 | 2017-05-08 | 4 | CONWAY ROBERT E | NVLS | Common Stock | D | 2.2800 | 15,000 | 34 | 60,000 | ||||
| 2017-05-10 | 2017-05-09 | 4 | CONWAY ROBERT E | NVLS | Common Stock | D | 2.3400 | 5,000 | 12 | 45,000 | ||||
| 2017-05-09 | 2017-05-05 | 4 | TROHA JANICE | NVLS | Common Stock | D | 2.3400 | 10,000 | 23 | 10,000 | ||||
| 2017-05-09 | 2017-05-05 | 4 | CONWAY ROBERT E | NVLS | Common Stock | D | 2.3000 | 20,000 | 46 | 40,000 | ||||
| 2017-05-08 | 2017-05-04 | 4 | CONWAY ROBERT E | NVLS | Common Stock | D | 2.2600 | 10,000 | 23 | 20,000 | ||||
| 2017-01-23 | 2017-01-12 | 4 | TROHA JANICE | NVLS | Stock Option (Right to Buy) | D | 2.21 | 200,000 | 200,000 | |||||
| 2017-01-23 | 2017-01-12 | 4 | Carruthers R Michael | NVLS | Stock Option (Right to Buy) | D | 2.21 | 200,000 | 200,000 | |||||
| 2017-01-05 | 2017-01-04 | 4 | Rodman David Malcom | NVLS | Common Stock | D | 2.2700 | -6,687 | -15 | 11,368 | ||||
| 2017-01-05 | 2017-01-03 | 4 | Rodman David Malcom | NVLS | Restricted Stock Units | D | 0.00 | -18,056 | 162,501 | |||||
| 2017-01-05 | 2017-01-03 | 4 | Rodman David Malcom | NVLS | Common Stock | D | 18,055 | 18,055 | ||||||
| 2016-12-05 | 2016-12-02 | 4 | Carruthers R Michael | NVLS | Common Stock | D | 2.0940 | 24,000 | 50 | 24,000 | ||||
| 2016-10-05 | 2016-10-04 | 4 | Rodman David Malcom | NVLS | Common Stock | D | 7.9600 | -5,820 | -46 | 12,236 | ||||
| 2016-10-05 | 2016-10-03 | 4 | Rodman David Malcom | NVLS | Restricted Stock Units | D | 0.00 | -18,056 | 180,556 | |||||
| 2016-10-05 | 2016-10-03 | 4 | Rodman David Malcom | NVLS | Common Stock | D | 18,056 | 18,056 | ||||||
| 2016-09-14 | 2016-09-12 | 4 | CONWAY ROBERT E | NVLS | Stock Option (Right to Buy) | D | 7.77 | 12,300 | 12,300 | |||||
| 2016-09-14 | 2016-09-12 | 4 | Furst Howard P. | NVLS | Stock Option (Right to Buy) | D | 7.77 | 12,300 | 12,300 | |||||
| 2016-09-14 | 2016-09-12 | 4 | Loh Evan | NVLS | Stock Option (Right to Buy) | D | 7.77 | 12,300 | 12,300 | |||||
| 2016-09-14 | 2016-09-12 | 4 | MOORE JOHN R | NVLS | Stock Option (Right to Buy) | D | 7.77 | 12,300 | 12,300 | |||||
| 2016-09-14 | 2016-09-12 | 4 | TROHA JANICE | NVLS | Stock Option (Right to Buy) | D | 7.77 | 110,000 | 110,000 | |||||
| 2016-09-14 | 2016-09-12 | 4 | SEKHRI PAUL J | NVLS | Stock Option (Right to Buy) | D | 7.77 | 12,300 | 12,300 | |||||
| 2016-09-14 | 2016-09-12 | 4 | Flynn James E Through Deerfield Management Company, L.P. | NVLS | Stock Option (right to buy) | I | 7.77 | 12,300 | 12,300 | |||||
| 2016-09-14 | 2016-09-12 | 4 | Carruthers R Michael | NVLS | Stock Option (Right to Buy) | D | 7.77 | 110,000 | 110,000 | |||||
| 2016-09-14 | 2016-09-12 | 4 | Congleton Jon | NVLS | Stock Option (Right to Buy) | D | 7.77 | 250,000 | 250,000 | |||||
| 2016-09-14 | 2016-09-12 | 4 | Rodman David Malcom | NVLS | Stock Option (Right to Buy) | D | 7.77 | 100,000 | 100,000 | |||||
| 2016-07-06 | 2016-07-05 | 4 | Rodman David Malcom | NVLS | Common Stock | D | 4.6600 | -5,950 | -28 | 12,105 | ||||
| 2016-07-06 | 2016-07-01 | 4 | Rodman David Malcom | NVLS | Restricted Stock Units | D | 0.00 | -18,055 | 198,612 | |||||
| 2016-07-06 | 2016-07-01 | 4 | Rodman David Malcom | NVLS | Common Stock | D | 18,055 | 18,055 | ||||||
| 2016-06-17 | 2016-06-16 | 4 | Congleton Jon | NVLS | Common Stock | D | 3.8689 | 5,000 | 19 | 20,000 | ||||
| 2016-03-25 | 2016-03-24 | 4 | Congleton Jon | NVLS | Common Stock | D | 4.2169 | 5,000 | 21 | 15,000 | ||||
| 2016-03-23 | 2016-03-22 | 4 | Congleton Jon | NVLS | Common Stock | D | 4.3815 | 5,000 | 22 | 10,000 | ||||
| 2015-12-14 | 2015-12-11 | 4 | Congleton Jon | NVLS | Common Stock | D | 8.1000 | 5,000 | 40 | 5,000 | ||||
| 2015-12-11 | 2015-12-09 | 4 | CONWAY ROBERT E | NVLS | Common Stock | D | 8.1000 | 10,000 | 81 | 10,000 | ||||
| 2015-09-15 | 2015-09-11 | 4 | Shoemaker Steven | NVLS | Stock Option (Right to Buy) | D | 15.28 | 39,700 | 39,700 | |||||
| 2015-09-15 | 2015-09-11 | 4 | Carruthers R Michael | NVLS | Stock Option (Right to Buy) | D | 15.28 | 55,400 | 55,400 | |||||
| 2015-09-15 | 2015-09-11 | 4 | Gabriel Sherif | NVLS | Stock Option (Right to Buy) | D | 15.28 | 24,700 | 24,700 | |||||
| 2015-09-15 | 2015-09-11 | 4 | Congleton Jon | NVLS | Stock Option (Right to Buy) | D | 15.28 | 121,100 | 121,100 | |||||
| 2015-09-15 | 2015-09-11 | 4 | Loh Evan | NVLS | Stock Option (Right to Buy) | D | 15.28 | 7,650 | 7,650 | |||||
| 2015-09-15 | 2015-09-11 | 4 | Furst Howard P. | NVLS | Stock Option (Right to Buy) | D | 15.28 | 7,650 | 7,650 | |||||
| 2015-09-15 | 2015-09-11 | 4 | LEFF JONATHAN S | NVLS | Stock Option (Right to Buy) | D | 15.28 | 7,650 | 7,650 | |||||
| 2015-09-15 | 2015-09-11 | 4 | TROHA JANICE | NVLS | Stock Option (Right to Buy) | D | 15.28 | 65,400 | 65,400 | |||||
| 2015-09-15 | 2015-09-11 | 4 | MOORE JOHN R | NVLS | Stock Option (Right to Buy) | D | 15.28 | 7,650 | 7,650 | |||||
| 2015-09-15 | 2015-09-11 | 4 | CONWAY ROBERT E | NVLS | Stock Option (Right to Buy) | D | 15.28 | 7,650 | 7,650 | |||||
| 2015-07-20 | 2015-07-16 | 4 | Furst Howard P. | NVLS | Stock Option (Right to Buy) | D | 17.49 | 11,475 | 11,475 | |||||
| 2015-07-20 | 2015-07-16 | 4 | LEFF JONATHAN S | NVLS | Stock Option (Right to Buy) | D | 17.49 | 11,475 | 11,475 | |||||
| 2015-07-20 | 2015-07-16 | 4 | CONWAY ROBERT E | NVLS | Stock Option (Right to Buy) | D | 17.49 | 11,475 | 11,475 | |||||
| 2015-06-25 | 2015-06-23 | 4 | Flynn James E Through Deerfield Private Design International II, L.P. | NVLS | Series 2 Preferred Stock | I | -936,839 | 0 | ||||||
| 2015-06-25 | 2015-06-23 | 4 | Flynn James E Through Deerfield Private Design Fund II, L.P. | NVLS | Series 2 Preferred Stock | I | -817,541 | 0 | ||||||
| 2015-06-25 | 2015-06-23 | 4 | Flynn James E Through Deerfield Private Design International, L.P. | NVLS | Series 2 Preferred Stock | I | -85,962 | 0 | ||||||
| 2015-06-25 | 2015-06-23 | 4 | Flynn James E Through Deerfield Private Design Fund, L.P. | NVLS | Series 2 Preferred Stock | I | -54,385 | 0 | ||||||
| 2015-06-25 | 2015-06-23 | 4 | Flynn James E Through Deerfield Special Situations Fund, L.P. | NVLS | Series 2 Preferred Stock | I | -385,962 | 0 | ||||||
| 2015-06-25 | 2015-06-23 | 4 | Flynn James E Through Deerfield Private Design International II, L.P. | NVLS | Series 1 Preferred Stock | I | -1,243,423 | 0 | ||||||
| 2015-06-25 | 2015-06-23 | 4 | Flynn James E Through Deerfield Private Design Fund II, L.P. | NVLS | Series 1 Preferred Stock | I | -1,085,085 | 0 | ||||||
| 2015-06-25 | 2015-06-23 | 4 | Flynn James E Through Deerfield Private Design International, L.P. | NVLS | Series 1 Preferred Stock | I | -1,401,003 | 0 | ||||||
| 2015-06-25 | 2015-06-23 | 4 | Flynn James E Through Deerfield Private Design Fund, L.P. | NVLS | Series 1 Preferred Stock | I | -869,667 | 0 | ||||||
| 2015-06-25 | 2015-06-23 | 4 | Flynn James E Through Deerfield Special Situations Fund, L.P. | NVLS | Series 1 Preferred Stock | I | -2,013,613 | 0 | ||||||
| 2015-06-25 | 2015-06-23 | 4 | Flynn James E Through Deerfield Private Design International II, L.P. | NVLS | Common Stock | I | 14.0000 | 77,539 | 1,086 | 832,216 | ||||
| 2015-06-25 | 2015-06-23 | 4 | Flynn James E Through Deerfield Private Design Fund II, L.P. | NVLS | Common Stock | I | 14.0000 | 67,666 | 947 | 726,242 | ||||
| 2015-06-25 | 2015-06-23 | 4 | Flynn James E Through Deerfield Special Situations Fund, L.P. | NVLS | Common Stock | I | 14.0000 | 104,795 | 1,467 | 1,124,740 | ||||
| 2015-06-25 | 2015-06-23 | 4 | Flynn James E Through Deerfield Private Design International II, L.P. | NVLS | Common Stock | I | 324,278 | 754,677 | ||||||
| 2015-06-25 | 2015-06-23 | 4 | Flynn James E Through Deerfield Private Design Fund II, L.P. | NVLS | Common Stock | I | 282,984 | 658,576 | ||||||
| 2015-06-25 | 2015-06-23 | 4 | Flynn James E Through Deerfield Private Design International, L.P. | NVLS | Common Stock | I | 29,755 | 647,152 | ||||||
| 2015-06-25 | 2015-06-23 | 4 | Flynn James E Through Deerfield Private Design Fund, L.P. | NVLS | Common Stock | I | 18,825 | 402,062 | ||||||
| 2015-06-25 | 2015-06-23 | 4 | Flynn James E Through Deerfield Special Situations Fund, L.P. | NVLS | Common Stock | I | 133,597 | 1,019,945 | ||||||
| 2015-06-25 | 2015-06-23 | 4 | Flynn James E Through Deerfield Private Design International II, L.P. | NVLS | Common Stock | I | 430,399 | 430,399 | ||||||
| 2015-06-25 | 2015-06-23 | 4 | Flynn James E Through Deerfield Private Design Fund II, L.P. | NVLS | Common Stock | I | 375,592 | 375,592 | ||||||
| 2015-06-25 | 2015-06-23 | 4 | Flynn James E Through Deerfield Private Design International, L.P. | NVLS | Common Stock | I | 484,944 | 617,397 | ||||||
| 2015-06-25 | 2015-06-23 | 4 | Flynn James E Through Deerfield Private Design Fund, L.P. | NVLS | Common Stock | I | 301,027 | 383,237 | ||||||
| 2015-06-25 | 2015-06-23 | 4 | Flynn James E Through Deerfield Special Situations Fund, L.P. | NVLS | Common Stock | I | 696,993 | 886,348 | ||||||
| 2015-06-24 | 2015-06-22 | 4 | Rock Springs Capital Management LP By Rock Springs Capital Master Fund LP | NVLS | Series 2 Convertible Preferred Stock | I | 2.85 | -364,358 | 0 | |||||
| 2015-06-24 | 2015-06-22 | 4 | Rock Springs Capital Management LP By Rock Springs Capital Master Fund LP | NVLS | Common Stock | I | 14.0000 | 200,000 | 2,800 | 564,358 | ||||
| 2015-06-24 | 2015-06-22 | 4 | Rock Springs Capital Management LP By Rock Springs Capital Master Fund LP | NVLS | Common Stock | I | 364,358 | 364,358 | ||||||
| 2015-06-23 | 2015-06-22 | 4 | Hadley Harbor Master Investors (Cayman) L.P. | NVLS | Series 2 convertible preferred stock | D | -1,052,631 | 0 | ||||||
| 2015-06-23 | 2015-06-22 | 4 | Hadley Harbor Master Investors (Cayman) L.P. | NVLS | Common stock | D | 364,358 | 364,358 | ||||||
| 2015-06-23 | 2015-06-22 | 4 | Hawkes Bay Master Investors (Cayman) L.P. | NVLS | Series 2 convertible preferred stock | D | -818,714 | 0 | ||||||
| 2015-06-23 | 2015-06-22 | 4 | Hawkes Bay Master Investors (Cayman) L.P. | NVLS | Common stock | D | 283,390 | 320,990 | ||||||
| 2015-06-23 | 2015-06-22 | 4 | Hawkes Bay Master Investors (Cayman) L.P. | NVLS | Common stock | D | 14.7479 | 5,500 | 81 | 37,600 | ||||
| 2015-06-23 | 2015-06-19 | 4 | Hawkes Bay Master Investors (Cayman) L.P. | NVLS | Common stock | D | 14.6659 | 11,700 | 172 | 32,100 | ||||
| 2015-06-22 | 2015-06-22 | 4 | Jennison Global Healthcare Master Fund, Ltd. | NVLS | Series 2 convertible preferred stock | D | 14.00 | -303,631 | 0 | |||||
| 2015-06-22 | 2015-06-22 | 4 | Jennison Global Healthcare Master Fund, Ltd. | NVLS | Common Stock | D | 14.0000 | 303,631 | 4,251 | 329,780 | ||||
| 2015-06-22 | 2015-06-22 | 4 | Estate of Arnold H. Snider, III | NVLS | Series 1 convertible preferred stock | D | -2,200,404 | 0 | ||||||
| 2015-06-22 | 2015-06-22 | 4 | Estate of Arnold H. Snider, III | NVLS | Common stock | D | 761,649 | 1,557,228 | ||||||
| 2015-06-19 | 2015-06-18 | 4 | Hawkes Bay Master Investors (Cayman) L.P. | NVLS | Common stock | D | 14.7500 | 6,200 | 91 | 20,400 | ||||
| 2015-06-19 | 2015-06-17 | 4 | Hawkes Bay Master Investors (Cayman) L.P. | NVLS | Common stock | D | 14.7500 | 6,700 | 99 | 14,200 | ||||
| 2015-06-19 | 2015-06-17 | 4 | Hawkes Bay Master Investors (Cayman) L.P. | NVLS | Common stock | D | 14.0000 | 7,500 | 105 | 7,500 | ||||
| 2015-06-19 | 2015-06-17 | 4 | Jennison Global Healthcare Master Fund, Ltd. | NVLS | Common Stock | D | 14.0000 | 26,149 | 366 | 26,149 | ||||
| 2015-06-18 | 3 | Tiger Partners GP, LLC | NVLS | Common Stock | D | 1,301,830 | ||||||||
| 2015-06-18 | 3 | Tiger Partners GP, LLC | NVLS | Common Stock | D | 1,301,830 | ||||||||
| 2015-06-18 | 3 | Tiger Partners GP, LLC | NVLS | Common Stock | D | 1,301,830 | ||||||||
| 2015-06-17 | 3 | TIGER MANAGEMENT L.L.C. | NVLS | Common Stock | I | 1,301,830 | ||||||||
| 2015-06-17 | 3 | TIGER MANAGEMENT L.L.C. | NVLS | Common Stock | I | 1,301,830 | ||||||||
| 2015-06-17 | 3 | Estate of Arnold H. Snider, III | NVLS | Common stock | D | 1,591,158 | ||||||||
| 2015-06-17 | 3 | Estate of Arnold H. Snider, III | NVLS | Common stock | D | 1,591,158 | ||||||||
| 2015-06-16 | 3 | Loh Evan | NVLS | Common Stock | D | 4,326 | ||||||||
| 2015-06-16 | 3 | Loh Evan | NVLS | Common Stock | D | 4,326 | ||||||||
| 2015-06-16 | 3 | TROHA JANICE | NVLS | Common Stock | D | 66,558 | ||||||||
| 2015-06-16 | 3 | TROHA JANICE | NVLS | Common Stock | D | 66,558 | ||||||||
| 2015-06-16 | 3 | MOORE JOHN R | NVLS | Common Stock | D | 4,326 | ||||||||
| 2015-06-16 | 3 | MOORE JOHN R | NVLS | Common Stock | D | 4,326 | ||||||||
| 2015-06-16 | 3 | Deerfield Special Situations Fund, L.P. Through Deerfield Private Design Fund, L.P. | NVLS | Common Stock | I | 486,233 | ||||||||
| 2015-06-16 | 3 | Deerfield Special Situations Fund, L.P. Through Deerfield Private Design International, L.P. | NVLS | Common Stock | I | 536,475 | ||||||||
| 2015-06-16 | 3 | Deerfield Special Situations Fund, L.P. Through Deerfield Special Situations Fund, L.P. | NVLS | Common Stock | I | 593,380 | ||||||||
| 2015-06-16 | 3 | Deerfield Special Situations Fund, L.P. Through Deerfield Private Design Fund, L.P. | NVLS | Common Stock | I | 486,233 | ||||||||
| 2015-06-16 | 3 | Deerfield Special Situations Fund, L.P. Through Deerfield Private Design International, L.P. | NVLS | Common Stock | I | 536,475 | ||||||||
| 2015-06-16 | 3 | Deerfield Special Situations Fund, L.P. Through Deerfield Special Situations Fund, L.P. | NVLS | Common Stock | I | 593,380 | ||||||||
| 2015-06-16 | 3 | Deerfield Special Situations Fund, L.P. Through Deerfield Special Situations Fund, L.P. | NVLS | Common Stock | I | 593,380 | ||||||||
| 2015-06-16 | 3 | Deerfield Special Situations Fund, L.P. Through Deerfield Private Design Fund, L.P. | NVLS | Common Stock | I | 486,233 | ||||||||
| 2015-06-16 | 3 | Deerfield Special Situations Fund, L.P. Through Deerfield Special Situations Fund, L.P. | NVLS | Common Stock | I | 593,380 | ||||||||
| 2015-06-16 | 3 | Deerfield Special Situations Fund, L.P. Through Deerfield Private Design Fund, L.P. | NVLS | Common Stock | I | 486,233 | ||||||||
| 2015-06-16 | 3 | Deerfield Special Situations Fund, L.P. Through Deerfield Special Situations Fund, L.P. | NVLS | Common Stock | I | 593,380 | ||||||||
| 2015-06-16 | 3 | Deerfield Special Situations Fund, L.P. Through Deerfield Private Design International, L.P. | NVLS | Common Stock | I | 536,475 | ||||||||
| 2015-06-16 | 3 | Deerfield Special Situations Fund, L.P. Through Deerfield Special Situations Fund, L.P. | NVLS | Common Stock | I | 593,380 | ||||||||
| 2015-06-16 | 3 | Deerfield Special Situations Fund, L.P. Through Deerfield Private Design International, L.P. | NVLS | Common Stock | I | 536,475 | ||||||||
| 2015-06-16 | 3 | Deerfield Special Situations Fund, L.P. Through Deerfield Private Design Fund, L.P. | NVLS | Common Stock | I | 486,233 | ||||||||
| 2015-06-16 | 3 | Deerfield Special Situations Fund, L.P. Through Deerfield Special Situations Fund, L.P. | NVLS | Common Stock | I | 593,380 | ||||||||
| 2015-06-16 | 3 | Deerfield Special Situations Fund, L.P. Through Deerfield Private Design International, L.P. | NVLS | Common Stock | I | 536,475 | ||||||||
| 2015-06-16 | 3 | Deerfield Special Situations Fund, L.P. Through Deerfield Private Design Fund, L.P. | NVLS | Common Stock | I | 486,233 | ||||||||
| 2015-06-16 | 3 | Deerfield Special Situations Fund, L.P. Through Deerfield Private Design International, L.P. | NVLS | Common Stock | I | 536,475 | ||||||||
| 2015-06-16 | 3 | Deerfield Special Situations Fund, L.P. Through Deerfield Private Design International, L.P. | NVLS | Common Stock | I | 536,475 | ||||||||
| 2015-06-16 | 3 | Deerfield Special Situations Fund, L.P. Through Deerfield Private Design Fund, L.P. | NVLS | Common Stock | I | 486,233 | ||||||||
| 2015-06-16 | 3 | Deerfield Special Situations Fund, L.P. Through Deerfield Special Situations Fund, L.P. | NVLS | Common Stock | I | 593,380 | ||||||||
| 2015-06-16 | 3 | Deerfield Special Situations Fund, L.P. Through Deerfield Private Design Fund, L.P. | NVLS | Common Stock | I | 486,233 | ||||||||
| 2015-06-16 | 3 | Deerfield Special Situations Fund, L.P. Through Deerfield Private Design Fund, L.P. | NVLS | Common Stock | I | 486,233 | ||||||||
| 2015-06-16 | 3 | Deerfield Special Situations Fund, L.P. Through Deerfield Private Design International, L.P. | NVLS | Common Stock | I | 536,475 | ||||||||
| 2015-06-16 | 3 | Deerfield Special Situations Fund, L.P. Through Deerfield Special Situations Fund, L.P. | NVLS | Common Stock | I | 593,380 | ||||||||
| 2015-06-16 | 3 | Deerfield Special Situations Fund, L.P. Through Deerfield Private Design International, L.P. | NVLS | Common Stock | I | 536,475 |
P
非衍生或衍生證券的公開市場或私下買入
S
非衍生或衍生證券的公開市場或私下賣出
A
公司向內部人員授予、獎勵或以其他方式獲取證券（例如股票期權）
C
衍生工具轉換
D
將證券賣出或轉讓回公司
F
使用從公司收到的證券的一部分來支付行使價或稅務負擔。
G
內部人士贈送或接收他人贈送公司股票
K
股權掉期和類似的避險交易
M
行使或轉換從公司獲得的衍生證券（例如期權）
V
內部人士透過Form 4自願報告的一筆交易
J
其他（附有交易描述的腳註）
